Kei Watase, Jennifer R Gatchel, Yaling Sun, Effat Emamian, Richard Atkinson, Ronald Richman, Hidehiro Mizusawa, Harry T Orr, Chad Shaw, Huda Y Zoghbi. PLoS Med 2007
Times Cited: 116
Times Cited: 116
Times Cited
Times Co-cited
Similarity
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.
Haibin Xia, Qinwen Mao, Steven L Eliason, Scott Q Harper, Inês H Martins, Harry T Orr, Henry L Paulson, Linda Yang, Robert M Kotin, Beverly L Davidson. Nat Med 2004
Haibin Xia, Qinwen Mao, Steven L Eliason, Scott Q Harper, Inês H Martins, Harry T Orr, Henry L Paulson, Linda Yang, Robert M Kotin, Beverly L Davidson. Nat Med 2004
22
A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.
Kei Watase, Edwin J Weeber, Bisong Xu, Barbara Antalffy, Lisa Yuva-Paylor, Kouichi Hashimoto, Masanobu Kano, Richard Atkinson, Yaling Sun, Dawna L Armstrong,[...]. Neuron 2002
Kei Watase, Edwin J Weeber, Bisong Xu, Barbara Antalffy, Lisa Yuva-Paylor, Kouichi Hashimoto, Masanobu Kano, Richard Atkinson, Yaling Sun, Dawna L Armstrong,[...]. Neuron 2002
21
A molecular mechanism for the effect of lithium on development.
P S Klein, D A Melton. Proc Natl Acad Sci U S A 1996
P S Klein, D A Melton. Proc Natl Acad Sci U S A 1996
18
GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.
Christopher J Phiel, Christina A Wilson, Virginia M-Y Lee, Peter S Klein. Nature 2003
Christopher J Phiel, Christina A Wilson, Virginia M-Y Lee, Peter S Klein. Nature 2003
16
Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation.
Nigel I Wood, A Jennifer Morton. Brain Res Bull 2003
Nigel I Wood, A Jennifer Morton. Brain Res Bull 2003
24
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1.
Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar-Nejad, Aaron B Bowman, Ronald Richman, David E Hill, Harry T Orr, Huda Y Zoghbi. Nature 2008
Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar-Nejad, Aaron B Bowman, Ronald Richman, David E Hill, Harry T Orr, Huda Y Zoghbi. Nature 2008
15
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells.
V Stambolic, L Ruel, J R Woodgett. Curr Biol 1996
V Stambolic, L Ruel, J R Woodgett. Curr Biol 1996
14
Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.
H T Orr, M Y Chung, S Banfi, T J Kwiatkowski, A Servadio, A L Beaudet, A E McCall, L A Duvick, L P Ranum, H Y Zoghbi. Nat Genet 1993
H T Orr, M Y Chung, S Banfi, T J Kwiatkowski, A Servadio, A L Beaudet, A E McCall, L A Duvick, L P Ranum, H Y Zoghbi. Nat Genet 1993
14
SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat.
E N Burright, H B Clark, A Servadio, T Matilla, R M Feddersen, W S Yunis, L A Duvick, H Y Zoghbi, H T Orr. Cell 1995
E N Burright, H B Clark, A Servadio, T Matilla, R M Feddersen, W S Yunis, L A Duvick, H Y Zoghbi, H T Orr. Cell 1995
14
Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation.
Jenny Carmichael, Katherine L Sugars, Yi Ping Bao, David C Rubinsztein. J Biol Chem 2002
Jenny Carmichael, Katherine L Sugars, Yi Ping Bao, David C Rubinsztein. J Biol Chem 2002
14
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3.
Fiona M Menzies, Jeannette Huebener, Maurizio Renna, Michael Bonin, Olaf Riess, David C Rubinsztein. Brain 2010
Fiona M Menzies, Jeannette Huebener, Maurizio Renna, Michael Bonin, Olaf Riess, David C Rubinsztein. Brain 2010
14
Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1.
