Alastair Aitken. Semin Cancer Biol 2006
Times Cited: 582
Times Cited: 582
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The structural basis for 14-3-3:phosphopeptide binding specificity.
M B Yaffe, K Rittinger, S Volinia, P R Caron, A Aitken, H Leffers, S J Gamblin, S J Smerdon, L C Cantley. Cell 1997
M B Yaffe, K Rittinger, S Volinia, P R Caron, A Aitken, H Leffers, S J Gamblin, S J Smerdon, L C Cantley. Cell 1997
36
14-3-3 proteins: structure, function, and regulation.
H Fu, R R Subramanian, S C Masters. Annu Rev Pharmacol Toxicol 2000
H Fu, R R Subramanian, S C Masters. Annu Rev Pharmacol Toxicol 2000
26
Structural basis of 14-3-3 protein functions.
Tomas Obsil, Veronika Obsilova. Semin Cell Dev Biol 2011
Tomas Obsil, Veronika Obsilova. Semin Cell Dev Biol 2011
21
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.
A J Muslin, J W Tanner, P M Allen, A S Shaw. Cell 1996
A J Muslin, J W Tanner, P M Allen, A S Shaw. Cell 1996
18
Structural basis for protein-protein interactions in the 14-3-3 protein family.
Xiaowen Yang, Wen Hwa Lee, Frank Sobott, Evangelos Papagrigoriou, Carol V Robinson, J Günter Grossmann, Michael Sundström, Declan A Doyle, Jonathan M Elkins. Proc Natl Acad Sci U S A 2006
Xiaowen Yang, Wen Hwa Lee, Frank Sobott, Evangelos Papagrigoriou, Carol V Robinson, J Günter Grossmann, Michael Sundström, Declan A Doyle, Jonathan M Elkins. Proc Natl Acad Sci U S A 2006
18
Crystal structure of the zeta isoform of the 14-3-3 protein.
D Liu, J Bienkowska, C Petosa, R J Collier, H Fu, R Liddington. Nature 1995
D Liu, J Bienkowska, C Petosa, R J Collier, H Fu, R Liddington. Nature 1995
16
Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes.
Carol Mackintosh. Biochem J 2004
Carol Mackintosh. Biochem J 2004
15
Modulators of 14-3-3 Protein-Protein Interactions.
Loes M Stevers, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Tomas Obsil, Isabelle Landrieu, Ylenia Cau, Andrew J Wilson, Anna Karawajczyk, Jan Eickhoff,[...]. J Med Chem 2018
Loes M Stevers, Eline Sijbesma, Maurizio Botta, Carol MacKintosh, Tomas Obsil, Isabelle Landrieu, Ylenia Cau, Andrew J Wilson, Anna Karawajczyk, Jan Eickhoff,[...]. J Med Chem 2018
15
How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis.
Michael B Yaffe. FEBS Lett 2002
Michael B Yaffe. FEBS Lett 2002
13
The role of the 14-3-3 protein family in health, disease, and drug development.
Yasaman Aghazadeh, Vassilios Papadopoulos. Drug Discov Today 2016
Yasaman Aghazadeh, Vassilios Papadopoulos. Drug Discov Today 2016
13
14-3-3-Pred: improved methods to predict 14-3-3-binding phosphopeptides.
Fábio Madeira, Michele Tinti, Gavuthami Murugesan, Emily Berrett, Margaret Stafford, Rachel Toth, Christian Cole, Carol MacKintosh, Geoffrey J Barton. Bioinformatics 2015
Fábio Madeira, Michele Tinti, Gavuthami Murugesan, Emily Berrett, Margaret Stafford, Rachel Toth, Christian Cole, Carol MacKintosh, Geoffrey J Barton. Bioinformatics 2015
14
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms.
Alexandra K Gardino, Stephen J Smerdon, Michael B Yaffe. Semin Cancer Biol 2006
Alexandra K Gardino, Stephen J Smerdon, Michael B Yaffe. Semin Cancer Biol 2006
12
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.
Deborah K Morrison. Trends Cell Biol 2009
Deborah K Morrison. Trends Cell Biol 2009
11
Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
T Obsil, R Ghirlando, D C Klein, S Ganguly, F Dyda. Cell 2001
T Obsil, R Ghirlando, D C Klein, S Ganguly, F Dyda. Cell 2001
11
Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.
