Mizuho Hasegawa, Yukari Fujimoto, Peter C Lucas, Hiroyasu Nakano, Koichi Fukase, Gabriel Núñez, Naohiro Inohara. EMBO J 2008
Times Cited: 367
Times Cited: 367
Times Cited
Times Co-cited
Similarity
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.
Y Ogura, N Inohara, A Benito, F F Chen, S Yamaoka, G Nunez. J Biol Chem 2001
Y Ogura, N Inohara, A Benito, F F Chen, S Yamaoka, G Nunez. J Biol Chem 2001
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RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs.
Jong-Hwan Park, Yun-Gi Kim, Christine McDonald, Thirumala-Devi Kanneganti, Mizuho Hasegawa, Mathilde Body-Malapel, Naohiro Inohara, Gabriel Núñez. J Immunol 2007
Jong-Hwan Park, Yun-Gi Kim, Christine McDonald, Thirumala-Devi Kanneganti, Mizuho Hasegawa, Mathilde Body-Malapel, Naohiro Inohara, Gabriel Núñez. J Immunol 2007
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NOD1 and NOD2: signaling, host defense, and inflammatory disease.
Roberta Caruso, Neil Warner, Naohiro Inohara, Gabriel Núñez. Immunity 2014
Roberta Caruso, Neil Warner, Naohiro Inohara, Gabriel Núñez. Immunity 2014
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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.
Leonardo H Travassos, Leticia A M Carneiro, Mahendrasingh Ramjeet, Seamus Hussey, Yun-Gi Kim, João G Magalhães, Linda Yuan, Fraser Soares, Evelyn Chea, Lionel Le Bourhis,[...]. Nat Immunol 2010
Leonardo H Travassos, Leticia A M Carneiro, Mahendrasingh Ramjeet, Seamus Hussey, Yun-Gi Kim, João G Magalhães, Linda Yuan, Fraser Soares, Evelyn Chea, Lionel Le Bourhis,[...]. Nat Immunol 2010
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Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.
Stephen E Girardin, Ivo G Boneca, Jérôme Viala, Mathias Chamaillard, Agnès Labigne, Gilles Thomas, Dana J Philpott, Philippe J Sansonetti. J Biol Chem 2003
Stephen E Girardin, Ivo G Boneca, Jérôme Viala, Mathias Chamaillard, Agnès Labigne, Gilles Thomas, Dana J Philpott, Philippe J Sansonetti. J Biol Chem 2003
24
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.
Stephen E Girardin, Ivo G Boneca, Leticia A M Carneiro, Aude Antignac, Muguette Jéhanno, Jérôme Viala, Karsten Tedin, Muhamed-Kheir Taha, Agnes Labigne, Ulrich Zähringer,[...]. Science 2003
Stephen E Girardin, Ivo G Boneca, Leticia A M Carneiro, Aude Antignac, Muguette Jéhanno, Jérôme Viala, Karsten Tedin, Muhamed-Kheir Taha, Agnes Labigne, Ulrich Zähringer,[...]. Science 2003
24
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
Rune Busk Damgaard, Ueli Nachbur, Monica Yabal, Wendy Wei-Lynn Wong, Berthe Katrine Fiil, Mischa Kastirr, Eva Rieser, James Arthur Rickard, Aleksandra Bankovacki, Christian Peschel,[...]. Mol Cell 2012
Rune Busk Damgaard, Ueli Nachbur, Monica Yabal, Wendy Wei-Lynn Wong, Berthe Katrine Fiil, Mischa Kastirr, Eva Rieser, James Arthur Rickard, Aleksandra Bankovacki, Christian Peschel,[...]. Mol Cell 2012
24
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
Mathieu J M Bertrand, Karine Doiron, Katherine Labbé, Robert G Korneluk, Philip A Barker, Maya Saleh. Immunity 2009
Mathieu J M Bertrand, Karine Doiron, Katherine Labbé, Robert G Korneluk, Philip A Barker, Maya Saleh. Immunity 2009
23
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.
