Janine Hertzog Santos, Joel N Meyer, Bennett Van Houten. Hum Mol Genet 2006
Times Cited: 136
Times Cited: 136
Times Cited
Times Co-cited
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Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage.
Judith Haendeler, Stefan Dröse, Nicole Büchner, Sascha Jakob, Joachim Altschmied, Christine Goy, Ioakim Spyridopoulos, Andreas M Zeiher, Ulrich Brandt, Stefanie Dimmeler. Arterioscler Thromb Vasc Biol 2009
Judith Haendeler, Stefan Dröse, Nicole Büchner, Sascha Jakob, Joachim Altschmied, Christine Goy, Ioakim Spyridopoulos, Andreas M Zeiher, Ulrich Brandt, Stefanie Dimmeler. Arterioscler Thromb Vasc Biol 2009
57
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress.
Shaheda Ahmed, João F Passos, Matthew J Birket, Tina Beckmann, Sebastian Brings, Heiko Peters, Mark A Birch-Machin, Thomas von Zglinicki, Gabriele Saretzki. J Cell Sci 2008
Shaheda Ahmed, João F Passos, Matthew J Birket, Tina Beckmann, Sebastian Brings, Heiko Peters, Mark A Birch-Machin, Thomas von Zglinicki, Gabriele Saretzki. J Cell Sci 2008
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Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage.
Janine Hertzog Santos, Joel N Meyer, Milan Skorvaga, Lois A Annab, Bennett Van Houten. Aging Cell 2004
Janine Hertzog Santos, Joel N Meyer, Milan Skorvaga, Lois A Annab, Bennett Van Houten. Aging Cell 2004
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Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.
Judith Haendeler, Jörg Hoffmann, Ralf P Brandes, Andreas M Zeiher, Stefanie Dimmeler. Mol Cell Biol 2003
Judith Haendeler, Jörg Hoffmann, Ralf P Brandes, Andreas M Zeiher, Stefanie Dimmeler. Mol Cell Biol 2003
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Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria.
Nilesh K Sharma, Aurelio Reyes, Paula Green, Matthieu J Caron, Marcelo G Bonini, Donna M Gordon, Ian J Holt, Janine Hertzog Santos. Nucleic Acids Res 2012
Nilesh K Sharma, Aurelio Reyes, Paula Green, Matthieu J Caron, Marcelo G Bonini, Donna M Gordon, Ian J Holt, Janine Hertzog Santos. Nucleic Acids Res 2012
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Telomere dysfunction induces metabolic and mitochondrial compromise.
Ergün Sahin, Simona Colla, Marc Liesa, Javid Moslehi, Florian L Müller, Mira Guo, Marcus Cooper, Darrell Kotton, Attila J Fabian, Carl Walkey,[...]. Nature 2011
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hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells.
Inthrani R Indran, Manoor P Hande, Shazib Pervaiz. Cancer Res 2011
Inthrani R Indran, Manoor P Hande, Shazib Pervaiz. Cancer Res 2011
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Telomerase modulates Wnt signalling by association with target gene chromatin.
Jae-Il Park, Andrew S Venteicher, Ji Yeon Hong, Jinkuk Choi, Sohee Jun, Marina Shkreli, Woody Chang, Zhaojing Meng, Peggie Cheung, Hong Ji,[...]. Nature 2009
Jae-Il Park, Andrew S Venteicher, Ji Yeon Hong, Jinkuk Choi, Sohee Jun, Marina Shkreli, Woody Chang, Zhaojing Meng, Peggie Cheung, Hong Ji,[...]. Nature 2009
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An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
Yoshiko Maida, Mami Yasukawa, Miho Furuuchi, Timo Lassmann, Richard Possemato, Naoko Okamoto, Vivi Kasim, Yoshihide Hayashizaki, William C Hahn, Kenkichi Masutomi. Nature 2009
Yoshiko Maida, Mami Yasukawa, Miho Furuuchi, Timo Lassmann, Richard Possemato, Naoko Okamoto, Vivi Kasim, Yoshihide Hayashizaki, William C Hahn, Kenkichi Masutomi. Nature 2009
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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.
