Akihiko Yokoyama, Tim C P Somervaille, Kevin S Smith, Orit Rozenblatt-Rosen, Matthew Meyerson, Michael L Cleary. Cell 2005
Times Cited: 375
Times Cited: 375
Times Cited
Times Co-cited
Similarity
Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Dmitry Borkin, Shihan He, Hongzhi Miao, Katarzyna Kempinska, Jonathan Pollock, Jennifer Chase, Trupta Purohit, Bhavna Malik, Ting Zhao, Jingya Wang,[...]. Cancer Cell 2015
Dmitry Borkin, Shihan He, Hongzhi Miao, Katarzyna Kempinska, Jonathan Pollock, Jennifer Chase, Trupta Purohit, Bhavna Malik, Ting Zhao, Jingya Wang,[...]. Cancer Cell 2015
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Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
Jolanta Grembecka, Shihan He, Aibin Shi, Trupta Purohit, Andrew G Muntean, Roderick J Sorenson, Hollis D Showalter, Marcelo J Murai, Amalia M Belcher, Thomas Hartley,[...]. Nat Chem Biol 2012
Jolanta Grembecka, Shihan He, Aibin Shi, Trupta Purohit, Andrew G Muntean, Roderick J Sorenson, Hollis D Showalter, Marcelo J Murai, Amalia M Belcher, Thomas Hartley,[...]. Nat Chem Biol 2012
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Menin critically links MLL proteins with LEDGF on cancer-associated target genes.
Akihiko Yokoyama, Michael L Cleary. Cancer Cell 2008
Akihiko Yokoyama, Michael L Cleary. Cancer Cell 2008
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A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
Andrei V Krivtsov, Kathryn Evans, Jayant Y Gadrey, Benjamin K Eschle, Charlie Hatton, Hannah J Uckelmann, Kenneth N Ross, Florian Perner, Sarah N Olsen, Tara Pritchard,[...]. Cancer Cell 2019
Andrei V Krivtsov, Kathryn Evans, Jayant Y Gadrey, Benjamin K Eschle, Charlie Hatton, Hannah J Uckelmann, Kenneth N Ross, Florian Perner, Sarah N Olsen, Tara Pritchard,[...]. Cancer Cell 2019
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The MLL recombinome of acute leukemias in 2017.
C Meyer, T Burmeister, D Gröger, G Tsaur, L Fechina, A Renneville, R Sutton, N C Venn, M Emerenciano, M S Pombo-de-Oliveira,[...]. Leukemia 2018
C Meyer, T Burmeister, D Gröger, G Tsaur, L Fechina, A Renneville, R Sutton, N C Venn, M Emerenciano, M S Pombo-de-Oliveira,[...]. Leukemia 2018
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Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
Szymon Klossowski, Hongzhi Miao, Katarzyna Kempinska, Tao Wu, Trupta Purohit, EunGi Kim, Brian M Linhares, Dong Chen, Gloria Jih, Eric Perkey,[...]. J Clin Invest 2020
Szymon Klossowski, Hongzhi Miao, Katarzyna Kempinska, Tao Wu, Trupta Purohit, EunGi Kim, Brian M Linhares, Dong Chen, Gloria Jih, Eric Perkey,[...]. J Clin Invest 2020
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Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Aibin Shi, Marcelo J Murai, Shihan He, George Lund, Thomas Hartley, Trupta Purohit, Gireesh Reddy, Maksymilian Chruszcz, Jolanta Grembecka, Tomasz Cierpicki. Blood 2012
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Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.
