Mario F Fraga, Esteban Ballestar, Maria F Paz, Santiago Ropero, Fernando Setien, Maria L Ballestar, Damia Heine-Suñer, Juan C Cigudosa, Miguel Urioste, Javier Benitez, Manuel Boix-Chornet, Abel Sanchez-Aguilera, Charlotte Ling, Emma Carlsson, Pernille Poulsen, Allan Vaag, Zarko Stephan, Tim D Spector, Yue-Zhong Wu, Christoph Plass, Manel Esteller. Proc Natl Acad Sci U S A 2005
Times Cited: 1949
Times Cited: 1949
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Genome-wide methylation profiles reveal quantitative views of human aging rates.
Gregory Hannum, Justin Guinney, Ling Zhao, Li Zhang, Guy Hughes, SriniVas Sadda, Brandy Klotzle, Marina Bibikova, Jian-Bing Fan, Yuan Gao,[...]. Mol Cell 2013
Gregory Hannum, Justin Guinney, Ling Zhao, Li Zhang, Guy Hughes, SriniVas Sadda, Brandy Klotzle, Marina Bibikova, Jian-Bing Fan, Yuan Gao,[...]. Mol Cell 2013
26
DNA methylation-based biomarkers and the epigenetic clock theory of ageing.
Steve Horvath, Kenneth Raj. Nat Rev Genet 2018
Steve Horvath, Kenneth Raj. Nat Rev Genet 2018
24
The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
20
An epigenetic biomarker of aging for lifespan and healthspan.
Morgan E Levine, Ake T Lu, Austin Quach, Brian H Chen, Themistocles L Assimes, Stefania Bandinelli, Lifang Hou, Andrea A Baccarelli, James D Stewart, Yun Li,[...]. Aging (Albany NY) 2018
Morgan E Levine, Ake T Lu, Austin Quach, Brian H Chen, Themistocles L Assimes, Stefania Bandinelli, Lifang Hou, Andrea A Baccarelli, James D Stewart, Yun Li,[...]. Aging (Albany NY) 2018
11
DNA methylation aging clocks: challenges and recommendations.
Christopher G Bell, Robert Lowe, Peter D Adams, Andrea A Baccarelli, Stephan Beck, Jordana T Bell, Brock C Christensen, Vadim N Gladyshev, Bastiaan T Heijmans, Steve Horvath,[...]. Genome Biol 2019
Christopher G Bell, Robert Lowe, Peter D Adams, Andrea A Baccarelli, Stephan Beck, Jordana T Bell, Brock C Christensen, Vadim N Gladyshev, Bastiaan T Heijmans, Steve Horvath,[...]. Genome Biol 2019
10
DNA methylation profiles in monozygotic and dizygotic twins.
Zachary A Kaminsky, Thomas Tang, Sun-Chong Wang, Carolyn Ptak, Gabriel H T Oh, Albert H C Wong, Laura A Feldcamp, Carl Virtanen, Jonas Halfvarson, Curt Tysk,[...]. Nat Genet 2009
Zachary A Kaminsky, Thomas Tang, Sun-Chong Wang, Carolyn Ptak, Gabriel H T Oh, Albert H C Wong, Laura A Feldcamp, Carl Virtanen, Jonas Halfvarson, Curt Tysk,[...]. Nat Genet 2009
9
Epigenetic Mechanisms of Longevity and Aging.
Payel Sen, Parisha P Shah, Raffaella Nativio, Shelley L Berger. Cell 2016
Payel Sen, Parisha P Shah, Raffaella Nativio, Shelley L Berger. Cell 2016
9
DNA methylation arrays as surrogate measures of cell mixture distribution.
Eugene Andres Houseman, William P Accomando, Devin C Koestler, Brock C Christensen, Carmen J Marsit, Heather H Nelson, John K Wiencke, Karl T Kelsey. BMC Bioinformatics 2012
Eugene Andres Houseman, William P Accomando, Devin C Koestler, Brock C Christensen, Carmen J Marsit, Heather H Nelson, John K Wiencke, Karl T Kelsey. BMC Bioinformatics 2012
9
Aging of blood can be tracked by DNA methylation changes at just three CpG sites.