Kenkichi Masutomi, Richard Possemato, Judy M Y Wong, Jennifer L Currier, Zuzana Tothova, Judith B Manola, Shridar Ganesan, Peter M Lansdorp, Kathleen Collins, William C Hahn. Proc Natl Acad Sci U S A 2005
Kenkichi Masutomi, Richard Possemato, Judy M Y Wong, Jennifer L Currier, Zuzana Tothova, Judith B Manola, Shridar Ganesan, Peter M Lansdorp, Kathleen Collins, William C Hahn. Proc Natl Acad Sci U S A 2005
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A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction.
Olga A Kovalenko, Matthieu J Caron, Perihan Ulema, Carolina Medrano, Andrew P Thomas, Masayuki Kimura, Marcelo G Bonini, Utz Herbig, Janine H Santos. Aging Cell 2010
Olga A Kovalenko, Matthieu J Caron, Perihan Ulema, Carolina Medrano, Andrew P Thomas, Masayuki Kimura, Marcelo G Bonini, Utz Herbig, Janine H Santos. Aging Cell 2010
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Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.
Judith Haendeler, Jörg Hoffmann, J Florian Diehl, Mariuca Vasa, Ioakim Spyridopoulos, Andreas M Zeiher, Stefanie Dimmeler. Circ Res 2004
Judith Haendeler, Jörg Hoffmann, J Florian Diehl, Mariuca Vasa, Ioakim Spyridopoulos, Andreas M Zeiher, Stefanie Dimmeler. Circ Res 2004
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Specific association of human telomerase activity with immortal cells and cancer.
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
N W Kim, M A Piatyszek, K R Prowse, C B Harley, M D West, P L Ho, G M Coviello, W E Wright, S L Weinrich, J W Shay. Science 1994
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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts.
C W Greider, E H Blackburn. Cell 1985
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Conditional telomerase induction causes proliferation of hair follicle stem cells.
Kavita Y Sarin, Peggie Cheung, Daniel Gilison, Eunice Lee, Ruth I Tennen, Estee Wang, Maja K Artandi, Anthony E Oro, Steven E Artandi. Nature 2005
Kavita Y Sarin, Peggie Cheung, Daniel Gilison, Eunice Lee, Ruth I Tennen, Estee Wang, Maja K Artandi, Anthony E Oro, Steven E Artandi. Nature 2005
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Extension of life-span by introduction of telomerase into normal human cells.
A G Bodnar, M Ouellette, M Frolkis, S E Holt, C P Chiu, G B Morin, C B Harley, J W Shay, S Lichtsteiner, W E Wright. Science 1998
A G Bodnar, M Ouellette, M Frolkis, S E Holt, C P Chiu, G B Morin, C B Harley, J W Shay, S Lichtsteiner, W E Wright. Science 1998
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Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent.
Nicole Büchner, Tim-Christian Zschauer, Margarete Lukosz, Joachim Altschmied, Judith Haendeler. Exp Gerontol 2010
Nicole Büchner, Tim-Christian Zschauer, Margarete Lukosz, Joachim Altschmied, Judith Haendeler. Exp Gerontol 2010
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Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis.
Chatchawan Singhapol, Deepali Pal, Rafal Czapiewski, Mahendar Porika, Glyn Nelson, Gabriele C Saretzki. PLoS One 2013
Chatchawan Singhapol, Deepali Pal, Rafal Czapiewski, Mahendar Porika, Glyn Nelson, Gabriele C Saretzki. PLoS One 2013
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Telomerase modulates expression of growth-controlling genes and enhances cell proliferation.
Laura L Smith, Hilary A Coller, James M Roberts. Nat Cell Biol 2003
Laura L Smith, Hilary A Coller, James M Roberts. Nat Cell Biol 2003
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TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.
Jinkuk Choi, Lucinda K Southworth, Kavita Y Sarin, Andrew S Venteicher, Wenxiu Ma, Woody Chang, Peggie Cheung, Sohee Jun, Maja K Artandi, Naman Shah,[...]. PLoS Genet 2008
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Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins.
Paula Martínez, María A Blasco. Nat Rev Cancer 2011
Paula Martínez, María A Blasco. Nat Rev Cancer 2011
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TERT promotes cellular and organismal survival independently of telomerase activity.
