A citation-based method for searching scientific literature

Jonathan C Cohen, Eric Boerwinkle, Thomas H Mosley, Helen H Hobbs. N Engl J Med 2006
Times Cited: 2007







List of co-cited articles
974 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.
Marianne Abifadel, Mathilde Varret, Jean-Pierre Rabès, Delphine Allard, Khadija Ouguerram, Martine Devillers, Corinne Cruaud, Suzanne Benjannet, Louise Wickham, Danièle Erlich,[...]. Nat Genet 2003
46

Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease.
Marc S Sabatine, Robert P Giugliano, Anthony C Keech, Narimon Honarpour, Stephen D Wiviott, Sabina A Murphy, Julia F Kuder, Huei Wang, Thomas Liu, Scott M Wasserman,[...]. N Engl J Med 2017
34

Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome.
Gregory G Schwartz, P Gabriel Steg, Michael Szarek, Deepak L Bhatt, Vera A Bittner, Rafael Diaz, Jay M Edelberg, Shaun G Goodman, Corinne Hanotin, Robert A Harrington,[...]. N Engl J Med 2018
30

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.
Jonathan Cohen, Alexander Pertsemlidis, Ingrid K Kotowski, Randall Graham, Christine Kim Garcia, Helen H Hobbs. Nat Genet 2005
905
29

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.
Kausik K Ray, R Scott Wright, David Kallend, Wolfgang Koenig, Lawrence A Leiter, Frederick J Raal, Jenna A Bisch, Tara Richardson, Mark Jaros, Peter L J Wijngaard,[...]. N Engl J Med 2020
257
16

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel.
Brian A Ference, Henry N Ginsberg, Ian Graham, Kausik K Ray, Chris J Packard, Eric Bruckert, Robert A Hegele, Ronald M Krauss, Frederick J Raal, Heribert Schunkert,[...]. Eur Heart J 2017
15

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates.
Kiran Musunuru, Alexandra C Chadwick, Taiji Mizoguchi, Sara P Garcia, Jamie E DeNizio, Caroline W Reiss, Kui Wang, Sowmya Iyer, Chaitali Dutta, Victoria Clendaniel,[...]. Nature 2021
91
16

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.
François Mach, Colin Baigent, Alberico L Catapano, Konstantinos C Koskinas, Manuela Casula, Lina Badimon, M John Chapman, Guy G De Backer, Victoria Delgado, Brian A Ference,[...]. Eur Heart J 2020
14

Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia.
Frederick J Raal, David Kallend, Kausik K Ray, Traci Turner, Wolfgang Koenig, R Scott Wright, Peter L J Wijngaard, Danielle Curcio, Mark J Jaros, Lawrence A Leiter,[...]. N Engl J Med 2020
172
13

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.
Nabil G Seidah, Suzanne Benjannet, Louise Wickham, Jadwiga Marcinkiewicz, Stephanie Belanger Jasmin, Stefano Stifani, Ajoy Basak, Annik Prat, Michel Chretien. Proc Natl Acad Sci U S A 2003
809
13

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.
Frederick E Dewey, Viktoria Gusarova, Richard L Dunbar, Colm O'Dushlaine, Claudia Schurmann, Omri Gottesman, Shane McCarthy, Cristopher V Van Hout, Shannon Bruse, Hayes M Dansky,[...]. N Engl J Med 2017
404
12

Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.
Christopher P Cannon, Michael A Blazing, Robert P Giugliano, Amy McCagg, Jennifer A White, Pierre Theroux, Harald Darius, Basil S Lewis, Ton Oude Ophuis, J Wouter Jukema,[...]. N Engl J Med 2015
12

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.
Jacy Crosby, Gina M Peloso, Paul L Auer, David R Crosslin, Nathan O Stitziel, Leslie A Lange, Yingchang Lu, Zheng-zheng Tang, He Zhang, George Hindy,[...]. N Engl J Med 2014
685
11

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.
Suzanne Benjannet, David Rhainds, Rachid Essalmani, Janice Mayne, Louise Wickham, Weijun Jin, Marie-Claude Asselin, Josée Hamelin, Mathilde Varret, Delphine Allard,[...]. J Biol Chem 2004
455
11

Variation in PCSK9 and HMGCR and Risk of Cardiovascular Disease and Diabetes.
Brian A Ference, Jennifer G Robinson, Robert D Brook, Alberico L Catapano, M John Chapman, David R Neff, Szilard Voros, Robert P Giugliano, George Davey Smith, Sergio Fazio,[...]. N Engl J Med 2016
409
10

