A citation-based method for searching scientific literature

Robert J Lipinski, Jerry J Gipp, Jingxian Zhang, Jason D Doles, Wade Bushman. Exp Cell Res 2006
Times Cited: 73







List of co-cited articles
446 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.
H L Park, C Bai, K A Platt, M P Matise, A Beeghly, C C Hui, M Nakashima, A L Joyner. Development 2000
521
20

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
J Taipale, J K Chen, M K Cooper, B Wang, R K Mann, L Milenkovic, M P Scott, P A Beachy. Nature 2000
20

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
Sarah P Thayer, Marina Pasca di Magliano, Patrick W Heiser, Corinne M Nielsen, Drucilla J Roberts, Gregory Y Lauwers, Yan Ping Qi, Stephan Gysin, Carlos Fernández-del Castillo, Vijay Yajnik,[...]. Nature 2003
19


Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
770
17

GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter.
Mohammed S Ikram, Graham W Neill, Gerhard Regl, Thomas Eichberger, Anna-Maria Frischauf, Fritz Aberger, Anthony Quinn, Mike Philpott. J Invest Dermatol 2004
128
17

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.
David M Berman, Sunil S Karhadkar, Anirban Maitra, Rocio Montes De Oca, Meg R Gerstenblith, Kimberly Briggs, Antony R Parker, Yutaka Shimada, James R Eshleman, D Neil Watkins,[...]. Nature 2003
16

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
16


Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.
Yong Pan, Chunyang Brian Bai, Alexandra L Joyner, Baolin Wang. Mol Cell Biol 2006
396
15

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling.
Pilar Sanchez, Ana Maria Hernández, Barbara Stecca, Andrea J Kahler, Amy M DeGueme, Andrea Barrett, Mercedes Beyna, Milton W Datta, Sumana Datta, Ariel Ruiz i Altaba. Proc Natl Acad Sci U S A 2004
422
13

Hedgehog signalling in cancer formation and maintenance.
Marina Pasca di Magliano, Matthias Hebrok. Nat Rev Cancer 2003
652
13

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.
C Brian Bai, Wojtek Auerbach, Joon S Lee, Daniel Stephen, Alexandra L Joyner. Development 2002
521
13

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.
R Mo, A M Freer, D L Zinyk, M A Crackower, J Michaud, H H Heng, K W Chik, X M Shi, L C Tsui, S H Cheng,[...]. Development 1997
478
13

Hedgehog signaling promotes prostate xenograft tumor growth.
Lian Fan, Carmen V Pepicelli, Christian C Dibble, Winnie Catbagan, Jodi L Zarycki, Robert Laciak, Jerry Gipp, Aubie Shaw, Marilyn L G Lamm, Alejandro Munoz,[...]. Endocrinology 2004
217
12

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
D Neil Watkins, David M Berman, Scott G Burkholder, Baolin Wang, Philip A Beachy, Stephen B Baylin. Nature 2003
850
12

Hedgehog signalling in prostate regeneration, neoplasia and metastasis.
Sunil S Karhadkar, G Steven Bova, Nadia Abdallah, Surajit Dhara, Dale Gardner, Anirban Maitra, John T Isaacs, David M Berman, Philip A Beachy. Nature 2004
823
12

GLI transcription factors: mediators of oncogenic Hedgehog signalling.
Maria Kasper, Gerhard Regl, Anna-Maria Frischauf, Fritz Aberger. Eur J Cancer 2006
304
10

Gli and hedgehog in cancer: tumours, embryos and stem cells.
Ariel Ruiz i Altaba, Pilar Sánchez, Nadia Dahmane. Nat Rev Cancer 2002
568
10

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
10

Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
10



Hedgehog signaling in development and cancer.
Jin Jiang, Chi-Chung Hui. Dev Cell 2008
767
10

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation.
Joon Won Yoon, Yasuhiro Kita, Daniel J Frank, Rebecca R Majewski, Beth A Konicek, Marcelo A Nobrega, Howard Jacob, David Walterhouse, Philip Iannaccone. J Biol Chem 2002
266
9

Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2.
Gerhard Regl, Maria Kasper, Harald Schnidar, Thomas Eichberger, Graham W Neill, Michael P Philpott, Harald Esterbauer, Cornelia Hauser-Kronberger, Anna-Maria Frischauf, Fritz Aberger. Cancer Res 2004
191
9

Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes.
Thomas Eichberger, Veronika Sander, Harald Schnidar, Gerhard Regl, Maria Kasper, Carmen Schmid, Sandra Plamberger, Alexandra Kaser, Fritz Aberger, Anna-Maria Frischauf. Genomics 2006
84
9

Developmental roles and clinical significance of hedgehog signaling.
Andrew P McMahon, Philip W Ingham, Clifford J Tabin. Curr Top Dev Biol 2003
681
9

Biochemical evidence that patched is the Hedgehog receptor.
V Marigo, R A Davey, Y Zuo, J M Cunningham, C J Tabin. Nature 1996
674
9


Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.
P Dai, H Akimaru, Y Tanaka, T Maekawa, M Nakafuku, S Ishii. J Biol Chem 1999
428
9


Basal cell carcinomas in mice overexpressing Gli2 in skin.
M Grachtchouk, R Mo, S Yu, X Zhang, H Sasaki, C C Hui, A A Dlugosz. Nat Genet 2000
309
8

Medulloblastoma growth inhibition by hedgehog pathway blockade.
David M Berman, Sunil S Karhadkar, Andrew R Hallahan, Joel I Pritchard, Charles G Eberhart, D Neil Watkins, James K Chen, Michael K Cooper, Jussi Taipale, James M Olson,[...]. Science 2002
643
8

Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.
Courtney J Haycraft, Boglarka Banizs, Yesim Aydin-Son, Qihong Zhang, Edward J Michaud, Bradley K Yoder. PLoS Genet 2005
670
8

The Hedgehog response network: sensors, switches, and routers.
Lawrence Lum, Philip A Beachy. Science 2004
630
8

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
8

Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.
Q Ding, J Motoyama, S Gasca, R Mo, H Sasaki, J Rossant, C C Hui. Development 1998
353
8


Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site.
Marie Agren, Priit Kogerman, Marika I Kleman, Martina Wessling, Rune Toftgård. Gene 2004
140
8

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis.
Ming Chang Hu, Rong Mo, Sita Bhella, Christopher W Wilson, Pao-Tien Chuang, Chi-Chung Hui, Norman D Rosenblum. Development 2006
133
8

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Matthias Lauth, Asa Bergström, Takashi Shimokawa, Rune Toftgård. Proc Natl Acad Sci U S A 2007
592
8

Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.
Sylviane Dennler, Jocelyne André, Ismini Alexaki, Allen Li, Thierry Magnaldo, Peter ten Dijke, Xiao-Jing Wang, Franck Verrecchia, Alain Mauviel. Cancer Res 2007
278
8

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.
Erich Roessler, Yang-Zhu Du, Jose L Mullor, Esther Casas, William P Allen, Gabriele Gillessen-Kaesbach, Elizabeth R Roeder, Jeffrey E Ming, Ariel Ruiz i Altaba, Maximilian Muenke. Proc Natl Acad Sci U S A 2003
239
8


The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
8

Activation of the hedgehog pathway in advanced prostate cancer.
Tao Sheng, Chengxin Li, Xiaoli Zhang, Sumin Chi, Nonggao He, Kai Chen, Frank McCormick, Zoran Gatalica, Jingwu Xie. Mol Cancer 2004
361
6

Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation.
Aileen McDermott, Marcus Gustafsson, Thomas Elsam, Chi-Chung Hui, Charles P Emerson, Anne-Gaëlle Borycki. Development 2005
116
6

Activating Smoothened mutations in sporadic basal-cell carcinoma.
J Xie, M Murone, S M Luoh, A Ryan, Q Gu, C Zhang, J M Bonifas, C W Lam, M Hynes, A Goddard,[...]. Nature 1998
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.