J Lee, Y H Sung, C Cheong, Y S Choi, H K Jeon, W Sun, W C Hahn, F Ishikawa, H-W Lee. Oncogene 2008
J Lee, Y H Sung, C Cheong, Y S Choi, H K Jeon, W Sun, W C Hahn, F Ishikawa, H-W Lee. Oncogene 2008
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Shelterin: the protein complex that shapes and safeguards human telomeres.
Titia de Lange. Genes Dev 2005
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Telomerase directly regulates NF-κB-dependent transcription.
Arkasubhra Ghosh, Gaye Saginc, Shi Chi Leow, Ekta Khattar, Eun Myong Shin, Ting Dong Yan, Marc Wong, Zhizhuo Zhang, Guoliang Li, Wing-Kin Sung,[...]. Nat Cell Biol 2012
Arkasubhra Ghosh, Gaye Saginc, Shi Chi Leow, Ekta Khattar, Eun Myong Shin, Ting Dong Yan, Marc Wong, Zhizhuo Zhang, Guoliang Li, Wing-Kin Sung,[...]. Nat Cell Biol 2012
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Telomeres shorten during ageing of human fibroblasts.
C B Harley, A B Futcher, C W Greider. Nature 1990
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13
Protein composition of catalytically active human telomerase from immortal cells.
Scott B Cohen, Mark E Graham, George O Lovrecz, Nicolai Bache, Phillip J Robinson, Roger R Reddel. Science 2007
Scott B Cohen, Mark E Graham, George O Lovrecz, Nicolai Bache, Phillip J Robinson, Roger R Reddel. Science 2007
13
Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function.
D Del Bufalo, A Rizzo, D Trisciuoglio, G Cardinali, M R Torrisi, U Zangemeister-Wittke, G Zupi, A Biroccio. Cell Death Differ 2005
D Del Bufalo, A Rizzo, D Trisciuoglio, G Cardinali, M R Torrisi, U Zangemeister-Wittke, G Zupi, A Biroccio. Cell Death Differ 2005
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Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.
Sascha Jakob, Peter Schroeder, Margarete Lukosz, Nicole Büchner, Ioakim Spyridopoulos, Joachim Altschmied, Judith Haendeler. J Biol Chem 2008
Sascha Jakob, Peter Schroeder, Margarete Lukosz, Nicole Büchner, Ioakim Spyridopoulos, Joachim Altschmied, Judith Haendeler. J Biol Chem 2008
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The major reverse transcriptase-incompetent splice variant of the human telomerase protein inhibits telomerase activity but protects from apoptosis.
Imke Listerman, Jie Sun, Francesca S Gazzaniga, Jason L Lukas, Elizabeth H Blackburn. Cancer Res 2013
Imke Listerman, Jie Sun, Francesca S Gazzaniga, Jason L Lukas, Elizabeth H Blackburn. Cancer Res 2013
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Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit.
S S Kang, T Kwon, D Y Kwon, S I Do. J Biol Chem 1999
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Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation.
Judith Haendeler, Jörg Hoffmann, Sandy Rahman, Andreas M Zeiher, Stefanie Dimmeler. FEBS Lett 2003
Judith Haendeler, Jörg Hoffmann, Sandy Rahman, Andreas M Zeiher, Stefanie Dimmeler. FEBS Lett 2003
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Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.
Katrin Hoffmeyer, Angelo Raggioli, Stefan Rudloff, Roman Anton, Andreas Hierholzer, Ignacio Del Valle, Kerstin Hein, Riana Vogt, Rolf Kemler. Science 2012
Katrin Hoffmeyer, Angelo Raggioli, Stefan Rudloff, Roman Anton, Andreas Hierholzer, Ignacio Del Valle, Kerstin Hein, Riana Vogt, Rolf Kemler. Science 2012
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Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria.
Ilaria Chiodi, Chiara Mondello. Front Oncol 2012
Ilaria Chiodi, Chiara Mondello. Front Oncol 2012
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Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
Masaharu Akiyama, Teru Hideshima, Toshiaki Hayashi, Yu-Tzu Tai, Constantine S Mitsiades, Nicholas Mitsiades, Dharminder Chauhan, Paul Richardson, Nikhil C Munshi, Kenneth C Anderson. Cancer Res 2003
Masaharu Akiyama, Teru Hideshima, Toshiaki Hayashi, Yu-Tzu Tai, Constantine S Mitsiades, Nicholas Mitsiades, Dharminder Chauhan, Paul Richardson, Nikhil C Munshi, Kenneth C Anderson. Cancer Res 2003
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hTERT associates with human telomeres and enhances genomic stability and DNA repair.
