DNA polymerase theta (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct.
Mineaki Seki, Richard D Wood. DNA Repair (Amst) 2008
Times Cited: 64
Times Cited: 64
Times Cited
Times Co-cited
Similarity
POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.
Mineaki Seki, Federica Marini, Richard D Wood. Nucleic Acids Res 2003
Mineaki Seki, Federica Marini, Richard D Wood. Nucleic Acids Res 2003
65
High-efficiency bypass of DNA damage by human DNA polymerase Q.
Mineaki Seki, Chikahide Masutani, Lee Wei Yang, Anthony Schuffert, Shigenori Iwai, Ivet Bahar, Richard D Wood. EMBO J 2004
Mineaki Seki, Chikahide Masutani, Lee Wei Yang, Anthony Schuffert, Shigenori Iwai, Ivet Bahar, Richard D Wood. EMBO J 2004
62
Low-fidelity DNA synthesis by human DNA polymerase theta.
Mercedes E Arana, Mineaki Seki, Richard D Wood, Igor B Rogozin, Thomas A Kunkel. Nucleic Acids Res 2008
Mercedes E Arana, Mineaki Seki, Richard D Wood, Igor B Rogozin, Thomas A Kunkel. Nucleic Acids Res 2008
54
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm.
Naoko Shima, Robert J Munroe, John C Schimenti. Mol Cell Biol 2004
Naoko Shima, Robert J Munroe, John C Schimenti. Mol Cell Biol 2004
45
Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.
Michio Yoshimura, Masaoki Kohzaki, Jun Nakamura, Kenjiro Asagoshi, Eiichiro Sonoda, Esther Hou, Rajendra Prasad, Samuel H Wilson, Keizo Tano, Akira Yasui,[...]. Mol Cell 2006
Michio Yoshimura, Masaoki Kohzaki, Jun Nakamura, Kenjiro Asagoshi, Eiichiro Sonoda, Esther Hou, Rajendra Prasad, Samuel H Wilson, Keizo Tano, Akira Yasui,[...]. Mol Cell 2006
42
Lesion bypass activity of DNA polymerase θ (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts.
Matthew Hogg, Mineaki Seki, Richard D Wood, Sylvie Doublié, Susan S Wallace. J Mol Biol 2011
Matthew Hogg, Mineaki Seki, Richard D Wood, Sylvie Doublié, Susan S Wallace. J Mol Biol 2011
41
DNA polymerase theta up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability.
Fanny Lemée, Valérie Bergoglio, Anne Fernandez-Vidal, Alice Machado-Silva, Marie-Jeanne Pillaire, Anne Bieth, Catherine Gentil, Lee Baker, Anne-Laure Martin, Claire Leduc,[...]. Proc Natl Acad Sci U S A 2010
Fanny Lemée, Valérie Bergoglio, Anne Fernandez-Vidal, Alice Machado-Silva, Marie-Jeanne Pillaire, Anne Bieth, Catherine Gentil, Lee Baker, Anne-Laure Martin, Claire Leduc,[...]. Proc Natl Acad Sci U S A 2010
37
Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro.
Rajendra Prasad, Matthew J Longley, Farida S Sharief, Esther W Hou, William C Copeland, Samuel H Wilson. Nucleic Acids Res 2009
Rajendra Prasad, Matthew J Longley, Farida S Sharief, Esther W Hou, William C Copeland, Samuel H Wilson. Nucleic Acids Res 2009
35
POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308.
Federica Marini, Nayun Kim, Anthony Schuffert, Richard D Wood. J Biol Chem 2003
Federica Marini, Nayun Kim, Anthony Schuffert, Richard D Wood. J Biol Chem 2003
32
Human DNA polymerase N (POLN) is a low fidelity enzyme capable of error-free bypass of 5S-thymine glycol.
Kei-ichi Takata, Tatsuhiko Shimizu, Shigenori Iwai, Richard D Wood. J Biol Chem 2006
Kei-ichi Takata, Tatsuhiko Shimizu, Shigenori Iwai, Richard D Wood. J Biol Chem 2006
29
The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta.
C Masutani, R Kusumoto, A Yamada, N Dohmae, M Yokoi, M Yuasa, M Araki, S Iwai, K Takio, F Hanaoka. Nature 1999
C Masutani, R Kusumoto, A Yamada, N Dohmae, M Yokoi, M Yuasa, M Araki, S Iwai, K Takio, F Hanaoka. Nature 1999
29
DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.
