Christopher P Baines, Robert A Kaiser, Nicole H Purcell, N Scott Blair, Hanna Osinska, Michael A Hambleton, Eric W Brunskill, M Richard Sayen, Roberta A Gottlieb, Gerald W Dorn, Jeffrey Robbins, Jeffery D Molkentin. Nature 2005
Times Cited: 1708
Times Cited: 1708
Times Cited
Times Co-cited
Similarity
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death.
Takashi Nakagawa, Shigeomi Shimizu, Tetsuya Watanabe, Osamu Yamaguchi, Kinya Otsu, Hirotaka Yamagata, Hidenori Inohara, Takeshi Kubo, Yoshihide Tsujimoto. Nature 2005
Takashi Nakagawa, Shigeomi Shimizu, Tetsuya Watanabe, Osamu Yamaguchi, Kinya Otsu, Hirotaka Yamagata, Hidenori Inohara, Takeshi Kubo, Yoshihide Tsujimoto. Nature 2005
41
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia.
Anna C Schinzel, Osamu Takeuchi, Zhihong Huang, Jill K Fisher, Zhipeng Zhou, Jeffery Rubens, Claudio Hetz, Nika N Danial, Michael A Moskowitz, Stanley J Korsmeyer. Proc Natl Acad Sci U S A 2005
Anna C Schinzel, Osamu Takeuchi, Zhihong Huang, Jill K Fisher, Zhipeng Zhou, Jeffery Rubens, Claudio Hetz, Nika N Danial, Michael A Moskowitz, Stanley J Korsmeyer. Proc Natl Acad Sci U S A 2005
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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.
Emy Basso, Lisa Fante, Jonathan Fowlkes, Valeria Petronilli, Michael A Forte, Paolo Bernardi. J Biol Chem 2005
Emy Basso, Lisa Fante, Jonathan Fowlkes, Valeria Petronilli, Michael A Forte, Paolo Bernardi. J Biol Chem 2005
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The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.
Paolo Bernardi, Andrea Rasola, Michael Forte, Giovanna Lippe. Physiol Rev 2015
Paolo Bernardi, Andrea Rasola, Michael Forte, Giovanna Lippe. Physiol Rev 2015
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Dimers of mitochondrial ATP synthase form the permeability transition pore.
Valentina Giorgio, Sophia von Stockum, Manuela Antoniel, Astrid Fabbro, Federico Fogolari, Michael Forte, Gary D Glick, Valeria Petronilli, Mario Zoratti, Ildikó Szabó,[...]. Proc Natl Acad Sci U S A 2013
Valentina Giorgio, Sophia von Stockum, Manuela Antoniel, Astrid Fabbro, Federico Fogolari, Michael Forte, Gary D Glick, Valeria Petronilli, Mario Zoratti, Ildikó Szabó,[...]. Proc Natl Acad Sci U S A 2013
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Inhibition of mitochondrial permeability transition by deletion of the ANT family and CypD.
Jason Karch, Michael J Bround, Hadi Khalil, Michelle A Sargent, Nadina Latchman, Naohiro Terada, Pablo M Peixoto, Jeffery D Molkentin. Sci Adv 2019
Jason Karch, Michael J Bround, Hadi Khalil, Michelle A Sargent, Nadina Latchman, Naohiro Terada, Pablo M Peixoto, Jeffery D Molkentin. Sci Adv 2019
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Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release.
Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott. Physiol Rev 2014
Dmitry B Zorov, Magdalena Juhaszova, Steven J Sollott. Physiol Rev 2014
15
Physiological and pathological roles of the mitochondrial permeability transition pore in the heart.
Jennifer Q Kwong, Jeffery D Molkentin. Cell Metab 2015
Jennifer Q Kwong, Jeffery D Molkentin. Cell Metab 2015
14
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.
Christopher P Baines, Robert A Kaiser, Tatiana Sheiko, William J Craigen, Jeffery D Molkentin. Nat Cell Biol 2007
Christopher P Baines, Robert A Kaiser, Tatiana Sheiko, William J Craigen, Jeffery D Molkentin. Nat Cell Biol 2007
14
An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore.