Girdhar G Sharma, Arun Gupta, Huichen Wang, Harry Scherthan, Sonu Dhar, Varsha Gandhi, George Iliakis, Jerry W Shay, Charles S H Young, Tej K Pandita. Oncogene 2003
Girdhar G Sharma, Arun Gupta, Huichen Wang, Harry Scherthan, Sonu Dhar, Varsha Gandhi, George Iliakis, Jerry W Shay, Charles S H Young, Tej K Pandita. Oncogene 2003
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hTERT: a novel endogenous inhibitor of the mitochondrial cell death pathway.
C Massard, Y Zermati, A-L Pauleau, N Larochette, D Métivier, L Sabatier, G Kroemer, J-C Soria. Oncogene 2006
C Massard, Y Zermati, A-L Pauleau, N Larochette, D Métivier, L Sabatier, G Kroemer, J-C Soria. Oncogene 2006
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Human telomerase and its regulation.
Yu-Sheng Cong, Woodring E Wright, Jerry W Shay. Microbiol Mol Biol Rev 2002
Yu-Sheng Cong, Woodring E Wright, Jerry W Shay. Microbiol Mol Biol Rev 2002
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Telomerase contributes to tumorigenesis by a telomere length-independent mechanism.
Sheila A Stewart, William C Hahn, Benjamin F O'Connor, Elisa N Banner, Ante S Lundberg, Poonam Modha, Hana Mizuno, Mary W Brooks, Mark Fleming, Drazen B Zimonjic,[...]. Proc Natl Acad Sci U S A 2002
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Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.
Margaret A Strong, Sofia L Vidal-Cardenas, Baktiar Karim, Huimin Yu, Nini Guo, Carol W Greider. Mol Cell Biol 2011
Margaret A Strong, Sofia L Vidal-Cardenas, Baktiar Karim, Huimin Yu, Nini Guo, Carol W Greider. Mol Cell Biol 2011
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Separation of telomerase functions by reverse genetics.
Shibani Mukherjee, Eduardo J Firpo, Yang Wang, James M Roberts. Proc Natl Acad Sci U S A 2011
Shibani Mukherjee, Eduardo J Firpo, Yang Wang, James M Roberts. Proc Natl Acad Sci U S A 2011
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The emerging role of telomerase reverse transcriptase in mitochondrial DNA metabolism.
Donna M Gordon, Janine Hertzog Santos. J Nucleic Acids 2010
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Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation.
Andreas M Beyer, Julie K Freed, Matthew J Durand, Michael Riedel, Karima Ait-Aissa, Paula Green, Joseph C Hockenberry, R Garret Morgan, Anthony J Donato, Refael Peleg,[...]. Circ Res 2016
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Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis.
Vera Gorbunova, Andrei Seluanov, Olivia M Pereira-Smith. J Biol Chem 2002
Vera Gorbunova, Andrei Seluanov, Olivia M Pereira-Smith. J Biol Chem 2002
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Death receptor signaling regulatory function for telomerase: hTERT abolishes TRAIL-induced apoptosis, independently of telomere maintenance.
Charles Dudognon, Frédéric Pendino, Josette Hillion, Anne Saumet, Michel Lanotte, Evelyne Ségal-Bendirdjian. Oncogene 2004
Charles Dudognon, Frédéric Pendino, Josette Hillion, Anne Saumet, Michel Lanotte, Evelyne Ségal-Bendirdjian. Oncogene 2004
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Telomerase catalytic subunit homologs from fission yeast and human.
T M Nakamura, G B Morin, K B Chapman, S L Weinrich, W H Andrews, J Lingner, C B Harley, T R Cech. Science 1997
T M Nakamura, G B Morin, K B Chapman, S L Weinrich, W H Andrews, J Lingner, C B Harley, T R Cech. Science 1997
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