Mathias Chamaillard, Masahito Hashimoto, Yasuo Horie, Junya Masumoto, Su Qiu, Lisa Saab, Yasunori Ogura, Akiko Kawasaki, Koichi Fukase, Shoichi Kusumoto,[...]. Nat Immunol 2003
Mathias Chamaillard, Masahito Hashimoto, Yasuo Horie, Junya Masumoto, Su Qiu, Lisa Saab, Yasunori Ogura, Akiko Kawasaki, Koichi Fukase, Shoichi Kusumoto,[...]. Nat Immunol 2003
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NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.
Rachel Cooney, John Baker, Oliver Brain, Benedicte Danis, Tica Pichulik, Philip Allan, David J P Ferguson, Barry J Campbell, Derek Jewell, Alison Simmons. Nat Med 2010
Rachel Cooney, John Baker, Oliver Brain, Benedicte Danis, Tica Pichulik, Philip Allan, David J P Ferguson, Barry J Campbell, Derek Jewell, Alison Simmons. Nat Med 2010
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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
J P Hugot, M Chamaillard, H Zouali, S Lesage, J P Cézard, J Belaiche, S Almer, C Tysk, C A O'Morain, M Gassull,[...]. Nature 2001
J P Hugot, M Chamaillard, H Zouali, S Lesage, J P Cézard, J Belaiche, S Almer, C Tysk, C A O'Morain, M Gassull,[...]. Nature 2001
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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.
Koichi Kobayashi, Naohiro Inohara, Lorraine D Hernandez, Jorge E Galán, Gabriel Núñez, Charles A Janeway, Ruslan Medzhitov, Richard A Flavell. Nature 2002
Koichi Kobayashi, Naohiro Inohara, Lorraine D Hernandez, Jorge E Galán, Gabriel Núñez, Charles A Janeway, Ruslan Medzhitov, Richard A Flavell. Nature 2002
21
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.
Y Ogura, D K Bonen, N Inohara, D L Nicolae, F F Chen, R Ramos, H Britton, T Moran, R Karaliuskas, R H Duerr,[...]. Nature 2001
Y Ogura, D K Bonen, N Inohara, D L Nicolae, F F Chen, R Ramos, H Britton, T Moran, R Karaliuskas, R H Duerr,[...]. Nature 2001
20
Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.
Justine T Tigno-Aranjuez, John M Asara, Derek W Abbott. Genes Dev 2010
Justine T Tigno-Aranjuez, John M Asara, Derek W Abbott. Genes Dev 2010
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An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways.
N Inohara, T Koseki, J Lin, L del Peso, P C Lucas, F F Chen, Y Ogura, G Núñez. J Biol Chem 2000
N Inohara, T Koseki, J Lin, L del Peso, P C Lucas, F F Chen, Y Ogura, G Núñez. J Biol Chem 2000
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XIAP mediates NOD signaling via interaction with RIP2.
Andreas Krieg, Ricardo G Correa, Jason B Garrison, Gaëlle Le Negrate, Kate Welsh, Ziwei Huang, Wolfram T Knoefel, John C Reed. Proc Natl Acad Sci U S A 2009
Andreas Krieg, Ricardo G Correa, Jason B Garrison, Gaëlle Le Negrate, Kate Welsh, Ziwei Huang, Wolfram T Knoefel, John C Reed. Proc Natl Acad Sci U S A 2009
19
NOD proteins: regulators of inflammation in health and disease.
Dana J Philpott, Matthew T Sorbara, Susan J Robertson, Kenneth Croitoru, Stephen E Girardin. Nat Rev Immunol 2014
Dana J Philpott, Matthew T Sorbara, Susan J Robertson, Kenneth Croitoru, Stephen E Girardin. Nat Rev Immunol 2014
18
NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.
Yibin Yang, Catherine Yin, Amit Pandey, Derek Abbott, Christopher Sassetti, Michelle A Kelliher. J Biol Chem 2007
Yibin Yang, Catherine Yin, Amit Pandey, Derek Abbott, Christopher Sassetti, Michelle A Kelliher. J Biol Chem 2007
17
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.
Naohiro Inohara, Yasunori Ogura, Ana Fontalba, Olga Gutierrez, Fernando Pons, Javier Crespo, Koichi Fukase, Seiichi Inamura, Shoichi Kusumoto, Masahito Hashimoto,[...]. J Biol Chem 2003
Naohiro Inohara, Yasunori Ogura, Ana Fontalba, Olga Gutierrez, Fernando Pons, Javier Crespo, Koichi Fukase, Seiichi Inamura, Shoichi Kusumoto, Masahito Hashimoto,[...]. J Biol Chem 2003
17
The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.