Kambiz N Alavian, Gisela Beutner, Emma Lazrove, Silvio Sacchetti, Han-A Park, Pawel Licznerski, Hongmei Li, Panah Nabili, Kathryn Hockensmith, Morven Graham,[...]. Proc Natl Acad Sci U S A 2014
Kambiz N Alavian, Gisela Beutner, Emma Lazrove, Silvio Sacchetti, Han-A Park, Pawel Licznerski, Hongmei Li, Panah Nabili, Kathryn Hockensmith, Morven Graham,[...]. Proc Natl Acad Sci U S A 2014
14
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore.
Jason E Kokoszka, Katrina G Waymire, Shawn E Levy, James E Sligh, Jiyang Cai, Dean P Jones, Grant R MacGregor, Douglas C Wallace. Nature 2004
Jason E Kokoszka, Katrina G Waymire, Shawn E Levy, James E Sligh, Jiyang Cai, Dean P Jones, Grant R MacGregor, Douglas C Wallace. Nature 2004
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The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site.
R A Haworth, D R Hunter. Arch Biochem Biophys 1979
R A Haworth, D R Hunter. Arch Biochem Biophys 1979
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Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex.
Valentina Giorgio, Elena Bisetto, Maria Eugenia Soriano, Federica Dabbeni-Sala, Emy Basso, Valeria Petronilli, Michael A Forte, Paolo Bernardi, Giovanna Lippe. J Biol Chem 2009
Valentina Giorgio, Elena Bisetto, Maria Eugenia Soriano, Federica Dabbeni-Sala, Emy Basso, Valeria Petronilli, Michael A Forte, Paolo Bernardi, Giovanna Lippe. J Biol Chem 2009
12
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Edward T Chouchani, Victoria R Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y Sundier, Ellen L Robb, Angela Logan, Sergiy M Nadtochiy, Emily N J Ord, Anthony C Smith,[...]. Nature 2014
Edward T Chouchani, Victoria R Pell, Edoardo Gaude, Dunja Aksentijević, Stephanie Y Sundier, Ellen L Robb, Angela Logan, Sergiy M Nadtochiy, Emily N J Ord, Anthony C Smith,[...]. Nature 2014
12
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
Joshua M Baughman, Fabiana Perocchi, Hany S Girgis, Molly Plovanich, Casey A Belcher-Timme, Yasemin Sancak, X Robert Bao, Laura Strittmatter, Olga Goldberger, Roman L Bogorad,[...]. Nature 2011
Joshua M Baughman, Fabiana Perocchi, Hany S Girgis, Molly Plovanich, Casey A Belcher-Timme, Yasemin Sancak, X Robert Bao, Laura Strittmatter, Olga Goldberger, Roman L Bogorad,[...]. Nature 2011
12
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
Diego De Stefani, Anna Raffaello, Enrico Teardo, Ildikò Szabò, Rosario Rizzuto. Nature 2011
Diego De Stefani, Anna Raffaello, Enrico Teardo, Ildikò Szabò, Rosario Rizzuto. Nature 2011
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Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.
M Crompton, H Ellinger, A Costi. Biochem J 1988
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11
The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition.
Anna W C Leung, Pinadda Varanyuwatana, Andrew P Halestrap. J Biol Chem 2008
Anna W C Leung, Pinadda Varanyuwatana, Andrew P Halestrap. J Biol Chem 2008
11
Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase.
Joe Carroll, Jiuya He, Shujing Ding, Ian M Fearnley, John E Walker. Proc Natl Acad Sci U S A 2019
Joe Carroll, Jiuya He, Shujing Ding, Ian M Fearnley, John E Walker. Proc Natl Acad Sci U S A 2019
14
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice.
Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily H-Y Cheng, Jeffrey Robbins,[...]. Elife 2013
Jason Karch, Jennifer Q Kwong, Adam R Burr, Michelle A Sargent, John W Elrod, Pablo M Peixoto, Sonia Martinez-Caballero, Hanna Osinska, Emily H-Y Cheng, Jeffrey Robbins,[...]. Elife 2013
11
Cyclosporine before PCI in Patients with Acute Myocardial Infarction.
Thien-Tri Cung, Olivier Morel, Guillaume Cayla, Gilles Rioufol, David Garcia-Dorado, Denis Angoulvant, Eric Bonnefoy-Cudraz, Patrice Guérin, Meier Elbaz, Nicolas Delarche,[...]. N Engl J Med 2015
Thien-Tri Cung, Olivier Morel, Guillaume Cayla, Gilles Rioufol, David Garcia-Dorado, Denis Angoulvant, Eric Bonnefoy-Cudraz, Patrice Guérin, Meier Elbaz, Nicolas Delarche,[...]. N Engl J Med 2015
10
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Angela V Hafner, Jing Dai, Ana P Gomes, Chun-Yang Xiao, Carlos M Palmeira, Anthony Rosenzweig, David A Sinclair. Aging (Albany NY) 2010
Angela V Hafner, Jing Dai, Ana P Gomes, Chun-Yang Xiao, Carlos M Palmeira, Anthony Rosenzweig, David A Sinclair. Aging (Albany NY) 2010
10
Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase.
A P Halestrap, A M Davidson. Biochem J 1990
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10
Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition.
Andrea Rasola, Marco Sciacovelli, Federica Chiara, Boris Pantic, William S Brusilow, Paolo Bernardi. Proc Natl Acad Sci U S A 2010
Andrea Rasola, Marco Sciacovelli, Federica Chiara, Boris Pantic, William S Brusilow, Paolo Bernardi. Proc Natl Acad Sci U S A 2010
10
Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy.
J Q Kwong, J Davis, C P Baines, M A Sargent, J Karch, X Wang, T Huang, J D Molkentin. Cell Death Differ 2014
J Q Kwong, J Davis, C P Baines, M A Sargent, J Karch, X Wang, T Huang, J D Molkentin. Cell Death Differ 2014
10
Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore.
M Crompton, S Virji, J M Ward. Eur J Biochem 1998
M Crompton, S Virji, J M Ward. Eur J Biochem 1998
10
The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.
Timothy S Luongo, Jonathan P Lambert, Polina Gross, Mary Nwokedi, Alyssa A Lombardi, Santhanam Shanmughapriya, April C Carpenter, Devin Kolmetzky, Erhe Gao, Jop H van Berlo,[...]. Nature 2017
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10
Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang,[...]. Cell 2012
Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang,[...]. Cell 2012
10
Mitochondrial permeability transition involves dissociation of F1FO ATP synthase dimers and C-ring conformation.
Massimo Bonora, Claudia Morganti, Giampaolo Morciano, Gaia Pedriali, Magdalena Lebiedzinska-Arciszewska, Giorgio Aquila, Carlotta Giorgi, Paola Rizzo, Gianluca Campo, Roberto Ferrari,[...]. EMBO Rep 2017
Massimo Bonora, Claudia Morganti, Giampaolo Morciano, Gaia Pedriali, Magdalena Lebiedzinska-Arciszewska, Giorgio Aquila, Carlotta Giorgi, Paola Rizzo, Gianluca Campo, Roberto Ferrari,[...]. EMBO Rep 2017
9
ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore.
Maria A Neginskaya, Maria E Solesio, Elena V Berezhnaya, Giuseppe F Amodeo, Nelli Mnatsakanyan, Elizabeth A Jonas, Evgeny V Pavlov. Cell Rep 2019
Maria A Neginskaya, Maria E Solesio, Elena V Berezhnaya, Giuseppe F Amodeo, Nelli Mnatsakanyan, Elizabeth A Jonas, Evgeny V Pavlov. Cell Rep 2019
9
Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.
