A citation-based method for searching scientific literature

Akihiko Yokoyama, Tim C P Somervaille, Kevin S Smith, Orit Rozenblatt-Rosen, Matthew Meyerson, Michael L Cleary. Cell 2005
Times Cited: 375







List of co-cited articles
1499 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Dmitry Borkin, Shihan He, Hongzhi Miao, Katarzyna Kempinska, Jonathan Pollock, Jennifer Chase, Trupta Purohit, Bhavna Malik, Ting Zhao, Jingya Wang,[...]. Cancer Cell 2015
205
59

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
Jolanta Grembecka, Shihan He, Aibin Shi, Trupta Purohit, Andrew G Muntean, Roderick J Sorenson, Hollis D Showalter, Marcelo J Murai, Amalia M Belcher, Thomas Hartley,[...]. Nat Chem Biol 2012
254
52


A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
Andrei V Krivtsov, Kathryn Evans, Jayant Y Gadrey, Benjamin K Eschle, Charlie Hatton, Hannah J Uckelmann, Kenneth N Ross, Florian Perner, Sarah N Olsen, Tara Pritchard,[...]. Cancer Cell 2019
114
44

The MLL recombinome of acute leukemias in 2017.
C Meyer, T Burmeister, D Gröger, G Tsaur, L Fechina, A Renneville, R Sutton, N C Venn, M Emerenciano, M S Pombo-de-Oliveira,[...]. Leukemia 2018
310
40

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
Szymon Klossowski, Hongzhi Miao, Katarzyna Kempinska, Tao Wu, Trupta Purohit, EunGi Kim, Brian M Linhares, Dong Chen, Gloria Jih, Eric Perkey,[...]. J Clin Invest 2020
75
48

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Aibin Shi, Marcelo J Murai, Shihan He, George Lund, Thomas Hartley, Trupta Purohit, Gireesh Reddy, Maksymilian Chruszcz, Jolanta Grembecka, Tomasz Cierpicki. Blood 2012
127
33

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.
Michael W M Kühn, Evelyn Song, Zhaohui Feng, Amit Sinha, Chun-Wei Chen, Aniruddha J Deshpande, Monica Cusan, Noushin Farnoud, Annalisa Mupo, Carolyn Grove,[...]. Cancer Discov 2016
96
31

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Kathrin M Bernt, Nan Zhu, Amit U Sinha, Sridhar Vempati, Joerg Faber, Andrei V Krivtsov, Zhaohui Feng, Natalie Punt, Amanda Daigle, Lars Bullinger,[...]. Cancer Cell 2011
590
29

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Christina R Majer, Christopher J Sneeringer, Jeffrey Song, L Danielle Johnston, Margaret Porter Scott, Jesse J Smith, Yonghong Xiao,[...]. Cancer Cell 2011
644
29

MLL translocations, histone modifications and leukaemia stem-cell development.
Andrei V Krivtsov, Scott A Armstrong. Nat Rev Cancer 2007
796
28

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Aravind Basavapathruni, Lei Jin, P Ann Boriack-Sjodin, Christina J Allain, Christine R Klaus, Alejandra Raimondi, Margaret Porter Scott,[...]. Blood 2013
457
28

Interaction of MLL amino terminal sequences with menin is required for transformation.
Corrado Caslini, Zhaohai Yang, Mohamad El-Osta, Thomas A Milne, Robert K Slany, Jay L Hess. Cancer Res 2007
128
26

Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia.
Hannah J Uckelmann, Stephanie M Kim, Eric M Wong, Charles Hatton, Hugh Giovinazzo, Jayant Y Gadrey, Andrei V Krivtsov, Frank G Rücker, Konstanze Döhner, Gerard M McGeehan,[...]. Science 2020
66
39

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.
Akihiko Yokoyama, Zhong Wang, Joanna Wysocka, Mrinmoy Sanyal, Deborah J Aufiero, Issay Kitabayashi, Winship Herr, Michael L Cleary. Mol Cell Biol 2004
512
25

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
Eytan M Stein, Guillermo Garcia-Manero, David A Rizzieri, Raoul Tibes, Jesus G Berdeja, Michael R Savona, Mojca Jongen-Lavrenic, Jessica K Altman, Blythe Thomson, Stephen J Blakemore,[...]. Blood 2018
185
24

