Andreas Bender, Kim J Krishnan, Christopher M Morris, Geoffrey A Taylor, Amy K Reeve, Robert H Perry, Evelyn Jaros, Joshua S Hersheson, Joanne Betts, Thomas Klopstock, Robert W Taylor, Douglass M Turnbull. Nat Genet 2006
Times Cited: 1014
Times Cited: 1014
Times Cited
Times Co-cited
Similarity
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.
Yevgenya Kraytsberg, Elena Kudryavtseva, Ann C McKee, Changiz Geula, Neil W Kowall, Konstantin Khrapko. Nat Genet 2006
Yevgenya Kraytsberg, Elena Kudryavtseva, Ann C McKee, Changiz Geula, Neil W Kowall, Konstantin Khrapko. Nat Genet 2006
30
Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease.
Christian Dölle, Irene Flønes, Gonzalo S Nido, Hrvoje Miletic, Nelson Osuagwu, Stine Kristoffersen, Peer K Lilleng, Jan Petter Larsen, Ole-Bjørn Tysnes, Kristoffer Haugarvoll,[...]. Nat Commun 2016
Christian Dölle, Irene Flønes, Gonzalo S Nido, Hrvoje Miletic, Nelson Osuagwu, Stine Kristoffersen, Peer K Lilleng, Jan Petter Larsen, Ole-Bjørn Tysnes, Kristoffer Haugarvoll,[...]. Nat Commun 2016
21
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
Derek Narendra, Atsushi Tanaka, Der-Fen Suen, Richard J Youle. J Cell Biol 2008
Derek Narendra, Atsushi Tanaka, Der-Fen Suen, Richard J Youle. J Cell Biol 2008
17
Mitochondrial DNA Depletion in Respiratory Chain-Deficient Parkinson Disease Neurons.
Anne Grünewald, Karolina A Rygiel, Philippa D Hepplewhite, Christopher M Morris, Martin Picard, Doug M Turnbull. Ann Neurol 2016
Anne Grünewald, Karolina A Rygiel, Philippa D Hepplewhite, Christopher M Morris, Martin Picard, Doug M Turnbull. Ann Neurol 2016
16
Mitochondrial complex I deficiency in Parkinson's disease.
A H Schapira, J M Cooper, D Dexter, J B Clark, P Jenner, C D Marsden. J Neurochem 1990
A H Schapira, J M Cooper, D Dexter, J B Clark, P Jenner, C D Marsden. J Neurochem 1990
14
Parkin and PINK1 mitigate STING-induced inflammation.
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
Danielle A Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D Fischer, Jonathon L Burman, Yan Li, Zhe Zhang, Derek P Narendra,[...]. Nature 2018
13
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.
J W Langston, P Ballard, J W Tetrud, I Irwin. Science 1983
J W Langston, P Ballard, J W Tetrud, I Irwin. Science 1983
13
Mitochondrial complex I deficiency in Parkinson's disease.
A H Schapira, J M Cooper, D Dexter, P Jenner, J B Clark, C D Marsden. Lancet 1989
A H Schapira, J M Cooper, D Dexter, P Jenner, J B Clark, C D Marsden. Lancet 1989
13
Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease.
Chung-Han Hsieh, Atossa Shaltouki, Ashley E Gonzalez, Alexandre Bettencourt da Cruz, Lena F Burbulla, Erica St Lawrence, Birgitt Schüle, Dimitri Krainc, Theo D Palmer, Xinnan Wang. Cell Stem Cell 2016
Chung-Han Hsieh, Atossa Shaltouki, Ashley E Gonzalez, Alexandre Bettencourt da Cruz, Lena F Burbulla, Erica St Lawrence, Birgitt Schüle, Dimitri Krainc, Theo D Palmer, Xinnan Wang. Cell Stem Cell 2016
13
Hereditary early-onset Parkinson's disease caused by mutations in PINK1.
Enza Maria Valente, Patrick M Abou-Sleiman, Viviana Caputo, Miratul M K Muqit, Kirsten Harvey, Suzana Gispert, Zeeshan Ali, Domenico Del Turco, Anna Rita Bentivoglio, Daniel G Healy,[...]. Science 2004
Enza Maria Valente, Patrick M Abou-Sleiman, Viviana Caputo, Miratul M K Muqit, Kirsten Harvey, Suzana Gispert, Zeeshan Ali, Domenico Del Turco, Anna Rita Bentivoglio, Daniel G Healy,[...]. Science 2004
13
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
T Kitada, S Asakawa, N Hattori, H Matsumine, Y Yamamura, S Minoshima, M Yokochi, Y Mizuno, N Shimizu. Nature 1998
T Kitada, S Asakawa, N Hattori, H Matsumine, Y Yamamura, S Minoshima, M Yokochi, Y Mizuno, N Shimizu. Nature 1998
12
Alpha-synuclein in Lewy bodies.
