A citation-based method for searching scientific literature

Robert J Lipinski, Paul R Hutson, Paul W Hannam, Robert J Nydza, Ida M Washington, Robert W Moore, Gary G Girdaukas, Richard E Peterson, Wade Bushman. Toxicol Sci 2008
Times Cited: 104







List of co-cited articles
796 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
29

Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications.
Robert J Lipinski, Chihwa Song, Kathleen K Sulik, Joshua L Everson, Jerry J Gipp, Dong Yan, Wade Bushman, Ian J Rowland. Birth Defects Res A Clin Mol Teratol 2010
65
30


Teratogen-mediated inhibition of target tissue response to Shh signaling.
M K Cooper, J A Porter, K E Young, P A Beachy. Science 1998
709
17

A paracrine requirement for hedgehog signalling in cancer.
Robert L Yauch, Stephen E Gould, Suzie J Scales, Tracy Tang, Hua Tian, Christina P Ahn, Derek Marshall, Ling Fu, Thomas Januario, Dara Kallop,[...]. Nature 2008
759
17

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Charles M Rudin, Christine L Hann, John Laterra, Robert L Yauch, Christopher A Callahan, Ling Fu, Thomas Holcomb, Jeremy Stinson, Stephen E Gould, Barbara Coleman,[...]. N Engl J Med 2009
768
17

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
Sarah P Thayer, Marina Pasca di Magliano, Patrick W Heiser, Corinne M Nielsen, Drucilla J Roberts, Gregory Y Lauwers, Yan Ping Qi, Stephan Gysin, Carlos Fernández-del Castillo, Vijay Yajnik,[...]. Nature 2003
16

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Matthias Lauth, Asa Bergström, Takashi Shimokawa, Rune Toftgård. Proc Natl Acad Sci U S A 2007
592
16

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.
Suzie J Scales, Frederic J de Sauvage. Trends Pharmacol Sci 2009
505
16

Efficacy and safety of vismodegib in advanced basal-cell carcinoma.
Aleksandar Sekulic, Michael R Migden, Anthony E Oro, Luc Dirix, Karl D Lewis, John D Hainsworth, James A Solomon, Simon Yoo, Sarah T Arron, Philip A Friedlander,[...]. N Engl J Med 2012
873
16

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.
David M Berman, Sunil S Karhadkar, Anirban Maitra, Rocio Montes De Oca, Meg R Gerstenblith, Kimberly Briggs, Antony R Parker, Yutaka Shimada, James R Eshleman, D Neil Watkins,[...]. Nature 2003
15

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Kenneth P Olive, Michael A Jacobetz, Christian J Davidson, Aarthi Gopinathan, Dominick McIntyre, Davina Honess, Basetti Madhu, Mae A Goldgraben, Meredith E Caldwell, David Allard,[...]. Science 2009
15

Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
770
14

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.
Daniel D Von Hoff, Patricia M LoRusso, Charles M Rudin, Josina C Reddy, Robert L Yauch, Raoul Tibes, Glen J Weiss, Mitesh J Borad, Christine L Hann, Julie R Brahmer,[...]. N Engl J Med 2009
819
14

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Robert L Yauch, Gerrit J P Dijkgraaf, Bruno Alicke, Thomas Januario, Christina P Ahn, Thomas Holcomb, Kanan Pujara, Jeremy Stinson, Christopher A Callahan, Tracy Tang,[...]. Science 2009
640
14

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.
Patricia M LoRusso, Charles M Rudin, Josina C Reddy, Raoul Tibes, Glen J Weiss, Mitesh J Borad, Christine L Hann, Julie R Brahmer, Ilsung Chang, Walter C Darbonne,[...]. Clin Cancer Res 2011
405
14

Medulloblastoma growth inhibition by hedgehog pathway blockade.
David M Berman, Sunil S Karhadkar, Andrew R Hallahan, Joel I Pritchard, Charles G Eberhart, D Neil Watkins, James K Chen, Michael K Cooper, Jussi Taipale, James M Olson,[...]. Science 2002
643
13

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.
D Neil Watkins, David M Berman, Scott G Burkholder, Baolin Wang, Philip A Beachy, Stephen B Baylin. Nature 2003
850
13

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.
J P Incardona, W Gaffield, R P Kapur, H Roelink. Development 1998
511
13

Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
867
13

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.
Justyna T Romer, Hiromichi Kimura, Susan Magdaleno, Ken Sasai, Christine Fuller, Helen Baines, Michele Connelly, Clinton F Stewart, Stephen Gould, Lee L Rubin,[...]. Cancer Cell 2004
404
13

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
J Taipale, J K Chen, M K Cooper, B Wang, R K Mann, L Milenkovic, M P Scott, P A Beachy. Nature 2000
13

HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.
Virginie Clement, Pilar Sanchez, Nicolas de Tribolet, Ivan Radovanovic, Ariel Ruiz i Altaba. Curr Biol 2007
817
12

Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling.
Pilar Sanchez, Ana Maria Hernández, Barbara Stecca, Andrea J Kahler, Amy M DeGueme, Andrea Barrett, Mercedes Beyna, Milton W Datta, Sumana Datta, Ariel Ruiz i Altaba. Proc Natl Acad Sci U S A 2004
422
12

Hedgehog signalling in prostate regeneration, neoplasia and metastasis.
Sunil S Karhadkar, G Steven Bova, Nadia Abdallah, Surajit Dhara, Dale Gardner, Anirban Maitra, John T Isaacs, David M Berman, Philip A Beachy. Nature 2004
823
12

