V Pétrilli, S Papin, C Dostert, A Mayor, F Martinon, J Tschopp. Cell Death Differ 2007
Times Cited: 974
Times Cited: 974
Times Cited
Times Co-cited
Similarity
K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.
Raúl Muñoz-Planillo, Peter Kuffa, Giovanny Martínez-Colón, Brenna L Smith, Thekkelnaycke M Rajendiran, Gabriel Núñez. Immunity 2013
Raúl Muñoz-Planillo, Peter Kuffa, Giovanny Martínez-Colón, Brenna L Smith, Thekkelnaycke M Rajendiran, Gabriel Núñez. Immunity 2013
46
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Franz G Bauernfeind, Gabor Horvath, Andrea Stutz, Emad S Alnemri, Kelly MacDonald, David Speert, Teresa Fernandes-Alnemri, Jianghong Wu, Brian G Monks, Katherine A Fitzgerald,[...]. J Immunol 2009
Franz G Bauernfeind, Gabor Horvath, Andrea Stutz, Emad S Alnemri, Kelly MacDonald, David Speert, Teresa Fernandes-Alnemri, Jianghong Wu, Brian G Monks, Katherine A Fitzgerald,[...]. J Immunol 2009
32
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
29
The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
29
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
Fabio Martinon, Kimberly Burns, Jürg Tschopp. Mol Cell 2002
Fabio Martinon, Kimberly Burns, Jürg Tschopp. Mol Cell 2002
26
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Veit Hornung, Franz Bauernfeind, Annett Halle, Eivind O Samstad, Hajime Kono, Kenneth L Rock, Katherine A Fitzgerald, Eicke Latz. Nat Immunol 2008
Veit Hornung, Franz Bauernfeind, Annett Halle, Eivind O Samstad, Hajime Kono, Kenneth L Rock, Katherine A Fitzgerald, Eicke Latz. Nat Immunol 2008
26
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Rebecca C Coll, Avril A B Robertson, Jae Jin Chae, Sarah C Higgins, Raúl Muñoz-Planillo, Marco C Inserra, Irina Vetter, Lara S Dungan, Brian G Monks, Andrea Stutz,[...]. Nat Med 2015
Rebecca C Coll, Avril A B Robertson, Jae Jin Chae, Sarah C Higgins, Raúl Muñoz-Planillo, Marco C Inserra, Irina Vetter, Lara S Dungan, Brian G Monks, Andrea Stutz,[...]. Nat Med 2015
26
Cryopyrin activates the inflammasome in response to toxins and ATP.
Sanjeev Mariathasan, David S Weiss, Kim Newton, Jacqueline McBride, Karen O'Rourke, Meron Roose-Girma, Wyne P Lee, Yvette Weinrauch, Denise M Monack, Vishva M Dixit. Nature 2006
Sanjeev Mariathasan, David S Weiss, Kim Newton, Jacqueline McBride, Karen O'Rourke, Meron Roose-Girma, Wyne P Lee, Yvette Weinrauch, Denise M Monack, Vishva M Dixit. Nature 2006
23
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
Yuan He, Melody Y Zeng, Dahai Yang, Benny Motro, Gabriel Núñez. Nature 2016
Yuan He, Melody Y Zeng, Dahai Yang, Benny Motro, Gabriel Núñez. Nature 2016
23
Inflammasomes: mechanism of assembly, regulation and signalling.
Petr Broz, Vishva M Dixit. Nat Rev Immunol 2016
Petr Broz, Vishva M Dixit. Nat Rev Immunol 2016
23
Gout-associated uric acid crystals activate the NALP3 inflammasome.
Fabio Martinon, Virginie Pétrilli, Annick Mayor, Aubry Tardivel, Jürg Tschopp. Nature 2006
Fabio Martinon, Virginie Pétrilli, Annick Mayor, Aubry Tardivel, Jürg Tschopp. Nature 2006
22
A role for mitochondria in NLRP3 inflammasome activation.
Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jürg Tschopp. Nature 2011
Rongbin Zhou, Amir S Yazdi, Philippe Menu, Jürg Tschopp. Nature 2011
21
Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Rongbin Zhou, Aubry Tardivel, Bernard Thorens, Inpyo Choi, Jürg Tschopp. Nat Immunol 2010
Rongbin Zhou, Aubry Tardivel, Bernard Thorens, Inpyo Choi, Jürg Tschopp. Nat Immunol 2010
21
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
Nobuhiko Kayagaki, Irma B Stowe, Bettina L Lee, Karen O'Rourke, Keith Anderson, Søren Warming, Trinna Cuellar, Benjamin Haley, Merone Roose-Girma, Qui T Phung,[...]. Nature 2015
Nobuhiko Kayagaki, Irma B Stowe, Bettina L Lee, Karen O'Rourke, Keith Anderson, Søren Warming, Trinna Cuellar, Benjamin Haley, Merone Roose-Girma, Qui T Phung,[...]. Nature 2015
19
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Geun-Shik Lee, Naeha Subramanian, Andrew I Kim, Ivona Aksentijevich, Raphaela Goldbach-Mansky, David B Sacks, Ronald N Germain, Daniel L Kastner, Jae Jin Chae. Nature 2012
Geun-Shik Lee, Naeha Subramanian, Andrew I Kim, Ivona Aksentijevich, Raphaela Goldbach-Mansky, David B Sacks, Ronald N Germain, Daniel L Kastner, Jae Jin Chae. Nature 2012
19
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
Rebecca C Coll, James R Hill, Christopher J Day, Alina Zamoshnikova, Dave Boucher, Nicholas L Massey, Jessica L Chitty, James A Fraser, Michael P Jennings, Avril A B Robertson,[...]. Nat Chem Biol 2019
Rebecca C Coll, James R Hill, Christopher J Day, Alina Zamoshnikova, Dave Boucher, Nicholas L Massey, Jessica L Chitty, James A Fraser, Michael P Jennings, Avril A B Robertson,[...]. Nat Chem Biol 2019
18
Critical role for calcium mobilization in activation of the NLRP3 inflammasome.
Tomohiko Murakami, Johan Ockinger, Jiujiu Yu, Vanessa Byles, Aisleen McColl, Aldebaran M Hofer, Tiffany Horng. Proc Natl Acad Sci U S A 2012
Tomohiko Murakami, Johan Ockinger, Jiujiu Yu, Vanessa Byles, Aisleen McColl, Aldebaran M Hofer, Tiffany Horng. Proc Natl Acad Sci U S A 2012
18
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
Xing Liu, Zhibin Zhang, Jianbin Ruan, Youdong Pan, Venkat Giri Magupalli, Hao Wu, Judy Lieberman. Nature 2016
17
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Catherine Dostert, Virginie Pétrilli, Robin Van Bruggen, Chad Steele, Brooke T Mossman, Jürg Tschopp. Science 2008
Catherine Dostert, Virginie Pétrilli, Robin Van Bruggen, Chad Steele, Brooke T Mossman, Jürg Tschopp. Science 2008
17
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation.
Anke Di, Shiqin Xiong, Zhiming Ye, R K Subbarao Malireddi, Satoshi Kometani, Ming Zhong, Manish Mittal, Zhigang Hong, Thirumala-Devi Kanneganti, Jalees Rehman,[...]. Immunity 2018
Anke Di, Shiqin Xiong, Zhiming Ye, R K Subbarao Malireddi, Satoshi Kometani, Ming Zhong, Manish Mittal, Zhigang Hong, Thirumala-Devi Kanneganti, Jalees Rehman,[...]. Immunity 2018
17
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius,[...]. Immunity 2012
Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius,[...]. Immunity 2012
16
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.
Alvin Lu, Venkat Giri Magupalli, Jianbin Ruan, Qian Yin, Maninjay K Atianand, Matthijn R Vos, Gunnar F Schröder, Katherine A Fitzgerald, Hao Wu, Edward H Egelman. Cell 2014
Alvin Lu, Venkat Giri Magupalli, Jianbin Ruan, Qian Yin, Maninjay K Atianand, Matthijn R Vos, Gunnar F Schröder, Katherine A Fitzgerald, Hao Wu, Edward H Egelman. Cell 2014
16
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Peter Duewell, Hajime Kono, Katey J Rayner, Cherilyn M Sirois, Gregory Vladimer, Franz G Bauernfeind, George S Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr,[...]. Nature 2010
Peter Duewell, Hajime Kono, Katey J Rayner, Cherilyn M Sirois, Gregory Vladimer, Franz G Bauernfeind, George S Abela, Luigi Franchi, Gabriel Nuñez, Max Schnurr,[...]. Nature 2010
16
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Annett Halle, Veit Hornung, Gabor C Petzold, Cameron R Stewart, Brian G Monks, Thomas Reinheckel, Katherine A Fitzgerald, Eicke Latz, Kathryn J Moore, Douglas T Golenbock. Nat Immunol 2008
Annett Halle, Veit Hornung, Gabor C Petzold, Cameron R Stewart, Brian G Monks, Thomas Reinheckel, Katherine A Fitzgerald, Eicke Latz, Kathryn J Moore, Douglas T Golenbock. Nat Immunol 2008
16
Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.