Michael W M Kühn, Evelyn Song, Zhaohui Feng, Amit Sinha, Chun-Wei Chen, Aniruddha J Deshpande, Monica Cusan, Noushin Farnoud, Annalisa Mupo, Carolyn Grove,[...]. Cancer Discov 2016
Michael W M Kühn, Evelyn Song, Zhaohui Feng, Amit Sinha, Chun-Wei Chen, Aniruddha J Deshpande, Monica Cusan, Noushin Farnoud, Annalisa Mupo, Carolyn Grove,[...]. Cancer Discov 2016
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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Kathrin M Bernt, Nan Zhu, Amit U Sinha, Sridhar Vempati, Joerg Faber, Andrei V Krivtsov, Zhaohui Feng, Natalie Punt, Amanda Daigle, Lars Bullinger,[...]. Cancer Cell 2011
Kathrin M Bernt, Nan Zhu, Amit U Sinha, Sridhar Vempati, Joerg Faber, Andrei V Krivtsov, Zhaohui Feng, Natalie Punt, Amanda Daigle, Lars Bullinger,[...]. Cancer Cell 2011
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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Christina R Majer, Christopher J Sneeringer, Jeffrey Song, L Danielle Johnston, Margaret Porter Scott, Jesse J Smith, Yonghong Xiao,[...]. Cancer Cell 2011
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Christina R Majer, Christopher J Sneeringer, Jeffrey Song, L Danielle Johnston, Margaret Porter Scott, Jesse J Smith, Yonghong Xiao,[...]. Cancer Cell 2011
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MLL translocations, histone modifications and leukaemia stem-cell development.
Andrei V Krivtsov, Scott A Armstrong. Nat Rev Cancer 2007
Andrei V Krivtsov, Scott A Armstrong. Nat Rev Cancer 2007
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Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Aravind Basavapathruni, Lei Jin, P Ann Boriack-Sjodin, Christina J Allain, Christine R Klaus, Alejandra Raimondi, Margaret Porter Scott,[...]. Blood 2013
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Interaction of MLL amino terminal sequences with menin is required for transformation.
Corrado Caslini, Zhaohai Yang, Mohamad El-Osta, Thomas A Milne, Robert K Slany, Jay L Hess. Cancer Res 2007
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Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia.
Hannah J Uckelmann, Stephanie M Kim, Eric M Wong, Charles Hatton, Hugh Giovinazzo, Jayant Y Gadrey, Andrei V Krivtsov, Frank G Rücker, Konstanze Döhner, Gerard M McGeehan,[...]. Science 2020
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Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.
Akihiko Yokoyama, Zhong Wang, Joanna Wysocka, Mrinmoy Sanyal, Deborah J Aufiero, Issay Kitabayashi, Winship Herr, Michael L Cleary. Mol Cell Biol 2004
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The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
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Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Christina M Hughes, Orit Rozenblatt-Rosen, Thomas A Milne, Terry D Copeland, Stuart S Levine, Jeffrey C Lee, D Neil Hayes, Kalai Selvi Shanmugam, Arindam Bhattacharjee, Christine A Biondi,[...]. Mol Cell 2004
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hDOT1L links histone methylation to leukemogenesis.
Yuki Okada, Qin Feng, Yihui Lin, Qi Jiang, Yaqiang Li, Vernon M Coffield, Lishan Su, Guoliang Xu, Yi Zhang. Cell 2005
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The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
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The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Jing Huang, Buddha Gurung, Bingbing Wan, Smita Matkar, Natalia A Veniaminova, Ke Wan, Juanita L Merchant, Xianxin Hua, Ming Lei. Nature 2012
Jing Huang, Buddha Gurung, Bingbing Wan, Smita Matkar, Natalia A Veniaminova, Ke Wan, Juanita L Merchant, Xianxin Hua, Ming Lei. Nature 2012
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MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.
Amanda C Winters, Kathrin M Bernt. Front Pediatr 2017
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Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
Andrei V Krivtsov, David Twomey, Zhaohui Feng, Matthew C Stubbs, Yingzi Wang, Joerg Faber, Jason E Levine, Jing Wang, William C Hahn, D Gary Gilliland,[...]. Nature 2006
Andrei V Krivtsov, David Twomey, Zhaohui Feng, Matthew C Stubbs, Yingzi Wang, Joerg Faber, Jason E Levine, Jing Wang, William C Hahn, D Gary Gilliland,[...]. Nature 2006
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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.
