Thanos D Halazonetis, Vassilis G Gorgoulis, Jiri Bartek. Science 2008
Times Cited: 1289
Times Cited: 1289
Times Cited
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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints.
Jirina Bartkova, Nousin Rezaei, Michalis Liontos, Panagiotis Karakaidos, Dimitris Kletsas, Natalia Issaeva, Leandros-Vassilios F Vassiliou, Evangelos Kolettas, Katerina Niforou, Vassilis C Zoumpourlis,[...]. Nature 2006
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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication.
Raffaella Di Micco, Marzia Fumagalli, Angelo Cicalese, Sara Piccinin, Patrizia Gasparini, Chiara Luise, Catherine Schurra, Massimiliano Garre', Paolo Giovanni Nuciforo, Aaron Bensimon,[...]. Nature 2006
Raffaella Di Micco, Marzia Fumagalli, Angelo Cicalese, Sara Piccinin, Patrizia Gasparini, Chiara Luise, Catherine Schurra, Massimiliano Garre', Paolo Giovanni Nuciforo, Aaron Bensimon,[...]. Nature 2006
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Genomic instability--an evolving hallmark of cancer.
Simona Negrini, Vassilis G Gorgoulis, Thanos D Halazonetis. Nat Rev Mol Cell Biol 2010
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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.
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Causes and consequences of replication stress.
Michelle K Zeman, Karlene A Cimprich. Nat Cell Biol 2014
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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.
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DNA replication stress as a hallmark of cancer.
Morgane Macheret, Thanos D Halazonetis. Annu Rev Pathol 2015
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Cellular Senescence: Defining a Path Forward.
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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
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The senescence-associated secretory phenotype: the dark side of tumor suppression.
Jean-Philippe Coppé, Pierre-Yves Desprez, Ana Krtolica, Judith Campisi. Annu Rev Pathol 2010
Jean-Philippe Coppé, Pierre-Yves Desprez, Ana Krtolica, Judith Campisi. Annu Rev Pathol 2010
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Cellular senescence: from physiology to pathology.
Daniel Muñoz-Espín, Manuel Serrano. Nat Rev Mol Cell Biol 2014
Daniel Muñoz-Espín, Manuel Serrano. Nat Rev Mol Cell Biol 2014
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Senescence-associated reprogramming promotes cancer stemness.
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The DNA damage response: making it safe to play with knives.
Alberto Ciccia, Stephen J Elledge. Mol Cell 2010
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Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place.
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Intragenic origins due to short G1 phases underlie oncogene-induced DNA replication stress.
Morgane Macheret, Thanos D Halazonetis. Nature 2018
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The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration.
Birgit Ritschka, Mekayla Storer, Alba Mas, Florian Heinzmann, Mari Carmen Ortells, Jennifer P Morton, Owen J Sansom, Lars Zender, William M Keyes. Genes Dev 2017
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Reversal of human cellular senescence: roles of the p53 and p16 pathways.
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Christian M Beauséjour, Ana Krtolica, Francesco Galimi, Masashi Narita, Scott W Lowe, Paul Yaswen, Judith Campisi. EMBO J 2003
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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.
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Nucleotide deficiency promotes genomic instability in early stages of cancer development.
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Increased global transcription activity as a mechanism of replication stress in cancer.
Panagiotis Kotsantis, Lara Marques Silva, Sarah Irmscher, Rebecca M Jones, Lisa Folkes, Natalia Gromak, Eva Petermann. Nat Commun 2016
Panagiotis Kotsantis, Lara Marques Silva, Sarah Irmscher, Rebecca M Jones, Lisa Folkes, Natalia Gromak, Eva Petermann. Nat Commun 2016
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Replication stress and cancer.
Hélène Gaillard, Tatiana García-Muse, Andrés Aguilera. Nat Rev Cancer 2015
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A complex secretory program orchestrated by the inflammasome controls paracrine senescence.
Juan Carlos Acosta, Ana Banito, Torsten Wuestefeld, Athena Georgilis, Peggy Janich, Jennifer P Morton, Dimitris Athineos, Tae-Won Kang, Felix Lasitschka, Mindaugas Andrulis,[...]. Nat Cell Biol 2013
Juan Carlos Acosta, Ana Banito, Torsten Wuestefeld, Athena Georgilis, Peggy Janich, Jennifer P Morton, Dimitris Athineos, Tae-Won Kang, Felix Lasitschka, Mindaugas Andrulis,[...]. Nat Cell Biol 2013
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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Yu Sun, Denise P Muñoz, Joshua Goldstein, Peter S Nelson, Pierre-Yves Desprez, Judith Campisi. PLoS Biol 2008
Jean-Philippe Coppé, Christopher K Patil, Francis Rodier, Yu Sun, Denise P Muñoz, Joshua Goldstein, Peter S Nelson, Pierre-Yves Desprez, Judith Campisi. PLoS Biol 2008
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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.
