A citation-based method for searching scientific literature

Jia-Yi Li, Elisabet Englund, Janice L Holton, Denis Soulet, Peter Hagell, Andrew J Lees, Tammaryn Lashley, Niall P Quinn, Stig Rehncrona, Anders Björklund, Håkan Widner, Tamas Revesz, Olle Lindvall, Patrik Brundin. Nat Med 2008
Times Cited: 1203







List of co-cited articles
1824 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease.
Jeffrey H Kordower, Yaping Chu, Robert A Hauser, Thomas B Freeman, C Warren Olanow. Nat Med 2008
79

Staging of brain pathology related to sporadic Parkinson's disease.
Heiko Braak, Kelly Del Tredici, Udo Rüb, Rob A I de Vos, Ernst N H Jansen Steur, Eva Braak. Neurobiol Aging 2003
55

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice.
Kelvin C Luk, Victoria Kehm, Jenna Carroll, Bin Zhang, Patrick O'Brien, John Q Trojanowski, Virginia M-Y Lee. Science 2012
45

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death.
Laura A Volpicelli-Daley, Kelvin C Luk, Tapan P Patel, Selcuk A Tanik, Dawn M Riddle, Anna Stieber, David F Meaney, John Q Trojanowski, Virginia M-Y Lee. Neuron 2011
932
38

Alpha-synuclein in Lewy bodies.
M G Spillantini, M L Schmidt, V M Lee, J Q Trojanowski, R Jakes, M Goedert. Nature 1997
37

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease.
M H Polymeropoulos, C Lavedan, E Leroy, S E Ide, A Dehejia, A Dutra, B Pike, H Root, J Rubenstein, R Boyer,[...]. Science 1997
26

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells.
Kelvin C Luk, Cheng Song, Patrick O'Brien, Anna Stieber, Jonathan R Branch, Kurt R Brunden, John Q Trojanowski, Virginia M-Y Lee. Proc Natl Acad Sci U S A 2009
619
26

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Sangjune Kim, Seung-Hwan Kwon, Tae-In Kam, Nikhil Panicker, Senthilkumar S Karuppagounder, Saebom Lee, Jun Hee Lee, Wonjoong Richard Kim, Minjee Kook, Catherine A Foss,[...]. Neuron 2019
506
25

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.
Paula Desplats, He-Jin Lee, Eun-Jin Bae, Christina Patrick, Edward Rockenstein, Leslie Crews, Brian Spencer, Eliezer Masliah, Seung-Jae Lee. Proc Natl Acad Sci U S A 2009
25

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.
Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S Karuppagounder, Tae-In Kam, Xiling Yin, Yulan Xiong, Preston Ge, George Essien Umanah, Saurav Brahmachari, Joo-Ho Shin,[...]. Science 2016
391
24

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.
Kelvin C Luk, Victoria M Kehm, Bin Zhang, Patrick O'Brien, John Q Trojanowski, Virginia M Y Lee. J Exp Med 2012
716
24

alpha-Synuclein locus triplication causes Parkinson's disease.
A B Singleton, M Farrer, J Johnson, A Singleton, S Hague, J Kachergus, M Hulihan, T Peuralinna, A Dutra, R Nussbaum,[...]. Science 2003
24

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.
W Peelaerts, L Bousset, A Van der Perren, A Moskalyuk, R Pulizzi, M Giugliano, C Van den Haute, R Melki, V Baekelandt. Nature 2015
726
22

Prion-like spreading of pathological α-synuclein in brain.
Masami Masuda-Suzukake, Takashi Nonaka, Masato Hosokawa, Takayuki Oikawa, Tetsuaki Arai, Haruhiko Akiyama, David M A Mann, Masato Hasegawa. Brain 2013
548
22

alpha-Synuclein is phosphorylated in synucleinopathy lesions.
Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae, Akiko Kawashima, Eliezer Masliah, Matthew S Goldberg, Jie Shen, Koji Takio, Takeshi Iwatsubo. Nat Cell Biol 2002
22

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.
Ariadna Recasens, Benjamin Dehay, Jordi Bové, Iria Carballo-Carbajal, Sandra Dovero, Ana Pérez-Villalba, Pierre-Olivier Fernagut, Javier Blesa, Annabelle Parent, Celine Perier,[...]. Ann Neurol 2014
428
22