Osamu Hitotsumatsu, Regina-Celeste Ahmad, Rita Tavares, Min Wang, Dana Philpott, Emre E Turer, Bettina L Lee, Nataliya Shiffin, Rommel Advincula, Barbara A Malynn,[...]. Immunity 2008
Osamu Hitotsumatsu, Regina-Celeste Ahmad, Rita Tavares, Min Wang, Dana Philpott, Emre E Turer, Bettina L Lee, Nataliya Shiffin, Rommel Advincula, Barbara A Malynn,[...]. Immunity 2008
16
A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.
Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk,[...]. Nat Commun 2015
Ueli Nachbur, Che A Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M Lindqvist, Berthe K Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J Sandow, Hendrik Falk,[...]. Nat Commun 2015
23
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
J V McCarthy, J Ni, V M Dixit. J Biol Chem 1998
J V McCarthy, J Ni, V M Dixit. J Biol Chem 1998
16
ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.
Mingfang Tao, Peter C Scacheri, Jill M Marinis, Edward W Harhaj, Lydia E Matesic, Derek W Abbott. Curr Biol 2009
Mingfang Tao, Peter C Scacheri, Jill M Marinis, Edward W Harhaj, Lydia E Matesic, Derek W Abbott. Curr Biol 2009
16
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker-Jensen, Philipp J Jost, Stephan Ehl, Niels Mailand, Mads Gyrd-Hansen. EMBO Mol Med 2013
Rune Busk Damgaard, Berthe Katrine Fiil, Carsten Speckmann, Monica Yabal, Udo zur Stadt, Simon Bekker-Jensen, Philipp J Jost, Stephan Ehl, Niels Mailand, Mads Gyrd-Hansen. EMBO Mol Med 2013
16
Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains.
Derek W Abbott, Yibin Yang, Jessica E Hutti, Swetha Madhavarapu, Michelle A Kelliher, Lewis C Cantley. Mol Cell Biol 2007
Derek W Abbott, Yibin Yang, Jessica E Hutti, Swetha Madhavarapu, Michelle A Kelliher, Lewis C Cantley. Mol Cell Biol 2007
15
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.
Shuo Yang, Bingwei Wang, Fiachra Humphries, Ruaidhri Jackson, Marc E Healy, Ronan Bergin, Gabriella Aviello, Barry Hall, Deirdre McNamara, Trevor Darby,[...]. Nat Immunol 2013
Shuo Yang, Bingwei Wang, Fiachra Humphries, Ruaidhri Jackson, Marc E Healy, Ronan Bergin, Gabriella Aviello, Barry Hall, Deirdre McNamara, Trevor Darby,[...]. Nat Immunol 2013
23
The immune receptor NOD1 and kinase RIP2 interact with bacterial peptidoglycan on early endosomes to promote autophagy and inflammatory signaling.
Aaron T Irving, Hitomi Mimuro, Thomas A Kufer, Camden Lo, Richard Wheeler, Lorinda J Turner, Belinda J Thomas, Christian Malosse, Michael P Gantier, Linda N Casillas,[...]. Cell Host Microbe 2014
Aaron T Irving, Hitomi Mimuro, Thomas A Kufer, Camden Lo, Richard Wheeler, Lorinda J Turner, Belinda J Thomas, Christian Malosse, Michael P Gantier, Linda N Casillas,[...]. Cell Host Microbe 2014
15
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.
N Inohara, T Koseki, L del Peso, Y Hu, C Yee, S Chen, R Carrio, J Merino, D Liu, J Ni,[...]. J Biol Chem 1999
N Inohara, T Koseki, L del Peso, Y Hu, C Yee, S Chen, R Carrio, J Merino, D Liu, J Ni,[...]. J Biol Chem 1999
14
Identification of a regulatory autophosphorylation site in the serine-threonine kinase RIP2.
