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Medulloblastoma comprises four distinct molecular variants.
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Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
Marcel Kool, Andrey Korshunov, Marc Remke, David T W Jones, Maria Schlanstein, Paul A Northcott, Yoon-Jae Cho, Jan Koster, Antoinette Schouten-van Meeteren, Dannis van Vuurden,[...]. Acta Neuropathol 2012
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Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial.
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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.
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Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma.
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Nataliya Zhukova, Vijay Ramaswamy, Marc Remke, Elke Pfaff, David J H Shih, Dianna C Martin, Pedro Castelo-Branco, Berivan Baskin, Peter N Ray, Eric Bouffet,[...]. J Clin Oncol 2013
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Intertumoral Heterogeneity within Medulloblastoma Subgroups.
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Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups.
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Subtypes of medulloblastoma have distinct developmental origins.
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Subgroup-specific structural variation across 1,000 medulloblastoma genomes.
Paul A Northcott, David J H Shih, John Peacock, Livia Garzia, A Sorana Morrissy, Thomas Zichner, Adrian M Stütz, Andrey Korshunov, Jüri Reimand, Steven E Schumacher,[...]. Nature 2012
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Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome.
Yoon-Jae Cho, Aviad Tsherniak, Pablo Tamayo, Sandro Santagata, Azra Ligon, Heidi Greulich, Rameen Berhoukim, Vladimir Amani, Liliana Goumnerova, Charles G Eberhart,[...]. J Clin Oncol 2011
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Dissecting the genomic complexity underlying medulloblastoma.
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Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
Marcel Kool, David T W Jones, Natalie Jäger, Paul A Northcott, Trevor J Pugh, Volker Hovestadt, Rosario M Piro, L Adriana Esparza, Shirley L Markant, Marc Remke,[...]. Cancer Cell 2014
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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.
Marcel Kool, Jan Koster, Jens Bunt, Nancy E Hasselt, Arjan Lakeman, Peter van Sluis, Dirk Troost, Netteke Schouten-van Meeteren, Huib N Caron, Jacqueline Cloos,[...]. PLoS One 2008
Marcel Kool, Jan Koster, Jens Bunt, Nancy E Hasselt, Arjan Lakeman, Peter van Sluis, Dirk Troost, Netteke Schouten-van Meeteren, Huib N Caron, Jacqueline Cloos,[...]. PLoS One 2008
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Medulloblastomics: the end of the beginning.
Paul A Northcott, David T W Jones, Marcel Kool, Giles W Robinson, Richard J Gilbertson, Yoon-Jae Cho, Scott L Pomeroy, Andrey Korshunov, Peter Lichter, Michael D Taylor,[...]. Nat Rev Cancer 2012
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Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma.
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
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The whole-genome landscape of medulloblastoma subtypes.
Paul A Northcott, Ivo Buchhalter, A Sorana Morrissy, Volker Hovestadt, Joachim Weischenfeldt, Tobias Ehrenberger, Susanne Gröbner, Maia Segura-Wang, Thomas Zichner, Vasilisa A Rudneva,[...]. Nature 2017
Paul A Northcott, Ivo Buchhalter, A Sorana Morrissy, Volker Hovestadt, Joachim Weischenfeldt, Tobias Ehrenberger, Susanne Gröbner, Maia Segura-Wang, Thomas Zichner, Vasilisa A Rudneva,[...]. Nature 2017
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Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.
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Cytogenetic prognostication within medulloblastoma subgroups.
David J H Shih, Paul A Northcott, Marc Remke, Andrey Korshunov, Vijay Ramaswamy, Marcel Kool, Betty Luu, Yuan Yao, Xin Wang, Adrian M Dubuc,[...]. J Clin Oncol 2014
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Novel mutations target distinct subgroups of medulloblastoma.