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.
Evangelia Emmanouilidou, Katerina Melachroinou, Theodoros Roumeliotis, Spiros D Garbis, Maria Ntzouni, Lukas H Margaritis, Leonidas Stefanis, Kostas Vekrellis. J Neurosci 2010
766
21

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia.
Changyoun Kim, Dong-Hwan Ho, Ji-Eun Suk, Sungyong You, Sarah Michael, Junghee Kang, Sung Joong Lee, Eliezer Masliah, Daehee Hwang, He-Jin Lee,[...]. Nat Commun 2013
494
19

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.
M G Spillantini, R A Crowther, R Jakes, M Hasegawa, M Goedert. Proc Natl Acad Sci U S A 1998
19

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.
Brandon B Holmes, Sarah L DeVos, Najla Kfoury, Mei Li, Rachel Jacks, Kiran Yanamandra, Mohand O Ouidja, Frances M Brodsky, Jayne Marasa, Devika P Bagchi,[...]. Proc Natl Acad Sci U S A 2013
518
17

In vivo demonstration that alpha-synuclein oligomers are toxic.
Beate Winner, Roberto Jappelli, Samir K Maji, Paula A Desplats, Leah Boyer, Stefan Aigner, Claudia Hetzer, Thomas Loher, Marçal Vilar, Silvia Campioni,[...]. Proc Natl Acad Sci U S A 2011
971
17

Parkinson's disease.
Lorraine V Kalia, Anthony E Lang. Lancet 2015
17

Structural and functional characterization of two alpha-synuclein strains.
Luc Bousset, Laura Pieri, Gemma Ruiz-Arlandis, Julia Gath, Poul Henning Jensen, Birgit Habenstein, Karine Madiona, Vincent Olieric, Anja Böckmann, Beat H Meier,[...]. Nat Commun 2013
545
17


Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.
Jacqueline Burré, Manu Sharma, Theodoros Tsetsenis, Vladimir Buchman, Mark R Etherton, Thomas C Südhof. Science 2010
17

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells.
Christian Hansen, Elodie Angot, Ann-Louise Bergström, Jennifer A Steiner, Laura Pieri, Gesine Paul, Tiago F Outeiro, Ronald Melki, Pekka Kallunki, Karina Fog,[...]. J Clin Invest 2011
609
17

Exosomal cell-to-cell transmission of alpha synuclein oligomers.
Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf, Ozge Cagsal-Getkin, Ashley R Winslow, Liya Zhu, Charles R Vanderburg, Pamela J McLean. Mol Neurodegener 2012
550
16

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.
He-Jin Lee, Smita Patel, Seung-Jae Lee. J Neurosci 2005
596
16

Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.
Hien T Tran, Charlotte Hiu-Yan Chung, Michiyo Iba, Bin Zhang, John Q Trojanowski, Kelvin C Luk, Virginia M Y Lee. Cell Rep 2014
223
16

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease.
Marie-Christine Chartier-Harlin, Jennifer Kachergus, Christophe Roumier, Vincent Mouroux, Xavier Douay, Sarah Lincoln, Clotilde Levecque, Lydie Larvor, Joris Andrieux, Mary Hulihan,[...]. Lancet 2004
16

Different species of alpha-synuclein oligomers induce calcium influx and seeding.
Karin M Danzer, Dorothea Haasen, Anne R Karow, Simon Moussaud, Matthias Habeck, Armin Giese, Hans Kretzschmar, Bastian Hengerer, Marcus Kostka. J Neurosci 2007
567
15

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.
Staffan Holmqvist, Oldriska Chutna, Luc Bousset, Patrick Aldrin-Kirk, Wen Li, Tomas Björklund, Zhan-You Wang, Laurent Roybon, Ronald Melki, Jia-Yi Li. Acta Neuropathol 2014
519
14


The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration.
Anne-Laure Mahul-Mellier, Johannes Burtscher, Niran Maharjan, Laura Weerens, Marie Croisier, Fabien Kuttler, Marion Leleu, Graham W Knott, Hilal A Lashuel. Proc Natl Acad Sci U S A 2020
218
14

Vagotomy and subsequent risk of Parkinson's disease.
Elisabeth Svensson, Erzsébet Horváth-Puhó, Reimar W Thomsen, Jens Christian Djurhuus, Lars Pedersen, Per Borghammer, Henrik Toft Sørensen. Ann Neurol 2015
441
14

