A citation-based method for searching scientific literature

Alexei Degterev, Junichi Hitomi, Megan Germscheid, Irene L Ch'en, Olga Korkina, Xin Teng, Derek Abbott, Gregory D Cuny, Chengye Yuan, Gerhard Wagner, Stephen M Hedrick, Scott A Gerber, Alexey Lugovskoy, Junying Yuan. Nat Chem Biol 2008
Times Cited: 1263







List of co-cited articles
1017 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
Liming Sun, Huayi Wang, Zhigao Wang, Sudan He, She Chen, Daohong Liao, Lai Wang, Jiacong Yan, Weilong Liu, Xiaoguang Lei,[...]. Cell 2012
51

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury.
Alexei Degterev, Zhihong Huang, Michael Boyce, Yaqiao Li, Prakash Jagtap, Noboru Mizushima, Gregory D Cuny, Timothy J Mitchison, Michael A Moskowitz, Junying Yuan. Nat Chem Biol 2005
44

Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.
Young Sik Cho, Sreerupa Challa, David Moquin, Ryan Genga, Tathagat Dutta Ray, Melissa Guildford, Francis Ka-Ming Chan. Cell 2009
38

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.
Sudan He, Lai Wang, Lin Miao, Tao Wang, Fenghe Du, Liping Zhao, Xiaodong Wang. Cell 2009
36

Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.
Huayi Wang, Liming Sun, Lijing Su, Josep Rizo, Lei Liu, Li-Feng Wang, Fu-Sheng Wang, Xiaodong Wang. Mol Cell 2014
861
32

Necroptosis and its role in inflammation.
Manolis Pasparakis, Peter Vandenabeele. Nature 2015
985
30

Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Zhenyu Cai, Siriporn Jitkaew, Jie Zhao, Hsueh-Cheng Chiang, Swati Choksi, Jie Liu, Yvona Ward, Ling-Gang Wu, Zheng-Gang Liu. Nat Cell Biol 2014
738
30

RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.
Duan-Wu Zhang, Jing Shao, Juan Lin, Na Zhang, Bao-Ju Lu, Sheng-Cai Lin, Meng-Qiu Dong, Jiahuai Han. Science 2009
30

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews,[...]. Cell Death Differ 2018
24

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
N Holler, R Zaru, O Micheau, M Thome, A Attinger, S Valitutti, J L Bodmer, P Schneider, B Seed, J Tschopp. Nat Immunol 2000
23

MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates.
Yves Dondelinger, Wim Declercq, Sylvie Montessuit, Ria Roelandt, Amanda Goncalves, Inge Bruggeman, Paco Hulpiau, Kathrin Weber, Clark A Sehon, Robert W Marquis,[...]. Cell Rep 2014
469
21

The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.
Jixi Li, Thomas McQuade, Ansgar B Siemer, Johanna Napetschnig, Kenta Moriwaki, Yu-Shan Hsiao, Ermelinda Damko, David Moquin, Thomas Walz, Ann McDermott,[...]. Cell 2012
677
21

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death.
Xin Chen, Wenjuan Li, Junming Ren, Deli Huang, Wan-Ting He, Yunlong Song, Chao Yang, Wanyun Li, Xinru Zheng, Pengda Chen,[...]. Cell Res 2014
459
21


Targeting RIPK1 for the treatment of human diseases.
Alexei Degterev, Dimitry Ofengeim, Junying Yuan. Proc Natl Acad Sci U S A 2019
122
18

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases.
Junying Yuan, Palak Amin, Dimitry Ofengeim. Nat Rev Neurosci 2019
232
18

Activation of necroptosis in multiple sclerosis.
Dimitry Ofengeim, Yasushi Ito, Ayaz Najafov, Yaoyang Zhang, Bing Shan, Judy Park DeWitt, Juanying Ye, Xumin Zhang, Ansi Chang, Helin Vakifahmetoglu-Norberg,[...]. Cell Rep 2015
257
18


Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
William J Kaiser, Haripriya Sridharan, Chunzi Huang, Pratyusha Mandal, Jason W Upton, Peter J Gough, Clark A Sehon, Robert W Marquis, John Bertin, Edward S Mocarski. J Biol Chem 2013
499
17

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.
Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan,[...]. Nat Commun 2017
137
16

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
James M Murphy, Peter E Czabotar, Joanne M Hildebrand, Isabelle S Lucet, Jian-Guo Zhang, Silvia Alvarez-Diaz, Rowena Lewis, Najoua Lalaoui, Donald Metcalf, Andrew I Webb,[...]. Immunity 2013
662
16

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome.
Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhentao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, Deli Huang, Rui Wu,[...]. Nat Commun 2017
196
15

Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Kim Newton, Debra L Dugger, Katherine E Wickliffe, Neeraj Kapoor, M Cristina de Almagro, Domagoj Vucic, Laszlo Komuves, Ronald E Ferrando, Dorothy M French, Joshua Webster,[...]. Science 2014
408
15

Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
Tom Vanden Berghe, Andreas Linkermann, Sandrine Jouan-Lanhouet, Henning Walczak, Peter Vandenabeele. Nat Rev Mol Cell Biol 2014
972
15

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
Yasushi Ito, Dimitry Ofengeim, Ayaz Najafov, Sudeshna Das, Shahram Saberi, Ying Li, Junichi Hitomi, Hong Zhu, Hongbo Chen, Lior Mayo,[...]. Science 2016
288
15

Ferroptosis: an iron-dependent form of nonapoptotic cell death.
Scott J Dixon, Kathryn M Lemberg, Michael R Lamprecht, Rachid Skouta, Eleina M Zaitsev, Caroline E Gleason, Darpan N Patel, Andras J Bauer, Alexandra M Cantley, Wan Seok Yang,[...]. Cell 2012
15