Loes M Stevers, Chan V Lam, Seppe F R Leysen, Femke A Meijer, Daphne S van Scheppingen, Rens M J M de Vries, Graeme W Carlile, Lech G Milroy, David Y Thomas, Luc Brunsveld,[...]. Proc Natl Acad Sci U S A 2016
Loes M Stevers, Chan V Lam, Seppe F R Leysen, Femke A Meijer, Daphne S van Scheppingen, Rens M J M de Vries, Graeme W Carlile, Lech G Milroy, David Y Thomas, Luc Brunsveld,[...]. Proc Natl Acad Sci U S A 2016
12
The dynamic and stress-adaptive signaling hub of 14-3-3: emerging mechanisms of regulation and context-dependent protein-protein interactions.
K L Pennington, T Y Chan, M P Torres, J L Andersen. Oncogene 2018
K L Pennington, T Y Chan, M P Torres, J L Andersen. Oncogene 2018
10
Association of Multiple Phosphorylated Proteins with the 14-3-3 Regulatory Hubs: Problems and Perspectives.
Nikolai N Sluchanko. J Mol Biol 2018
Nikolai N Sluchanko. J Mol Biol 2018
27
The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization.
Anne Benzinger, Grzegorz M Popowicz, Joma K Joy, Sudipta Majumdar, Tad A Holak, Heiko Hermeking. Cell Res 2005
Anne Benzinger, Grzegorz M Popowicz, Joma K Joy, Sudipta Majumdar, Tad A Holak, Heiko Hermeking. Cell Res 2005
11
A structural basis for 14-3-3sigma functional specificity.
Erik W Wilker, Robert A Grant, Stephen C Artim, Michael B Yaffe. J Biol Chem 2005
Erik W Wilker, Robert A Grant, Stephen C Artim, Michael B Yaffe. J Biol Chem 2005
9
14-3-3 Proteins in Brain Development: Neurogenesis, Neuronal Migration and Neuromorphogenesis.
Brett Cornell, Kazuhito Toyo-Oka. Front Mol Neurosci 2017
Brett Cornell, Kazuhito Toyo-Oka. Front Mol Neurosci 2017
18
Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding.
K Rittinger, J Budman, J Xu, S Volinia, L C Cantley, S J Smerdon, S J Gamblin, M B Yaffe. Mol Cell 1999
K Rittinger, J Budman, J Xu, S Volinia, L C Cantley, S J Smerdon, S J Gamblin, M B Yaffe. Mol Cell 1999
9
Bioinformatic and experimental survey of 14-3-3-binding sites.
Catherine Johnson, Sandra Crowther, Margaret J Stafford, David G Campbell, Rachel Toth, Carol MacKintosh. Biochem J 2010
Catherine Johnson, Sandra Crowther, Margaret J Stafford, David G Campbell, Rachel Toth, Carol MacKintosh. Biochem J 2010
9
14-3-3zeta binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove.
C Petosa, S C Masters, L A Bankston, J Pohl, B Wang, H Fu, R C Liddington. J Biol Chem 1998
C Petosa, S C Masters, L A Bankston, J Pohl, B Wang, H Fu, R C Liddington. J Biol Chem 1998
9
C-terminal binding: an expanded repertoire and function of 14-3-3 proteins.
Brian Coblitz, Meng Wu, Sojin Shikano, Min Li. FEBS Lett 2006
Brian Coblitz, Meng Wu, Sojin Shikano, Min Li. FEBS Lett 2006
9
9
14-3-3 proteins: a number of functions for a numbered protein.
Dave Bridges, Greg B G Moorhead. Sci STKE 2005
Dave Bridges, Greg B G Moorhead. Sci STKE 2005
8
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways.
B Xiao, S J Smerdon, D H Jones, G G Dodson, Y Soneji, A Aitken, S J Gamblin. Nature 1995
B Xiao, S J Smerdon, D H Jones, G G Dodson, Y Soneji, A Aitken, S J Gamblin. Nature 1995
8
14-3-3 proteins: key regulators of cell division, signalling and apoptosis.
M J van Hemert, H Y Steensma, G P van Heusden. Bioessays 2001
M J van Hemert, H Y Steensma, G P van Heusden. Bioessays 2001
8
Structural interface between LRRK2 and 14-3-3 protein.
