A citation-based method for searching scientific literature

Jing Tan, Xiaojing Yang, Li Zhuang, Xia Jiang, Wei Chen, Puay Leng Lee, R K Murthy Karuturi, Patrick Boon Ooi Tan, Edison T Liu, Qiang Yu. Genes Dev 2007
Times Cited: 692







List of co-cited articles
1100 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.
Michael T McCabe, Heidi M Ott, Gopinath Ganji, Susan Korenchuk, Christine Thompson, Glenn S Van Aller, Yan Liu, Alan P Graves, Anthony Della Pietra, Elsie Diaz,[...]. Nature 2012
34

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
Tina Branscombe Miranda, Connie C Cortez, Christine B Yoo, Gangning Liang, Masanobu Abe, Theresa K Kelly, Victor E Marquez, Peter A Jones. Mol Cancer Ther 2009
416
32

A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Sarah K Knutson, Tim J Wigle, Natalie M Warholic, Christopher J Sneeringer, Christina J Allain, Christine R Klaus, Joelle D Sacks, Alejandra Raimondi, Christina R Majer, Jeffrey Song,[...]. Nat Chem Biol 2012
568
23

Targeting EZH2 in cancer.
Kimberly H Kim, Charles W M Roberts. Nat Med 2016
798
23

The Polycomb complex PRC2 and its mark in life.
Raphaël Margueron, Danny Reinberg. Nature 2011
22

The polycomb group protein EZH2 is involved in progression of prostate cancer.
Sooryanarayana Varambally, Saravana M Dhanasekaran, Ming Zhou, Terrence R Barrette, Chandan Kumar-Sinha, Martin G Sanda, Debashis Ghosh, Kenneth J Pienta, Richard G A B Sewalt, Arie P Otte,[...]. Nature 2002
22

Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
Ru Cao, Liangjun Wang, Hengbin Wang, Li Xia, Hediye Erdjument-Bromage, Paul Tempst, Richard S Jones, Yi Zhang. Science 2002
20

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1.
Kyle D Konze, Anqi Ma, Fengling Li, Dalia Barsyte-Lovejoy, Trevor Parton, Christopher J Macnevin, Feng Liu, Cen Gao, Xi-Ping Huang, Ekaterina Kuznetsova,[...]. ACS Chem Biol 2013
304
17

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells.
Celina G Kleer, Qi Cao, Sooryanarayana Varambally, Ronglai Shen, Ichiro Ota, Scott A Tomlins, Debashis Ghosh, Richard G A B Sewalt, Arie P Otte, Daniel F Hayes,[...]. Proc Natl Acad Sci U S A 2003
17

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.
Wei Qi, HoMan Chan, Lin Teng, Ling Li, Shannon Chuai, Ruipeng Zhang, Jue Zeng, Min Li, Hong Fan, Ying Lin,[...]. Proc Natl Acad Sci U S A 2012
410
15

Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma.
Sarah K Knutson, Satoshi Kawano, Yukinori Minoshima, Natalie M Warholic, Kuan-Chun Huang, Yonghong Xiao, Tadashi Kadowaki, Mai Uesugi, Galina Kuznetsov, Namita Kumar,[...]. Mol Cancer Ther 2014
367
15

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.
Sharad K Verma, Xinrong Tian, Louis V LaFrance, Céline Duquenne, Dominic P Suarez, Kenneth A Newlander, Stuart P Romeril, Joelle L Burgess, Seth W Grant, James A Brackley,[...]. ACS Med Chem Lett 2012
260
15

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer.
Woojin Kim, Gregory H Bird, Tobias Neff, Guoji Guo, Marc A Kerenyi, Loren D Walensky, Stuart H Orkin. Nat Chem Biol 2013
242
15

EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent.
Kexin Xu, Zhenhua Jeremy Wu, Anna C Groner, Housheng Hansen He, Changmeng Cai, Rosina T Lis, Xiaoqiu Wu, Edward C Stack, Massimo Loda, Tao Liu,[...]. Science 2012
556
14