Marija Cvetanovic, Jay M Patel, Hugo H Marti, Ameet R Kini, Puneet Opal. Nat Med 2011
Marija Cvetanovic, Jay M Patel, Hugo H Marti, Ameet R Kini, Puneet Opal. Nat Med 2011
21
Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel.
O Zhuchenko, J Bailey, P Bonnen, T Ashizawa, D W Stockton, C Amos, W B Dobyns, S H Subramony, H Y Zoghbi, C C Lee. Nat Genet 1997
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13
Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis.
Ludger Schöls, Peter Bauer, Thorsten Schmidt, Thorsten Schulte, Olaf Riess. Lancet Neurol 2004
Ludger Schöls, Peter Bauer, Thorsten Schmidt, Thorsten Schulte, Olaf Riess. Lancet Neurol 2004
13
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.
Jing Liu, Tie-Shan Tang, Huiping Tu, Omar Nelson, Emily Herndon, Duong P Huynh, Stefan M Pulst, Ilya Bezprozvanny. J Neurosci 2009
Jing Liu, Tie-Shan Tang, Huiping Tu, Omar Nelson, Emily Herndon, Duong P Huynh, Stefan M Pulst, Ilya Bezprozvanny. J Neurosci 2009
13
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane,[...]. Nat Genet 2004
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13
Chronic lithium treatment magnifies learning in rats.
C Nocjar, M D Hammonds, S S Shim. Neuroscience 2007
C Nocjar, M D Hammonds, S S Shim. Neuroscience 2007
24
Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.
Edward Rockenstein, Magdalena Torrance, Anthony Adame, Michael Mante, Pazit Bar-on, John B Rose, Leslie Crews, Eliezer Masliah. J Neurosci 2007
Edward Rockenstein, Magdalena Torrance, Anthony Adame, Michael Mante, Pazit Bar-on, John B Rose, Leslie Crews, Eliezer Masliah. J Neurosci 2007
12
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.
Sovan Sarkar, Gauri Krishna, Sara Imarisio, Shinji Saiki, Cahir J O'Kane, David C Rubinsztein. Hum Mol Genet 2008
Sovan Sarkar, Gauri Krishna, Sara Imarisio, Shinji Saiki, Cahir J O'Kane, David C Rubinsztein. Hum Mol Genet 2008
12
Lithium induces autophagy by inhibiting inositol monophosphatase.
Sovan Sarkar, R Andres Floto, Zdenek Berger, Sara Imarisio, Axelle Cordenier, Matthieu Pasco, Lynnette J Cook, David C Rubinsztein. J Cell Biol 2005
Sovan Sarkar, R Andres Floto, Zdenek Berger, Sara Imarisio, Axelle Cordenier, Matthieu Pasco, Lynnette J Cook, David C Rubinsztein. J Cell Biol 2005
12
Lithium delays progression of amyotrophic lateral sclerosis.
Francesco Fornai, Patrizia Longone, Luisa Cafaro, Olga Kastsiuchenka, Michela Ferrucci, Maria Laura Manca, Gloria Lazzeri, Alida Spalloni, Natascia Bellio, Paola Lenzi,[...]. Proc Natl Acad Sci U S A 2008
Francesco Fornai, Patrizia Longone, Luisa Cafaro, Olga Kastsiuchenka, Michela Ferrucci, Maria Laura Manca, Gloria Lazzeri, Alida Spalloni, Natascia Bellio, Paola Lenzi,[...]. Proc Natl Acad Sci U S A 2008
12
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Xi Chen, Tie-Shan Tang, Huiping Tu, Omar Nelson, Mark Pook, Robert Hammer, Nobuyuki Nukina, Ilya Bezprozvanny. J Neurosci 2008
Xi Chen, Tie-Shan Tang, Huiping Tu, Omar Nelson, Mark Pook, Robert Hammer, Nobuyuki Nukina, Ilya Bezprozvanny. J Neurosci 2008
12
Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.