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.
Sarah H Shahmoradian, Amanda J Lewis, Christel Genoud, Jürgen Hench, Tim E Moors, Paula P Navarro, Daniel Castaño-Díez, Gabriel Schweighauser, Alexandra Graff-Meyer, Kenneth N Goldie,[...]. Nat Neurosci 2019
355
14

α-Synuclein strains target distinct brain regions and cell types.
Angus Lau, Raphaella W L So, Heather H C Lau, Jason C Sang, Alejandro Ruiz-Riquelme, Shelaine C Fleck, Erica Stuart, Sindhu Menon, Naomi P Visanji, Georg Meisl,[...]. Nat Neurosci 2020
112
14

The many faces of α-synuclein: from structure and toxicity to therapeutic target.
Hilal A Lashuel, Cassia R Overk, Abid Oueslati, Eliezer Masliah. Nat Rev Neurosci 2013
939
13

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma.
Omar M A El-Agnaf, Sultan A Salem, Katerina E Paleologou, Leanne J Cooper, Nigel J Fullwood, Mark J Gibson, Martin D Curran, Jennifer A Court, David M A Mann, Shu-ichi Ikeda,[...]. FASEB J 2003
443
13

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.
Lydia Alvarez-Erviti, Yiqi Seow, Anthony H Schapira, Chris Gardiner, Ian L Sargent, Matthew J A Wood, J Mark Cooper. Neurobiol Dis 2011
478
13

Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy.
Mohammad Shahnawaz, Abhisek Mukherjee, Sandra Pritzkow, Nicolas Mendez, Prakruti Rabadia, Xiangan Liu, Bo Hu, Ann Schmeichel, Wolfgang Singer, Gang Wu,[...]. Nature 2020
251
13

Tunneling nanotubes spread fibrillar α-synuclein by intercellular trafficking of lysosomes.
Saïda Abounit, Luc Bousset, Frida Loria, Seng Zhu, Fabrice de Chaumont, Laura Pieri, Jean-Christophe Olivo-Marin, Ronald Melki, Chiara Zurzolo. EMBO J 2016
211
12

Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-α-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial.
Joseph Jankovic, Ira Goodman, Beth Safirstein, Tonya K Marmon, Dale B Schenk, Martin Koller, Wagner Zago, Daniel K Ness, Sue G Griffith, Michael Grundman,[...]. JAMA Neurol 2018
152
12

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission.
Eun-Jin Bae, He-Jin Lee, Edward Rockenstein, Dong-Hwan Ho, Eun-Bi Park, Na-Young Yang, Paula Desplats, Eliezer Masliah, Seung-Jae Lee. J Neurosci 2012
233
12

Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term.
Nolwen L Rey, Sonia George, Jennifer A Steiner, Zachary Madaj, Kelvin C Luk, John Q Trojanowski, Virginia M-Y Lee, Patrik Brundin. Acta Neuropathol 2018
106
12

α-synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities.
Parvez Alam, Luc Bousset, Ronald Melki, Daniel E Otzen. J Neurochem 2019
119
12

Structures of α-synuclein filaments from multiple system atrophy.
Manuel Schweighauser, Yang Shi, Airi Tarutani, Fuyuki Kametani, Alexey G Murzin, Bernardino Ghetti, Tomoyasu Matsubara, Taisuke Tomita, Takashi Ando, Kazuko Hasegawa,[...]. Nature 2020
238
12

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice.
Collin Challis, Acacia Hori, Timothy R Sampson, Bryan B Yoo, Rosemary C Challis, Adam M Hamilton, Sarkis K Mazmanian, Laura A Volpicelli-Daley, Viviana Gradinaru. Nat Neurosci 2020
128
12

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease.
Wei Zhang, Tongguang Wang, Zhong Pei, David S Miller, Xuefei Wu, Michelle L Block, Belinda Wilson, Wanqin Zhang, Yong Zhou, Jau-Shyong Hong,[...]. FASEB J 2005
866
12

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.
Juan J Zarranz, Javier Alegre, Juan C Gómez-Esteban, Elena Lezcano, Raquel Ros, Israel Ampuero, Lídice Vidal, Janet Hoenicka, Olga Rodriguez, Begoña Atarés,[...]. Ann Neurol 2004
12


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.