Nanette Van Damme, Daniel Goff, Chris Katsura, Rebecca L Jorgenson, Richard Mitchell, Marc C Johnson, Edward B Stephens, John Guatelli. Cell Host Microbe 2008
Times Cited: 795
Times Cited: 795
Times Cited
Times Co-cited
Similarity
Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.
Stuart J D Neil, Trinity Zang, Paul D Bieniasz. Nature 2008
Stuart J D Neil, Trinity Zang, Paul D Bieniasz. Nature 2008
89
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.
Yoshiko Usami, Yuanfei Wu, Heinrich G Göttlinger. Nature 2015
Yoshiko Usami, Yuanfei Wu, Heinrich G Göttlinger. Nature 2015
32
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.
Annachiara Rosa, Ajit Chande, Serena Ziglio, Veronica De Sanctis, Roberto Bertorelli, Shih Lin Goh, Sean M McCauley, Anetta Nowosielska, Stylianos E Antonarakis, Jeremy Luban,[...]. Nature 2015
Annachiara Rosa, Ajit Chande, Serena Ziglio, Veronica De Sanctis, Roberto Bertorelli, Shih Lin Goh, Sean M McCauley, Anetta Nowosielska, Stylianos E Antonarakis, Jeremy Luban,[...]. Nature 2015
31
Tetherin inhibits HIV-1 release by directly tethering virions to cells.
David Perez-Caballero, Trinity Zang, Alaleh Ebrahimi, Matthew W McNatt, Devon A Gregory, Marc C Johnson, Paul D Bieniasz. Cell 2009
David Perez-Caballero, Trinity Zang, Alaleh Ebrahimi, Matthew W McNatt, Devon A Gregory, Marc C Johnson, Paul D Bieniasz. Cell 2009
30
Innate sensing of HIV-1 assembly by Tetherin induces NFκB-dependent proinflammatory responses.
Rui Pedro Galão, Anna Le Tortorec, Suzanne Pickering, Tonya Kueck, Stuart J D Neil. Cell Host Microbe 2012
Rui Pedro Galão, Anna Le Tortorec, Suzanne Pickering, Tonya Kueck, Stuart J D Neil. Cell Host Microbe 2012
25
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.
Ann M Sheehy, Nathan C Gaddis, Jonathan D Choi, Michael H Malim. Nature 2002
Ann M Sheehy, Nathan C Gaddis, Jonathan D Choi, Michael H Malim. Nature 2002
21
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx.
Nadine Laguette, Bijan Sobhian, Nicoletta Casartelli, Mathieu Ringeard, Christine Chable-Bessia, Emmanuel Ségéral, Ahmad Yatim, Stéphane Emiliani, Olivier Schwartz, Monsef Benkirane. Nature 2011
Nadine Laguette, Bijan Sobhian, Nicoletta Casartelli, Mathieu Ringeard, Christine Chable-Bessia, Emmanuel Ségéral, Ahmad Yatim, Stéphane Emiliani, Olivier Schwartz, Monsef Benkirane. Nature 2011
20
Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology.
Sabine Kupzig, Viktor Korolchuk, Ruth Rollason, Anna Sugden, Andrew Wilde, George Banting. Traffic 2003
Sabine Kupzig, Viktor Korolchuk, Ruth Rollason, Anna Sugden, Andrew Wilde, George Banting. Traffic 2003
20
Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.
Daniel Sauter, Michael Schindler, Anke Specht, Wilmina N Landford, Jan Münch, Kyeong-Ae Kim, Jörg Votteler, Ulrich Schubert, Frederic Bibollet-Ruche, Brandon F Keele,[...]. Cell Host Microbe 2009
Daniel Sauter, Michael Schindler, Anke Specht, Wilmina N Landford, Jan Münch, Kyeong-Ae Kim, Jörg Votteler, Ulrich Schubert, Frederic Bibollet-Ruche, Brandon F Keele,[...]. Cell Host Microbe 2009
19
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.
F Margottin, S P Bour, H Durand, L Selig, S Benichou, V Richard, D Thomas, K Strebel, R Benarous. Mol Cell 1998
F Margottin, S P Bour, H Durand, L Selig, S Benichou, V Richard, D Thomas, K Strebel, R Benarous. Mol Cell 1998
18
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein.