M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert. Nature 1997
M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert. Nature 1997
12
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons.
Mats I Ekstrand, Mügen Terzioglu, Dagmar Galter, Shunwei Zhu, Christoph Hofstetter, Eva Lindqvist, Sebastian Thams, Anita Bergstrand, Fredrik Sterky Hansson, Aleksandra Trifunovic,[...]. Proc Natl Acad Sci U S A 2007
Mats I Ekstrand, Mügen Terzioglu, Dagmar Galter, Shunwei Zhu, Christoph Hofstetter, Eva Lindqvist, Sebastian Thams, Anita Bergstrand, Fredrik Sterky Hansson, Aleksandra Trifunovic,[...]. Proc Natl Acad Sci U S A 2007
12
Reduced mitochondrial DNA copy number is a biomarker of Parkinson's disease.
Angela Pyle, Haidyan Anugrha, Marzena Kurzawa-Akanbi, Alison Yarnall, David Burn, Gavin Hudson. Neurobiol Aging 2016
Angela Pyle, Haidyan Anugrha, Marzena Kurzawa-Akanbi, Alison Yarnall, David Burn, Gavin Hudson. Neurobiol Aging 2016
11
Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress.
Alicia M Pickrell, Chiu-Hui Huang, Scott R Kennedy, Alban Ordureau, Dionisia P Sideris, Jake G Hoekstra, J Wade Harper, Richard J Youle. Neuron 2015
Alicia M Pickrell, Chiu-Hui Huang, Scott R Kennedy, Alban Ordureau, Dionisia P Sideris, Jake G Hoekstra, J Wade Harper, Richard J Youle. Neuron 2015
11
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.
Pinar E Coskun, M Flint Beal, Douglas C Wallace. Proc Natl Acad Sci U S A 2004
Pinar E Coskun, M Flint Beal, Douglas C Wallace. Proc Natl Acad Sci U S A 2004
11
PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Joo-Ho Shin, Han Seok Ko, Hochul Kang, Yunjong Lee, Yun-Il Lee, Olga Pletinkova, Juan C Troconso, Valina L Dawson, Ted M Dawson. Cell 2011
Joo-Ho Shin, Han Seok Ko, Hochul Kang, Yunjong Lee, Yun-Il Lee, Olga Pletinkova, Juan C Troconso, Valina L Dawson, Ted M Dawson. Cell 2011
10
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
Alicia M Pickrell, Richard J Youle. Neuron 2015
Alicia M Pickrell, Richard J Youle. Neuron 2015
10
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging.
G C Kujoth, A Hiona, T D Pugh, S Someya, K Panzer, S E Wohlgemuth, T Hofer, A Y Seo, R Sullivan, W A Jobling,[...]. Science 2005
G C Kujoth, A Hiona, T D Pugh, S Someya, K Panzer, S E Wohlgemuth, T Hofer, A Y Seo, R Sullivan, W A Jobling,[...]. Science 2005
10
Premature ageing in mice expressing defective mitochondrial DNA polymerase.
Aleksandra Trifunovic, Anna Wredenberg, Maria Falkenberg, Johannes N Spelbrink, Anja T Rovio, Carl E Bruder, Mohammad Bohlooly-Y, Sebastian Gidlöf, Anders Oldfors, Rolf Wibom,[...]. Nature 2004
Aleksandra Trifunovic, Anna Wredenberg, Maria Falkenberg, Johannes N Spelbrink, Anja T Rovio, Carl E Bruder, Mohammad Bohlooly-Y, Sebastian Gidlöf, Anders Oldfors, Rolf Wibom,[...]. Nature 2004
10
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
10
Parkinson disease.
Werner Poewe, Klaus Seppi, Caroline M Tanner, Glenda M Halliday, Patrik Brundin, Jens Volkmann, Anette-Eleonore Schrag, Anthony E Lang. Nat Rev Dis Primers 2017
Werner Poewe, Klaus Seppi, Caroline M Tanner, Glenda M Halliday, Patrik Brundin, Jens Volkmann, Anette-Eleonore Schrag, Anthony E Lang. Nat Rev Dis Primers 2017
9
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1.
Xinglong Wang, Michael H Yan, Hisashi Fujioka, Jun Liu, Amy Wilson-Delfosse, Shu G Chen, George Perry, Gemma Casadesus, Xiongwei Zhu. Hum Mol Genet 2012
Xinglong Wang, Michael H Yan, Hisashi Fujioka, Jun Liu, Amy Wilson-Delfosse, Shu G Chen, George Perry, Gemma Casadesus, Xiongwei Zhu. Hum Mol Genet 2012
9
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain.
