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Times Cited: 281
Times Cited: 281
Times Cited
Times Co-cited
Similarity
Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes.
Michael Kohlhaas, Ting Liu, Andreas Knopp, Tanja Zeller, Mei Fang Ong, Michael Böhm, Brian O'Rourke, Christoph Maack. Circulation 2010
Michael Kohlhaas, Ting Liu, Andreas Knopp, Tanja Zeller, Mei Fang Ong, Michael Böhm, Brian O'Rourke, Christoph Maack. Circulation 2010
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The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart.
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A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.
Diego De Stefani, Anna Raffaello, Enrico Teardo, Ildikò Szabò, Rosario Rizzuto. Nature 2011
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The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.
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NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.
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The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition.
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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.
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Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching.
Ting Liu, Brian O'Rourke. Circ Res 2008
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Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure.
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The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.
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Mitochondrial calcium overload is a key determinant in heart failure.
Gaetano Santulli, Wenjun Xie, Steven R Reiken, Andrew R Marks. Proc Natl Acad Sci U S A 2015
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Edoardo Bertero, Christoph Maack. Circ Res 2018
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The mitochondrial uniporter controls fight or flight heart rate increases.
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The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit.
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EMRE is an essential component of the mitochondrial calcium uniporter complex.
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Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged.
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The mitochondrial calcium uniporter is a highly selective ion channel.
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MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.
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Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.
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MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake.
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Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.
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Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes.
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MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity.
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MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling.
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MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
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Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter.
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Empagliflozin decreases myocardial cytoplasmic Na+ through inhibition of the cardiac Na+/H+ exchanger in rats and rabbits.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.