Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
Times Cited: 2457
Times Cited: 2457
Times Cited
Times Co-cited
Similarity
TSC2 mediates cellular energy response to control cell growth and survival.
Ken Inoki, Tianqing Zhu, Kun-Liang Guan. Cell 2003
Ken Inoki, Tianqing Zhu, Kun-Liang Guan. Cell 2003
33
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
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AMPK: guardian of metabolism and mitochondrial homeostasis.
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
Sébastien Herzig, Reuben J Shaw. Nat Rev Mol Cell Biol 2018
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Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
Chen-Song Zhang, Simon A Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu,[...]. Nature 2017
Chen-Song Zhang, Simon A Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu,[...]. Nature 2017
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Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Daniel F Egan, David B Shackelford, Maria M Mihaylova, Sara Gelino, Rebecca A Kohnz, William Mair, Debbie S Vasquez, Aashish Joshi, Dana M Gwinn, Rebecca Taylor,[...]. Science 2011
Daniel F Egan, David B Shackelford, Maria M Mihaylova, Sara Gelino, Rebecca A Kohnz, William Mair, Debbie S Vasquez, Aashish Joshi, Dana M Gwinn, Rebecca Taylor,[...]. Science 2011
10
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
10
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
10
AMPK: a nutrient and energy sensor that maintains energy homeostasis.
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
D Grahame Hardie, Fiona A Ross, Simon A Hawley. Nat Rev Mol Cell Biol 2012
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Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Amanda L Souza, Ellen Triantafellow, Qicheng Ma, Regina Gorski, Stephen Cleaver,[...]. Mol Cell 2010
9
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
9
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
Nao Hosokawa, Taichi Hara, Takeshi Kaizuka, Chieko Kishi, Akito Takamura, Yutaka Miura, Shun-ichiro Iemura, Tohru Natsume, Kenji Takehana, Naoyuki Yamada,[...]. Mol Biol Cell 2009
Nao Hosokawa, Taichi Hara, Takeshi Kaizuka, Chieko Kishi, Akito Takamura, Yutaka Miura, Shun-ichiro Iemura, Tohru Natsume, Kenji Takehana, Naoyuki Yamada,[...]. Mol Biol Cell 2009
9
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
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A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard,[...]. EMBO J 2012
Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard,[...]. EMBO J 2012
8
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
8
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
Reuben J Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L Hurley, Lee A Witters, Ronald A DePinho, Lewis C Cantley. Proc Natl Acad Sci U S A 2004
Reuben J Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L Hurley, Lee A Witters, Ronald A DePinho, Lewis C Cantley. Proc Natl Acad Sci U S A 2004
8
AMPK: Sensing Glucose as well as Cellular Energy Status.
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
Sheng-Cai Lin, D Grahame Hardie. Cell Metab 2018
7
Mechanism and medical implications of mammalian autophagy.
Ivan Dikic, Zvulun Elazar. Nat Rev Mol Cell Biol 2018
Ivan Dikic, Zvulun Elazar. Nat Rev Mol Cell Biol 2018
7
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Jingxiang Huang, Brendan D Manning. Biochem J 2008
Jingxiang Huang, Brendan D Manning. Biochem J 2008
7
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
Suchithra Menon, Christian C Dibble, George Talbott, Gerta Hoxhaj, Alexander J Valvezan, Hidenori Takahashi, Lewis C Cantley, Brendan D Manning. Cell 2014
7
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
7
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
7
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
Jose A Martina, Yong Chen, Marjan Gucek, Rosa Puertollano. Autophagy 2012
Jose A Martina, Yong Chen, Marjan Gucek, Rosa Puertollano. Autophagy 2012
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mTOR: from growth signal integration to cancer, diabetes and ageing.
Roberto Zoncu, Alejo Efeyan, David M Sabatini. Nat Rev Mol Cell Biol 2011
Roberto Zoncu, Alejo Efeyan, David M Sabatini. Nat Rev Mol Cell Biol 2011
7
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress.
Naomi X Y Ling, Adrian Kaczmarek, Ashfaqul Hoque, Elizabeth Davie, Kevin R W Ngoei, Kaitlin R Morrison, William J Smiles, Gabriella M Forte, Tingting Wang, Shervi Lie,[...]. Nat Metab 2020
Naomi X Y Ling, Adrian Kaczmarek, Ashfaqul Hoque, Elizabeth Davie, Kevin R W Ngoei, Kaitlin R Morrison, William J Smiles, Gabriella M Forte, Tingting Wang, Shervi Lie,[...]. Nat Metab 2020
16
TFEB links autophagy to lysosomal biogenesis.
Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, Serpil Uckac Erdin, Tuong Huynh, Diego Medina, Pasqualina Colella,[...]. Science 2011
Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, Serpil Uckac Erdin, Tuong Huynh, Diego Medina, Pasqualina Colella,[...]. Science 2011
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AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.
Daniel Garcia, Reuben J Shaw. Mol Cell 2017
Daniel Garcia, Reuben J Shaw. Mol Cell 2017
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The LKB1 tumor suppressor negatively regulates mTOR signaling.