Raphael Hourez, Laurent Servais, David Orduz, David Gall, Isabelle Millard, Alban de Kerchove d'Exaerde, Guy Cheron, Harry T Orr, Massimo Pandolfo, Serge N Schiffmann. J Neurosci 2011
Raphael Hourez, Laurent Servais, David Orduz, David Gall, Isabelle Millard, Alban de Kerchove d'Exaerde, Guy Cheron, Harry T Orr, Massimo Pandolfo, Serge N Schiffmann. J Neurosci 2011
13
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes.
Richard S Jope. Trends Pharmacol Sci 2003
Richard S Jope. Trends Pharmacol Sci 2003
11
Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder.
Paula V Nunes, Orestes V Forlenza, Wagner F Gattaz. Br J Psychiatry 2007
Paula V Nunes, Orestes V Forlenza, Wagner F Gattaz. Br J Psychiatry 2007
11
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model.
H-L Feng, Y Leng, C-H Ma, J Zhang, M Ren, D-M Chuang. Neuroscience 2008
H-L Feng, Y Leng, C-H Ma, J Zhang, M Ren, D-M Chuang. Neuroscience 2008
11
Gene profiling links SCA1 pathophysiology to glutamate signaling in Purkinje cells of transgenic mice.
Heliane G Serra, Courtney E Byam, Jeffrey D Lande, Susan K Tousey, Huda Y Zoghbi, Harry T Orr. Hum Mol Genet 2004
Heliane G Serra, Courtney E Byam, Jeffrey D Lande, Susan K Tousey, Huda Y Zoghbi, Harry T Orr. Hum Mol Genet 2004
11
Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.
X Lin, B Antalffy, D Kang, H T Orr, H Y Zoghbi. Nat Neurosci 2000
X Lin, B Antalffy, D Kang, H T Orr, H Y Zoghbi. Nat Neurosci 2000
11
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
Daniel Goti, Scott M Katzen, Jesse Mez, Noam Kurtis, Jennifer Kiluk, Lea Ben-Haïem, Nancy A Jenkins, Neal G Copeland, Akira Kakizuka, Alan H Sharp,[...]. J Neurosci 2004
Daniel Goti, Scott M Katzen, Jesse Mez, Noam Kurtis, Jennifer Kiluk, Lea Ben-Haïem, Nancy A Jenkins, Neal G Copeland, Akira Kakizuka, Alan H Sharp,[...]. J Neurosci 2004
11
Lithium chloride alleviates neurodegeneration partly by inhibiting activity of GSK3β in a SCA3 Drosophila model.
Dan-Dan Jia, Li Zhang, Zhao Chen, Chun-Rong Wang, Feng-Zhen Huang, Ran-Hui Duan, Kun Xia, Bei-Sha Tang, Hong Jiang. Cerebellum 2013
Dan-Dan Jia, Li Zhang, Zhao Chen, Chun-Rong Wang, Feng-Zhen Huang, Ran-Hui Duan, Kun Xia, Bei-Sha Tang, Hong Jiang. Cerebellum 2013
42
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade.
Jean-Martin Beaulieu, Tatyana D Sotnikova, Wei-Dong Yao, Lisa Kockeritz, James R Woodgett, Raul R Gainetdinov, Marc G Caron. Proc Natl Acad Sci U S A 2004
Jean-Martin Beaulieu, Tatyana D Sotnikova, Wei-Dong Yao, Lisa Kockeritz, James R Woodgett, Raul R Gainetdinov, Marc G Caron. Proc Natl Acad Sci U S A 2004
10
Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium.
W Timothy O'Brien, Amber DeAra Harper, Fernando Jové, James R Woodgett, Silvia Maretto, Stefano Piccolo, Peter S Klein. J Neurosci 2004
W Timothy O'Brien, Amber DeAra Harper, Fernando Jové, James R Woodgett, Silvia Maretto, Stefano Piccolo, Peter S Klein. J Neurosci 2004
10
Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.