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Christina M Hughes, Orit Rozenblatt-Rosen, Thomas A Milne, Terry D Copeland, Stuart S Levine, Jeffrey C Lee, D Neil Hayes, Kalai Selvi Shanmugam, Arindam Bhattacharjee, Christine A Biondi,[...]. Mol Cell 2004
468
22

hDOT1L links histone methylation to leukemogenesis.
Yuki Okada, Qin Feng, Yihui Lin, Qi Jiang, Yaqiang Li, Vernon M Coffield, Lishan Su, Guoliang Xu, Yi Zhang. Cell 2005
589
22

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
Ya-Xiong Chen, Jizhou Yan, Karen Keeshan, Anthony T Tubbs, Haoren Wang, Albert Silva, Eric J Brown, Jay L Hess, Warren S Pear, Xianxin Hua. Proc Natl Acad Sci U S A 2006
117
22

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Jing Huang, Buddha Gurung, Bingbing Wan, Smita Matkar, Natalia A Veniaminova, Ke Wan, Juanita L Merchant, Xianxin Hua, Ming Lei. Nature 2012
180
22

MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.
Amanda C Winters, Kathrin M Bernt. Front Pediatr 2017
193
21

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
Andrei V Krivtsov, David Twomey, Zhaohui Feng, Matthew C Stubbs, Yingzi Wang, Joerg Faber, Jason E Levine, Jing Wang, William C Hahn, D Gary Gilliland,[...]. Nature 2006
21


Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
Dmitry Borkin, Szymon Klossowski, Jonathan Pollock, Hongzhi Miao, Brian M Linhares, Katarzyna Kempinska, Zhuang Jin, Trupta Purohit, Bo Wen, Miao He,[...]. J Med Chem 2018
34
58

MLL targets SET domain methyltransferase activity to Hox gene promoters.
Thomas A Milne, Scott D Briggs, Hugh W Brock, Mary Ellen Martin, Denise Gibbs, C David Allis, Jay L Hess. Mol Cell 2002
786
19

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.
C Dafflon, V J Craig, H Méreau, J Gräsel, B Schacher Engstler, G Hoffman, F Nigsch, S Gaulis, L Barys, M Ito,[...]. Leukemia 2017
53
35

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.
Thomas A Milne, Jaehoon Kim, Gang G Wang, Sonja C Stadler, Venkatesha Basrur, Sarah J Whitcomb, Zhanxin Wang, Alexander J Ruthenburg, Kojo S J Elenitoba-Johnson, Robert G Roeder,[...]. Mol Cell 2010
150
18

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.
Andrew G Muntean, Jiaying Tan, Kajal Sitwala, Yongsheng Huang, Joel Bronstein, James A Connelly, Venkatesha Basrur, Kojo S J Elenitoba-Johnson, Jay L Hess. Cancer Cell 2010
159
18

Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Fang Cao, Elizabeth C Townsend, Hacer Karatas, Jing Xu, Li Li, Shirley Lee, Liu Liu, Yong Chen, Peter Ouillette, Jidong Zhu,[...]. Mol Cell 2014
196
17

Regulation of MLL1 H3K4 methyltransferase activity by its core components.
Yali Dou, Thomas A Milne, Alexander J Ruthenburg, Seunghee Lee, Jae Woon Lee, Gregory L Verdine, C David Allis, Robert G Roeder. Nat Struct Mol Biol 2006
529
17

Transcription control by the ENL YEATS domain in acute leukaemia.
Michael A Erb, Thomas G Scott, Bin E Li, Huafeng Xie, Joshiawa Paulk, Hyuk-Soo Seo, Amanda Souza, Justin M Roberts, Shiva Dastjerdi, Dennis L Buckley,[...]. Nature 2017
142
17

Genomic Classification and Prognosis in Acute Myeloid Leukemia.
Elli Papaemmanuil, Moritz Gerstung, Lars Bullinger, Verena I Gaidzik, Peter Paschka, Nicola D Roberts, Nicola E Potter, Michael Heuser, Felicitas Thol, Niccolo Bolli,[...]. N Engl J Med 2016
17

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
Dmitry Borkin, Jonathan Pollock, Katarzyna Kempinska, Trupta Purohit, Xiaoqin Li, Bo Wen, Ting Zhao, Hongzhi Miao, Shirish Shukla, Miao He,[...]. J Med Chem 2016
41
41