Hongbin He, Hua Jiang, Yun Chen, Jin Ye, Aoli Wang, Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng, Wei Jiang,[...]. Nat Commun 2018
Hongbin He, Hua Jiang, Yun Chen, Jin Ye, Aoli Wang, Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng, Wei Jiang,[...]. Nat Commun 2018
15
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.
Christina J Groß, Ritu Mishra, Katharina S Schneider, Guillaume Médard, Jennifer Wettmarshausen, Daniela C Dittlein, Hexin Shi, Oliver Gorka, Paul-Albert Koenig, Stephan Fromm,[...]. Immunity 2016
Christina J Groß, Ritu Mishra, Katharina S Schneider, Guillaume Médard, Jennifer Wettmarshausen, Daniela C Dittlein, Hexin Shi, Oliver Gorka, Paul-Albert Koenig, Stephan Fromm,[...]. Immunity 2016
15
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation.
Nathan Kelley, Devon Jeltema, Yanhui Duan, Yuan He. Int J Mol Sci 2019
Nathan Kelley, Devon Jeltema, Yanhui Duan, Yuan He. Int J Mol Sci 2019
15
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Kiichi Nakahira, Jeffrey Adam Haspel, Vijay A K Rathinam, Seon-Jin Lee, Tamas Dolinay, Hilaire C Lam, Joshua A Englert, Marlene Rabinovitch, Manuela Cernadas, Hong Pyo Kim,[...]. Nat Immunol 2011
Kiichi Nakahira, Jeffrey Adam Haspel, Vijay A K Rathinam, Seon-Jin Lee, Tamas Dolinay, Hilaire C Lam, Joshua A Englert, Marlene Rabinovitch, Manuela Cernadas, Hong Pyo Kim,[...]. Nat Immunol 2011
14
Targeting the NLRP3 inflammasome in inflammatory diseases.
Matthew S J Mangan, Edward J Olhava, William R Roush, H Martin Seidel, Gary D Glick, Eicke Latz. Nat Rev Drug Discov 2018
Matthew S J Mangan, Edward J Olhava, William R Roush, H Martin Seidel, Gary D Glick, Eicke Latz. Nat Rev Drug Discov 2018
14
Non-canonical inflammasome activation targets caspase-11.
Nobuhiko Kayagaki, Søren Warming, Mohamed Lamkanfi, Lieselotte Vande Walle, Salina Louie, Jennifer Dong, Kim Newton, Yan Qu, Jinfeng Liu, Sherry Heldens,[...]. Nature 2011
Nobuhiko Kayagaki, Søren Warming, Mohamed Lamkanfi, Lieselotte Vande Walle, Salina Louie, Jennifer Dong, Kim Newton, Yan Qu, Jinfeng Liu, Sherry Heldens,[...]. Nature 2011
14
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity.
Dave Boucher, Mercedes Monteleone, Rebecca C Coll, Kaiwen W Chen, Connie M Ross, Jessica L Teo, Guillermo A Gomez, Caroline L Holley, Damien Bierschenk, Katryn J Stacey,[...]. J Exp Med 2018
Dave Boucher, Mercedes Monteleone, Rebecca C Coll, Kaiwen W Chen, Connie M Ross, Jessica L Teo, Guillermo A Gomez, Caroline L Holley, Damien Bierschenk, Katryn J Stacey,[...]. J Exp Med 2018
14
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Carlo Marchetti, Benjamin Swartzwelter, Fabia Gamboni, Charles P Neff, Katrin Richter, Tania Azam, Sonia Carta, Isak Tengesdal, Travis Nemkov, Angelo D'Alessandro,[...]. Proc Natl Acad Sci U S A 2018
Carlo Marchetti, Benjamin Swartzwelter, Fabia Gamboni, Charles P Neff, Katrin Richter, Tania Azam, Sonia Carta, Isak Tengesdal, Travis Nemkov, Angelo D'Alessandro,[...]. Proc Natl Acad Sci U S A 2018
14
NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
Jurg Tschopp, Kate Schroder. Nat Rev Immunol 2010
Jurg Tschopp, Kate Schroder. Nat Rev Immunol 2010
13
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng,[...]. Nature 2013
Michael T Heneka, Markus P Kummer, Andrea Stutz, Andrea Delekate, Stephanie Schwartz, Ana Vieira-Saecker, Angelika Griep, Daisy Axt, Anita Remus, Te-Chen Tzeng,[...]. Nature 2013
13
Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation.
Michelle E Heid, Peter A Keyel, Christelle Kamga, Sruti Shiva, Simon C Watkins, Russell D Salter. J Immunol 2013
Michelle E Heid, Peter A Keyel, Christelle Kamga, Sruti Shiva, Simon C Watkins, Russell D Salter. J Immunol 2013
13
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation.
