A citation-based method for searching scientific literature

Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
Times Cited: 1958







List of co-cited articles
805 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
29

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
22

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
21

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
20

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
19

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
801
14

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
14

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
699
14

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Carson C Thoreen, Seong A Kang, Jae Won Chang, Qingsong Liu, Jianming Zhang, Yi Gao, Laurie J Reichling, Taebo Sim, David M Sabatini, Nathanael S Gray. J Biol Chem 2009
13

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
12

TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
11

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
11


mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Kathryn E O'Reilly, Fredi Rojo, Qing-Bai She, David Solit, Gordon B Mills, Debra Smith, Heidi Lane, Francesco Hofmann, Daniel J Hicklin, Dale L Ludwig,[...]. Cancer Res 2006
10

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Kenta Hara, Yoshiko Maruki, Xiaomeng Long, Ken-ichi Yoshino, Noriko Oshiro, Sujuti Hidayat, Chiharu Tokunaga, Joseph Avruch, Kazuyoshi Yonezawa. Cell 2002
10

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
10

A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
E J Brown, M W Albers, T B Shin, K Ichikawa, C T Keith, W S Lane, S L Schreiber. Nature 1994
10

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
10

mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
291
10

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
9

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
9

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.
Ian G Ganley, Du H Lam, Junru Wang, Xiaojun Ding, She Chen, Xuejun Jiang. J Biol Chem 2009
873
9

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
9


DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
795
9

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Estela Jacinto, Valeria Facchinetti, Dou Liu, Nelyn Soto, Shiniu Wei, Sung Yun Jung, Qiaojia Huang, Jun Qin, Bing Su. Cell 2006
9

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.
Vanessa S Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao, Chris J Novotny, Claire McWhirter, Arpitha Banaji, Helen Won, Wai Wong, Mike Berger, Elisa de Stanchina,[...]. Nature 2016
193
8

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Robbie Loewith, Estela Jacinto, Stephan Wullschleger, Anja Lorberg, José L Crespo, Débora Bonenfant, Wolfgang Oppliger, Paul Jenoe, Michael N Hall. Mol Cell 2002
8

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
Peggy P Hsu, Seong A Kang, Jonathan Rameseder, Yi Zhang, Kathleen A Ottina, Daniel Lim, Timothy R Peterson, Yongmun Choi, Nathanael S Gray, Michael B Yaffe,[...]. Science 2011
712
8

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
David A Guertin, Deanna M Stevens, Carson C Thoreen, Aurora A Burds, Nada Y Kalaany, Jason Moffat, Michael Brown, Kevin J Fitzgerald, David M Sabatini. Dev Cell 2006
8

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.
Andrew Y Choo, Sang-Oh Yoon, Sang Gyun Kim, Philippe P Roux, John Blenis. Proc Natl Acad Sci U S A 2008
580
8

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Kim. Nat Cell Biol 2007
804
8

Rapamycin passes the torch: a new generation of mTOR inhibitors.
Don Benjamin, Marco Colombi, Christoph Moroni, Michael N Hall. Nat Rev Drug Discov 2011
583
7

mTOR kinase structure, mechanism and regulation.
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
505
7

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
Arkaitz Carracedo, Li Ma, Julie Teruya-Feldstein, Federico Rojo, Leonardo Salmena, Andrea Alimonti, Ainara Egia, Atsuo T Sasaki, George Thomas, Sara C Kozma,[...]. J Clin Invest 2008
7

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
Nao Hosokawa, Taichi Hara, Takeshi Kaizuka, Chieko Kishi, Akito Takamura, Yutaka Miura, Shun-ichiro Iemura, Tohru Natsume, Kenji Takehana, Naoyuki Yamada,[...]. Mol Biol Cell 2009
7


Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells.
C J Sabers, M M Martin, G J Brunn, J M Williams, F J Dumont, G Wiederrecht, R T Abraham. J Biol Chem 1995
629
7

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
7

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Pengda Liu, Wenjian Gan, Y Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C Cantley, Alex Toker,[...]. Cancer Discov 2015
188
7

Regulation of TORC1 by Rag GTPases in nutrient response.
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
849
7

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard,[...]. EMBO J 2012
981
7

Cryo-EM structure of human mTOR complex 2.
Xizi Chen, Mengjie Liu, Yuan Tian, Jiabei Li, Yilun Qi, Dan Zhao, Zihan Wu, Min Huang, Catherine C L Wong, Hong-Wei Wang,[...]. Cell Res 2018
46
15


PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Yasemin Sancak, Carson C Thoreen, Timothy R Peterson, Robert A Lindquist, Seong A Kang, Eric Spooner, Steven A Carr, David M Sabatini. Mol Cell 2007
850
7

Defining the role of mTOR in cancer.
David A Guertin, David M Sabatini. Cancer Cell 2007
7

mTOR: from growth signal integration to cancer, diabetes and ageing.
Roberto Zoncu, Alejo Efeyan, David M Sabatini. Nat Rev Mol Cell Biol 2011
7

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
653
7

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
432
7

AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity.
Christine M Chresta, Barry R Davies, Ian Hickson, Tom Harding, Sabina Cosulich, Susan E Critchlow, John P Vincent, Rebecca Ellston, Darren Jones, Patrizia Sini,[...]. Cancer Res 2010
553
6


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.