Kiyoko Kawamura, Rumana Bahar, Mika Seimiya, Masako Chiyo, Akihiko Wada, Seiji Okada, Masahiko Hatano, Takeshi Tokuhisa, Hideki Kimura, Satoshi Watanabe,[...]. Int J Cancer 2004
Kiyoko Kawamura, Rumana Bahar, Mika Seimiya, Masako Chiyo, Akihiko Wada, Seiji Okada, Masahiko Hatano, Takeshi Tokuhisa, Hideki Kimura, Satoshi Watanabe,[...]. Int J Cancer 2004
29
Phenotype-based identification of mouse chromosome instability mutants.
Naoko Shima, Suzanne A Hartford, Ted Duffy, Lawriston A Wilson, Kerry J Schimenti, John C Schimenti. Genetics 2003
Naoko Shima, Suzanne A Hartford, Ted Duffy, Lawriston A Wilson, Kerry J Schimenti, John C Schimenti. Genetics 2003
29
Lack of DNA polymerase theta (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei after total-body irradiation.
Julie P Goff, Donna S Shields, Mineaki Seki, Serah Choi, Michael W Epperly, Tracy Dixon, Hong Wang, Christopher J Bakkenist, Stephen D Dertinger, Dorothea K Torous,[...]. Radiat Res 2009
Julie P Goff, Donna S Shields, Mineaki Seki, Serah Choi, Michael W Epperly, Tracy Dixon, Hong Wang, Christopher J Bakkenist, Stephen D Dertinger, Dorothea K Torous,[...]. Radiat Res 2009
39
Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.
Sze Ham Chan, Amy Marie Yu, Mitch McVey. PLoS Genet 2010
Sze Ham Chan, Amy Marie Yu, Mitch McVey. PLoS Genet 2010
29
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination.
Pedro A Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M Miller, Eros Lazzerini-Denchi, Agnel Sfeir. Nature 2015
Pedro A Mateos-Gomez, Fade Gong, Nidhi Nair, Kyle M Miller, Eros Lazzerini-Denchi, Agnel Sfeir. Nature 2015
29
Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden,[...]. PLoS Genet 2014
Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden,[...]. PLoS Genet 2014
28
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I R Petalcorin, Kevin W O'Connor, Panagiotis A Konstantinopoulos, Stephen J Elledge, Simon J Boulton,[...]. Nature 2015
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I R Petalcorin, Kevin W O'Connor, Panagiotis A Konstantinopoulos, Stephen J Elledge, Simon J Boulton,[...]. Nature 2015
28
DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.
Keiji Masuda, Rika Ouchida, Masaki Hikida, Tomohiro Kurosaki, Masayuki Yokoi, Chikahide Masutani, Mineaki Seki, Richard D Wood, Fumio Hanaoka, Jiyang O-Wang. J Biol Chem 2007
Keiji Masuda, Rika Ouchida, Masaki Hikida, Tomohiro Kurosaki, Masayuki Yokoi, Chikahide Masutani, Mineaki Seki, Richard D Wood, Fumio Hanaoka, Jiyang O-Wang. J Biol Chem 2007
31
DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.
Keiji Masuda, Rika Ouchida, Arata Takeuchi, Takashi Saito, Haruhiko Koseki, Kiyoko Kawamura, Masatoshi Tagawa, Takeshi Tokuhisa, Takachika Azuma, Jiyang O-Wang. Proc Natl Acad Sci U S A 2005
Keiji Masuda, Rika Ouchida, Arata Takeuchi, Takashi Saito, Haruhiko Koseki, Kiyoko Kawamura, Masatoshi Tagawa, Takeshi Tokuhisa, Takachika Azuma, Jiyang O-Wang. Proc Natl Acad Sci U S A 2005
26
A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown.
Geoff S Higgins, Remko Prevo, Yin-Fai Lee, Thomas Helleday, Ruth J Muschel, Steve Taylor, Michio Yoshimura, Ian D Hickson, Eric J Bernhard, W Gillies McKenna. Cancer Res 2010
Geoff S Higgins, Remko Prevo, Yin-Fai Lee, Thomas Helleday, Ruth J Muschel, Steve Taylor, Michio Yoshimura, Ian D Hickson, Eric J Bernhard, W Gillies McKenna. Cancer Res 2010
26
A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites.
Wouter Koole, Robin van Schendel, Andrea E Karambelas, Jane T van Heteren, Kristy L Okihara, Marcel Tijsterman. Nat Commun 2014
Wouter Koole, Robin van Schendel, Andrea E Karambelas, Jane T van Heteren, Kristy L Okihara, Marcel Tijsterman. Nat Commun 2014
26
Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes.