Kasia Hrecka, Caili Hao, Magda Gierszewska, Selene K Swanson, Malgorzata Kesik-Brodacka, Smita Srivastava, Laurence Florens, Michael P Washburn, Jacek Skowronski. Nature 2011
Kasia Hrecka, Caili Hao, Magda Gierszewska, Selene K Swanson, Malgorzata Kesik-Brodacka, Smita Srivastava, Laurence Florens, Michael P Washburn, Jacek Skowronski. Nature 2011
17
Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2.
Bin Jia, Ruth Serra-Moreno, William Neidermyer, Andrew Rahmberg, John Mackey, Ismael Ben Fofana, Welkin E Johnson, Susan Westmoreland, David T Evans. PLoS Pathog 2009
Bin Jia, Ruth Serra-Moreno, William Neidermyer, Andrew Rahmberg, John Mackey, Ismael Ben Fofana, Welkin E Johnson, Susan Westmoreland, David T Evans. PLoS Pathog 2009
16
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
Matthew Stremlau, Christopher M Owens, Michel J Perron, Michael Kiessling, Patrick Autissier, Joseph Sodroski. Nature 2004
Matthew Stremlau, Christopher M Owens, Michel J Perron, Michael Kiessling, Patrick Autissier, Joseph Sodroski. Nature 2004
15
HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes.
Yukie Iwabu, Hideaki Fujita, Masanobu Kinomoto, Keiko Kaneko, Yukihito Ishizaka, Yoshitaka Tanaka, Tetsutaro Sata, Kenzo Tokunaga. J Biol Chem 2009
Yukie Iwabu, Hideaki Fujita, Masanobu Kinomoto, Keiko Kaneko, Yukihito Ishizaka, Yoshitaka Tanaka, Tetsutaro Sata, Kenzo Tokunaga. J Biol Chem 2009
15
Nef proteins from simian immunodeficiency viruses are tetherin antagonists.
Fengwen Zhang, Sam J Wilson, Wilmina C Landford, Beatriz Virgen, Devon Gregory, Marc C Johnson, Jan Munch, Frank Kirchhoff, Paul D Bieniasz, Theodora Hatziioannou. Cell Host Microbe 2009
Fengwen Zhang, Sam J Wilson, Wilmina C Landford, Beatriz Virgen, Devon Gregory, Marc C Johnson, Jan Munch, Frank Kirchhoff, Paul D Bieniasz, Theodora Hatziioannou. Cell Host Microbe 2009
15
Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.
Nolwenn Jouvenet, Stuart J D Neil, Maria Zhadina, Trinity Zang, Zerina Kratovac, Youngnam Lee, Matthew McNatt, Theodora Hatziioannou, Paul D Bieniasz. J Virol 2009
Nolwenn Jouvenet, Stuart J D Neil, Maria Zhadina, Trinity Zang, Zerina Kratovac, Youngnam Lee, Matthew McNatt, Theodora Hatziioannou, Paul D Bieniasz. J Virol 2009
14
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates.
Hichem Lahouassa, Waaqo Daddacha, Henning Hofmann, Diana Ayinde, Eric C Logue, Loïc Dragin, Nicolin Bloch, Claire Maudet, Matthieu Bertrand, Thomas Gramberg,[...]. Nat Immunol 2012
Hichem Lahouassa, Waaqo Daddacha, Henning Hofmann, Diana Ayinde, Eric C Logue, Loïc Dragin, Nicolin Bloch, Claire Maudet, Matthieu Bertrand, Thomas Gramberg,[...]. Nat Immunol 2012
14
Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein.
Rachel L Kaletsky, Joseph R Francica, Caroline Agrawal-Gamse, Paul Bates. Proc Natl Acad Sci U S A 2009
Rachel L Kaletsky, Joseph R Francica, Caroline Agrawal-Gamse, Paul Bates. Proc Natl Acad Sci U S A 2009
13
Stimulation of NF-κB activity by the HIV restriction factor BST2.
Andrey Tokarev, Marissa Suarez, Wilson Kwan, Kathleen Fitzpatrick, Rajendra Singh, John Guatelli. J Virol 2013
Andrey Tokarev, Marissa Suarez, Wilson Kwan, Kathleen Fitzpatrick, Rajendra Singh, John Guatelli. J Virol 2013
13
Antagonism of tetherin restriction of HIV-1 release by Vpu involves binding and sequestration of the restriction factor in a perinuclear compartment.
