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Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis.
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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia.
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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia.
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TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD.
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ALS Genetics: Gains, Losses, and Implications for Future Therapies.
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Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.
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ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
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Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization.
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Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS.
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C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
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ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.