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.
Marc S Sabatine, Robert P Giugliano, Stephen D Wiviott, Frederick J Raal, Dirk J Blom, Jennifer Robinson, Christie M Ballantyne, Ransi Somaratne, Jason Legg, Scott M Wasserman,[...]. N Engl J Med 2015
10

Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk Factors.
Karin Leander, Anders Mälarstig, Ferdinand M Van't Hooft, Craig Hyde, Mai-Lis Hellénius, Jason S Troutt, Robert J Konrad, John Öhrvik, Anders Hamsten, Ulf de Faire. Circulation 2016
122
10

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote.
Zhenze Zhao, Yetsa Tuakli-Wosornu, Thomas A Lagace, Lisa Kinch, Nicholas V Grishin, Jay D Horton, Jonathan C Cohen, Helen H Hobbs. Am J Hum Genet 2006
442
10

Permanent alteration of PCSK9 with in vivo CRISPR-Cas9 genome editing.
Qiurong Ding, Alanna Strong, Kevin M Patel, Sze-Ling Ng, Bridget S Gosis, Stephanie N Regan, Chad A Cowan, Daniel J Rader, Kiran Musunuru. Circ Res 2014
306
9

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events.
Jennifer G Robinson, Michel Farnier, Michel Krempf, Jean Bergeron, Gérald Luc, Maurizio Averna, Erik S Stroes, Gisle Langslet, Frederick J Raal, Mahfouz El Shahawy,[...]. N Engl J Med 2015
9


Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations.
Amit V Khera, Mark Chaffin, Krishna G Aragam, Mary E Haas, Carolina Roselli, Seung Hoan Choi, Pradeep Natarajan, Eric S Lander, Steven A Lubitz, Patrick T Ellinor,[...]. Nat Genet 2018
990
9

Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk.
Michelle L O'Donoghue, Sergio Fazio, Robert P Giugliano, Erik S G Stroes, Estella Kanevsky, Ioanna Gouni-Berthold, KyungAh Im, Armando Lira Pineda, Scott M Wasserman, Richard Češka,[...]. Circulation 2019
282
9

The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population.
Amanda J Hooper, A David Marais, Donald M Tanyanyiwa, John R Burnett. Atherosclerosis 2007
253
9

Reduced Blood Lipid Levels With In Vivo CRISPR-Cas9 Base Editing of ANGPTL3.
Alexandra C Chadwick, Niklaus H Evitt, Wenjian Lv, Kiran Musunuru. Circulation 2018
68
11

Inactivating mutations in NPC1L1 and protection from coronary heart disease.
Nathan O Stitziel, Hong-Hee Won, Alanna C Morrison, Gina M Peloso, Ron Do, Leslie A Lange, Pierre Fontanillas, Namrata Gupta, Stefano Duga, Anuj Goel,[...]. N Engl J Med 2014
292
8

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.
Kevin Fitzgerald, Maria Frank-Kamenetsky, Svetlana Shulga-Morskaya, Abigail Liebow, Brian R Bettencourt, Jessica E Sutherland, Renta M Hutabarat, Valerie A Clausen, Verena Karsten, Jeffrey Cehelsky,[...]. Lancet 2014
382
8

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.
Mark J Graham, Richard G Lee, Teresa A Brandt, Li-Jung Tai, Wuxia Fu, Raechel Peralta, Rosie Yu, Eunju Hurh, Erika Paz, Bradley W McEvoy,[...]. N Engl J Med 2017
327
8

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.
Kevin Fitzgerald, Suellen White, Anna Borodovsky, Brian R Bettencourt, Andrew Strahs, Valerie Clausen, Peter Wijngaard, Jay D Horton, Jorg Taubel, Ashley Brooks,[...]. N Engl J Med 2017
363
8

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
Majid Nikpay, Anuj Goel, Hong-Hee Won, Leanne M Hall, Christina Willenborg, Stavroula Kanoni, Danish Saleheen, Theodosios Kyriakou, Christopher P Nelson, Jemma C Hopewell,[...]. Nat Genet 2015
8

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
Paul M Ridker, Brendan M Everett, Tom Thuren, Jean G MacFadyen, William H Chang, Christie Ballantyne, Francisco Fonseca, Jose Nicolau, Wolfgang Koenig, Stefan D Anker,[...]. N Engl J Med 2017
8

Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials.
J L Mega, N O Stitziel, J G Smith, D I Chasman, M Caulfield, J J Devlin, F Nordio, C Hyde, C P Cannon, F Sacks,[...]. Lancet 2015
349
8

PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver.
Annie Demers, Samaneh Samami, Benjamin Lauzier, Christine Des Rosiers, Emilienne Tudor Ngo Sock, Huy Ong, Gaetan Mayer. Arterioscler Thromb Vasc Biol 2015
106
8


Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.
Kiran Musunuru, James P Pirruccello, Ron Do, Gina M Peloso, Candace Guiducci, Carrie Sougnez, Kiran V Garimella, Sheila Fisher, Justin Abreu, Andrew J Barry,[...]. N Engl J Med 2010
442
8

Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration.
Ahmed Zaid, Anna Roubtsova, Rachid Essalmani, Jadwiga Marcinkiewicz, Ann Chamberland, Josée Hamelin, Michel Tremblay, Hélène Jacques, Weijun Jin, Jean Davignon,[...]. Hepatology 2008
281
8

In vivo genome editing using Staphylococcus aureus Cas9.
F Ann Ran, Le Cong, Winston X Yan, David A Scott, Jonathan S Gootenberg, Andrea J Kriz, Bernd Zetsche, Ophir Shalem, Xuebing Wu, Kira S Makarova,[...]. Nature 2015
7

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.
Nathan O Stitziel, Amit V Khera, Xiao Wang, Andrew J Bierhals, A Christina Vourakis, Alexandra E Sperry, Pradeep Natarajan, Derek Klarin, Connor A Emdin, Seyedeh M Zekavat,[...]. J Am Coll Cardiol 2017
222
7

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol.
Kausik K Ray, Ulf Landmesser, Lawrence A Leiter, David Kallend, Robert Dufour, Mahir Karakas, Tim Hall, Roland P T Troquay, Traci Turner, Frank L J Visseren,[...]. N Engl J Med 2017
439
7

Biological, clinical and population relevance of 95 loci for blood lipids.
Tanya M Teslovich, Kiran Musunuru, Albert V Smith, Andrew C Edmondson, Ioannis M Stylianou, Masahiro Koseki, James P Pirruccello, Samuli Ripatti, Daniel I Chasman, Cristen J Willer,[...]. Nature 2010
7

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
Derek Klarin, Scott M Damrauer, Kelly Cho, Yan V Sun, Tanya M Teslovich, Jacqueline Honerlaw, David R Gagnon, Scott L DuVall, Jin Li, Gina M Peloso,[...]. Nat Genet 2018
254
7

Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association.
Emelia J Benjamin, Paul Muntner, Alvaro Alonso, Marcio S Bittencourt, Clifton W Callaway, April P Carson, Alanna M Chamberlain, Alexander R Chang, Susan Cheng, Sandeep R Das,[...]. Circulation 2019
7

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab.
Paul M Ridker, Jean-Claude Tardif, Pierre Amarenco, William Duggan, Robert J Glynn, J Wouter Jukema, John J P Kastelein, Albert M Kim, Wolfgang Koenig, Steven Nissen,[...]. N Engl J Med 2017
206
7

Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.
Thomas A Lagace, David E Curtis, Rita Garuti, Markey C McNutt, Sahng Wook Park, Heidi B Prather, Norma N Anderson, Y K Ho, Robert E Hammer, Jay D Horton. J Clin Invest 2006
472
7

The biology and therapeutic targeting of the proprotein convertases.
Nabil G Seidah, Annik Prat. Nat Rev Drug Discov 2012
488
7


Inflammation stimulates the expression of PCSK9.
Kenneth R Feingold, Arthur H Moser, Judy K Shigenaga, Sophie M Patzek, Carl Grunfeld. Biochem Biophys Res Commun 2008
154
7

PCSK9 induces a pro-inflammatory response in macrophages.
Chiara Ricci, Massimiliano Ruscica, Marina Camera, Laura Rossetti, Chiara Macchi, Alessandra Colciago, Ilaria Zanotti, Maria Giovanna Lupo, Maria Pia Adorni, Arrigo F G Cicero,[...]. Sci Rep 2018
102
7

PCSK9 is a critical regulator of the innate immune response and septic shock outcome.
Keith R Walley, Katherine R Thain, James A Russell, Muredach P Reilly, Nuala J Meyer, Jane F Ferguson, Jason D Christie, Taka-aki Nakada, Chris D Fjell, Simone A Thair,[...]. Sci Transl Med 2014
215
7

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Tanja Rothgangl, Melissa K Dennis, Paulo J C Lin, Rurika Oka, Dominik Witzigmann, Lukas Villiger, Weihong Qi, Martina Hruzova, Lucas Kissling, Daniela Lenggenhager,[...]. Nat Biotechnol 2021
50
14


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.