Latha Devi, Vijayendran Raghavendran, Badanavalu M Prabhu, Narayan G Avadhani, Hindupur K Anandatheerthavarada. J Biol Chem 2008
Latha Devi, Vijayendran Raghavendran, Badanavalu M Prabhu, Narayan G Avadhani, Hindupur K Anandatheerthavarada. J Biol Chem 2008
9
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin.
Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle. PLoS Biol 2010
Derek P Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Clement A Gautier, Jie Shen, Mark R Cookson, Richard J Youle. PLoS Biol 2010
9
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.
Jeehye Park, Sung Bae Lee, Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim,[...]. Nature 2006
Jeehye Park, Sung Bae Lee, Sungkyu Lee, Yongsung Kim, Saera Song, Sunhong Kim, Eunkyung Bae, Jaeseob Kim, Minho Shong, Jin-Man Kim,[...]. Nature 2006
9
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin.
Ira E Clark, Mark W Dodson, Changan Jiang, Joseph H Cao, Jun R Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A Hay, Ming Guo. Nature 2006
Ira E Clark, Mark W Dodson, Changan Jiang, Joseph H Cao, Jun R Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A Hay, Ming Guo. Nature 2006
9
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1.
Sven Geisler, Kira M Holmström, Diana Skujat, Fabienne C Fiesel, Oliver C Rothfuss, Philipp J Kahle, Wolfdieter Springer. Nat Cell Biol 2010
Sven Geisler, Kira M Holmström, Diana Skujat, Fabienne C Fiesel, Oliver C Rothfuss, Philipp J Kahle, Wolfdieter Springer. Nat Cell Biol 2010
9
9
Chronic systemic pesticide exposure reproduces features of Parkinson's disease.
R Betarbet, T B Sherer, G MacKenzie, M Garcia-Osuna, A V Panov, J T Greenamyre. Nat Neurosci 2000
R Betarbet, T B Sherer, G MacKenzie, M Garcia-Osuna, A V Panov, J T Greenamyre. Nat Neurosci 2000
9
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
Laurie H Sanders, Josée Laganière, Oliver Cooper, Sally K Mak, B Joseph Vu, Y Anne Huang, David E Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D Urnov,[...]. Neurobiol Dis 2014
Laurie H Sanders, Josée Laganière, Oliver Cooper, Sally K Mak, B Joseph Vu, Y Anne Huang, David E Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D Urnov,[...]. Neurobiol Dis 2014
8
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.
Daniel A Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A Andrabi, Valina L Dawson,[...]. Proc Natl Acad Sci U S A 2015
Daniel A Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A Andrabi, Valina L Dawson,[...]. Proc Natl Acad Sci U S A 2015
8
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.
M H Polymeropoulos, C Lavedan, E Leroy, S E Ide, A Dehejia, A Dutra, B Pike, H Root, J Rubenstein, R Boyer,[...]. Science 1997
M H Polymeropoulos, C Lavedan, E Leroy, S E Ide, A Dehejia, A Dutra, B Pike, H Root, J Rubenstein, R Boyer,[...]. Science 1997
8
Abnormalities of the electron transport chain in idiopathic Parkinson's disease.
W D Parker, S J Boyson, J K Parks. Ann Neurol 1989
W D Parker, S J Boyson, J K Parks. Ann Neurol 1989
8
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity.
Lesley A Kane, Michael Lazarou, Adam I Fogel, Yan Li, Koji Yamano, Shireen A Sarraf, Soojay Banerjee, Richard J Youle. J Cell Biol 2014
Lesley A Kane, Michael Lazarou, Adam I Fogel, Yan Li, Koji Yamano, Shireen A Sarraf, Soojay Banerjee, Richard J Youle. J Cell Biol 2014
8
Severe nigrostriatal degeneration without clinical parkinsonism in patients with polymerase gamma mutations.
Charalampos Tzoulis, Gia Tuong Tran, Thomas Schwarzlmüller, Karsten Specht, Kristoffer Haugarvoll, Novin Balafkan, Peer K Lilleng, Hrvoje Miletic, Martin Biermann, Laurence A Bindoff. Brain 2013
Charalampos Tzoulis, Gia Tuong Tran, Thomas Schwarzlmüller, Karsten Specht, Kristoffer Haugarvoll, Novin Balafkan, Peer K Lilleng, Hrvoje Miletic, Martin Biermann, Laurence A Bindoff. Brain 2013
11
Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.
Paula M Keeney, Jing Xie, Roderick A Capaldi, James P Bennett. J Neurosci 2006
Paula M Keeney, Jing Xie, Roderick A Capaldi, James P Bennett. J Neurosci 2006
7
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain.