D C Tkachuk, S Kohler, M L Cleary. Cell 1992
D C Tkachuk, S Kohler, M L Cleary. Cell 1992
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Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
Dmitry Borkin, Szymon Klossowski, Jonathan Pollock, Hongzhi Miao, Brian M Linhares, Katarzyna Kempinska, Zhuang Jin, Trupta Purohit, Bo Wen, Miao He,[...]. J Med Chem 2018
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MLL targets SET domain methyltransferase activity to Hox gene promoters.
Thomas A Milne, Scott D Briggs, Hugh W Brock, Mary Ellen Martin, Denise Gibbs, C David Allis, Jay L Hess. Mol Cell 2002
Thomas A Milne, Scott D Briggs, Hugh W Brock, Mary Ellen Martin, Denise Gibbs, C David Allis, Jay L Hess. Mol Cell 2002
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Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.
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Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.
Thomas A Milne, Jaehoon Kim, Gang G Wang, Sonja C Stadler, Venkatesha Basrur, Sarah J Whitcomb, Zhanxin Wang, Alexander J Ruthenburg, Kojo S J Elenitoba-Johnson, Robert G Roeder,[...]. Mol Cell 2010
Thomas A Milne, Jaehoon Kim, Gang G Wang, Sonja C Stadler, Venkatesha Basrur, Sarah J Whitcomb, Zhanxin Wang, Alexander J Ruthenburg, Kojo S J Elenitoba-Johnson, Robert G Roeder,[...]. Mol Cell 2010
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The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.
Andrew G Muntean, Jiaying Tan, Kajal Sitwala, Yongsheng Huang, Joel Bronstein, James A Connelly, Venkatesha Basrur, Kojo S J Elenitoba-Johnson, Jay L Hess. Cancer Cell 2010
Andrew G Muntean, Jiaying Tan, Kajal Sitwala, Yongsheng Huang, Joel Bronstein, James A Connelly, Venkatesha Basrur, Kojo S J Elenitoba-Johnson, Jay L Hess. Cancer Cell 2010
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Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Fang Cao, Elizabeth C Townsend, Hacer Karatas, Jing Xu, Li Li, Shirley Lee, Liu Liu, Yong Chen, Peter Ouillette, Jidong Zhu,[...]. Mol Cell 2014
Fang Cao, Elizabeth C Townsend, Hacer Karatas, Jing Xu, Li Li, Shirley Lee, Liu Liu, Yong Chen, Peter Ouillette, Jidong Zhu,[...]. Mol Cell 2014
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Regulation of MLL1 H3K4 methyltransferase activity by its core components.
Yali Dou, Thomas A Milne, Alexander J Ruthenburg, Seunghee Lee, Jae Woon Lee, Gregory L Verdine, C David Allis, Robert G Roeder. Nat Struct Mol Biol 2006
Yali Dou, Thomas A Milne, Alexander J Ruthenburg, Seunghee Lee, Jae Woon Lee, Gregory L Verdine, C David Allis, Robert G Roeder. Nat Struct Mol Biol 2006
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Transcription control by the ENL YEATS domain in acute leukaemia.
Michael A Erb, Thomas G Scott, Bin E Li, Huafeng Xie, Joshiawa Paulk, Hyuk-Soo Seo, Amanda Souza, Justin M Roberts, Shiva Dastjerdi, Dennis L Buckley,[...]. Nature 2017
Michael A Erb, Thomas G Scott, Bin E Li, Huafeng Xie, Joshiawa Paulk, Hyuk-Soo Seo, Amanda Souza, Justin M Roberts, Shiva Dastjerdi, Dennis L Buckley,[...]. Nature 2017
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Genomic Classification and Prognosis in Acute Myeloid Leukemia.
Elli Papaemmanuil, Moritz Gerstung, Lars Bullinger, Verena I Gaidzik, Peter Paschka, Nicola D Roberts, Nicola E Potter, Michael Heuser, Felicitas Thol, Niccolo Bolli,[...]. N Engl J Med 2016
Elli Papaemmanuil, Moritz Gerstung, Lars Bullinger, Verena I Gaidzik, Peter Paschka, Nicola D Roberts, Nicola E Potter, Michael Heuser, Felicitas Thol, Niccolo Bolli,[...]. N Engl J Med 2016
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Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).