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.
Kim Newton, Katherine E Wickliffe, Debra L Dugger, Allie Maltzman, Merone Roose-Girma, Monika Dohse, László Kőműves, Joshua D Webster, Vishva M Dixit. Nature 2019
152
14

RIP3 induces apoptosis independent of pronecrotic kinase activity.
Pratyusha Mandal, Scott B Berger, Sirika Pillay, Kenta Moriwaki, Chunzi Huang, Hongyan Guo, John D Lich, Joshua Finger, Viera Kasparcova, Bart Votta,[...]. Mol Cell 2014
339
14

Molecular mechanisms of necroptosis: an ordered cellular explosion.
Peter Vandenabeele, Lorenzo Galluzzi, Tom Vanden Berghe, Guido Kroemer. Nat Rev Mol Cell Biol 2010
14

RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome.
Linde Duprez, Nozomi Takahashi, Filip Van Hauwermeiren, Benjamin Vandendriessche, Vera Goossens, Tom Vanden Berghe, Wim Declercq, Claude Libert, Anje Cauwels, Peter Vandenabeele. Immunity 2011
357
14

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis.
Jie Zhao, Siriporn Jitkaew, Zhenyu Cai, Swati Choksi, Qiuning Li, Ji Luo, Zheng-Gang Liu. Proc Natl Acad Sci U S A 2012
502
14

Necroptosis.
Andreas Linkermann, Douglas R Green. N Engl J Med 2014
648
14

Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice.
Scott B Berger, Viera Kasparcova, Sandy Hoffman, Barb Swift, Lauren Dare, Michelle Schaeffer, Carol Capriotti, Michael Cook, Joshua Finger, Angela Hughes-Earle,[...]. J Immunol 2014
251
13

Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo.
Apostolos Polykratis, Nicole Hermance, Matija Zelic, Justine Roderick, Chun Kim, Trieu-My Van, Thomas H Lee, Francis K M Chan, Manolis Pasparakis, Michelle A Kelliher. J Immunol 2014
195
13

NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling.
Yves Dondelinger, Sandrine Jouan-Lanhouet, Tatyana Divert, Emilie Theatre, John Bertin, Peter J Gough, Piero Giansanti, Albert J R Heck, Emmanuel Dejardin, Peter Vandenabeele,[...]. Mol Cell 2015
236
13

RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3.
Christopher P Dillon, Ricardo Weinlich, Diego A Rodriguez, James G Cripps, Giovanni Quarato, Prajwal Gurung, Katherine C Verbist, Taylor L Brewer, Fabien Llambi, Yi-Nan Gong,[...]. Cell 2014
352
13

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
Philip A Harris, Scott B Berger, Jae U Jeong, Rakesh Nagilla, Deepak Bandyopadhyay, Nino Campobasso, Carol A Capriotti, Julie A Cox, Lauren Dare, Xiaoyang Dong,[...]. J Med Chem 2017
206
13

Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target.
Lauren Mifflin, Dimitry Ofengeim, Junying Yuan. Nat Rev Drug Discov 2020
73
17

TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
Daichao Xu, Taijie Jin, Hong Zhu, Hongbo Chen, Dimitry Ofengeim, Chengyu Zou, Lauren Mifflin, Lifeng Pan, Palak Amin, Wanjin Li,[...]. Cell 2018
163
12

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Andrew Oberst, Christopher P Dillon, Ricardo Weinlich, Laura L McCormick, Patrick Fitzgerald, Cristina Pop, Razq Hakem, Guy S Salvesen, Douglas R Green. Nature 2011
811
12

RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.
James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton,[...]. Cell 2014
377
12

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
12

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death.
Joanne M Hildebrand, Maria C Tanzer, Isabelle S Lucet, Samuel N Young, Sukhdeep K Spall, Pooja Sharma, Catia Pierotti, Jean-Marc Garnier, Renwick C J Dobson, Andrew I Webb,[...]. Proc Natl Acad Sci U S A 2014
329
12

Necroptosis in development, inflammation and disease.
Ricardo Weinlich, Andrew Oberst, Helen M Beere, Douglas R Green. Nat Rev Mol Cell Biol 2017
397
12

RIPK1 inhibits ZBP1-driven necroptosis during development.
Kim Newton, Katherine E Wickliffe, Allie Maltzman, Debra L Dugger, Andreas Strasser, Victoria C Pham, Jennie R Lill, Merone Roose-Girma, Søren Warming, Margaret Solon,[...]. Nature 2016
187
11

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.
Juan Lin, Snehlata Kumari, Chun Kim, Trieu-My Van, Laurens Wachsmuth, Apostolos Polykratis, Manolis Pasparakis. Nature 2016
178
11

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel,[...]. Nat Commun 2019
69
15

Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.
Chee-Kwee Ea, Li Deng, Zong-Ping Xia, Gabriel Pineda, Zhijian J Chen. Mol Cell 2006
750
11

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress-induced myocardial necroptosis.
Ting Zhang, Yan Zhang, Mingyao Cui, Li Jin, Yimei Wang, Fengxiang Lv, Yuli Liu, Wen Zheng, Haibao Shang, Jun Zhang,[...]. Nat Med 2016
376
11

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.
N Takahashi, L Duprez, S Grootjans, A Cauwels, W Nerinckx, J B DuHadaway, V Goossens, R Roelandt, F Van Hauwermeiren, C Libert,[...]. Cell Death Dis 2012
272
11


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.