Giuseppe Nicastro, Rajesh P Menon, Laura Masino, Philip P Knowles, Neil Q McDonald, Annalisa Pastore. Proc Natl Acad Sci U S A 2005
Times Cited: 138
Times Cited: 138
Times Cited
Times Co-cited
Similarity
The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity.
Barrington Burnett, Fusheng Li, Randall N Pittman. Hum Mol Genet 2003
Barrington Burnett, Fusheng Li, Randall N Pittman. Hum Mol Genet 2003
49
Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain.
Yuxin Mao, Francesca Senic-Matuglia, Pier Paolo Di Fiore, Simona Polo, Michael E Hodsdon, Pietro De Camilli. Proc Natl Acad Sci U S A 2005
Yuxin Mao, Francesca Senic-Matuglia, Pier Paolo Di Fiore, Simona Polo, Michael E Hodsdon, Pietro De Camilli. Proc Natl Acad Sci U S A 2005
49
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.
Brett J Winborn, Sue M Travis, Sokol V Todi, K Matthew Scaglione, Ping Xu, Aislinn J Williams, Robert E Cohen, Junmin Peng, Henry L Paulson. J Biol Chem 2008
Brett J Winborn, Sue M Travis, Sokol V Todi, K Matthew Scaglione, Ping Xu, Aislinn J Williams, Robert E Cohen, Junmin Peng, Henry L Paulson. J Biol Chem 2008
43
Josephin domain of ataxin-3 contains two distinct ubiquitin-binding sites.
Giuseppe Nicastro, Laura Masino, Veronica Esposito, Rajesh P Menon, Alfonso De Simone, Franca Fraternali, Annalisa Pastore. Biopolymers 2009
Giuseppe Nicastro, Laura Masino, Veronica Esposito, Rajesh P Menon, Alfonso De Simone, Franca Fraternali, Annalisa Pastore. Biopolymers 2009
64
CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1.
Y Kawaguchi, T Okamoto, M Taniwaki, M Aizawa, M Inoue, S Katayama, H Kawakami, S Nakamura, M Nishimura, I Akiguchi. Nat Genet 1994
Y Kawaguchi, T Okamoto, M Taniwaki, M Aizawa, M Inoue, S Katayama, H Kawakami, S Nakamura, M Nishimura, I Akiguchi. Nat Genet 1994
41
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.
Andrew M Ellisdon, Bronwen Thomas, Stephen P Bottomley. J Biol Chem 2006
Andrew M Ellisdon, Bronwen Thomas, Stephen P Bottomley. J Biol Chem 2006
38
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3.
Laura Masino, Giuseppe Nicastro, Rajesh P Menon, Fabrizio Dal Piaz, Lesley Calder, Annalisa Pastore. J Mol Biol 2004
Laura Masino, Giuseppe Nicastro, Rajesh P Menon, Fabrizio Dal Piaz, Lesley Calder, Annalisa Pastore. J Mol Biol 2004
35
Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis.
Ellen W Doss-Pepe, Edward S Stenroos, William G Johnson, Kiran Madura. Mol Cell Biol 2003
Ellen W Doss-Pepe, Edward S Stenroos, William G Johnson, Kiran Madura. Mol Cell Biol 2003
31
Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.
Laura Masino, Valeria Musi, Rajesh P Menon, Paola Fusi, Geoff Kelly, Thomas A Frenkiel, Yvon Trottier, Annalisa Pastore. FEBS Lett 2003
Laura Masino, Valeria Musi, Rajesh P Menon, Paola Fusi, Geoff Kelly, Thomas A Frenkiel, Yvon Trottier, Annalisa Pastore. FEBS Lett 2003
32
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3.
Sokol V Todi, Brett J Winborn, K Matthew Scaglione, Jessica R Blount, Sue M Travis, Henry L Paulson. EMBO J 2009
Sokol V Todi, Brett J Winborn, K Matthew Scaglione, Jessica R Blount, Sue M Travis, Henry L Paulson. EMBO J 2009
27
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.
Xiaoyan Zhong, Randall N Pittman. Hum Mol Genet 2006
Xiaoyan Zhong, Randall N Pittman. Hum Mol Genet 2006
26
Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein.
Andrew M Ellisdon, Mary C Pearce, Stephen P Bottomley. J Mol Biol 2007
Andrew M Ellisdon, Mary C Pearce, Stephen P Bottomley. J Mol Biol 2007
45
Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3.
Sarah J Shoesmith Berke, Yaohui Chai, Ginger L Marrs, Hsiang Wen, Henry L Paulson. J Biol Chem 2005
Sarah J Shoesmith Berke, Yaohui Chai, Ginger L Marrs, Hsiang Wen, Henry L Paulson. J Biol Chem 2005
32
Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways.