P V Harris, O M Mazina, E A Leonhardt, R B Case, J B Boyd, K C Burtis. Mol Cell Biol 1996
P V Harris, O M Mazina, E A Leonhardt, R B Case, J B Boyd, K C Burtis. Mol Cell Biol 1996
25
The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation.
Hong Zan, Naoko Shima, Zhenming Xu, Ahmed Al-Qahtani, Albert J Evinger Iii, Yuan Zhong, John C Schimenti, Paolo Casali. EMBO J 2005
Hong Zan, Naoko Shima, Zhenming Xu, Ahmed Al-Qahtani, Albert J Evinger Iii, Yuan Zhong, John C Schimenti, Paolo Casali. EMBO J 2005
25
Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.
Diego M Muzzini, Paolo Plevani, Simon J Boulton, Giuseppe Cassata, Federica Marini. DNA Repair (Amst) 2008
Diego M Muzzini, Paolo Plevani, Simon J Boulton, Giuseppe Cassata, Federica Marini. DNA Repair (Amst) 2008
25
Promiscuous DNA synthesis by human DNA polymerase θ.
Matthew Hogg, A Elisabeth Sauer-Eriksson, Erik Johansson. Nucleic Acids Res 2012
Matthew Hogg, A Elisabeth Sauer-Eriksson, Erik Johansson. Nucleic Acids Res 2012
36
Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ.
Tatiana Kent, Gurushankar Chandramouly, Shane Michael McDevitt, Ahmet Y Ozdemir, Richard T Pomerantz. Nat Struct Mol Biol 2015
Tatiana Kent, Gurushankar Chandramouly, Shane Michael McDevitt, Ahmet Y Ozdemir, Richard T Pomerantz. Nat Struct Mol Biol 2015
25
Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase.
F S Sharief, P J Vojta, P A Ropp, W C Copeland. Genomics 1999
F S Sharief, P J Vojta, P A Ropp, W C Copeland. Genomics 1999
23
Reevaluation of the role of DNA polymerase theta in somatic hypermutation of immunoglobulin genes.
Stella A Martomo, Huseyin Saribasak, Masayuki Yokoi, Fumio Hanaoka, Patricia J Gearhart. DNA Repair (Amst) 2008
Stella A Martomo, Huseyin Saribasak, Masayuki Yokoi, Fumio Hanaoka, Patricia J Gearhart. DNA Repair (Amst) 2008
38
Deoxycytidyl transferase activity of yeast REV1 protein.
J R Nelson, C W Lawrence, D C Hinkle. Nature 1996
J R Nelson, C W Lawrence, D C Hinkle. Nature 1996
21
The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases.
Scott D McCulloch, Thomas A Kunkel. Cell Res 2008
Scott D McCulloch, Thomas A Kunkel. Cell Res 2008
21
Overexpression of POLQ confers a poor prognosis in early breast cancer patients.
Geoff S Higgins, Adrian L Harris, Remko Prevo, Thomas Helleday, W Gillies McKenna, Francesca M Buffa. Oncotarget 2010
Geoff S Higgins, Adrian L Harris, Remko Prevo, Thomas Helleday, W Gillies McKenna, Francesca M Buffa. Oncotarget 2010
21
A role for DNA polymerase θ in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.
Jung-Hoon Yoon, Jayati Roy Choudhury, Jeseong Park, Satya Prakash, Louise Prakash. J Biol Chem 2014
Jung-Hoon Yoon, Jayati Roy Choudhury, Jeseong Park, Satya Prakash, Louise Prakash. J Biol Chem 2014
31
hRAD30 mutations in the variant form of xeroderma pigmentosum.
R E Johnson, C M Kondratick, S Prakash, L Prakash. Science 1999
R E Johnson, C M Kondratick, S Prakash, L Prakash. Science 1999
20
Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions.
R E Johnson, M T Washington, L Haracska, S Prakash, L Prakash. Nature 2000
R E Johnson, M T Washington, L Haracska, S Prakash, L Prakash. Nature 2000
20
Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance.
Lauren S Waters, Brenda K Minesinger, Mary Ellen Wiltrout, Sanjay D'Souza, Rachel V Woodruff, Graham C Walker. Microbiol Mol Biol Rev 2009
Lauren S Waters, Brenda K Minesinger, Mary Ellen Wiltrout, Sanjay D'Souza, Rachel V Woodruff, Graham C Walker. Microbiol Mol Biol Rev 2009
20
20
Human DNA polymerase θ grasps the primer terminus to mediate DNA repair.