Marion Dorsch, Anlai Wang, Hong Cheng, Chafen Lu, Andrew Bielecki, Kathryn Charron, Karl Clauser, Hong Ren, Roberto D Polakiewicz, Tom Parsons,[...]. Cell Signal 2006
Marion Dorsch, Anlai Wang, Hong Cheng, Chafen Lu, Andrew Bielecki, Kathryn Charron, Karl Clauser, Hong Ren, Roberto D Polakiewicz, Tom Parsons,[...]. Cell Signal 2006
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OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
Berthe Katrine Fiil, Rune Busk Damgaard, Sebastian Alexander Wagner, Kirstin Keusekotten, Melanie Fritsch, Simon Bekker-Jensen, Niels Mailand, Chunaram Choudhary, David Komander, Mads Gyrd-Hansen. Mol Cell 2013
Berthe Katrine Fiil, Rune Busk Damgaard, Sebastian Alexander Wagner, Kirstin Keusekotten, Melanie Fritsch, Simon Bekker-Jensen, Niels Mailand, Chunaram Choudhary, David Komander, Mads Gyrd-Hansen. Mol Cell 2013
14
13
Activation of innate immune antiviral responses by Nod2.
Ahmed Sabbah, Te Hung Chang, Rosalinda Harnack, Victoria Frohlich, Kaoru Tominaga, Peter H Dube, Yan Xiang, Santanu Bose. Nat Immunol 2009
Ahmed Sabbah, Te Hung Chang, Rosalinda Harnack, Victoria Frohlich, Kaoru Tominaga, Peter H Dube, Yan Xiang, Santanu Bose. Nat Immunol 2009
13
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands.
Yun-Gi Kim, Jong-Hwan Park, Michael H Shaw, Luigi Franchi, Naohiro Inohara, Gabriel Núñez. Immunity 2008
Yun-Gi Kim, Jong-Hwan Park, Michael H Shaw, Luigi Franchi, Naohiro Inohara, Gabriel Núñez. Immunity 2008
13
In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
Justine T Tigno-Aranjuez, Pascal Benderitter, Frederik Rombouts, Frederik Deroose, XiaoDong Bai, Benedetta Mattioli, Fabio Cominelli, Theresa T Pizarro, Jan Hoflack, Derek W Abbott. J Biol Chem 2014
Justine T Tigno-Aranjuez, Pascal Benderitter, Frederik Rombouts, Frederik Deroose, XiaoDong Bai, Benedetta Mattioli, Fabio Cominelli, Theresa T Pizarro, Jan Hoflack, Derek W Abbott. J Biol Chem 2014
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ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.
Craig R Homer, Amy L Richmond, Nancy A Rebert, Jean-Paul Achkar, Christine McDonald. Gastroenterology 2010
Craig R Homer, Amy L Richmond, Nancy A Rebert, Jean-Paul Achkar, Christine McDonald. Gastroenterology 2010
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NOD-like receptors: role in innate immunity and inflammatory disease.
Grace Chen, Michael H Shaw, Yun-Gi Kim, Gabriel Nuñez. Annu Rev Pathol 2009
Grace Chen, Michael H Shaw, Yun-Gi Kim, Gabriel Nuñez. Annu Rev Pathol 2009
12
The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.
Matthew T Sorbara, Lisa K Ellison, Mahendrasingh Ramjeet, Leonardo H Travassos, Nicola L Jones, Stephen E Girardin, Dana J Philpott. Immunity 2013
Matthew T Sorbara, Lisa K Ellison, Mahendrasingh Ramjeet, Leonardo H Travassos, Nicola L Jones, Stephen E Girardin, Dana J Philpott. Immunity 2013
12
Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.
Norihiro Nakamura, Jennie R Lill, Qui Phung, Zhaoshi Jiang, Corey Bakalarski, Ann de Mazière, Judith Klumperman, Megan Schlatter, Lélia Delamarre, Ira Mellman. Nature 2014
Norihiro Nakamura, Jennie R Lill, Qui Phung, Zhaoshi Jiang, Corey Bakalarski, Ann de Mazière, Judith Klumperman, Megan Schlatter, Lélia Delamarre, Ira Mellman. Nature 2014
12
Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.