Loes M Stevers, Rens M J M de Vries, Richard G Doveston, Lech-Gustav Milroy, Luc Brunsveld, Christian Ottmann. Biochem J 2017
Loes M Stevers, Rens M J M de Vries, Richard G Doveston, Lech-Gustav Milroy, Luc Brunsveld, Christian Ottmann. Biochem J 2017
25
Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Nikolai N Sluchanko, Steven Beelen, Alexandra A Kulikova, Stephen D Weeks, Alfred A Antson, Nikolai B Gusev, Sergei V Strelkov. Structure 2017
Nikolai N Sluchanko, Steven Beelen, Alexandra A Kulikova, Stephen D Weeks, Alfred A Antson, Nikolai B Gusev, Sergei V Strelkov. Structure 2017
11
14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain.
Kazuhito Toyo-oka, Tomoka Wachi, Robert F Hunt, Scott C Baraban, Shinichiro Taya, Hayley Ramshaw, Kozo Kaibuchi, Quenten P Schwarz, Angel F Lopez, Anthony Wynshaw-Boris. J Neurosci 2014
Kazuhito Toyo-oka, Tomoka Wachi, Robert F Hunt, Scott C Baraban, Shinichiro Taya, Hayley Ramshaw, Kozo Kaibuchi, Quenten P Schwarz, Angel F Lopez, Anthony Wynshaw-Boris. J Neurosci 2014
10
Structural view of a fungal toxin acting on a 14-3-3 regulatory complex.
Martin Würtele, Christian Jelich-Ottmann, Alfred Wittinghofer, Claudia Oecking. EMBO J 2003
Martin Würtele, Christian Jelich-Ottmann, Alfred Wittinghofer, Claudia Oecking. EMBO J 2003
7
Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis.
Christian Ottmann, Lubna Yasmin, Michael Weyand, Jeffrey L Veesenmeyer, Maureen H Diaz, Ruth H Palmer, Matthew S Francis, Alan R Hauser, Alfred Wittinghofer, Bengt Hallberg. EMBO J 2007
Christian Ottmann, Lubna Yasmin, Michael Weyand, Jeffrey L Veesenmeyer, Maureen H Diaz, Ruth H Palmer, Matthew S Francis, Alan R Hauser, Alfred Wittinghofer, Bengt Hallberg. EMBO J 2007
7
Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1.
Miroslava Alblova, Aneta Smidova, Vojtech Docekal, Jan Vesely, Petr Herman, Veronika Obsilova, Tomas Obsil. Proc Natl Acad Sci U S A 2017
Miroslava Alblova, Aneta Smidova, Vojtech Docekal, Jan Vesely, Petr Herman, Veronika Obsilova, Tomas Obsil. Proc Natl Acad Sci U S A 2017
20
Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners.
Nikolai N Sluchanko, Kristina V Tugaeva, Sandra J Greive, Alfred A Antson. Sci Rep 2017
Nikolai N Sluchanko, Kristina V Tugaeva, Sandra J Greive, Alfred A Antson. Sci Rep 2017
50
14-3-3 proteins activate Pseudomonas exotoxins-S and -T by chaperoning a hydrophobic surface.
Tobias Karlberg, Peter Hornyak, Ana Filipa Pinto, Stefina Milanova, Mahsa Ebrahimi, Mikael Lindberg, Nikolai Püllen, Axel Nordström, Elinor Löverli, Rémi Caraballo,[...]. Nat Commun 2018
Tobias Karlberg, Peter Hornyak, Ana Filipa Pinto, Stefina Milanova, Mahsa Ebrahimi, Mikael Lindberg, Nikolai Püllen, Axel Nordström, Elinor Löverli, Rémi Caraballo,[...]. Nat Commun 2018
35
14-3-3 proteins in the nervous system.
Daniela Berg, Carsten Holzmann, Olaf Riess. Nat Rev Neurosci 2003
Daniela Berg, Carsten Holzmann, Olaf Riess. Nat Rev Neurosci 2003
7
Visualization and biochemical analyses of the emerging mammalian 14-3-3-phosphoproteome.