John W Elrod, Renee Wong, Shikha Mishra, Ronald J Vagnozzi, Bhuvana Sakthievel, Sanjeewa A Goonasekera, Jason Karch, Scott Gabel, John Farber, Thomas Force,[...]. J Clin Invest 2010
John W Elrod, Renee Wong, Shikha Mishra, Ronald J Vagnozzi, Bhuvana Sakthievel, Sanjeewa A Goonasekera, Jason Karch, Scott Gabel, John Farber, Thomas Force,[...]. J Clin Invest 2010
9
Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase.
Andrea Carrer, Ludovica Tommasin, Justina Šileikytė, Francesco Ciscato, Riccardo Filadi, Andrea Urbani, Michael Forte, Andrea Rasola, Ildikò Szabò, Michela Carraro,[...]. Nat Commun 2021
Andrea Carrer, Ludovica Tommasin, Justina Šileikytė, Francesco Ciscato, Riccardo Filadi, Andrea Urbani, Michael Forte, Andrea Rasola, Ildikò Szabò, Michela Carraro,[...]. Nat Commun 2021
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Cyclophilin D, Somehow a Master Regulator of Mitochondrial Function.
George A Porter, Gisela Beutner. Biomolecules 2018
George A Porter, Gisela Beutner. Biomolecules 2018
15
Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death.
Tyler M Bauer, Elizabeth Murphy. Circ Res 2020
Tyler M Bauer, Elizabeth Murphy. Circ Res 2020
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What is the mitochondrial permeability transition pore?
Andrew P Halestrap. J Mol Cell Cardiol 2009
Andrew P Halestrap. J Mol Cell Cardiol 2009
8
Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase.
Jiuya He, Holly C Ford, Joe Carroll, Shujing Ding, Ian M Fearnley, John E Walker. Proc Natl Acad Sci U S A 2017
Jiuya He, Holly C Ford, Joe Carroll, Shujing Ding, Ian M Fearnley, John E Walker. Proc Natl Acad Sci U S A 2017
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Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets.
Thomas Briston, David L Selwood, Gyorgy Szabadkai, Michael R Duchen. Trends Pharmacol Sci 2019
Thomas Briston, David L Selwood, Gyorgy Szabadkai, Michael R Duchen. Trends Pharmacol Sci 2019
8
Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition.
Manuel Gutiérrez-Aguilar, Diana L Douglas, Anne K Gibson, Timothy L Domeier, Jeffery D Molkentin, Christopher P Baines. J Mol Cell Cardiol 2014
Manuel Gutiérrez-Aguilar, Diana L Douglas, Anne K Gibson, Timothy L Domeier, Jeffery D Molkentin, Christopher P Baines. J Mol Cell Cardiol 2014
10
Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition.
Massimo Bonora, Angela Bononi, Elena De Marchi, Carlotta Giorgi, Magdalena Lebiedzinska, Saverio Marchi, Simone Patergnani, Alessandro Rimessi, Jan M Suski, Aleksandra Wojtala,[...]. Cell Cycle 2013
Massimo Bonora, Angela Bononi, Elena De Marchi, Carlotta Giorgi, Magdalena Lebiedzinska, Saverio Marchi, Simone Patergnani, Alessandro Rimessi, Jan M Suski, Aleksandra Wojtala,[...]. Cell Cycle 2013
8
Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase.
Jiuya He, Joe Carroll, Shujing Ding, Ian M Fearnley, John E Walker. Proc Natl Acad Sci U S A 2017
Jiuya He, Joe Carroll, Shujing Ding, Ian M Fearnley, John E Walker. Proc Natl Acad Sci U S A 2017
8
NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.
Raz Palty, William F Silverman, Michal Hershfinkel, Teresa Caporale, Stefano L Sensi, Julia Parnis, Christiane Nolte, Daniel Fishman, Varda Shoshan-Barmatz, Sharon Herrmann,[...]. Proc Natl Acad Sci U S A 2010
Raz Palty, William F Silverman, Michal Hershfinkel, Teresa Caporale, Stefano L Sensi, Julia Parnis, Christiane Nolte, Daniel Fishman, Varda Shoshan-Barmatz, Sharon Herrmann,[...]. Proc Natl Acad Sci U S A 2010
8
p53 opens the mitochondrial permeability transition pore to trigger necrosis.