Mark Windheim, Christine Lang, Mark Peggie, Lorna A Plater, Philip Cohen. Biochem J 2007
Mark Windheim, Christine Lang, Mark Peggie, Lorna A Plater, Philip Cohen. Biochem J 2007
12
Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.
Peter Canning, Qui Ruan, Tobias Schwerd, Matous Hrdinka, Jenny L Maki, Danish Saleh, Chalada Suebsuwong, Soumya Ray, Paul E Brennan, Gregory D Cuny,[...]. Chem Biol 2015
Peter Canning, Qui Ruan, Tobias Schwerd, Matous Hrdinka, Jenny L Maki, Danish Saleh, Chalada Suebsuwong, Soumya Ray, Paul E Brennan, Gregory D Cuny,[...]. Chem Biol 2015
20
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
M Thome, K Hofmann, K Burns, F Martinon, J L Bodmer, C Mattmann, J Tschopp. Curr Biol 1998
M Thome, K Hofmann, K Burns, F Martinon, J L Bodmer, C Mattmann, J Tschopp. Curr Biol 1998
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Signalling pathways and molecular interactions of NOD1 and NOD2.
Warren Strober, Peter J Murray, Atsushi Kitani, Tomohiro Watanabe. Nat Rev Immunol 2006
Warren Strober, Peter J Murray, Atsushi Kitani, Tomohiro Watanabe. Nat Rev Immunol 2006
12
CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.
S E Girardin, R Tournebize, M Mavris, A L Page, X Li, G R Stark, J Bertin, P S DiStefano, M Yaniv, P J Sansonetti,[...]. EMBO Rep 2001
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12
NOD1 and NOD2 signalling links ER stress with inflammation.
A Marijke Keestra-Gounder, Mariana X Byndloss, Núbia Seyffert, Briana M Young, Alfredo Chávez-Arroyo, April Y Tsai, Stephanie A Cevallos, Maria G Winter, Oanh H Pham, Connor R Tiffany,[...]. Nature 2016
A Marijke Keestra-Gounder, Mariana X Byndloss, Núbia Seyffert, Briana M Young, Alfredo Chávez-Arroyo, April Y Tsai, Stephanie A Cevallos, Maria G Winter, Oanh H Pham, Connor R Tiffany,[...]. Nature 2016
11
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract.
Koichi S Kobayashi, Mathias Chamaillard, Yasunori Ogura, Octavian Henegariu, Naohiro Inohara, Gabriel Nuñez, Richard A Flavell. Science 2005
Koichi S Kobayashi, Mathias Chamaillard, Yasunori Ogura, Octavian Henegariu, Naohiro Inohara, Gabriel Nuñez, Richard A Flavell. Science 2005
11
RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis.
N Inohara, L del Peso, T Koseki, S Chen, G Núñez. J Biol Chem 1998
N Inohara, L del Peso, T Koseki, S Chen, G Núñez. J Biol Chem 1998
11
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
Pamela A Haile, Bartholomew J Votta, Robert W Marquis, Michael J Bury, John F Mehlmann, Robert Singhaus, Adam K Charnley, Ami S Lakdawala, Máire A Convery, David B Lipshutz,[...]. J Med Chem 2016
Pamela A Haile, Bartholomew J Votta, Robert W Marquis, Michael J Bury, John F Mehlmann, Robert Singhaus, Adam K Charnley, Ami S Lakdawala, Máire A Convery, David B Lipshutz,[...]. J Med Chem 2016
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NOD1 and NOD2 Signaling in Infection and Inflammation.
Lilian O Moreira, Dario S Zamboni. Front Immunol 2012
Lilian O Moreira, Dario S Zamboni. Front Immunol 2012
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Structural basis of RIP2 activation and signaling.
Qin Gong, Ziqi Long, Franklin L Zhong, Daniel Eng Thiam Teo, Yibo Jin, Zhan Yin, Zhao Zhi Boo, Yaming Zhang, Jiawen Zhang, Renliang Yang,[...]. Nat Commun 2018
Qin Gong, Ziqi Long, Franklin L Zhong, Daniel Eng Thiam Teo, Yibo Jin, Zhan Yin, Zhao Zhi Boo, Yaming Zhang, Jiawen Zhang, Renliang Yang,[...]. Nat Commun 2018
35
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.