Bing Hao, Stephanie Oehlmann, Mathew E Sowa, J Wade Harper, Nikola P Pavletich. Mol Cell 2007
Times Cited: 331
Times Cited: 331
Times Cited
Times Co-cited
Similarity
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.
Markus Welcker, Bruce E Clurman. Nat Rev Cancer 2008
Markus Welcker, Bruce E Clurman. Nat Rev Cancer 2008
32
Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.
Ryan J Davis, Markus Welcker, Bruce E Clurman. Cancer Cell 2014
Ryan J Davis, Markus Welcker, Bruce E Clurman. Cancer Cell 2014
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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase.
D M Koepp, L K Schaefer, X Ye, K Keyomarsi, C Chu, J W Harper, S J Elledge. Science 2001
D M Koepp, L K Schaefer, X Ye, K Keyomarsi, C Chu, J W Harper, S J Elledge. Science 2001
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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
Masayoshi Yada, Shigetsugu Hatakeyama, Takumi Kamura, Masaaki Nishiyama, Ryosuke Tsunematsu, Hiroyuki Imaki, Noriko Ishida, Fumihiko Okumura, Keiko Nakayama, Keiichi I Nakayama. EMBO J 2004
Masayoshi Yada, Shigetsugu Hatakeyama, Takumi Kamura, Masaaki Nishiyama, Ryosuke Tsunematsu, Hiroyuki Imaki, Noriko Ishida, Fumihiko Okumura, Keiko Nakayama, Keiichi I Nakayama. EMBO J 2004
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Fbw7 dimerization determines the specificity and robustness of substrate degradation.
Markus Welcker, Elizabeth A Larimore, Jherek Swanger, Maria T Bengoechea-Alonso, Jonathan E Grim, Johan Ericsson, Ning Zheng, Bruce E Clurman. Genes Dev 2013
Markus Welcker, Elizabeth A Larimore, Jherek Swanger, Maria T Bengoechea-Alonso, Jonathan E Grim, Johan Ericsson, Ning Zheng, Bruce E Clurman. Genes Dev 2013
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FBXW7/hCDC4 is a general tumor suppressor in human cancer.
Shahab Akhoondi, Dahui Sun, Natalie von der Lehr, Sophia Apostolidou, Kathleen Klotz, Alena Maljukova, Diana Cepeda, Heidi Fiegl, Dimitra Dafou, Christian Marth,[...]. Cancer Res 2007
Shahab Akhoondi, Dahui Sun, Natalie von der Lehr, Sophia Apostolidou, Kathleen Klotz, Alena Maljukova, Diana Cepeda, Heidi Fiegl, Dimitra Dafou, Christian Marth,[...]. Cancer Res 2007
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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.
Markus Welcker, Amir Orian, Jianping Jin, Jonathan E Grim, J Wade Harper, Robert N Eisenman, Bruce E Clurman. Proc Natl Acad Sci U S A 2004
Markus Welcker, Amir Orian, Jianping Jin, Jonathan E Grim, J Wade Harper, Robert N Eisenman, Bruce E Clurman. Proc Natl Acad Sci U S A 2004
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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.
Stephen Orlicky, Xiaojing Tang, Andrew Willems, Mike Tyers, Frank Sicheri. Cell 2003
Stephen Orlicky, Xiaojing Tang, Andrew Willems, Mike Tyers, Frank Sicheri. Cell 2003
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SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, Daming Gao, Alan Tseng, Richard S Maser, Bo Zhai, Lixin Wan, Alejandro Gutierrez, Alan W Lau,[...]. Nature 2011
Hiroyuki Inuzuka, Shavali Shaik, Ichiro Onoyama, Daming Gao, Alan Tseng, Richard S Maser, Bo Zhai, Lixin Wan, Alejandro Gutierrez, Alan W Lau,[...]. Nature 2011
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Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.
Xiaojing Tang, Stephen Orlicky, Zhenyuan Lin, Andrew Willems, Dante Neculai, Derek Ceccarelli, Frank Mercurio, Brian H Shilton, Frank Sicheri, Mike Tyers. Cell 2007
Xiaojing Tang, Stephen Orlicky, Zhenyuan Lin, Andrew Willems, Dante Neculai, Derek Ceccarelli, Frank Mercurio, Brian H Shilton, Frank Sicheri, Mike Tyers. Cell 2007
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Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
Geng Wu, Guozhou Xu, Brenda A Schulman, Philip D Jeffrey, J Wade Harper, Nikola P Pavletich. Mol Cell 2003
Geng Wu, Guozhou Xu, Brenda A Schulman, Philip D Jeffrey, J Wade Harper, Nikola P Pavletich. Mol Cell 2003
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Mechanisms and function of substrate recruitment by F-box proteins.