Catherine Johnson, Michele Tinti, Nicola T Wood, David G Campbell, Rachel Toth, Fanny Dubois, Kathryn M Geraghty, Barry H C Wong, Laura J Brown, Jennifer Tyler,[...]. Mol Cell Proteomics 2011
Catherine Johnson, Michele Tinti, Nicola T Wood, David G Campbell, Rachel Toth, Fanny Dubois, Kathryn M Geraghty, Barry H C Wong, Laura J Brown, Jennifer Tyler,[...]. Mol Cell Proteomics 2011
12
Neurodevelopmental and neuropsychiatric behaviour defects arise from 14-3-3ζ deficiency.
P S Cheah, H S Ramshaw, P Q Thomas, K Toyo-Oka, X Xu, S Martin, P Coyle, M A Guthridge, F Stomski, M van den Buuse,[...]. Mol Psychiatry 2012
P S Cheah, H S Ramshaw, P Q Thomas, K Toyo-Oka, X Xu, S Martin, P Coyle, M A Guthridge, F Stomski, M van den Buuse,[...]. Mol Psychiatry 2012
9
14-3-3ζ deficient mice in the BALB/c background display behavioural and anatomical defects associated with neurodevelopmental disorders.
Xiangjun Xu, Emily J Jaehne, Zarina Greenberg, Peter McCarthy, Eiman Saleh, Clare L Parish, Daria Camera, Julian Heng, Matilda Haas, Bernhard T Baune,[...]. Sci Rep 2015
Xiangjun Xu, Emily J Jaehne, Zarina Greenberg, Peter McCarthy, Eiman Saleh, Clare L Parish, Daria Camera, Julian Heng, Matilda Haas, Bernhard T Baune,[...]. Sci Rep 2015
24
14-3-3 Proteins Are on the Crossroads of Cancer, Aging, and Age-Related Neurodegenerative Disease.
Xiaolan Fan, Lang Cui, Yao Zeng, Wenhao Song, Uma Gaur, Mingyao Yang. Int J Mol Sci 2019
Xiaolan Fan, Lang Cui, Yao Zeng, Wenhao Song, Uma Gaur, Mingyao Yang. Int J Mol Sci 2019
17
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Jing Jin, F Donelson Smith, Chris Stark, Clark D Wells, James P Fawcett, Sarang Kulkarni, Pavel Metalnikov, Paul O'Donnell, Paul Taylor, Lorne Taylor,[...]. Curr Biol 2004
Jing Jin, F Donelson Smith, Chris Stark, Clark D Wells, James P Fawcett, Sarang Kulkarni, Pavel Metalnikov, Paul O'Donnell, Paul Taylor, Lorne Taylor,[...]. Curr Biol 2004
6
14-3-3 proteins as potential oncogenes.
Guri Tzivion, Vinita Singh Gupta, Ludmila Kaplun, Vitaly Balan. Semin Cancer Biol 2006
Guri Tzivion, Vinita Singh Gupta, Ludmila Kaplun, Vitaly Balan. Semin Cancer Biol 2006
6
The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface.
Joanna M Woodcock, Jane Murphy, Frank C Stomski, Michael C Berndt, Angel F Lopez. J Biol Chem 2003
Joanna M Woodcock, Jane Murphy, Frank C Stomski, Michael C Berndt, Angel F Lopez. J Biol Chem 2003
6
Functional specificity in 14-3-3 isoform interactions through dimer formation and phosphorylation. Chromosome location of mammalian isoforms and variants.
Alastair Aitken. Plant Mol Biol 2002
Alastair Aitken. Plant Mol Biol 2002
6
Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers.
Manuela Molzan, Stefan Kasper, Lars Röglin, Malgorzata Skwarczynska, Takeshi Sassa, Takatsugu Inoue, Frank Breitenbuecher, Junko Ohkanda, Nobuo Kato, Martin Schuler,[...]. ACS Chem Biol 2013
Manuela Molzan, Stefan Kasper, Lars Röglin, Malgorzata Skwarczynska, Takeshi Sassa, Takatsugu Inoue, Frank Breitenbuecher, Junko Ohkanda, Nobuo Kato, Martin Schuler,[...]. ACS Chem Biol 2013
8
Isoforms of 14-3-3 protein can form homo- and heterodimers in vivo and in vitro: implications for function as adapter proteins.
D H Jones, S Ley, A Aitken. FEBS Lett 1995
D H Jones, S Ley, A Aitken. FEBS Lett 1995
6
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