Activating Smoothened mutations in sporadic basal-cell carcinoma.
J Xie, M Murone, S M Luoh, A Ryan, Q Gu, C Zhang, J M Bonifas, C W Lam, M Hynes, A Goddard,[...]. Nature 1998
12

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
12

Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
Martin R Tremblay, André Lescarbeau, Michael J Grogan, Eddy Tan, Grace Lin, Brian C Austad, Lin-Chen Yu, Mark L Behnke, Somarajan J Nair, Margit Hagel,[...]. J Med Chem 2009
179
12

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
James Kim, Jean Y Tang, Ruoyu Gong, Jynho Kim, John J Lee, Karl V Clemons, Curtis R Chong, Kris S Chang, Mark Fereshteh, Dale Gardner,[...]. Cancer Cell 2010
362
12

Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.
Georg Feldmann, Surajit Dhara, Volker Fendrich, Djahida Bedja, Robert Beaty, Michael Mullendore, Collins Karikari, Hector Alvarez, Christine Iacobuzio-Donahue, Antonio Jimeno,[...]. Cancer Res 2007
534
11

An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
Georg Feldmann, Volker Fendrich, Karen McGovern, Djahida Bedja, Savita Bisht, Hector Alvarez, Jan-Bart M Koorstra, Nils Habbe, Collins Karikari, Michael Mullendore,[...]. Mol Cancer Ther 2008
218
11

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
11

GDC-0449-a potent inhibitor of the hedgehog pathway.
Kirk D Robarge, Shirley A Brunton, Georgette M Castanedo, Yong Cui, Michael S Dina, Richard Goldsmith, Stephen E Gould, Oivin Guichert, Janet L Gunzner, Jason Halladay,[...]. Bioorg Med Chem Lett 2009
287
11

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector.
Jynho Kim, John J Lee, James Kim, Dale Gardner, Philip A Beachy. Proc Natl Acad Sci U S A 2010
226
11

Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
R L Johnson, A L Rothman, J Xie, L V Goodrich, J W Bare, J M Bonifas, A G Quinn, R M Myers, D R Cox, E H Epstein,[...]. Science 1996
10

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.
Juliet A Williams, Oivin M Guicherit, Beatrice I Zaharian, Yin Xu, Ling Chai, Hynek Wichterle, Charlene Kon, Christine Gatchalian, Jeffery A Porter, Lee L Rubin,[...]. Proc Natl Acad Sci U S A 2003
253
10


Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.
H Hahn, C Wicking, P G Zaphiropoulous, M R Gailani, S Shanley, A Chidambaram, I Vorechovsky, E Holmberg, A B Unden, S Gillies,[...]. Cell 1996
10

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway.
Elspeth M Beauchamp, Lymor Ringer, Gülay Bulut, Kamal P Sajwan, Michael D Hall, Yi-Chien Lee, Daniel Peaceman, Metin Ozdemirli, Olga Rodriguez, Tobey J Macdonald,[...]. J Clin Invest 2011
248
10

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome.
Jean Y Tang, Julian M Mackay-Wiggan, Michelle Aszterbaum, Robert L Yauch, Joselyn Lindgren, Kris Chang, Carol Coppola, Anita M Chanana, Jackleen Marji, David R Bickers,[...]. N Engl J Med 2012
393
10

Essential role of stromally induced hedgehog signaling in B-cell malignancies.
Christine Dierks, Jovana Grbic, Katja Zirlik, Ronak Beigi, Nathan P Englund, Gui-Rong Guo, Hendrik Veelken, Monika Engelhardt, Roland Mertelsmann, Joseph F Kelleher,[...]. Nat Med 2007
257
9

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.
Hua Tian, Christopher A Callahan, Kelly J DuPree, Walter C Darbonne, Christina P Ahn, Suzie J Scales, Frederic J de Sauvage. Proc Natl Acad Sci U S A 2009
324
9

Identification of an amplified, highly expressed gene in a human glioma.
K W Kinzler, S H Bigner, D D Bigner, J M Trent, M L Law, S J O'Brien, A J Wong, B Vogelstein. Science 1987
585
9

Sporadic medulloblastomas contain PTCH mutations.
C Raffel, R B Jenkins, L Frederick, D Hebrink, B Alderete, D W Fults, C D James. Cancer Res 1997
443
9

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.
Chen Zhao, Alan Chen, Catriona H Jamieson, Mark Fereshteh, Annelie Abrahamsson, Jordan Blum, Hyog Young Kwon, Jynho Kim, John P Chute, David Rizzieri,[...]. Nature 2009
648
9

Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
9

Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes.
Dwight Cordero, Ralph Marcucio, Diane Hu, William Gaffield, Minal Tapadia, Jill A Helms. J Clin Invest 2004
139
9

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
Silvia Buonamici, Juliet Williams, Michael Morrissey, Anlai Wang, Ribo Guo, Anthony Vattay, Kathy Hsiao, Jing Yuan, John Green, Beatriz Ospina,[...]. Sci Transl Med 2010
360
9

The Hedgehog's tale: developing strategies for targeting cancer.
Jessica M Y Ng, Tom Curran. Nat Rev Cancer 2011
302
9

Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.
G Feldmann, N Habbe, S Dhara, S Bisht, H Alvarez, V Fendrich, R Beaty, M Mullendore, C Karikari, N Bardeesy,[...]. Gut 2008
140
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.