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Yufei Chen, Konstantinos Anastassiadis, Andrea Kranz, A Francis Stewart, Kathrin Arndt, Claudia Waskow, Akihiko Yokoyama, Kenneth Jones, Tobias Neff, Yoo Lee,[...]. Cancer Cell 2017
52
30

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Chun-Wei Chen, Richard P Koche, Amit U Sinha, Aniruddha J Deshpande, Nan Zhu, Rowena Eng, John G Doench, Haiming Xu, Scott H Chu, Jun Qi,[...]. Nat Med 2015
142
16

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.
Thomas A Milne, Christina M Hughes, Ricardo Lloyd, Zhaohai Yang, Orit Rozenblatt-Rosen, Yali Dou, Robert W Schnepp, Cynthia Krankel, Virginia A Livolsi, Denise Gibbs,[...]. Proc Natl Acad Sci U S A 2005
339
16

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.
Scott A Armstrong, Jane E Staunton, Lewis B Silverman, Rob Pieters, Monique L den Boer, Mark D Minden, Stephen E Sallan, Eric S Lander, Todd R Golub, Stanley J Korsmeyer. Nat Genet 2002
16

High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction.
Shihan He, Timothy J Senter, Jonathan Pollock, Changho Han, Sunil Kumar Upadhyay, Trupta Purohit, Rocco D Gogliotti, Craig W Lindsley, Tomasz Cierpicki, Shaun R Stauffer,[...]. J Med Chem 2014
60
26

Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Shilin Xu, Angelo Aguilar, Tianfeng Xu, Ke Zheng, Liyue Huang, Jeanne Stuckey, Krishnapriya Chinnaswamy, Denzil Bernard, Ester Fernández-Salas, Liu Liu,[...]. Angew Chem Int Ed Engl 2018
34
44

AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.
Chengqi Lin, Edwin R Smith, Hidehisa Takahashi, Ka Chun Lai, Skylar Martin-Brown, Laurence Florens, Michael P Washburn, Joan W Conaway, Ronald C Conaway, Ali Shilatifard. Mol Cell 2010
397
15

H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Andrei V Krivtsov, Zhaohui Feng, Madeleine E Lemieux, Joerg Faber, Sridhar Vempati, Amit U Sinha, Xiaobo Xia, Jonathan Jesneck, Adrian P Bracken, Lewis B Silverman,[...]. Cancer Cell 2008
390
15

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Johannes Zuber, Junwei Shi, Eric Wang, Amy R Rappaport, Harald Herrmann, Edward A Sison, Daniel Magoon, Jun Qi, Katharina Blatt, Mark Wunderlich,[...]. Nature 2011
15

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
Li Zhu, Qin Li, Stephen H K Wong, Min Huang, Brianna J Klein, Jinfeng Shen, Larissa Ikenouye, Masayuki Onishi, Dominik Schneidawind, Corina Buechele,[...]. Cancer Discov 2016
78
17

The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis.
Bibhu P Mishra, Kristin M Zaffuto, Erika L Artinger, Tonis Org, Hanna K A Mikkola, Chao Cheng, Malek Djabali, Patricia Ernst. Cell Rep 2014
87
16

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Mark A Dawson, Rab K Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M Savitski,[...]. Nature 2011
14

Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.
S He, B Malik, D Borkin, H Miao, S Shukla, K Kempinska, T Purohit, J Wang, L Chen, B Parkin,[...]. Leukemia 2016
35
40

Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein.
Marcelo J Murai, Maksymilian Chruszcz, Gireesh Reddy, Jolanta Grembecka, Tomasz Cierpicki. J Biol Chem 2011
67
20

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.
Akihiko Yokoyama, Min Lin, Alpana Naresh, Issay Kitabayashi, Michael L Cleary. Cancer Cell 2010
252
14

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.
Liling Wan, Hong Wen, Yuanyuan Li, Jie Lyu, Yuanxin Xi, Takayuki Hoshii, Julia K Joseph, Xiaolu Wang, Yong-Hwee E Loh, Michael A Erb,[...]. Nature 2017
117
14

Menin: a scaffold protein that controls gene expression and cell signaling.
Smita Matkar, Austin Thiel, Xianxin Hua. Trends Biochem Sci 2013
125
14


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.