Yaohui Chai, Sarah Shoesmith Berke, Robert E Cohen, Henry L Paulson. J Biol Chem 2004
Yaohui Chai, Sarah Shoesmith Berke, Robert E Cohen, Henry L Paulson. J Biol Chem 2004
25
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
Giuseppe Nicastro, Sokol V Todi, Ezgi Karaca, Alexandre M J J Bonvin, Henry L Paulson, Annalisa Pastore. PLoS One 2010
Giuseppe Nicastro, Sokol V Todi, Ezgi Karaca, Alexandre M J J Bonvin, Henry L Paulson, Annalisa Pastore. PLoS One 2010
52
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
H L Paulson, M K Perez, Y Trottier, J Q Trojanowski, S H Subramony, S S Das, P Vig, J L Mandel, K H Fischbeck, R N Pittman. Neuron 1997
H L Paulson, M K Perez, Y Trottier, J Q Trojanowski, S H Subramony, S S Das, P Vig, J L Mandel, K H Fischbeck, R N Pittman. Neuron 1997
24
Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
Sokol V Todi, K Matthew Scaglione, Jessica R Blount, Venkatesha Basrur, Kevin P Conlon, Annalisa Pastore, Kojo Elenitoba-Johnson, Henry L Paulson. J Biol Chem 2010
Sokol V Todi, K Matthew Scaglione, Jessica R Blount, Venkatesha Basrur, Kevin P Conlon, Annalisa Pastore, Kojo Elenitoba-Johnson, Henry L Paulson. J Biol Chem 2010
35
Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.
John M Warrick, Lance M Morabito, Julide Bilen, Beth Gordesky-Gold, Lynn Z Faust, Henry L Paulson, Nancy M Bonini. Mol Cell 2005
John M Warrick, Lance M Morabito, Julide Bilen, Beth Gordesky-Gold, Lynn Z Faust, Henry L Paulson, Nancy M Bonini. Mol Cell 2005
22
Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
G Wang, N Sawai, S Kotliarova, I Kanazawa, N Nukina. Hum Mol Genet 2000
G Wang, N Sawai, S Kotliarova, I Kanazawa, N Nukina. Hum Mol Genet 2000
21
Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3.
Michelle K M Chow, Joel P Mackay, James C Whisstock, Martin J Scanlon, Stephen P Bottomley. Biochem Biophys Res Commun 2004
Michelle K M Chow, Joel P Mackay, James C Whisstock, Martin J Scanlon, Stephen P Bottomley. Biochem Biophys Res Commun 2004
43
Towards a structural understanding of the fibrillization pathway in Machado-Joseph's disease: trapping early oligomers of non-expanded ataxin-3.
Luís Gales, Luísa Cortes, Carla Almeida, Carlos V Melo, Maria do Carmo Costa, Patrícia Maciel, David T Clarke, Ana Margarida Damas, Sandra Macedo-Ribeiro. J Mol Biol 2005
Luís Gales, Luísa Cortes, Carla Almeida, Carlos V Melo, Maria do Carmo Costa, Patrícia Maciel, David T Clarke, Ana Margarida Damas, Sandra Macedo-Ribeiro. J Mol Biol 2005
35
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
Laura Masino, Giuseppe Nicastro, Alfonso De Simone, Lesley Calder, Justin Molloy, Annalisa Pastore. Biophys J 2011
Laura Masino, Giuseppe Nicastro, Alfonso De Simone, Lesley Calder, Justin Molloy, Annalisa Pastore. Biophys J 2011
53
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
Barrington G Burnett, Randall N Pittman. Proc Natl Acad Sci U S A 2005
Barrington G Burnett, Randall N Pittman. Proc Natl Acad Sci U S A 2005
20
Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3.
Qiuyan Wang, Lianyun Li, Yihong Ye. J Cell Biol 2006
Qiuyan Wang, Lianyun Li, Yihong Ye. J Cell Biol 2006
19
Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.
Giuseppe Nicastro, Michael Habeck, Laura Masino, Dmitri I Svergun, Annalisa Pastore. J Biomol NMR 2006
Giuseppe Nicastro, Michael Habeck, Laura Masino, Dmitri I Svergun, Annalisa Pastore. J Biomol NMR 2006
55
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation.
Bernd O Evert, Julieta Araujo, Ana M Vieira-Saecker, Rob A I de Vos, Sigrid Harendza, Thomas Klockgether, Ullrich Wüllner. J Neurosci 2006
Bernd O Evert, Julieta Araujo, Ana M Vieira-Saecker, Rob A I de Vos, Sigrid Harendza, Thomas Klockgether, Ullrich Wüllner. J Neurosci 2006
19
Functional interactions as a survival strategy against abnormal aggregation.