Mathieu Dubé, Bibhuti Bhusan Roy, Pierre Guiot-Guillain, Julie Binette, Johanne Mercier, Antoine Chiasson, Eric A Cohen. PLoS Pathog 2010
Mathieu Dubé, Bibhuti Bhusan Roy, Pierre Guiot-Guillain, Julie Binette, Johanne Mercier, Antoine Chiasson, Eric A Cohen. PLoS Pathog 2010
13
Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection.
Caroline Goujon, Olivier Moncorgé, Hélène Bauby, Tomas Doyle, Christopher C Ward, Torsten Schaller, Stéphane Hué, Wendy S Barclay, Reiner Schulz, Michael H Malim. Nature 2013
Caroline Goujon, Olivier Moncorgé, Hélène Bauby, Tomas Doyle, Christopher C Ward, Torsten Schaller, Stéphane Hué, Wendy S Barclay, Reiner Schulz, Michael H Malim. Nature 2013
13
Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking.
Richard S Mitchell, Chris Katsura, Mark A Skasko, Katie Fitzpatrick, David Lau, Autumn Ruiz, Edward B Stephens, Florence Margottin-Goguet, Richard Benarous, John C Guatelli. PLoS Pathog 2009
Richard S Mitchell, Chris Katsura, Mark A Skasko, Katie Fitzpatrick, David Lau, Autumn Ruiz, Edward B Stephens, Florence Margottin-Goguet, Richard Benarous, John C Guatelli. PLoS Pathog 2009
13
Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein.
Anna Le Tortorec, Stuart J D Neil. J Virol 2009
Anna Le Tortorec, Stuart J D Neil. J Virol 2009
13
Inhibition of Lassa and Marburg virus production by tetherin.
Toshie Sakuma, Takeshi Noda, Shuzo Urata, Yoshihiro Kawaoka, Jiro Yasuda. J Virol 2009
Toshie Sakuma, Takeshi Noda, Shuzo Urata, Yoshihiro Kawaoka, Jiro Yasuda. J Virol 2009
12
Molecular mechanism of BST2/tetherin downregulation by K5/MIR2 of Kaposi's sarcoma-associated herpesvirus.
Mandana Mansouri, Kasinath Viswanathan, Janet L Douglas, Jennie Hines, Jean Gustin, Ashlee V Moses, Klaus Früh. J Virol 2009
Mandana Mansouri, Kasinath Viswanathan, Janet L Douglas, Jennie Hines, Jean Gustin, Ashlee V Moses, Klaus Früh. J Virol 2009
12
Vpu directs the degradation of the human immunodeficiency virus restriction factor BST-2/Tetherin via a {beta}TrCP-dependent mechanism.
Janet L Douglas, Kasinath Viswanathan, Matthew N McCarroll, Jean K Gustin, Klaus Früh, Ashlee V Moses. J Virol 2009
Janet L Douglas, Kasinath Viswanathan, Matthew N McCarroll, Jean K Gustin, Klaus Früh, Ashlee V Moses. J Virol 2009
12
MX2 is an interferon-induced inhibitor of HIV-1 infection.
Melissa Kane, Shalini S Yadav, Julia Bitzegeio, Sebla B Kutluay, Trinity Zang, Sam J Wilson, John W Schoggins, Charles M Rice, Masahiro Yamashita, Theodora Hatziioannou,[...]. Nature 2013
Melissa Kane, Shalini S Yadav, Julia Bitzegeio, Sebla B Kutluay, Trinity Zang, Sam J Wilson, John W Schoggins, Charles M Rice, Masahiro Yamashita, Theodora Hatziioannou,[...]. Nature 2013
12
Species-specific activity of HIV-1 Vpu and positive selection of tetherin transmembrane domain variants.
Matthew W McNatt, Trinity Zang, Theodora Hatziioannou, Mackenzie Bartlett, Ismael Ben Fofana, Welkin E Johnson, Stuart J D Neil, Paul D Bieniasz. PLoS Pathog 2009
Matthew W McNatt, Trinity Zang, Theodora Hatziioannou, Mackenzie Bartlett, Ismael Ben Fofana, Welkin E Johnson, Stuart J D Neil, Paul D Bieniasz. PLoS Pathog 2009
12
Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef.
Nicholas J Matheson, Jonathan Sumner, Kim Wals, Radu Rapiteanu, Michael P Weekes, Raphael Vigan, Julia Weinelt, Michael Schindler, Robin Antrobus, Ana S H Costa,[...]. Cell Host Microbe 2015
Nicholas J Matheson, Jonathan Sumner, Kim Wals, Radu Rapiteanu, Michael P Weekes, Raphael Vigan, Julia Weinelt, Michael Schindler, Robin Antrobus, Ana S H Costa,[...]. Cell Host Microbe 2015
12
HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.