Jeffrey R Skaar, Julia K Pagan, Michele Pagano. Nat Rev Mol Cell Biol 2013
Jeffrey R Skaar, Julia K Pagan, Michele Pagano. Nat Rev Mol Cell Biol 2013
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The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase.
Wenyi Wei, Jianping Jin, Susanne Schlisio, J Wade Harper, William G Kaelin. Cancer Cell 2005
Wenyi Wei, Jianping Jin, Susanne Schlisio, J Wade Harper, William G Kaelin. Cancer Cell 2005
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Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
Markus Welcker, Jeffrey Singer, Keith R Loeb, Jonathan Grim, Andrew Bloecher, Mark Gurien-West, Bruce E Clurman, James M Roberts. Mol Cell 2003
Markus Welcker, Jeffrey Singer, Keith R Loeb, Jonathan Grim, Andrew Bloecher, Mark Gurien-West, Bruce E Clurman, James M Roberts. Mol Cell 2003
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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P Meijerink, Rob Pieters,[...]. J Exp Med 2007
Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P Meijerink, Rob Pieters,[...]. J Exp Med 2007
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FBXW7: a critical tumor suppressor of human cancers.
Chien-Hung Yeh, Marcia Bellon, Christophe Nicot. Mol Cancer 2018
Chien-Hung Yeh, Marcia Bellon, Christophe Nicot. Mol Cancer 2018
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Function and regulation of cullin-RING ubiquitin ligases.
Matthew D Petroski, Raymond J Deshaies. Nat Rev Mol Cell Biol 2005
Matthew D Petroski, Raymond J Deshaies. Nat Rev Mol Cell Biol 2005
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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line.
H Strohmaier, C H Spruck, P Kaiser, K A Won, O Sangfelt, S I Reed. Nature 2001
H Strohmaier, C H Spruck, P Kaiser, K A Won, O Sangfelt, S I Reed. Nature 2001
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FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Jian-Hua Mao, Il-Jin Kim, Di Wu, Joan Climent, Hio Chung Kang, Reyno DelRosario, Allan Balmain. Science 2008
Jian-Hua Mao, Il-Jin Kim, Di Wu, Joan Climent, Hio Chung Kang, Reyno DelRosario, Allan Balmain. Science 2008
14
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling.
Abdolrahman S Nateri, Lluís Riera-Sans, Clive Da Costa, Axel Behrens. Science 2004
Abdolrahman S Nateri, Lluís Riera-Sans, Clive Da Costa, Axel Behrens. Science 2004
13
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Ingrid E Wertz, Saritha Kusam, Cynthia Lam, Toru Okamoto, Wendy Sandoval, Daniel J Anderson, Elizabeth Helgason, James A Ernst, Mike Eby, Jinfeng Liu,[...]. Nature 2011
Ingrid E Wertz, Saritha Kusam, Cynthia Lam, Toru Okamoto, Wendy Sandoval, Daniel J Anderson, Elizabeth Helgason, James A Ernst, Mike Eby, Jinfeng Liu,[...]. Nature 2011
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Fbw7/hCDC4 dimerization regulates its substrate interactions.
Markus Welcker, Bruce E Clurman. Cell Div 2007
Markus Welcker, Bruce E Clurman. Cell Div 2007
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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.
P Nash, X Tang, S Orlicky, Q Chen, F B Gertler, M D Mendenhall, F Sicheri, T Pawson, M Tyers. Nature 2001
P Nash, X Tang, S Orlicky, Q Chen, F B Gertler, M D Mendenhall, F Sicheri, T Pawson, M Tyers. Nature 2001
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Ubiquitin ligases: cell-cycle control and cancer.