Jueqi Chen, Zhijian J Chen. Nature 2018
Jueqi Chen, Zhijian J Chen. Nature 2018
12
The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.
Naeha Subramanian, Kannan Natarajan, Menna R Clatworthy, Ze Wang, Ronald N Germain. Cell 2013
Naeha Subramanian, Kannan Natarajan, Menna R Clatworthy, Ze Wang, Ronald N Germain. Cell 2013
12
Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang,[...]. EMBO Mol Med 2018
Yi Huang, Hua Jiang, Yun Chen, Xiaqiong Wang, Yanqing Yang, Jinhui Tao, Xianming Deng, Gaolin Liang, Huafeng Zhang, Wei Jiang,[...]. EMBO Mol Med 2018
12
Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation.
Christine Juliana, Teresa Fernandes-Alnemri, Seokwon Kang, Andrew Farias, Fengsong Qin, Emad S Alnemri. J Biol Chem 2012
Christine Juliana, Teresa Fernandes-Alnemri, Seokwon Kang, Andrew Farias, Fengsong Qin, Emad S Alnemri. J Biol Chem 2012
12
Initiation and perpetuation of NLRP3 inflammasome activation and assembly.
Eric I Elliott, Fayyaz S Sutterwala. Immunol Rev 2015
Eric I Elliott, Fayyaz S Sutterwala. Immunol Rev 2015
12
Mechanism and Regulation of NLRP3 Inflammasome Activation.
Yuan He, Hideki Hara, Gabriel Núñez. Trends Biochem Sci 2016
Yuan He, Hideki Hara, Gabriel Núñez. Trends Biochem Sci 2016
11
Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.
Shankar S Iyer, Qiong He, John R Janczy, Eric I Elliott, Zhenyu Zhong, Alicia K Olivier, Jeffrey J Sadler, Vickie Knepper-Adrian, Renzhi Han, Liang Qiao,[...]. Immunity 2013
Shankar S Iyer, Qiong He, John R Janczy, Eric I Elliott, Zhenyu Zhong, Alicia K Olivier, Jeffrey J Sadler, Vickie Knepper-Adrian, Renzhi Han, Liang Qiao,[...]. Immunity 2013
11
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
Auvro R Mridha, Alexander Wree, Avril A B Robertson, Matthew M Yeh, Casey D Johnson, Derrick M Van Rooyen, Fahrettin Haczeyni, Narci C-H Teoh, Christopher Savard, George N Ioannou,[...]. J Hepatol 2017
Auvro R Mridha, Alexander Wree, Avril A B Robertson, Matthew M Yeh, Casey D Johnson, Derrick M Van Rooyen, Fahrettin Haczeyni, Narci C-H Teoh, Christopher Savard, George N Ioannou,[...]. J Hepatol 2017
11
Activation and regulation of the inflammasomes.
Eicke Latz, T Sam Xiao, Andrea Stutz. Nat Rev Immunol 2013
Eicke Latz, T Sam Xiao, Andrea Stutz. Nat Rev Immunol 2013
11
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.
Mohamed Lamkanfi, James L Mueller, Alberto C Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P Lee, Hal M Hoffman, Vishva M Dixit. J Cell Biol 2009
Mohamed Lamkanfi, James L Mueller, Alberto C Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P Lee, Hal M Hoffman, Vishva M Dixit. J Cell Biol 2009
11
The inflammasomes: guardians of the body.
Fabio Martinon, Annick Mayor, Jürg Tschopp. Annu Rev Immunol 2009
Fabio Martinon, Annick Mayor, Jürg Tschopp. Annu Rev Immunol 2009
11
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.
Hua Jiang, Hongbin He, Yun Chen, Wei Huang, Jinbo Cheng, Jin Ye, Aoli Wang, Jinhui Tao, Chao Wang, Qingsong Liu,[...]. J Exp Med 2017
Hua Jiang, Hongbin He, Yun Chen, Wei Huang, Jinbo Cheng, Jin Ye, Aoli Wang, Jinhui Tao, Chao Wang, Qingsong Liu,[...]. J Exp Med 2017
11
Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.
Christine Juliana, Teresa Fernandes-Alnemri, Jianghong Wu, Pinaki Datta, Leobaldo Solorzano, Je-Wook Yu, Rong Meng, Andrew A Quong, Eicke Latz, Charles P Scott,[...]. J Biol Chem 2010
Christine Juliana, Teresa Fernandes-Alnemri, Jianghong Wu, Pinaki Datta, Leobaldo Solorzano, Je-Wook Yu, Rong Meng, Andrew A Quong, Eicke Latz, Charles P Scott,[...]. J Biol Chem 2010
11
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.