Carola Ingrid Weidner, Qiong Lin, Carmen Maike Koch, Lewin Eisele, Fabian Beier, Patrick Ziegler, Dirk Olaf Bauerschlag, Karl-Heinz Jöckel, Raimund Erbel, Thomas Walter Mühleisen,[...]. Genome Biol 2014
Carola Ingrid Weidner, Qiong Lin, Carmen Maike Koch, Lewin Eisele, Fabian Beier, Patrick Ziegler, Dirk Olaf Bauerschlag, Karl-Heinz Jöckel, Raimund Erbel, Thomas Walter Mühleisen,[...]. Genome Biol 2014
9
Distinct DNA methylomes of newborns and centenarians.
Holger Heyn, Ning Li, Humberto J Ferreira, Sebastian Moran, David G Pisano, Antonio Gomez, Javier Diez, Jose V Sanchez-Mut, Fernando Setien, F Javier Carmona,[...]. Proc Natl Acad Sci U S A 2012
Holger Heyn, Ning Li, Humberto J Ferreira, Sebastian Moran, David G Pisano, Antonio Gomez, Javier Diez, Jose V Sanchez-Mut, Fernando Setien, F Javier Carmona,[...]. Proc Natl Acad Sci U S A 2012
8
DNA methylation-based measures of biological age: meta-analysis predicting time to death.
Brian H Chen, Riccardo E Marioni, Elena Colicino, Marjolein J Peters, Cavin K Ward-Caviness, Pei-Chien Tsai, Nicholas S Roetker, Allan C Just, Ellen W Demerath, Weihua Guan,[...]. Aging (Albany NY) 2016
Brian H Chen, Riccardo E Marioni, Elena Colicino, Marjolein J Peters, Cavin K Ward-Caviness, Pei-Chien Tsai, Nicholas S Roetker, Allan C Just, Ellen W Demerath, Weihua Guan,[...]. Aging (Albany NY) 2016
8
DNA methylation GrimAge strongly predicts lifespan and healthspan.
Ake T Lu, Austin Quach, James G Wilson, Alex P Reiner, Abraham Aviv, Kenneth Raj, Lifang Hou, Andrea A Baccarelli, Yun Li, James D Stewart,[...]. Aging (Albany NY) 2019
Ake T Lu, Austin Quach, James G Wilson, Alex P Reiner, Abraham Aviv, Kenneth Raj, Lifang Hou, Andrea A Baccarelli, Yun Li, James D Stewart,[...]. Aging (Albany NY) 2019
8
An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.
Steve Horvath, Michael Gurven, Morgan E Levine, Benjamin C Trumble, Hillard Kaplan, Hooman Allayee, Beate R Ritz, Brian Chen, Ake T Lu, Tammy M Rickabaugh,[...]. Genome Biol 2016
Steve Horvath, Michael Gurven, Morgan E Levine, Benjamin C Trumble, Hillard Kaplan, Hooman Allayee, Beate R Ritz, Brian Chen, Ake T Lu, Tammy M Rickabaugh,[...]. Genome Biol 2016
7
DNA methylation and healthy human aging.
Meaghan J Jones, Sarah J Goodman, Michael S Kobor. Aging Cell 2015
Meaghan J Jones, Sarah J Goodman, Michael S Kobor. Aging Cell 2015
7
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays.
Martin J Aryee, Andrew E Jaffe, Hector Corrada-Bravo, Christine Ladd-Acosta, Andrew P Feinberg, Kasper D Hansen, Rafael A Irizarry. Bioinformatics 2014
Martin J Aryee, Andrew E Jaffe, Hector Corrada-Bravo, Christine Ladd-Acosta, Andrew P Feinberg, Kasper D Hansen, Rafael A Irizarry. Bioinformatics 2014
7
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.