Keiichi I Nakayama, Keiko Nakayama. Nat Rev Cancer 2006
Keiichi I Nakayama, Keiko Nakayama. Nat Rev Cancer 2006
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Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
Bing Hao, Ning Zheng, Brenda A Schulman, Geng Wu, Julie J Miller, Michele Pagano, Nikola P Pavletich. Mol Cell 2005
Bing Hao, Ning Zheng, Brenda A Schulman, Geng Wu, Julie J Miller, Michele Pagano, Nikola P Pavletich. Mol Cell 2005
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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Teresa A Soucy, Peter G Smith, Michael A Milhollen, Allison J Berger, James M Gavin, Sharmila Adhikari, James E Brownell, Kristine E Burke, David P Cardin, Stephen Critchley,[...]. Nature 2009
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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
C Bai, P Sen, K Hofmann, L Ma, M Goebl, J W Harper, S J Elledge. Cell 1996
C Bai, P Sen, K Hofmann, L Ma, M Goebl, J W Harper, S J Elledge. Cell 1996
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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia.
Benjamin J Thompson, Silvia Buonamici, Maria Luisa Sulis, Teresa Palomero, Tomas Vilimas, Giuseppe Basso, Adolfo Ferrando, Iannis Aifantis. J Exp Med 2007
Benjamin J Thompson, Silvia Buonamici, Maria Luisa Sulis, Teresa Palomero, Tomas Vilimas, Giuseppe Basso, Adolfo Ferrando, Iannis Aifantis. J Exp Med 2007
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Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
David M Duda, Laura A Borg, Daniel C Scott, Harold W Hunt, Michal Hammel, Brenda A Schulman. Cell 2008
David M Duda, Laura A Borg, Daniel C Scott, Harold W Hunt, Michal Hammel, Brenda A Schulman. Cell 2008
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Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase.
Mardo Kõivomägi, Ervin Valk, Rainis Venta, Anna Iofik, Martin Lepiku, Eva Rose M Balog, Seth M Rubin, David O Morgan, Mart Loog. Nature 2011
Mardo Kõivomägi, Ervin Valk, Rainis Venta, Anna Iofik, Martin Lepiku, Eva Rose M Balog, Seth M Rubin, David O Morgan, Mart Loog. Nature 2011
10
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
Ning Zheng, Brenda A Schulman, Langzhou Song, Julie J Miller, Philip D Jeffrey, Ping Wang, Claire Chu, Deanna M Koepp, Stephen J Elledge, Michele Pagano,[...]. Nature 2002
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10
10
Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines.
K H Moberg, D W Bell, D C Wahrer, D A Haber, I K Hariharan. Nature 2001
K H Moberg, D W Bell, D C Wahrer, D A Haber, I K Hariharan. Nature 2001
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The SCF ubiquitin ligase: insights into a molecular machine.
Timothy Cardozo, Michele Pagano. Nat Rev Mol Cell Biol 2004
Timothy Cardozo, Michele Pagano. Nat Rev Mol Cell Biol 2004
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Systematic analysis and nomenclature of mammalian F-box proteins.
Jianping Jin, Timothy Cardozo, Ruth C Lovering, Stephen J Elledge, Michele Pagano, J Wade Harper. Genes Dev 2004
Jianping Jin, Timothy Cardozo, Ruth C Lovering, Stephen J Elledge, Michele Pagano, J Wade Harper. Genes Dev 2004
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Inactivation of hCDC4 can cause chromosomal instability.
Harith Rajagopalan, Prasad V Jallepalli, Carlo Rago, Victor E Velculescu, Kenneth W Kinzler, Bert Vogelstein, Christoph Lengauer. Nature 2004
Harith Rajagopalan, Prasad V Jallepalli, Carlo Rago, Victor E Velculescu, Kenneth W Kinzler, Bert Vogelstein, Christoph Lengauer. Nature 2004
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Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Xu Tan, Luz Irina A Calderon-Villalobos, Michal Sharon, Changxue Zheng, Carol V Robinson, Mark Estelle, Ning Zheng. Nature 2007
Xu Tan, Luz Irina A Calderon-Villalobos, Michal Sharon, Changxue Zheng, Carol V Robinson, Mark Estelle, Ning Zheng. Nature 2007
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Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer.
David Frescas, Michele Pagano. Nat Rev Cancer 2008
David Frescas, Michele Pagano. Nat Rev Cancer 2008
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Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Min Zhuang, Matthew F Calabrese, Jiang Liu, M Brett Waddell, Amanda Nourse, Michal Hammel, Darcie J Miller, Helen Walden, David M Duda, Steven N Seyedin,[...]. Mol Cell 2009
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hCDC4 gene mutations in endometrial cancer.