Angelina V Vaseva, Natalie D Marchenko, Kyungmin Ji, Stella E Tsirka, Sonja Holzmann, Ute M Moll. Cell 2012
Angelina V Vaseva, Natalie D Marchenko, Kyungmin Ji, Stella E Tsirka, Sonja Holzmann, Ute M Moll. Cell 2012
8
Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore.
John W Elrod, Jeffery D Molkentin. Circ J 2013
John W Elrod, Jeffery D Molkentin. Circ J 2013
8
Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion.
Stephen Hurst, Fabrice Gonnot, Maya Dia, Claire Crola Da Silva, Ludovic Gomez, Shey-Shing Sheu. Cell Death Dis 2020
Stephen Hurst, Fabrice Gonnot, Maya Dia, Claire Crola Da Silva, Ludovic Gomez, Shey-Shing Sheu. Cell Death Dis 2020
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The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.
Xin Pan, Jie Liu, Tiffany Nguyen, Chengyu Liu, Junhui Sun, Yanjie Teng, Maria M Fergusson, Ilsa I Rovira, Michele Allen, Danielle A Springer,[...]. Nat Cell Biol 2013
Xin Pan, Jie Liu, Tiffany Nguyen, Chengyu Liu, Junhui Sun, Yanjie Teng, Maria M Fergusson, Ilsa I Rovira, Michele Allen, Danielle A Springer,[...]. Nat Cell Biol 2013
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Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D.
T Bochaton, C Crola-Da-Silva, B Pillot, C Villedieu, L Ferreras, M R Alam, H Thibault, M Strina, A Gharib, M Ovize,[...]. J Mol Cell Cardiol 2015
T Bochaton, C Crola-Da-Silva, B Pillot, C Villedieu, L Ferreras, M R Alam, H Thibault, M Strina, A Gharib, M Ovize,[...]. J Mol Cell Cardiol 2015
9
Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore.
Tiffany T Nguyen, Mark V Stevens, Mark Kohr, Charles Steenbergen, Michael N Sack, Elizabeth Murphy. J Biol Chem 2011
Tiffany T Nguyen, Mark V Stevens, Mark Kohr, Charles Steenbergen, Michael N Sack, Elizabeth Murphy. J Biol Chem 2011
7
Cyclophilin D-mediated regulation of the permeability transition pore is altered in mice lacking the mitochondrial calcium uniporter.
Randi J Parks, Sara Menazza, Kira M Holmström, Georgios Amanakis, Maria Fergusson, Hanley Ma, Angel M Aponte, Paolo Bernardi, Toren Finkel, Elizabeth Murphy. Cardiovasc Res 2019
Randi J Parks, Sara Menazza, Kira M Holmström, Georgios Amanakis, Maria Fergusson, Hanley Ma, Angel M Aponte, Paolo Bernardi, Toren Finkel, Elizabeth Murphy. Cardiovasc Res 2019
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Effect of cyclosporine on reperfusion injury in acute myocardial infarction.
Christophe Piot, Pierre Croisille, Patrick Staat, Hélène Thibault, Gilles Rioufol, Nathan Mewton, Rachid Elbelghiti, Thien Tri Cung, Eric Bonnefoy, Denis Angoulvant,[...]. N Engl J Med 2008
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7
The unique histidine in OSCP subunit of F-ATP synthase mediates inhibition of the permeability transition pore by acidic pH.
Manuela Antoniel, Kristen Jones, Salvatore Antonucci, Barbara Spolaore, Federico Fogolari, Valeria Petronilli, Valentina Giorgio, Michela Carraro, Fabio Di Lisa, Michael Forte,[...]. EMBO Rep 2018
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10
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.