Reuben J Shaw, Nabeel Bardeesy, Brendan D Manning, Lyle Lopez, Monica Kosmatka, Ronald A DePinho, Lewis C Cantley. Cancer Cell 2004
Reuben J Shaw, Nabeel Bardeesy, Brendan D Manning, Lyle Lopez, Monica Kosmatka, Ronald A DePinho, Lewis C Cantley. Cancer Cell 2004
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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway.
Brendan D Manning, Andrew R Tee, M Nicole Logsdon, John Blenis, Lewis C Cantley. Mol Cell 2002
Brendan D Manning, Andrew R Tee, M Nicole Logsdon, John Blenis, Lewis C Cantley. Mol Cell 2002
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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J Yang, Meredith Miller, Angela Yang, Ankita Dhar, Nikola P Pavletich. Nature 2017
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J Yang, Meredith Miller, Angela Yang, Ankita Dhar, Nikola P Pavletich. Nature 2017
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Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Liron Bar-Peled, Lawrence D Schweitzer, Roberto Zoncu, David M Sabatini. Cell 2012
Liron Bar-Peled, Lawrence D Schweitzer, Roberto Zoncu, David M Sabatini. Cell 2012
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Localization of mTORC2 activity inside cells.
Michael Ebner, Benjamin Sinkovics, Magdalena Szczygieł, Daniela Wolfschoon Ribeiro, Ivan Yudushkin. J Cell Biol 2017
Michael Ebner, Benjamin Sinkovics, Magdalena Szczygieł, Daniela Wolfschoon Ribeiro, Ivan Yudushkin. J Cell Biol 2017
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Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks.
Brian Magnuson, Bilgen Ekim, Diane C Fingar. Biochem J 2012
Brian Magnuson, Bilgen Ekim, Diane C Fingar. Biochem J 2012
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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
Roberto Zoncu, Liron Bar-Peled, Alejo Efeyan, Shuyu Wang, Yasemin Sancak, David M Sabatini. Science 2011
Roberto Zoncu, Liron Bar-Peled, Alejo Efeyan, Shuyu Wang, Yasemin Sancak, David M Sabatini. Science 2011
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Dihydroxyacetone phosphate signals glucose availability to mTORC1.
Jose M Orozco, Patrycja A Krawczyk, Sonia M Scaria, Andrew L Cangelosi, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, David M Sabatini. Nat Metab 2020
Jose M Orozco, Patrycja A Krawczyk, Sonia M Scaria, Andrew L Cangelosi, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, David M Sabatini. Nat Metab 2020
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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Kim. Nat Cell Biol 2007
Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Kim. Nat Cell Biol 2007
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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Brian C Grabiner, Eric D Spear, Scott L Carter, Matthew Meyerson, David M Sabatini. Science 2013
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Brian C Grabiner, Eric D Spear, Scott L Carter, Matthew Meyerson, David M Sabatini. Science 2013
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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Li Ma, Zhenbang Chen, Hediye Erdjument-Bromage, Paul Tempst, Pier Paolo Pandolfi. Cell 2005
Li Ma, Zhenbang Chen, Hediye Erdjument-Bromage, Paul Tempst, Pier Paolo Pandolfi. Cell 2005
6
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
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Regulation of TORC1 by Rag GTPases in nutrient response.
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
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mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
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Oxidative stress and autophagy: the clash between damage and metabolic needs.
G Filomeni, D De Zio, F Cecconi. Cell Death Differ 2015
G Filomeni, D De Zio, F Cecconi. Cell Death Differ 2015
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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade.
Angela Woods, Stephen R Johnstone, Kristina Dickerson, Fiona C Leiper, Lee G D Fryer, Dietbert Neumann, Uwe Schlattner, Theo Wallimann, Marian Carlson, David Carling. Curr Biol 2003
Angela Woods, Stephen R Johnstone, Kristina Dickerson, Fiona C Leiper, Lee G D Fryer, Dietbert Neumann, Uwe Schlattner, Theo Wallimann, Marian Carlson, David Carling. Curr Biol 2003
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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
5
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.
Xin Gu, Jose M Orozco, Robert A Saxton, Kendall J Condon, Grace Y Liu, Patrycja A Krawczyk, Sonia M Scaria, J Wade Harper, Steven P Gygi, David M Sabatini. Science 2017
Xin Gu, Jose M Orozco, Robert A Saxton, Kendall J Condon, Grace Y Liu, Patrycja A Krawczyk, Sonia M Scaria, J Wade Harper, Steven P Gygi, David M Sabatini. Science 2017
5
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
Francesca Nazio, Flavie Strappazzon, Manuela Antonioli, Pamela Bielli, Valentina Cianfanelli, Matteo Bordi, Christine Gretzmeier, Joern Dengjel, Mauro Piacentini, Gian Maria Fimia,[...]. Nat Cell Biol 2013
Francesca Nazio, Flavie Strappazzon, Manuela Antonioli, Pamela Bielli, Valentina Cianfanelli, Matteo Bordi, Christine Gretzmeier, Joern Dengjel, Mauro Piacentini, Gian Maria Fimia,[...]. Nat Cell Biol 2013
5
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.