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
Ryan D Morin, Nathalie A Johnson, Tesa M Severson, Andrew J Mungall, Jianghong An, Rodrigo Goya, Jessica E Paul, Merrill Boyle, Bruce W Woolcock, Florian Kuchenbauer,[...]. Nat Genet 2010
14


Role of the polycomb protein EED in the propagation of repressive histone marks.
Raphael Margueron, Neil Justin, Katsuhito Ohno, Miriam L Sharpe, Jinsook Son, William J Drury, Philipp Voigt, Stephen R Martin, William R Taylor, Valeria De Marco,[...]. Nature 2009
780
13

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.
Sarah K Knutson, Natalie M Warholic, Tim J Wigle, Christine R Klaus, Christina J Allain, Alejandra Raimondi, Margaret Porter Scott, Richard Chesworth, Mikel P Moyer, Robert A Copeland,[...]. Proc Natl Acad Sci U S A 2013
487
13

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein.
Andrei Kuzmichev, Kenichi Nishioka, Hediye Erdjument-Bromage, Paul Tempst, Danny Reinberg. Genes Dev 2002
13

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Yupeng He, Sujatha Selvaraju, Michael L Curtin, Clarissa G Jakob, Haizhong Zhu, Kenneth M Comess, Bailin Shaw, Juliana The, Evelyne Lima-Fernandes, Magdalena M Szewczyk,[...]. Nat Chem Biol 2017
130
12

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
Wei Qi, Kehao Zhao, Justin Gu, Ying Huang, Youzhen Wang, Hailong Zhang, Man Zhang, Jeff Zhang, Zhengtian Yu, Ling Li,[...]. Nat Chem Biol 2017
183
12

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells.
Eunhee Kim, Misuk Kim, Dong-Hun Woo, Yongjae Shin, Jihye Shin, Nakho Chang, Young Taek Oh, Hong Kim, Jingeun Rheey, Ichiro Nakano,[...]. Cancer Cell 2013
507
12

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites.
Birgit Czermin, Raffaella Melfi, Donna McCabe, Volker Seitz, Axel Imhof, Vincenzo Pirrotta. Cell 2002
12


Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.
Christopher J Sneeringer, Margaret Porter Scott, Kevin W Kuntz, Sarah K Knutson, Roy M Pollock, Victoria M Richon, Robert A Copeland. Proc Natl Acad Sci U S A 2010
467
12

EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Adrian P Bracken, Diego Pasini, Maria Capra, Elena Prosperini, Elena Colli, Kristian Helin. EMBO J 2003
897
12

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
Wendy Béguelin, Relja Popovic, Matt Teater, Yanwen Jiang, Karen L Bunting, Monica Rosen, Hao Shen, Shao Ning Yang, Ling Wang, Teresa Ezponda,[...]. Cancer Cell 2013
536
11

Context-specific regulation of NF-κB target gene expression by EZH2 in breast cancers.
Shuet Theng Lee, Zhimei Li, Zhenlong Wu, Meiyee Aau, Peiyong Guan, R K Murthy Karuturi, Yih Cherng Liou, Qiang Yu. Mol Cell 2011
267
11

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
Michael T McCabe, Alan P Graves, Gopinath Ganji, Elsie Diaz, Wendy S Halsey, Yong Jiang, Kimberly N Smitheman, Heidi M Ott, Melissa B Pappalardi, Kimberly E Allen,[...]. Proc Natl Acad Sci U S A 2012
332
11

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells.
Warren Fiskus, Yongchao Wang, Arun Sreekumar, Kathleen M Buckley, Huidong Shi, Anand Jillella, Celalettin Ustun, Rekha Rao, Pravina Fernandez, Jianguang Chen,[...]. Blood 2009
277
11

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Damian B Yap, Justin Chu, Tobias Berg, Matthieu Schapira, S-W Grace Cheng, Annie Moradian, Ryan D Morin, Andrew J Mungall, Barbara Meissner, Merrill Boyle,[...]. Blood 2011
407
10

Roles of the EZH2 histone methyltransferase in cancer epigenetics.
Jeffrey A Simon, Carol A Lange. Mutat Res 2008
621
10

EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast.
Ingeborg M Bachmann, Ole J Halvorsen, Karin Collett, Ingunn M Stefansson, Oddbjørn Straume, Svein A Haukaas, Helga B Salvesen, Arie P Otte, Lars A Akslen. J Clin Oncol 2006
598
10

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
Raphael Margueron, Guohong Li, Kavitha Sarma, Alexandre Blais, Jiri Zavadil, Christopher L Woodcock, Brian D Dynlacht, Danny Reinberg. Mol Cell 2008
564
10

Discovery of a first-in-class EZH2 selective degrader.
Anqi Ma, Elias Stratikopoulos, Kwang-Su Park, Jieli Wei, Tiphaine C Martin, Xiaobao Yang, Megan Schwarz, Violetta Leshchenko, Alexander Rialdi, Brandon Dale,[...]. Nat Chem Biol 2020
75
13

Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2.
Xiangqian Kong, Limin Chen, Lianying Jiao, Xiangrui Jiang, Fulin Lian, Junyan Lu, Kongkai Zhu, Daohai Du, Jingqiu Liu, Hong Ding,[...]. J Med Chem 2014
63
14

Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.
Diego Pasini, Adrian P Bracken, Michael R Jensen, Eros Lazzerini Denchi, Kristian Helin. EMBO J 2004
636
9

Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Bowen Xu, Doan M On, Anqi Ma, Trevor Parton, Kyle D Konze, Samantha G Pattenden, David F Allison, Ling Cai, Shira Rockowitz, Shichong Liu,[...]. Blood 2015
151
8

Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
Serena Sanulli, Neil Justin, Aurélie Teissandier, Katia Ancelin, Manuela Portoso, Matthieu Caron, Audrey Michaud, Berangère Lombard, Simao T da Rocha, John Offer,[...]. Mol Cell 2015
165
8

Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study.
Antoine Italiano, Jean-Charles Soria, Maud Toulmonde, Jean-Marie Michot, Carlo Lucchesi, Andrea Varga, Jean-Michel Coindre, Stephen J Blakemore, Alicia Clawson, Benjamin Suttle,[...]. Lancet Oncol 2018
323
8

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression.
Reinhard Kalb, Sebastian Latwiel, H Irem Baymaz, Pascal W T C Jansen, Christoph W Müller, Michiel Vermeulen, Jürg Müller. Nat Struct Mol Biol 2014
267
8

Mechanisms of polycomb gene silencing: knowns and unknowns.
Jeffrey A Simon, Robert E Kingston. Nat Rev Mol Cell Biol 2009
8


Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer.
Francesco Crea, Elaine M Hurt, Lesley A Mathews, Stephanie M Cabarcas, Lei Sun, Victor E Marquez, Romano Danesi, William L Farrar. Mol Cancer 2011
118
8

A687V EZH2 is a gain-of-function mutation found in lymphoma patients.
Christina R Majer, Lei Jin, Margaret Porter Scott, Sarah K Knutson, Kevin W Kuntz, Heike Keilhack, Jesse J Smith, Mikel P Moyer, Victoria M Richon, Robert A Copeland,[...]. FEBS Lett 2012
109
8

EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity.
Junli Yan, Siok-Bian Ng, Jim Liang-Seah Tay, Baohong Lin, Tze Loong Koh, Joy Tan, Viknesvaran Selvarajan, Shaw-Cheng Liu, Chonglei Bi, Shi Wang,[...]. Blood 2013
103
8

3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
R I Glazer, K D Hartman, M C Knode, M M Richard, P K Chiang, C K Tseng, V E Marquez. Biochem Biophys Res Commun 1986
122
8


A High-Density Map for Navigating the Human Polycomb Complexome.
Simon Hauri, Federico Comoglio, Makiko Seimiya, Moritz Gerstung, Timo Glatter, Klaus Hansen, Ruedi Aebersold, Renato Paro, Matthias Gstaiger, Christian Beisel. Cell Rep 2016
146
8

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F Haire, Philip A Walker, Danny Reinberg,[...]. Nat Commun 2016
232
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.