Austin Quach, Morgan E Levine, Toshiko Tanaka, Ake T Lu, Brian H Chen, Luigi Ferrucci, Beate Ritz, Stefania Bandinelli, Marian L Neuhouser, Jeannette M Beasley,[...]. Aging (Albany NY) 2017
Austin Quach, Morgan E Levine, Toshiko Tanaka, Ake T Lu, Brian H Chen, Luigi Ferrucci, Beate Ritz, Stefania Bandinelli, Marian L Neuhouser, Jeannette M Beasley,[...]. Aging (Albany NY) 2017
7
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context.
Brock C Christensen, E Andres Houseman, Carmen J Marsit, Shichun Zheng, Margaret R Wrensch, Joseph L Wiemels, Heather H Nelson, Margaret R Karagas, James F Padbury, Raphael Bueno,[...]. PLoS Genet 2009
Brock C Christensen, E Andres Houseman, Carmen J Marsit, Shichun Zheng, Margaret R Wrensch, Joseph L Wiemels, Heather H Nelson, Margaret R Karagas, James F Padbury, Raphael Bueno,[...]. PLoS Genet 2009
7
Functions of DNA methylation: islands, start sites, gene bodies and beyond.
Peter A Jones. Nat Rev Genet 2012
Peter A Jones. Nat Rev Genet 2012
7
DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.
Adam E Field, Neil A Robertson, Tina Wang, Aaron Havas, Trey Ideker, Peter D Adams. Mol Cell 2018
Adam E Field, Neil A Robertson, Tina Wang, Aaron Havas, Trey Ideker, Peter D Adams. Mol Cell 2018
6
Integrative analysis of 111 reference human epigenomes.
Anshul Kundaje, Wouter Meuleman, Jason Ernst, Misha Bilenky, Angela Yen, Alireza Heravi-Moussavi, Pouya Kheradpour, Zhizhuo Zhang, Jianrong Wang, Michael J Ziller,[...]. Nature 2015
Anshul Kundaje, Wouter Meuleman, Jason Ernst, Misha Bilenky, Angela Yen, Alireza Heravi-Moussavi, Pouya Kheradpour, Zhizhuo Zhang, Jianrong Wang, Michael J Ziller,[...]. Nature 2015
6
limma powers differential expression analyses for RNA-sequencing and microarray studies.
Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth. Nucleic Acids Res 2015
Matthew E Ritchie, Belinda Phipson, Di Wu, Yifang Hu, Charity W Law, Wei Shi, Gordon K Smyth. Nucleic Acids Res 2015
6
Decline in genomic DNA methylation through aging in a cohort of elderly subjects.
Valentina Bollati, Joel Schwartz, Robert Wright, Augusto Litonjua, Letizia Tarantini, Helen Suh, David Sparrow, Pantel Vokonas, Andrea Baccarelli. Mech Ageing Dev 2009
Valentina Bollati, Joel Schwartz, Robert Wright, Augusto Litonjua, Letizia Tarantini, Helen Suh, David Sparrow, Pantel Vokonas, Andrea Baccarelli. Mech Ageing Dev 2009
6
Epigenetic regulation of ageing: linking environmental inputs to genomic stability.
Bérénice A Benayoun, Elizabeth A Pollina, Anne Brunet. Nat Rev Mol Cell Biol 2015
Bérénice A Benayoun, Elizabeth A Pollina, Anne Brunet. Nat Rev Mol Cell Biol 2015
6
Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer's disease related cognitive functioning.
Morgan E Levine, Ake T Lu, David A Bennett, Steve Horvath. Aging (Albany NY) 2015
Morgan E Levine, Ake T Lu, David A Bennett, Steve Horvath. Aging (Albany NY) 2015
6
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains.