Laura Masino, Giuseppe Nicastro, Lesley Calder, Michele Vendruscolo, Annalisa Pastore. FASEB J 2011
Laura Masino, Giuseppe Nicastro, Lesley Calder, Michele Vendruscolo, Annalisa Pastore. FASEB J 2011
30
A genomic and functional inventory of deubiquitinating enzymes.
Sebastian M B Nijman, Mark P A Luna-Vargas, Arno Velds, Thijn R Brummelkamp, Annette M G Dirac, Titia K Sixma, René Bernards. Cell 2005
Sebastian M B Nijman, Mark P A Luna-Vargas, Arno Velds, Thijn R Brummelkamp, Annette M G Dirac, Titia K Sixma, René Bernards. Cell 2005
18
Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities.
Fusheng Li, Todd Macfarlan, Randall N Pittman, Debabrata Chakravarti. J Biol Chem 2002
Fusheng Li, Todd Macfarlan, Randall N Pittman, Debabrata Chakravarti. J Biol Chem 2002
18
An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.
A E Bevivino, P J Loll. Proc Natl Acad Sci U S A 2001
A E Bevivino, P J Loll. Proc Natl Acad Sci U S A 2001
18
Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.
Ashwani K Thakur, Murali Jayaraman, Rakesh Mishra, Monika Thakur, Veronique M Chellgren, In-Ja L Byeon, Dalaver H Anjum, Ravindra Kodali, Trevor P Creamer, James F Conway,[...]. Nat Struct Mol Biol 2009
Ashwani K Thakur, Murali Jayaraman, Rakesh Mishra, Monika Thakur, Veronique M Chellgren, In-Ja L Byeon, Dalaver H Anjum, Ravindra Kodali, Trevor P Creamer, James F Conway,[...]. Nat Struct Mol Biol 2009
18
Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain.
H L Paulson, S S Das, P B Crino, M K Perez, S C Patel, D Gotsdiner, K H Fischbeck, R N Pittman. Ann Neurol 1997
H L Paulson, S S Das, P B Crino, M K Perez, S C Patel, D Gotsdiner, K H Fischbeck, R N Pittman. Ann Neurol 1997
17
Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics.
Hartmut Scheel, Stefan Tomiuk, Kay Hofmann. Hum Mol Genet 2003
Hartmut Scheel, Stefan Tomiuk, Kay Hofmann. Hum Mol Genet 2003
17
Polyglutamine diseases: the special case of ataxin-3 and Machado-Joseph disease.
Carlos A Matos, Sandra de Macedo-Ribeiro, Ana Luísa Carvalho. Prog Neurobiol 2011
Carlos A Matos, Sandra de Macedo-Ribeiro, Ana Luísa Carvalho. Prog Neurobiol 2011
18
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.
Min Hu, Pingwei Li, Muyang Li, Wenyu Li, Tingting Yao, Jia-Wei Wu, Wei Gu, Robert E Cohen, Yigong Shi. Cell 2002
Min Hu, Pingwei Li, Muyang Li, Wenyu Li, Tingting Yao, Jia-Wei Wu, Wei Gu, Robert E Cohen, Yigong Shi. Cell 2002
16
Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3.
Ana-João Rodrigues, Giovanni Coppola, Cláudia Santos, Maria do Carmo Costa, Michael Ailion, Jorge Sequeiros, Daniel H Geschwind, Patrícia Maciel. FASEB J 2007
Ana-João Rodrigues, Giovanni Coppola, Cláudia Santos, Maria do Carmo Costa, Michael Ailion, Jorge Sequeiros, Daniel H Geschwind, Patrícia Maciel. FASEB J 2007
31
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Ina Schmitt, Marion Linden, Hassan Khazneh, Bernd O Evert, Peter Breuer, Thomas Klockgether, Ullrich Wuellner. Biochem Biophys Res Commun 2007
Ina Schmitt, Marion Linden, Hassan Khazneh, Bernd O Evert, Peter Breuer, Thomas Klockgether, Ullrich Wuellner. Biochem Biophys Res Commun 2007
16
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
Annett Boeddrich, Sébastien Gaumer, Annette Haacke, Nikolay Tzvetkov, Mario Albrecht, Bernd O Evert, Eva C Müller, Rudi Lurz, Peter Breuer, Nancy Schugardt,[...]. EMBO J 2006
Annett Boeddrich, Sébastien Gaumer, Annette Haacke, Nikolay Tzvetkov, Mario Albrecht, Bernd O Evert, Eva C Müller, Rudi Lurz, Peter Breuer, Nancy Schugardt,[...]. EMBO J 2006
16
Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.