H B Clark, E N Burright, W S Yunis, S Larson, C Wilcox, B Hartman, A Matilla, H Y Zoghbi, H T Orr. J Neurosci 1997
H B Clark, E N Burright, W S Yunis, S Larson, C Wilcox, B Hartman, A Matilla, H Y Zoghbi, H T Orr. J Neurosci 1997
10
Lithium ameliorates altered glycogen synthase kinase-3 and behavior in a mouse model of fragile X syndrome.
Christopher J Yuskaitis, Marjelo A Mines, Margaret K King, J David Sweatt, Courtney A Miller, Richard S Jope. Biochem Pharmacol 2010
Christopher J Yuskaitis, Marjelo A Mines, Margaret K King, J David Sweatt, Courtney A Miller, Richard S Jope. Biochem Pharmacol 2010
10
Lithium prevents and ameliorates experimental autoimmune encephalomyelitis.
Patrizia De Sarno, Robert C Axtell, Chander Raman, Kevin A Roth, Dario R Alessi, Richard S Jope. J Immunol 2008
Patrizia De Sarno, Robert C Axtell, Chander Raman, Kevin A Roth, Dario R Alessi, Richard S Jope. J Immunol 2008
10
Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.
Tao Zu, Lisa A Duvick, Michael D Kaytor, Michael S Berlinger, Huda Y Zoghbi, H Brent Clark, Harry T Orr. J Neurosci 2004
Tao Zu, Lisa A Duvick, Michael D Kaytor, Michael S Berlinger, Huda Y Zoghbi, H Brent Clark, Harry T Orr. J Neurosci 2004
10
Grafting neural precursor cells promotes functional recovery in an SCA1 mouse model.
Satyan Chintawar, Raphael Hourez, Ajay Ravella, David Gall, David Orduz, Myriam Rai, Don Patrick Bishop, Stefano Geuna, Serge N Schiffmann, Massimo Pandolfo. J Neurosci 2009
Satyan Chintawar, Raphael Hourez, Ajay Ravella, David Gall, David Orduz, Myriam Rai, Don Patrick Bishop, Stefano Geuna, Serge N Schiffmann, Massimo Pandolfo. J Neurosci 2009
19
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.
I A Klement, P J Skinner, M D Kaytor, H Yi, S M Hersch, H B Clark, H Y Zoghbi, H T Orr. Cell 1998
I A Klement, P J Skinner, M D Kaytor, H Yi, S M Hersch, H B Clark, H Y Zoghbi, H T Orr. Cell 1998
10
Chronic treatment with 17-DMAG improves balance and coordination in a new mouse model of Machado-Joseph disease.
Anabela Silva-Fernandes, Sara Duarte-Silva, Andreia Neves-Carvalho, Marina Amorim, Carina Soares-Cunha, Pedro Oliveira, Kenneth Thirstrup, Andreia Teixeira-Castro, Patrícia Maciel. Neurotherapeutics 2014
Anabela Silva-Fernandes, Sara Duarte-Silva, Andreia Neves-Carvalho, Marina Amorim, Carina Soares-Cunha, Pedro Oliveira, Kenneth Thirstrup, Andreia Teixeira-Castro, Patrícia Maciel. Neurotherapeutics 2014
14
Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity.
R W Chen, D M Chuang. J Biol Chem 1999
R W Chen, D M Chuang. J Biol Chem 1999
9
Neural and developmental actions of lithium: a unifying hypothesis.
M J Berridge, C P Downes, M R Hanley. Cell 1989
M J Berridge, C P Downes, M R Hanley. Cell 1989
9
Clinical, genetic, molecular, and pathophysiological insights into spinocerebellar ataxia type 1.
Antoni Matilla-Dueñas, Robert Goold, Paola Giunti. Cerebellum 2008
Antoni Matilla-Dueñas, Robert Goold, Paola Giunti. Cerebellum 2008
13
Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels.