Giles Robinson, Matthew Parker, Tanya A Kranenburg, Charles Lu, Xiang Chen, Li Ding, Timothy N Phoenix, Erin Hedlund, Lei Wei, Xiaoyan Zhu,[...]. Nature 2012
Giles Robinson, Matthew Parker, Tanya A Kranenburg, Charles Lu, Xiang Chen, Li Ding, Timothy N Phoenix, Erin Hedlund, Lei Wei, Xiaoyan Zhu,[...]. Nature 2012
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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations.
Trevor J Pugh, Shyamal Dilhan Weeraratne, Tenley C Archer, Daniel A Pomeranz Krummel, Daniel Auclair, James Bochicchio, Mauricio O Carneiro, Scott L Carter, Kristian Cibulskis, Rachel L Erlich,[...]. Nature 2012
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Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
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Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort.
Torsten Pietsch, Rene Schmidt, Marc Remke, Andrey Korshunov, Volker Hovestadt, David T W Jones, Jörg Felsberg, Kerstin Kaulich, Tobias Goschzik, Marcel Kool,[...]. Acta Neuropathol 2014
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Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis.
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Claudia C Faria, Sebastien Perreault, Yoon-Jae Cho, David J Shih, Betty Luu, Adrian M Dubuc, Paul A Northcott,[...]. Lancet Oncol 2013
Vijay Ramaswamy, Marc Remke, Eric Bouffet, Claudia C Faria, Sebastien Perreault, Yoon-Jae Cho, David J Shih, Betty Luu, Adrian M Dubuc, Paul A Northcott,[...]. Lancet Oncol 2013
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Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Giles W Robinson, Brent A Orr, Gang Wu, Sridharan Gururangan, Tong Lin, Ibrahim Qaddoumi, Roger J Packer, Stewart Goldman, Michael D Prados, Annick Desjardins,[...]. J Clin Oncol 2015
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Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.
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Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables.
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Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial.
Birgitta Lannering, Stefan Rutkowski, Francois Doz, Barry Pizer, Göran Gustafsson, Aurora Navajas, Maura Massimino, Roel Reddingius, Martin Benesch, Christian Carrie,[...]. J Clin Oncol 2012
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DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies.
Edward C Schwalbe, Daniel Williamson, Janet C Lindsey, Dolores Hamilton, Sarra L Ryan, Hisham Megahed, Miklós Garami, Peter Hauser, Bożena Dembowska-Baginska, Danuta Perek,[...]. Acta Neuropathol 2013
Edward C Schwalbe, Daniel Williamson, Janet C Lindsey, Dolores Hamilton, Sarra L Ryan, Hisham Megahed, Miklós Garami, Peter Hauser, Bożena Dembowska-Baginska, Danuta Perek,[...]. Acta Neuropathol 2013
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Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study.
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Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.
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Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays.
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The 2007 WHO classification of tumours of the central nervous system.
David N Louis, Hiroko Ohgaki, Otmar D Wiestler, Webster K Cavenee, Peter C Burger, Anne Jouvet, Bernd W Scheithauer, Paul Kleihues. Acta Neuropathol 2007
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Treatment of early childhood medulloblastoma by postoperative chemotherapy alone.
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Prediction of central nervous system embryonal tumour outcome based on gene expression.
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Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
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Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters.
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Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples.
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Adult medulloblastoma comprises three major molecular variants.
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Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis.
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MRI surrogates for molecular subgroups of medulloblastoma.
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Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics.
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BET bromodomain inhibition of MYC-amplified medulloblastoma.
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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma.
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Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial.
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Active medulloblastoma enhancers reveal subgroup-specific cellular origins.
Charles Y Lin, Serap Erkek, Yiai Tong, Linlin Yin, Alexander J Federation, Marc Zapatka, Parthiv Haldipur, Daisuke Kawauchi, Thomas Risch, Hans-Jörg Warnatz,[...]. Nature 2016
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Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.
Paul A Northcott, Catherine Lee, Thomas Zichner, Adrian M Stütz, Serap Erkek, Daisuke Kawauchi, David J H Shih, Volker Hovestadt, Marc Zapatka, Dominik Sturm,[...]. Nature 2014
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An animal model of MYC-driven medulloblastoma.
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14
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.