Vardhman K Rakyan, Thomas A Down, Siarhei Maslau, Toby Andrew, Tsun-Po Yang, Huriya Beyan, Pamela Whittaker, Owen T McCann, Sarah Finer, Ana M Valdes,[...]. Genome Res 2010
Vardhman K Rakyan, Thomas A Down, Siarhei Maslau, Toby Andrew, Tsun-Po Yang, Huriya Beyan, Pamela Whittaker, Owen T McCann, Sarah Finer, Ana M Valdes,[...]. Genome Res 2010
6
Epigenetics of discordant monozygotic twins: implications for disease.
Juan E Castillo-Fernandez, Tim D Spector, Jordana T Bell. Genome Med 2014
Juan E Castillo-Fernandez, Tim D Spector, Jordana T Bell. Genome Med 2014
7
Epigenetics and the environment: emerging patterns and implications.
Robert Feil, Mario F Fraga. Nat Rev Genet 2012
Robert Feil, Mario F Fraga. Nat Rev Genet 2012
6
Persistent epigenetic differences associated with prenatal exposure to famine in humans.
Bastiaan T Heijmans, Elmar W Tobi, Aryeh D Stein, Hein Putter, Gerard J Blauw, Ezra S Susser, P Eline Slagboom, L H Lumey. Proc Natl Acad Sci U S A 2008
Bastiaan T Heijmans, Elmar W Tobi, Aryeh D Stein, Hein Putter, Gerard J Blauw, Ezra S Susser, P Eline Slagboom, L H Lumey. Proc Natl Acad Sci U S A 2008
6
Geroscience: linking aging to chronic disease.
Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin,[...]. Cell 2014
Brian K Kennedy, Shelley L Berger, Anne Brunet, Judith Campisi, Ana Maria Cuervo, Elissa S Epel, Claudio Franceschi, Gordon J Lithgow, Richard I Morimoto, Jeffrey E Pessin,[...]. Cell 2014
5
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus.
Biola M Javierre, Agustin F Fernandez, Julia Richter, Fatima Al-Shahrour, J Ignacio Martin-Subero, Javier Rodriguez-Ubreva, Maria Berdasco, Mario F Fraga, Terrance P O'Hanlon, Lisa G Rider,[...]. Genome Res 2010
Biola M Javierre, Agustin F Fernandez, Julia Richter, Fatima Al-Shahrour, J Ignacio Martin-Subero, Javier Rodriguez-Ubreva, Maria Berdasco, Mario F Fraga, Terrance P O'Hanlon, Lisa G Rider,[...]. Genome Res 2010
5
A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data.
Andrew E Teschendorff, Francesco Marabita, Matthias Lechner, Thomas Bartlett, Jesper Tegner, David Gomez-Cabrero, Stephan Beck. Bioinformatics 2013
Andrew E Teschendorff, Francesco Marabita, Matthias Lechner, Thomas Bartlett, Jesper Tegner, David Gomez-Cabrero, Stephan Beck. Bioinformatics 2013
5
Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic Variations with Aging.
Peggie Cheung, Francesco Vallania, Hayley C Warsinske, Michele Donato, Steven Schaffert, Sarah E Chang, Mai Dvorak, Cornelia L Dekker, Mark M Davis, Paul J Utz,[...]. Cell 2018
Peggie Cheung, Francesco Vallania, Hayley C Warsinske, Michele Donato, Steven Schaffert, Sarah E Chang, Mai Dvorak, Cornelia L Dekker, Mark M Davis, Paul J Utz,[...]. Cell 2018
5
The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation.
Yvonne Chan, Jason E Fish, Cheryl D'Abreo, Steven Lin, G Brett Robb, Anouk-Martine Teichert, Fotula Karantzoulis-Fegaras, Angela Keightley, Brent M Steer, Philip A Marsden. J Biol Chem 2004
Yvonne Chan, Jason E Fish, Cheryl D'Abreo, Steven Lin, G Brett Robb, Anouk-Martine Teichert, Fotula Karantzoulis-Fegaras, Angela Keightley, Brent M Steer, Philip A Marsden. J Biol Chem 2004
5
The epigenetic basis of twin discordance in age-related diseases.