Thomas Kuilman, Chrysiis Michaloglou, Liesbeth C W Vredeveld, Sirith Douma, Remco van Doorn, Christophe J Desmet, Lucien A Aarden, Wolter J Mooi, Daniel S Peeper. Cell 2008
Thomas Kuilman, Chrysiis Michaloglou, Liesbeth C W Vredeveld, Sirith Douma, Remco van Doorn, Christophe J Desmet, Lucien A Aarden, Wolter J Mooi, Daniel S Peeper. Cell 2008
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Tumour biology: senescence in premalignant tumours.
Manuel Collado, Jesús Gil, Alejo Efeyan, Carmen Guerra, Alberto J Schuhmacher, Marta Barradas, Alberto Benguría, Angel Zaballos, Juana M Flores, Mariano Barbacid,[...]. Nature 2005
Manuel Collado, Jesús Gil, Alejo Efeyan, Carmen Guerra, Alberto J Schuhmacher, Marta Barradas, Alberto Benguría, Angel Zaballos, Juana M Flores, Mariano Barbacid,[...]. Nature 2005
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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
Darren J Baker, Tobias Wijshake, Tamar Tchkonia, Nathan K LeBrasseur, Bennett G Childs, Bart van de Sluis, James L Kirkland, Jan M van Deursen. Nature 2011
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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Shuhei Matsuoka, Bryan A Ballif, Agata Smogorzewska, E Robert McDonald, Kristen E Hurov, Ji Luo, Corey E Bakalarski, Zhenming Zhao, Nicole Solimini, Yaniv Lerenthal,[...]. Science 2007
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Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress.
Apolinar Maya-Mendoza, Jitka Ostrakova, Martin Kosar, Arnaldur Hall, Pavlina Duskova, Martin Mistrik, Joanna Maria Merchut-Maya, Zdenek Hodny, Jirina Bartkova, Claus Christensen,[...]. Mol Oncol 2015
Apolinar Maya-Mendoza, Jitka Ostrakova, Martin Kosar, Arnaldur Hall, Pavlina Duskova, Martin Mistrik, Joanna Maria Merchut-Maya, Zdenek Hodny, Jirina Bartkova, Claus Christensen,[...]. Mol Oncol 2015
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
Helen E Bryant, Niklas Schultz, Huw D Thomas, Kayan M Parker, Dan Flower, Elena Lopez, Suzanne Kyle, Mark Meuth, Nicola J Curtin, Thomas Helleday. Nature 2005
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Living on a break: cellular senescence as a DNA-damage response.
Fabrizio d'Adda di Fagagna. Nat Rev Cancer 2008
Fabrizio d'Adda di Fagagna. Nat Rev Cancer 2008
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Robust, universal biomarker assay to detect senescent cells in biological specimens.
Konstantinos Evangelou, Nikolaos Lougiakis, Sophia V Rizou, Athanassios Kotsinas, Dimitris Kletsas, Daniel Muñoz-Espín, Nikolaos G Kastrinakis, Nicole Pouli, Panagiotis Marakos, Paul Townsend,[...]. Aging Cell 2017
Konstantinos Evangelou, Nikolaos Lougiakis, Sophia V Rizou, Athanassios Kotsinas, Dimitris Kletsas, Daniel Muñoz-Espín, Nikolaos G Kastrinakis, Nicole Pouli, Panagiotis Marakos, Paul Townsend,[...]. Aging Cell 2017
6
Cytoplasmic chromatin triggers inflammation in senescence and cancer.
Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu, Payel Sen, Kirk J Wangensteen, Johayra Simithy, Yemin Lan, Yanping Lin, Zhuo Zhou,[...]. Nature 2017
Zhixun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu, Payel Sen, Kirk J Wangensteen, Johayra Simithy, Yemin Lan, Yanping Lin, Zhuo Zhou,[...]. Nature 2017
6
Oncogene-induced senescence as an initial barrier in lymphoma development.
Melanie Braig, Soyoung Lee, Christoph Loddenkemper, Cornelia Rudolph, Antoine H F M Peters, Brigitte Schlegelberger, Harald Stein, Bernd Dörken, Thomas Jenuwein, Clemens A Schmitt. Nature 2005
Melanie Braig, Soyoung Lee, Christoph Loddenkemper, Cornelia Rudolph, Antoine H F M Peters, Brigitte Schlegelberger, Harald Stein, Bernd Dörken, Thomas Jenuwein, Clemens A Schmitt. Nature 2005
6
Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.