Charles H Spruck, Heimo Strohmaier, Olle Sangfelt, Hannes M Müller, Michael Hubalek, Elisabeth Müller-Holzner, Christian Marth, Martin Widschwendter, Steven I Reed. Cancer Res 2002
Charles H Spruck, Heimo Strohmaier, Olle Sangfelt, Hannes M Müller, Michael Hubalek, Elisabeth Müller-Holzner, Christian Marth, Martin Widschwendter, Steven I Reed. Cancer Res 2002
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Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.
Luca Busino, Scott E Millman, Luigi Scotto, Christos A Kyratsous, Venkatesha Basrur, Owen O'Connor, Alexander Hoffmann, Kojo S Elenitoba-Johnson, Michele Pagano. Nat Cell Biol 2012
Luca Busino, Scott E Millman, Luigi Scotto, Christos A Kyratsous, Venkatesha Basrur, Owen O'Connor, Alexander Hoffmann, Kojo S Elenitoba-Johnson, Michele Pagano. Nat Cell Biol 2012
9
A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.
Markus Welcker, Amir Orian, Jonathan E Grim, Robert N Eisenman, Bruce E Clurman. Curr Biol 2004
Markus Welcker, Amir Orian, Jonathan E Grim, Robert N Eisenman, Bruce E Clurman. Curr Biol 2004
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hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53.
Takashi Kimura, Mitsukazu Gotoh, Yusuke Nakamura, Hirofumi Arakawa. Cancer Sci 2003
Takashi Kimura, Mitsukazu Gotoh, Yusuke Nakamura, Hirofumi Arakawa. Cancer Sci 2003
8
Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.
Azadeh Arabi, Karim Ullah, Rui M M Branca, Johan Johansson, Daniel Bandarra, Moritz Haneklaus, Jing Fu, Ingrid Ariës, Peter Nilsson, Monique L Den Boer,[...]. Nat Commun 2012
Azadeh Arabi, Karim Ullah, Rui M M Branca, Johan Johansson, Daniel Bandarra, Moritz Haneklaus, Jing Fu, Ingrid Ariës, Peter Nilsson, Monique L Den Boer,[...]. Nat Commun 2012
12
Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7.
Benjamin J Thompson, Vladimir Jankovic, Jie Gao, Silvia Buonamici, Alan Vest, Jennifer May Lee, Jiri Zavadil, Stephen D Nimer, Iannis Aifantis. J Exp Med 2008
Benjamin J Thompson, Vladimir Jankovic, Jie Gao, Silvia Buonamici, Alan Vest, Jennifer May Lee, Jiri Zavadil, Stephen D Nimer, Iannis Aifantis. J Exp Med 2008
8
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
Roya Babaei-Jadidi, Ningning Li, Anas Saadeddin, Bradley Spencer-Dene, Anett Jandke, Belal Muhammad, ElSayed E Ibrahim, Ranjithmenon Muraleedharan, Mohammed Abuzinadah, Hayley Davis,[...]. J Exp Med 2011
Roya Babaei-Jadidi, Ningning Li, Anas Saadeddin, Bradley Spencer-Dene, Anett Jandke, Belal Muhammad, ElSayed E Ibrahim, Ranjithmenon Muraleedharan, Mohammed Abuzinadah, Hayley Davis,[...]. J Exp Med 2011
8
Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase.
Jonathan E Grim, Michael P Gustafson, Roli K Hirata, Amanda C Hagar, Jherek Swanger, Markus Welcker, Harry C Hwang, Johan Ericsson, David W Russell, Bruce E Clurman. J Cell Biol 2008
Jonathan E Grim, Michael P Gustafson, Roli K Hirata, Amanda C Hagar, Jherek Swanger, Markus Welcker, Harry C Hwang, Johan Ericsson, David W Russell, Bruce E Clurman. J Cell Biol 2008
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Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Christy J Fryer, J Brandon White, Katherine A Jones. Mol Cell 2004
Christy J Fryer, J Brandon White, Katherine A Jones. Mol Cell 2004
8
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.
C Oberg, J Li, A Pauley, E Wolf, M Gurney, U Lendahl. J Biol Chem 2001
C Oberg, J Li, A Pauley, E Wolf, M Gurney, U Lendahl. J Biol Chem 2001
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.