Pernille Poulsen, Manel Esteller, Allan Vaag, Mario F Fraga. Pediatr Res 2007
Pernille Poulsen, Manel Esteller, Allan Vaag, Mario F Fraga. Pediatr Res 2007
5
Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort.
Qihua Tan, Bastiaan T Heijmans, Jacob V B Hjelmborg, Mette Soerensen, Kaare Christensen, Lene Christiansen. Int J Epidemiol 2016
Qihua Tan, Bastiaan T Heijmans, Jacob V B Hjelmborg, Mette Soerensen, Kaare Christensen, Lene Christiansen. Int J Epidemiol 2016
10
Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in mouse muscle stem cells.
Irene Hernando-Herraez, Brendan Evano, Thomas Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen Clark, Simon Andrews, Shahragim Tajbakhsh, Wolf Reik. Nat Commun 2019
Irene Hernando-Herraez, Brendan Evano, Thomas Stubbs, Pierre-Henri Commere, Marc Jan Bonder, Stephen Clark, Simon Andrews, Shahragim Tajbakhsh, Wolf Reik. Nat Commun 2019
11
Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan.
Asa Johansson, Stefan Enroth, Ulf Gyllensten. PLoS One 2013
Asa Johansson, Stefan Enroth, Ulf Gyllensten. PLoS One 2013
5
DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative.
Morgan E Levine, H Dean Hosgood, Brian Chen, Devin Absher, Themistocles Assimes, Steve Horvath. Aging (Albany NY) 2015
Morgan E Levine, H Dean Hosgood, Brian Chen, Devin Absher, Themistocles Assimes, Steve Horvath. Aging (Albany NY) 2015
5
Charting a dynamic DNA methylation landscape of the human genome.
Michael J Ziller, Hongcang Gu, Fabian Müller, Julie Donaghey, Linus T-Y Tsai, Oliver Kohlbacher, Philip L De Jager, Evan D Rosen, David A Bennett, Bradley E Bernstein,[...]. Nature 2013
Michael J Ziller, Hongcang Gu, Fabian Müller, Julie Donaghey, Linus T-Y Tsai, Oliver Kohlbacher, Philip L De Jager, Evan D Rosen, David A Bennett, Bradley E Bernstein,[...]. Nature 2013
5
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms.
Roderick C Slieker, Maarten van Iterson, René Luijk, Marian Beekman, Daria V Zhernakova, Matthijs H Moed, Hailiang Mei, Michiel van Galen, Patrick Deelen, Marc Jan Bonder,[...]. Genome Biol 2016
Roderick C Slieker, Maarten van Iterson, René Luijk, Marian Beekman, Daria V Zhernakova, Matthijs H Moed, Hailiang Mei, Michiel van Galen, Patrick Deelen, Marc Jan Bonder,[...]. Genome Biol 2016
9
5
The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis.
Peter D Fransquet, Jo Wrigglesworth, Robyn L Woods, Michael E Ernst, Joanne Ryan. Clin Epigenetics 2019
Peter D Fransquet, Jo Wrigglesworth, Robyn L Woods, Michael E Ernst, Joanne Ryan. Clin Epigenetics 2019
9
Regulation of chromatin by histone modifications.
Andrew J Bannister, Tony Kouzarides. Cell Res 2011
Andrew J Bannister, Tony Kouzarides. Cell Res 2011
5
Epigenetic Signatures of Cigarette Smoking.
Roby Joehanes, Allan C Just, Riccardo E Marioni, Luke C Pilling, Lindsay M Reynolds, Pooja R Mandaviya, Weihua Guan, Tao Xu, Cathy E Elks, Stella Aslibekyan,[...]. Circ Cardiovasc Genet 2016
Roby Joehanes, Allan C Just, Riccardo E Marioni, Luke C Pilling, Lindsay M Reynolds, Pooja R Mandaviya, Weihua Guan, Tao Xu, Cathy E Elks, Stella Aslibekyan,[...]. Circ Cardiovasc Genet 2016
5
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