Karl E Zahn, April M Averill, Pierre Aller, Richard D Wood, Sylvie Doublié. Nat Struct Mol Biol 2015
Karl E Zahn, April M Averill, Pierre Aller, Richard D Wood, Sylvie Doublié. Nat Struct Mol Biol 2015
20
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis.
Caixia Guo, Paula L Fischhaber, Margaret J Luk-Paszyc, Yuji Masuda, Jing Zhou, Kenji Kamiya, Caroline Kisker, Errol C Friedberg. EMBO J 2003
Caixia Guo, Paula L Fischhaber, Margaret J Luk-Paszyc, Yuji Masuda, Jing Zhou, Kenji Kamiya, Caroline Kisker, Errol C Friedberg. EMBO J 2003
18
Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes.
Keiji Masuda, Rika Ouchida, Masaki Hikida, Manabu Nakayama, Osamu Ohara, Tomohiro Kurosaki, Jiyang O-Wang. DNA Repair (Amst) 2006
Keiji Masuda, Rika Ouchida, Masaki Hikida, Manabu Nakayama, Osamu Ohara, Tomohiro Kurosaki, Jiyang O-Wang. DNA Repair (Amst) 2006
35
A 'DNA replication' signature of progression and negative outcome in colorectal cancer.
M-J Pillaire, J Selves, K Gordien, P-A Gourraud, C Gentil, M Danjoux, C Do, V Negre, A Bieth, R Guimbaud,[...]. Oncogene 2010
M-J Pillaire, J Selves, K Gordien, P-A Gourraud, C Gentil, M Danjoux, C Do, V Negre, A Bieth, R Guimbaud,[...]. Oncogene 2010
18
DNA polymerase POLQ and cellular defense against DNA damage.
Matthew J Yousefzadeh, Richard D Wood. DNA Repair (Amst) 2013
Matthew J Yousefzadeh, Richard D Wood. DNA Repair (Amst) 2013
19
Loss of DNA polymerase zeta causes chromosomal instability in mammalian cells.
John P Wittschieben, Shalini C Reshmi, Susanne M Gollin, Richard D Wood. Cancer Res 2006
John P Wittschieben, Shalini C Reshmi, Susanne M Gollin, Richard D Wood. Cancer Res 2006
17
Disruption of the Rev3l-encoded catalytic subunit of polymerase zeta in mice results in early embryonic lethality.
G Esposito, I Godindagger, U Klein, M L Yaspo, A Cumano, K Rajewsky. Curr Biol 2000
G Esposito, I Godindagger, U Klein, M L Yaspo, A Cumano, K Rajewsky. Curr Biol 2000
17
Disruption of the developmentally regulated Rev3l gene causes embryonic lethality.
J Wittschieben, M K Shivji, E Lalani, M A Jacobs, F Marini, P J Gearhart, I Rosewell, G Stamp, R D Wood. Curr Biol 2000
J Wittschieben, M K Shivji, E Lalani, M A Jacobs, F Marini, P J Gearhart, I Rosewell, G Stamp, R D Wood. Curr Biol 2000
17
Disruption of mouse polymerase zeta (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro.
M Bemark, A A Khamlichi, S L Davies, M S Neuberger. Curr Biol 2000
M Bemark, A A Khamlichi, S L Davies, M S Neuberger. Curr Biol 2000
15
Mechanisms of accurate translesion synthesis by human DNA polymerase eta.
C Masutani, R Kusumoto, S Iwai, F Hanaoka. EMBO J 2000
C Masutani, R Kusumoto, S Iwai, F Hanaoka. EMBO J 2000
15
Thymine-thymine dimer bypass by yeast DNA polymerase zeta.
J R Nelson, C W Lawrence, D C Hinkle. Science 1996
J R Nelson, C W Lawrence, D C Hinkle. Science 1996
15
The Y-family of DNA polymerases.
H Ohmori, E C Friedberg, R P Fuchs, M F Goodman, F Hanaoka, D Hinkle, T A Kunkel, C W Lawrence, Z Livneh, T Nohmi,[...]. Mol Cell 2001
H Ohmori, E C Friedberg, R P Fuchs, M F Goodman, F Hanaoka, D Hinkle, T A Kunkel, C W Lawrence, Z Livneh, T Nohmi,[...]. Mol Cell 2001
15
Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links.
Laura Zietlow, Leigh Anne Smith, Mika Bessho, Tadayoshi Bessho. Biochemistry 2009
Laura Zietlow, Leigh Anne Smith, Mika Bessho, Tadayoshi Bessho. Biochemistry 2009
26
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.