Dmitry Borkin, Jonathan Pollock, Katarzyna Kempinska, Trupta Purohit, Xiaoqin Li, Bo Wen, Ting Zhao, Hongzhi Miao, Shirish Shukla, Miao He,[...]. J Med Chem 2016
Dmitry Borkin, Jonathan Pollock, Katarzyna Kempinska, Trupta Purohit, Xiaoqin Li, Bo Wen, Ting Zhao, Hongzhi Miao, Shirish Shukla, Miao He,[...]. J Med Chem 2016
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MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Yufei Chen, Konstantinos Anastassiadis, Andrea Kranz, A Francis Stewart, Kathrin Arndt, Claudia Waskow, Akihiko Yokoyama, Kenneth Jones, Tobias Neff, Yoo Lee,[...]. Cancer Cell 2017
Yufei Chen, Konstantinos Anastassiadis, Andrea Kranz, A Francis Stewart, Kathrin Arndt, Claudia Waskow, Akihiko Yokoyama, Kenneth Jones, Tobias Neff, Yoo Lee,[...]. Cancer Cell 2017
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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Chun-Wei Chen, Richard P Koche, Amit U Sinha, Aniruddha J Deshpande, Nan Zhu, Rowena Eng, John G Doench, Haiming Xu, Scott H Chu, Jun Qi,[...]. Nat Med 2015
Chun-Wei Chen, Richard P Koche, Amit U Sinha, Aniruddha J Deshpande, Nan Zhu, Rowena Eng, John G Doench, Haiming Xu, Scott H Chu, Jun Qi,[...]. Nat Med 2015
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Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors.
Thomas A Milne, Christina M Hughes, Ricardo Lloyd, Zhaohai Yang, Orit Rozenblatt-Rosen, Yali Dou, Robert W Schnepp, Cynthia Krankel, Virginia A Livolsi, Denise Gibbs,[...]. Proc Natl Acad Sci U S A 2005
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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia.
Scott A Armstrong, Jane E Staunton, Lewis B Silverman, Rob Pieters, Monique L den Boer, Mark D Minden, Stephen E Sallan, Eric S Lander, Todd R Golub, Stanley J Korsmeyer. Nat Genet 2002
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High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction.
Shihan He, Timothy J Senter, Jonathan Pollock, Changho Han, Sunil Kumar Upadhyay, Trupta Purohit, Rocco D Gogliotti, Craig W Lindsley, Tomasz Cierpicki, Shaun R Stauffer,[...]. J Med Chem 2014
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Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction.
Shilin Xu, Angelo Aguilar, Tianfeng Xu, Ke Zheng, Liyue Huang, Jeanne Stuckey, Krishnapriya Chinnaswamy, Denzil Bernard, Ester Fernández-Salas, Liu Liu,[...]. Angew Chem Int Ed Engl 2018
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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.
Chengqi Lin, Edwin R Smith, Hidehisa Takahashi, Ka Chun Lai, Skylar Martin-Brown, Laurence Florens, Michael P Washburn, Joan W Conaway, Ronald C Conaway, Ali Shilatifard. Mol Cell 2010
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H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Andrei V Krivtsov, Zhaohui Feng, Madeleine E Lemieux, Joerg Faber, Sridhar Vempati, Amit U Sinha, Xiaobo Xia, Jonathan Jesneck, Adrian P Bracken, Lewis B Silverman,[...]. Cancer Cell 2008
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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
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ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
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The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis.
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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Mark A Dawson, Rab K Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M Savitski,[...]. Nature 2011
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Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner.
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Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein.
Marcelo J Murai, Maksymilian Chruszcz, Gireesh Reddy, Jolanta Grembecka, Tomasz Cierpicki. J Biol Chem 2011
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A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.
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ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.
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Menin: a scaffold protein that controls gene expression and cell signaling.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.