Bastien Mangeat, Gustavo Gers-Huber, Martin Lehmann, Madeleine Zufferey, Jeremy Luban, Vincent Piguet. PLoS Pathog 2009
Bastien Mangeat, Gustavo Gers-Huber, Martin Lehmann, Madeleine Zufferey, Jeremy Luban, Vincent Piguet. PLoS Pathog 2009
11
BST-2/tetherin: a new component of the innate immune response to enveloped viruses.
David T Evans, Ruth Serra-Moreno, Rajendra K Singh, John C Guatelli. Trends Microbiol 2010
David T Evans, Ruth Serra-Moreno, Rajendra K Singh, John C Guatelli. Trends Microbiol 2010
11
HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells.
Raymond A Alvarez, Rebecca E Hamlin, Anthony Monroe, Brian Moldt, Mathew T Hotta, Gabriela Rodriguez Caprio, Daniel S Fierer, Viviana Simon, Benjamin K Chen. J Virol 2014
Raymond A Alvarez, Rebecca E Hamlin, Anthony Monroe, Brian Moldt, Mathew T Hotta, Gabriela Rodriguez Caprio, Daniel S Fierer, Viviana Simon, Benjamin K Chen. J Virol 2014
11
The interferon-inducible MxB protein inhibits HIV-1 infection.
Zhenlong Liu, Qinghua Pan, Shilei Ding, Jin Qian, Fengwen Xu, Jinming Zhou, Shan Cen, Fei Guo, Chen Liang. Cell Host Microbe 2013
Zhenlong Liu, Qinghua Pan, Shilei Ding, Jin Qian, Fengwen Xu, Jinming Zhou, Shan Cen, Fei Guo, Chen Liang. Cell Host Microbe 2013
11
The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif.
Ann M Sheehy, Nathan C Gaddis, Michael H Malim. Nat Med 2003
Ann M Sheehy, Nathan C Gaddis, Michael H Malim. Nat Med 2003
11
Determinants of tetherin antagonism in the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein.
Raphaël Vigan, Stuart J D Neil. J Virol 2010
Raphaël Vigan, Stuart J D Neil. J Virol 2010
11
Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity.
Maxime Veillette, Anik Désormeaux, Halima Medjahed, Nour-Elhouda Gharsallah, Mathieu Coutu, Joshua Baalwa, Yongjun Guan, George Lewis, Guido Ferrari, Beatrice H Hahn,[...]. J Virol 2014
Maxime Veillette, Anik Désormeaux, Halima Medjahed, Nour-Elhouda Gharsallah, Mathieu Coutu, Joshua Baalwa, Yongjun Guan, George Lewis, Guido Ferrari, Beatrice H Hahn,[...]. J Virol 2014
10
HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor.
Christine Goffinet, Ina Allespach, Stefanie Homann, Hanna-Mari Tervo, Anja Habermann, Daniel Rupp, Lena Oberbremer, Christian Kern, Nadine Tibroni, Sonja Welsch,[...]. Cell Host Microbe 2009
Christine Goffinet, Ina Allespach, Stefanie Homann, Hanna-Mari Tervo, Anja Habermann, Daniel Rupp, Lena Oberbremer, Christian Kern, Nadine Tibroni, Sonja Welsch,[...]. Cell Host Microbe 2009
10
A cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.
Tonya Kueck, Stuart J D Neil. PLoS Pathog 2012
Tonya Kueck, Stuart J D Neil. PLoS Pathog 2012
12
Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.
Sheli R Radoshitzky, Lian Dong, Xiaoli Chi, Jeremiah C Clester, Cary Retterer, Kevin Spurgers, Jens H Kuhn, Sarah Sandwick, Gordon Ruthel, Krishna Kota,[...]. J Virol 2010
Sheli R Radoshitzky, Lian Dong, Xiaoli Chi, Jeremiah C Clester, Cary Retterer, Kevin Spurgers, Jens H Kuhn, Sarah Sandwick, Gordon Ruthel, Krishna Kota,[...]. J Virol 2010
10
HIV Restriction Factors and Mechanisms of Evasion.
Michael H Malim, Paul D Bieniasz. Cold Spring Harb Perspect Med 2012
Michael H Malim, Paul D Bieniasz. Cold Spring Harb Perspect Med 2012
10
IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread.