Lluc Mosteiro, Cristina Pantoja, Noelia Alcazar, Rosa M Marión, Dafni Chondronasiou, Miguel Rovira, Pablo J Fernandez-Marcos, Maribel Muñoz-Martin, Carmen Blanco-Aparicio, Joaquin Pastor,[...]. Science 2016
Lluc Mosteiro, Cristina Pantoja, Noelia Alcazar, Rosa M Marión, Dafni Chondronasiou, Miguel Rovira, Pablo J Fernandez-Marcos, Maribel Muñoz-Martin, Carmen Blanco-Aparicio, Joaquin Pastor,[...]. Science 2016
6
Mitotic progression following DNA damage enables pattern recognition within micronuclei.
Shane M Harding, Joseph L Benci, Jerome Irianto, Dennis E Discher, Andy J Minn, Roger A Greenberg. Nature 2017
Shane M Harding, Joseph L Benci, Jerome Irianto, Dennis E Discher, Andy J Minn, Roger A Greenberg. Nature 2017
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BRAFE600-associated senescence-like cell cycle arrest of human naevi.
Chrysiis Michaloglou, Liesbeth C W Vredeveld, Maria S Soengas, Christophe Denoyelle, Thomas Kuilman, Chantal M A M van der Horst, Donné M Majoor, Jerry W Shay, Wolter J Mooi, Daniel S Peeper. Nature 2005
Chrysiis Michaloglou, Liesbeth C W Vredeveld, Maria S Soengas, Christophe Denoyelle, Thomas Kuilman, Chantal M A M van der Horst, Donné M Majoor, Jerry W Shay, Wolter J Mooi, Daniel S Peeper. Nature 2005
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Unmasking Transcriptional Heterogeneity in Senescent Cells.
Alejandra Hernandez-Segura, Tristan V de Jong, Simon Melov, Victor Guryev, Judith Campisi, Marco Demaria. Curr Biol 2017
Alejandra Hernandez-Segura, Tristan V de Jong, Simon Melov, Victor Guryev, Judith Campisi, Marco Demaria. Curr Biol 2017
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Chemokine signaling via the CXCR2 receptor reinforces senescence.
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Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
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Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I R Petalcorin, Kevin W O'Connor, Panagiotis A Konstantinopoulos, Stephen J Elledge, Simon J Boulton,[...]. Nature 2015
Raphael Ceccaldi, Jessica C Liu, Ravindra Amunugama, Ildiko Hajdu, Benjamin Primack, Mark I R Petalcorin, Kevin W O'Connor, Panagiotis A Konstantinopoulos, Stephen J Elledge, Simon J Boulton,[...]. Nature 2015
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Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.
Katharina Schlacher, Nicole Christ, Nicolas Siaud, Akinori Egashira, Hong Wu, Maria Jasin. Cell 2011
Katharina Schlacher, Nicole Christ, Nicolas Siaud, Akinori Egashira, Hong Wu, Maria Jasin. Cell 2011
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Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors.
Matilde Murga, Stefano Campaner, Andres J Lopez-Contreras, Luis I Toledo, Rebeca Soria, Maria F Montaña, Luana D' Artista, Thomas Schleker, Carmen Guerra, Elena Garcia,[...]. Nat Struct Mol Biol 2011
Matilde Murga, Stefano Campaner, Andres J Lopez-Contreras, Luis I Toledo, Rebeca Soria, Maria F Montaña, Luana D' Artista, Thomas Schleker, Carmen Guerra, Elena Garcia,[...]. Nat Struct Mol Biol 2011
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DNA replication and oncogene-induced replicative stress.
Stephanie A Hills, John F X Diffley. Curr Biol 2014
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ATR: an essential regulator of genome integrity.
Karlene A Cimprich, David Cortez. Nat Rev Mol Cell Biol 2008
Karlene A Cimprich, David Cortez. Nat Rev Mol Cell Biol 2008
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The essential kinase ATR: ensuring faithful duplication of a challenging genome.
Joshua C Saldivar, David Cortez, Karlene A Cimprich. Nat Rev Mol Cell Biol 2017
Joshua C Saldivar, David Cortez, Karlene A Cimprich. Nat Rev Mol Cell Biol 2017
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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
Marzia Fumagalli, Francesca Rossiello, Michela Clerici, Sara Barozzi, Davide Cittaro, Jessica M Kaplunov, Gabriele Bucci, Miryana Dobreva, Valentina Matti, Christian M Beausejour,[...]. Nat Cell Biol 2012
Marzia Fumagalli, Francesca Rossiello, Michela Clerici, Sara Barozzi, Davide Cittaro, Jessica M Kaplunov, Gabriele Bucci, Miryana Dobreva, Valentina Matti, Christian M Beausejour,[...]. Nat Cell Biol 2012
5
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.