Kei Watase, Curtis F Barrett, Taisuke Miyazaki, Taro Ishiguro, Kinya Ishikawa, Yuanxin Hu, Toshinori Unno, Yaling Sun, Sayumi Kasai, Masahiko Watanabe,[...]. Proc Natl Acad Sci U S A 2008
Kei Watase, Curtis F Barrett, Taisuke Miyazaki, Taro Ishiguro, Kinya Ishikawa, Yuanxin Hu, Toshinori Unno, Yaling Sun, Sayumi Kasai, Masahiko Watanabe,[...]. Proc Natl Acad Sci U S A 2008
9
ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology.
Yung C Lam, Aaron B Bowman, Paymaan Jafar-Nejad, Janghoo Lim, Ronald Richman, John D Fryer, Eric D Hyun, Lisa A Duvick, Harry T Orr, Juan Botas,[...]. Cell 2006
Yung C Lam, Aaron B Bowman, Paymaan Jafar-Nejad, Janghoo Lim, Ronald Richman, John D Fryer, Eric D Hyun, Lisa A Duvick, Harry T Orr, Juan Botas,[...]. Cell 2006
9
A feasibility and tolerability study of lithium in Alzheimer's disease.
Alastair Macdonald, Kate Briggs, Michaela Poppe, Andrea Higgins, Latha Velayudhan, Simon Lovestone. Int J Geriatr Psychiatry 2008
Alastair Macdonald, Kate Briggs, Michaela Poppe, Andrea Higgins, Latha Velayudhan, Simon Lovestone. Int J Geriatr Psychiatry 2008
9
Rapamycin alleviates toxicity of different aggregate-prone proteins.
Zdenek Berger, Brinda Ravikumar, Fiona M Menzies, Lourdes Garcia Oroz, Benjamin R Underwood, Menelas N Pangalos, Ina Schmitt, Ullrich Wullner, Bernd O Evert, Cahir J O'Kane,[...]. Hum Mol Genet 2006
Zdenek Berger, Brinda Ravikumar, Fiona M Menzies, Lourdes Garcia Oroz, Benjamin R Underwood, Menelas N Pangalos, Ina Schmitt, Ullrich Wullner, Bernd O Evert, Cahir J O'Kane,[...]. Hum Mol Genet 2006
9
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.
Oksana Kaidanovich-Beilin, Tatiana V Lipina, Keizo Takao, Matthijs van Eede, Satoko Hattori, Christine Laliberté, Mustafa Khan, Kenichi Okamoto, John W Chambers, Paul J Fletcher,[...]. Mol Brain 2009
Oksana Kaidanovich-Beilin, Tatiana V Lipina, Keizo Takao, Matthijs van Eede, Satoko Hattori, Christine Laliberté, Mustafa Khan, Kenichi Okamoto, John W Chambers, Paul J Fletcher,[...]. Mol Brain 2009
9
HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.
An-Hsun Chou, Si-Ying Chen, Tu-Hsueh Yeh, Yi-Hsin Weng, Hung-Li Wang. Neurobiol Dis 2011
An-Hsun Chou, Si-Ying Chen, Tu-Hsueh Yeh, Yi-Hsin Weng, Hung-Li Wang. Neurobiol Dis 2011
12
YAC transgenic mice carrying pathological alleles of the MJD1 locus exhibit a mild and slowly progressive cerebellar deficit.
Cemal K Cemal, Christopher J Carroll, Lorraine Lawrence, Margaret B Lowrie, Piers Ruddle, Sahar Al-Mahdawi, Rosalind H M King, Mark A Pook, Clare Huxley, Susan Chamberlain. Hum Mol Genet 2002
Cemal K Cemal, Christopher J Carroll, Lorraine Lawrence, Margaret B Lowrie, Piers Ruddle, Sahar Al-Mahdawi, Rosalind H M King, Mark A Pook, Clare Huxley, Susan Chamberlain. Hum Mol Genet 2002
9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.