Michelle K M Chow, Andrew M Ellisdon, Lisa D Cabrita, Stephen P Bottomley. J Biol Chem 2004
Michelle K M Chow, Andrew M Ellisdon, Lisa D Cabrita, Stephen P Bottomley. J Biol Chem 2004
28
Breaking the chains: structure and function of the deubiquitinases.
David Komander, Michael J Clague, Sylvie Urbé. Nat Rev Mol Cell Biol 2009
David Komander, Michael J Clague, Sylvie Urbé. Nat Rev Mol Cell Biol 2009
16
Structural transformation of the tandem ubiquitin-interacting motifs in ataxin-3 and their cooperative interactions with ubiquitin chains.
Ai-Xin Song, Chen-Jie Zhou, Yu Peng, Xue-Chao Gao, Zi-Ren Zhou, Qing-Shan Fu, Jing Hong, Dong-Hai Lin, Hong-Yu Hu. PLoS One 2010
Ai-Xin Song, Chen-Jie Zhou, Yu Peng, Xue-Chao Gao, Zi-Ren Zhou, Qing-Shan Fu, Jing Hong, Dong-Hai Lin, Hong-Yu Hu. PLoS One 2010
47
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP.
K Matthew Scaglione, Eszter Zavodszky, Sokol V Todi, Srikanth Patury, Ping Xu, Edgardo Rodríguez-Lebrón, Svetlana Fischer, John Konen, Ana Djarmati, Junmin Peng,[...]. Mol Cell 2011
K Matthew Scaglione, Eszter Zavodszky, Sokol V Todi, Srikanth Patury, Ping Xu, Edgardo Rodríguez-Lebrón, Svetlana Fischer, John Konen, Ana Djarmati, Junmin Peng,[...]. Mol Cell 2011
16
Proteotoxic stress increases nuclear localization of ataxin-3.
Christopher P Reina, Xiaoyan Zhong, Randall N Pittman. Hum Mol Genet 2010
Christopher P Reina, Xiaoyan Zhong, Randall N Pittman. Hum Mol Genet 2010
24
Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.
Nihar Ranjan Jana, Priyanka Dikshit, Anand Goswami, Svetlana Kotliarova, Shigeo Murata, Keiji Tanaka, Nobuyuki Nukina. J Biol Chem 2005
Nihar Ranjan Jana, Priyanka Dikshit, Anand Goswami, Svetlana Kotliarova, Shigeo Murata, Keiji Tanaka, Nobuyuki Nukina. J Biol Chem 2005
15
Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.
Amy L Robertson, Stephen J Headey, Helen M Saunders, Heath Ecroyd, Martin J Scanlon, John A Carver, Stephen P Bottomley. Proc Natl Acad Sci U S A 2010
Amy L Robertson, Stephen J Headey, Helen M Saunders, Heath Ecroyd, Martin J Scanlon, John A Carver, Stephen P Bottomley. Proc Natl Acad Sci U S A 2010
21
Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity.
Sokol V Todi, Mario N Laco, Brett J Winborn, Sue M Travis, Hsiang M Wen, Henry L Paulson. J Biol Chem 2007
Sokol V Todi, Mario N Laco, Brett J Winborn, Sue M Travis, Hsiang M Wen, Henry L Paulson. J Biol Chem 2007
36
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
Masaki Matsumoto, Masayoshi Yada, Shigetsugu Hatakeyama, Hiroshi Ishimoto, Teiichi Tanimura, Shoji Tsuji, Akira Kakizuka, Masatoshi Kitagawa, Keiichi I Nakayama. EMBO J 2004
Masaki Matsumoto, Masayoshi Yada, Shigetsugu Hatakeyama, Hiroshi Ishimoto, Teiichi Tanimura, Shoji Tsuji, Akira Kakizuka, Masatoshi Kitagawa, Keiichi I Nakayama. EMBO J 2004
14
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.
Thorsten Mueller, Peter Breuer, Ina Schmitt, Jochen Walter, Bernd O Evert, Ullrich Wüllner. Hum Mol Genet 2009
Thorsten Mueller, Peter Breuer, Ina Schmitt, Jochen Walter, Bernd O Evert, Ullrich Wüllner. Hum Mol Genet 2009
20
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.
Francisca E Reyes-Turcu, Karen H Ventii, Keith D Wilkinson. Annu Rev Biochem 2009
Francisca E Reyes-Turcu, Karen H Ventii, Keith D Wilkinson. Annu Rev Biochem 2009
14
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.