A citation-based method for searching scientific literature

D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
Times Cited: 4762







List of co-cited articles
699 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
16

AKT/PKB Signaling: Navigating the Network.
Brendan D Manning, Alex Toker. Cell 2017
15

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
D R Alessi, S R James, C P Downes, A B Holmes, P R Gaffney, C B Reese, P Cohen. Curr Biol 1997
15

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
14

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
823
13

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
13

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
10

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
10

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Yasemin Sancak, Carson C Thoreen, Timothy R Peterson, Robert A Lindquist, Seong A Kang, Eric Spooner, Steven A Carr, David M Sabatini. Mol Cell 2007
868
10

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
David A Guertin, Deanna M Stevens, Carson C Thoreen, Aurora A Burds, Nada Y Kalaany, Jason Moffat, Michael Brown, Kevin J Fitzgerald, David M Sabatini. Dev Cell 2006
10

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
10

AKT/PKB signaling: navigating downstream.
Brendan D Manning, Lewis C Cantley. Cell 2007
10

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
665
9

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Estela Jacinto, Valeria Facchinetti, Dou Liu, Nelyn Soto, Shiniu Wei, Sung Yun Jung, Qiaojia Huang, Jun Qin, Bing Su. Cell 2006
9

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
9

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
9



Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Kim. Nat Cell Biol 2007
820
8

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
8

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Kenta Hara, Yoshiko Maruki, Xiaomeng Long, Ken-ichi Yoshino, Noriko Oshiro, Sujuti Hidayat, Chiharu Tokunaga, Joseph Avruch, Kazuyoshi Yonezawa. Cell 2002
7

mTOR: from growth signal integration to cancer, diabetes and ageing.
Roberto Zoncu, Alejo Efeyan, David M Sabatini. Nat Rev Mol Cell Biol 2011
7

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
452
7

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
Jeffrey A Engelman, Ji Luo, Lewis C Cantley. Nat Rev Genet 2006
7

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.
Chang Hwa Jung, Chang Bong Jun, Seung-Hyun Ro, Young-Mi Kim, Neil Michael Otto, Jing Cao, Mondira Kundu, Do-Hyung Kim. Mol Biol Cell 2009
7

Defining the role of mTOR in cancer.
David A Guertin, David M Sabatini. Cancer Cell 2007
7

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
Arkaitz Carracedo, Li Ma, Julie Teruya-Feldstein, Federico Rojo, Leonardo Salmena, Andrea Alimonti, Ainara Egia, Atsuo T Sasaki, George Thomas, Sara C Kozma,[...]. J Clin Invest 2008
6

mTOR kinase structure, mechanism and regulation.
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
529
6

Fiji: an open-source platform for biological-image analysis.
Johannes Schindelin, Ignacio Arganda-Carreras, Erwin Frise, Verena Kaynig, Mark Longair, Tobias Pietzsch, Stephan Preibisch, Curtis Rueden, Stephan Saalfeld, Benjamin Schmid,[...]. Nat Methods 2012
6

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
John D Carpten, Andrew L Faber, Candice Horn, Gregory P Donoho, Stephen L Briggs, Christiane M Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y Moses, Stephanie Savage,[...]. Nature 2007
898
6

Targeting PI3K in cancer: mechanisms and advances in clinical trials.
Jing Yang, Ji Nie, Xuelei Ma, Yuquan Wei, Yong Peng, Xiawei Wei. Mol Cancer 2019
343
6

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
6


Rheb binds and regulates the mTOR kinase.
Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Kazuyoshi Yonezawa, Joseph Avruch. Curr Biol 2005
666
6

mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
411
6

The PI3K Pathway in Human Disease.
David A Fruman, Honyin Chiu, Benjamin D Hopkins, Shubha Bagrodia, Lewis C Cantley, Robert T Abraham. Cell 2017
822
6

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Louis-Andre Julien, Audrey Carriere, Julie Moreau, Philippe P Roux. Mol Cell Biol 2010
303
6

mTOR signalling and cellular metabolism are mutual determinants in cancer.
Dirk Mossmann, Sujin Park, Michael N Hall. Nat Rev Cancer 2018
262
6

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
6

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
A Brunet, A Bonni, M J Zigmond, M Z Lin, P Juo, L S Hu, M J Anderson, K C Arden, J Blenis, M E Greenberg. Cell 1999
5

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.
Maria A Frias, Carson C Thoreen, Jacob D Jaffe, Wayne Schroder, Tom Sculley, Steven A Carr, David M Sabatini. Curr Biol 2006
486
5

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.
Tsuneo Ikenoue, Ken Inoki, Qian Yang, Xiaoming Zhou, Kun-Liang Guan. EMBO J 2008
460
5

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Carson C Thoreen, Seong A Kang, Jae Won Chang, Qingsong Liu, Jianming Zhang, Yi Gao, Laurie J Reichling, Taebo Sim, David M Sabatini, Nathanael S Gray. J Biol Chem 2009
5


Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
Laura R Pearce, Xu Huang, Jérôme Boudeau, Rafał Pawłowski, Stephan Wullschleger, Maria Deak, Adel F M Ibrahim, Robert Gourlay, Mark A Magnuson, Dario R Alessi. Biochem J 2007
310
5

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.
Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C Newton, Yuxin Mao, Robert Q Miao,[...]. EMBO J 2008
384
5

High frequency of mutations of the PIK3CA gene in human cancers.
Yardena Samuels, Zhenghe Wang, Alberto Bardelli, Natalie Silliman, Janine Ptak, Steve Szabo, Hai Yan, Adi Gazdar, Steven M Powell, Gregory J Riggins,[...]. Science 2004
5

PI3K/Akt: getting it right matters.
T F Franke. Oncogene 2008
490
5

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Omotooke Arojo, Dou Liu, Lixin Wan, Bo Zhai, Yonghao Yu,[...]. Nat Cell Biol 2013
171
5

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
Peggy P Hsu, Seong A Kang, Jonathan Rameseder, Yi Zhang, Kathleen A Ottina, Daniel Lim, Timothy R Peterson, Yongmun Choi, Nathanael S Gray, Michael B Yaffe,[...]. Science 2011
730
5


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.