Michal Minczuk, Monika A Papworth, Paulina Kolasinska, Michael P Murphy, Aaron Klug. Proc Natl Acad Sci U S A 2006
Times Cited: 102
Times Cited: 102
Times Cited
Times Co-cited
Similarity
Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs.
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Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.
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Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria.
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Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations.
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Selective elimination of mitochondrial mutations in the germline by genome editing.
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Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model.
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Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs.
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MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation.
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Linear mitochondrial DNA is rapidly degraded by components of the replication machinery.
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mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels.
Claudia V Pereira, Sandra R Bacman, Tania Arguello, Ugne Zekonyte, Sion L Williams, David R Edgell, Carlos T Moraes. EMBO Mol Med 2018
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A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.