Alex A Compton, Timothée Bruel, Françoise Porrot, Adeline Mallet, Martin Sachse, Marine Euvrard, Chen Liang, Nicoletta Casartelli, Olivier Schwartz. Cell Host Microbe 2014
Alex A Compton, Timothée Bruel, Françoise Porrot, Adeline Mallet, Martin Sachse, Marine Euvrard, Chen Liang, Nicoletta Casartelli, Olivier Schwartz. Cell Host Microbe 2014
10
The IFITM proteins inhibit HIV-1 infection.
Jennifer Lu, Qinghua Pan, Liwei Rong, Wei He, Shan-Lu Liu, Chen Liang. J Virol 2011
Jennifer Lu, Qinghua Pan, Liwei Rong, Wei He, Shan-Lu Liu, Chen Liang. J Virol 2011
10
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Hanna-Mari Baldauf, Xiaoyu Pan, Elina Erikson, Sarah Schmidt, Waaqo Daddacha, Manja Burggraf, Kristina Schenkova, Ina Ambiel, Guido Wabnitz, Thomas Gramberg,[...]. Nat Med 2012
Hanna-Mari Baldauf, Xiaoyu Pan, Elina Erikson, Sarah Schmidt, Waaqo Daddacha, Manja Burggraf, Kristina Schenkova, Ina Ambiel, Guido Wabnitz, Thomas Gramberg,[...]. Nat Med 2012
10
Induction of APOBEC3G ubiquitination and degradation by an HIV-1 Vif-Cul5-SCF complex.
Xianghui Yu, Yunkai Yu, Bindong Liu, Kun Luo, Wei Kong, Panyong Mao, Xiao-Fang Yu. Science 2003
Xianghui Yu, Yunkai Yu, Bindong Liu, Kun Luo, Wei Kong, Panyong Mao, Xiao-Fang Yu. Science 2003
10
MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins.
Takuya Tada, Yanzhao Zhang, Takayoshi Koyama, Minoru Tobiume, Yasuko Tsunetsugu-Yokota, Shoji Yamaoka, Hideaki Fujita, Kenzo Tokunaga. Nat Med 2015
Takuya Tada, Yanzhao Zhang, Takayoshi Koyama, Minoru Tobiume, Yasuko Tsunetsugu-Yokota, Shoji Yamaoka, Hideaki Fujita, Kenzo Tokunaga. Nat Med 2015
13
Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4.
R L Willey, F Maldarelli, M A Martin, K Strebel. J Virol 1992
R L Willey, F Maldarelli, M A Martin, K Strebel. J Virol 1992
10
Vpu binds directly to tetherin and displaces it from nascent virions.
Matthew W McNatt, Trinity Zang, Paul D Bieniasz. PLoS Pathog 2013
Matthew W McNatt, Trinity Zang, Paul D Bieniasz. PLoS Pathog 2013
11
Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity.
Christian Krapp, Dominik Hotter, Ali Gawanbacht, Paul J McLaren, Silvia F Kluge, Christina M Stürzel, Katharina Mack, Elisabeth Reith, Susanne Engelhart, Angela Ciuffi,[...]. Cell Host Microbe 2016
Christian Krapp, Dominik Hotter, Ali Gawanbacht, Paul J McLaren, Silvia F Kluge, Christina M Stürzel, Katharina Mack, Elisabeth Reith, Susanne Engelhart, Angela Ciuffi,[...]. Cell Host Microbe 2016
10
The Potency of Nef-Mediated SERINC5 Antagonism Correlates with the Prevalence of Primate Lentiviruses in the Wild.
Anke Heigele, Dorota Kmiec, Kerstin Regensburger, Simon Langer, Lukas Peiffer, Christina M Stürzel, Daniel Sauter, Martine Peeters, Massimo Pizzato, Gerald H Learn,[...]. Cell Host Microbe 2016
Anke Heigele, Dorota Kmiec, Kerstin Regensburger, Simon Langer, Lukas Peiffer, Christina M Stürzel, Daniel Sauter, Martine Peeters, Massimo Pizzato, Gerald H Learn,[...]. Cell Host Microbe 2016
14
Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.
Jessica M Weidner, Dong Jiang, Xiao-Ben Pan, Jinhong Chang, Timothy M Block, Ju-Tao Guo. J Virol 2010
Jessica M Weidner, Dong Jiang, Xiao-Ben Pan, Jinhong Chang, Timothy M Block, Ju-Tao Guo. J Virol 2010
9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.