Michael T Lin, David K Simon, Colette H Ahn, Lauren M Kim, M Flint Beal. Hum Mol Genet 2002
Michael T Lin, David K Simon, Colette H Ahn, Lauren M Kim, M Flint Beal. Hum Mol Genet 2002
7
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
I Irrcher, H Aleyasin, E L Seifert, S J Hewitt, S Chhabra, M Phillips, A K Lutz, M W C Rousseaux, L Bevilacqua, A Jahani-Asl,[...]. Hum Mol Genet 2010
I Irrcher, H Aleyasin, E L Seifert, S J Hewitt, S Chhabra, M Phillips, A K Lutz, M W C Rousseaux, L Bevilacqua, A Jahani-Asl,[...]. Hum Mol Genet 2010
7
Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes.
Wenzhang Wang, Xinglong Wang, Hisashi Fujioka, Charles Hoppel, Alan L Whone, Maeve A Caldwell, Peter J Cullen, Jun Liu, Xiongwei Zhu. Nat Med 2016
Wenzhang Wang, Xinglong Wang, Hisashi Fujioka, Charles Hoppel, Alan L Whone, Maeve A Caldwell, Peter J Cullen, Jun Liu, Xiongwei Zhu. Nat Med 2016
7
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL.
Seok Min Jin, Michael Lazarou, Chunxin Wang, Lesley A Kane, Derek P Narendra, Richard J Youle. J Cell Biol 2010
Seok Min Jin, Michael Lazarou, Chunxin Wang, Lesley A Kane, Derek P Narendra, Richard J Youle. J Cell Biol 2010
7
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease.
Alexander Zimprich, Anna Benet-Pagès, Walter Struhal, Elisabeth Graf, Sebastian H Eck, Marc N Offman, Dietrich Haubenberger, Sabine Spielberger, Eva C Schulte, Peter Lichtner,[...]. Am J Hum Genet 2011
Alexander Zimprich, Anna Benet-Pagès, Walter Struhal, Elisabeth Graf, Sebastian H Eck, Marc N Offman, Dietrich Haubenberger, Sabine Spielberger, Eva C Schulte, Peter Lichtner,[...]. Am J Hum Genet 2011
7
Investigation of mitochondrial biogenesis defects in single substantia nigra neurons using post-mortem human tissues.
Chun Chen, Amy E Vincent, Alasdair P Blain, Anna L Smith, Doug M Turnbull, Amy K Reeve. Neurobiol Dis 2020
Chun Chen, Amy E Vincent, Alasdair P Blain, Anna L Smith, Doug M Turnbull, Amy K Reeve. Neurobiol Dis 2020
38
Mitochondrial DNA point mutations and relative copy number in 1363 disease and control human brains.
Wei Wei, Michael J Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot,[...]. Acta Neuropathol Commun 2017
Wei Wei, Michael J Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot,[...]. Acta Neuropathol Commun 2017
12
Mitochondrial DNA copy numbers in pyramidal neurons are decreased and mitochondrial biogenesis transcriptome signaling is disrupted in Alzheimer's disease hippocampi.
Ann C Rice, Paula M Keeney, Norah K Algarzae, Amy C Ladd, Ravindar R Thomas, James P Bennett. J Alzheimers Dis 2014
Ann C Rice, Paula M Keeney, Norah K Algarzae, Amy C Ladd, Ravindar R Thomas, James P Bennett. J Alzheimers Dis 2014
11
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age.
M Corral-Debrinski, T Horton, M T Lott, J M Shoffner, M F Beal, D C Wallace. Nat Genet 1992
M Corral-Debrinski, T Horton, M T Lott, J M Shoffner, M F Beal, D C Wallace. Nat Genet 1992
7
Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early-stage Parkinson's disease.
Angela Pyle, Rebecca Brennan, Marzena Kurzawa-Akanbi, Alison Yarnall, Anais Thouin, Brit Mollenhauer, David Burn, Patrick F Chinnery, Gavin Hudson. Ann Neurol 2015
Angela Pyle, Rebecca Brennan, Marzena Kurzawa-Akanbi, Alison Yarnall, Anais Thouin, Brit Mollenhauer, David Burn, Patrick F Chinnery, Gavin Hudson. Ann Neurol 2015
10
Mammalian Mitochondria and Aging: An Update.
Timo E S Kauppila, Johanna H K Kauppila, Nils-Göran Larsson. Cell Metab 2017
Timo E S Kauppila, Johanna H K Kauppila, Nils-Göran Larsson. Cell Metab 2017
7
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.
Ulziibat Shirendeb, Arubala P Reddy, Maria Manczak, Marcus J Calkins, Peizhong Mao, Danilo A Tagle, P Hemachandra Reddy. Hum Mol Genet 2011
Ulziibat Shirendeb, Arubala P Reddy, Maria Manczak, Marcus J Calkins, Peizhong Mao, Danilo A Tagle, P Hemachandra Reddy. Hum Mol Genet 2011
7
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.