A citation-based method for searching scientific literature

Estela Jacinto, Valeria Facchinetti, Dou Liu, Nelyn Soto, Shiniu Wei, Sung Yun Jung, Qiaojia Huang, Jun Qin, Bing Su. Cell 2006
Times Cited: 1035







List of co-cited articles
1004 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
45

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
35

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
David A Guertin, Deanna M Stevens, Carson C Thoreen, Aurora A Burds, Nada Y Kalaany, Jason Moffat, Michael Brown, Kevin J Fitzgerald, David M Sabatini. Dev Cell 2006
34

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
31

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
823
22

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Pengda Liu, Wenjian Gan, Y Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C Cantley, Alex Toker,[...]. Cancer Discov 2015
204
22



mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
21

AKT/PKB Signaling: Navigating the Network.
Brendan D Manning, Alex Toker. Cell 2017
20

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.
Maria A Frias, Carson C Thoreen, Jacob D Jaffe, Wayne Schroder, Tom Sculley, Steven A Carr, David M Sabatini. Curr Biol 2006
486
19

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.
Guang Yang, Danielle S Murashige, Sean J Humphrey, David E James. Cell Rep 2015
165
19

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
18

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
17

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
17

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
17

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.
Tsuneo Ikenoue, Ken Inoki, Qian Yang, Xiaoming Zhou, Kun-Liang Guan. EMBO J 2008
460
16

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
16

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
665
15

Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
Laura R Pearce, Xu Huang, Jérôme Boudeau, Rafał Pawłowski, Stephan Wullschleger, Maria Deak, Adel F M Ibrahim, Robert Gourlay, Mark A Magnuson, Dario R Alessi. Biochem J 2007
310
15

Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
15

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
886
15

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
15


mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
411
15

Localization of mTORC2 activity inside cells.
Michael Ebner, Benjamin Sinkovics, Magdalena Szczygieł, Daniela Wolfschoon Ribeiro, Ivan Yudushkin. J Cell Biol 2017
93
15

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
14

Rheb binds and regulates the mTOR kinase.
Xiaomeng Long, Yenshou Lin, Sara Ortiz-Vega, Kazuyoshi Yonezawa, Joseph Avruch. Curr Biol 2005
666
14

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
14


A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
E J Brown, M W Albers, T B Shin, K Ichikawa, C T Keith, W S Lane, S L Schreiber. Nature 1994
13

Mechanism of activation of protein kinase B by insulin and IGF-1.
D R Alessi, M Andjelkovic, B Caudwell, P Cron, N Morrice, P Cohen, B A Hemmings. EMBO J 1996
13

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Louis-Andre Julien, Audrey Carriere, Julie Moreau, Philippe P Roux. Mol Cell Biol 2010
303
13

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Kenta Hara, Yoshiko Maruki, Xiaomeng Long, Ken-ichi Yoshino, Noriko Oshiro, Sujuti Hidayat, Chiharu Tokunaga, Joseph Avruch, Kazuyoshi Yonezawa. Cell 2002
13

Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology.
Charles Betz, Daniele Stracka, Cristina Prescianotto-Baschong, Maud Frieden, Nicolas Demaurex, Michael N Hall. Proc Natl Acad Sci U S A 2013
315
12


Activation of mTORC2 by association with the ribosome.
Vittoria Zinzalla, Daniele Stracka, Wolfgang Oppliger, Michael N Hall. Cell 2011
442
12

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth.
Thomas Porstmann, Claudio R Santos, Beatrice Griffiths, Megan Cully, Mary Wu, Sally Leevers, John R Griffiths, Yuen-Li Chung, Almut Schulze. Cell Metab 2008
785
12

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells.
C J Sabers, M M Martin, G J Brunn, J M Williams, F J Dumont, G Wiederrecht, R T Abraham. J Biol Chem 1995
637
12

mTOR as a central hub of nutrient signalling and cell growth.
Joungmok Kim, Kun-Liang Guan. Nat Cell Biol 2019
337
12


Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Yonghao Yu, Sang-Oh Yoon, George Poulogiannis, Qian Yang, Xiaoju Max Ma, Judit Villén, Neil Kubica, Gregory R Hoffman, Lewis C Cantley, Steven P Gygi,[...]. Science 2011
588
12

Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Asami Hagiwara, Marion Cornu, Nadine Cybulski, Pazit Polak, Charles Betz, Francesca Trapani, Luigi Terracciano, Markus H Heim, Markus A Rüegg, Michael N Hall. Cell Metab 2012
336
11

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.
Won Jun Oh, Chang-chih Wu, Sung Jin Kim, Valeria Facchinetti, Louis-André Julien, Monica Finlan, Philippe P Roux, Bing Su, Estela Jacinto. EMBO J 2010
222
11

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.
Pengda Liu, Wenjian Gan, Hiroyuki Inuzuka, Adam S Lazorchak, Daming Gao, Omotooke Arojo, Dou Liu, Lixin Wan, Bo Zhai, Yonghao Yu,[...]. Nat Cell Biol 2013
171
11

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.
Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C Newton, Yuxin Mao, Robert Q Miao,[...]. EMBO J 2008
384
11

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
727
11


Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
11

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Yasemin Sancak, Carson C Thoreen, Timothy R Peterson, Robert A Lindquist, Seong A Kang, Eric Spooner, Steven A Carr, David M Sabatini. Mol Cell 2007
868
11


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.