A citation-based method for searching scientific literature

Akihiko Yokoyama, Michael L Cleary. Cancer Cell 2008
Times Cited: 336







List of co-cited articles
1661 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis.
Akihiko Yokoyama, Tim C P Somervaille, Kevin S Smith, Orit Rozenblatt-Rosen, Matthew Meyerson, Michael L Cleary. Cell 2005
365
56

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.
Dmitry Borkin, Shihan He, Hongzhi Miao, Katarzyna Kempinska, Jonathan Pollock, Jennifer Chase, Trupta Purohit, Bhavna Malik, Ting Zhao, Jingya Wang,[...]. Cancer Cell 2015
194
46

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.
Jolanta Grembecka, Shihan He, Aibin Shi, Trupta Purohit, Andrew G Muntean, Roderick J Sorenson, Hollis D Showalter, Marcelo J Murai, Amalia M Belcher, Thomas Hartley,[...]. Nat Chem Biol 2012
247
38

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.
Aibin Shi, Marcelo J Murai, Shihan He, George Lund, Thomas Hartley, Trupta Purohit, Gireesh Reddy, Maksymilian Chruszcz, Jolanta Grembecka, Tomasz Cierpicki. Blood 2012
122
35

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Aravind Basavapathruni, Lei Jin, P Ann Boriack-Sjodin, Christina J Allain, Christine R Klaus, Alejandra Raimondi, Margaret Porter Scott,[...]. Blood 2013
443
30

The MLL recombinome of acute leukemias in 2017.
C Meyer, T Burmeister, D Gröger, G Tsaur, L Fechina, A Renneville, R Sutton, N C Venn, M Emerenciano, M S Pombo-de-Oliveira,[...]. Leukemia 2018
277
29

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Scott R Daigle, Edward J Olhava, Carly A Therkelsen, Christina R Majer, Christopher J Sneeringer, Jeffrey Song, L Danielle Johnston, Margaret Porter Scott, Jesse J Smith, Yonghong Xiao,[...]. Cancer Cell 2011
629
27

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Kathrin M Bernt, Nan Zhu, Amit U Sinha, Sridhar Vempati, Joerg Faber, Andrei V Krivtsov, Zhaohui Feng, Natalie Punt, Amanda Daigle, Lars Bullinger,[...]. Cancer Cell 2011
576
26

The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Jing Huang, Buddha Gurung, Bingbing Wan, Smita Matkar, Natalia A Veniaminova, Ke Wan, Juanita L Merchant, Xianxin Hua, Ming Lei. Nature 2012
175
25

MLL translocations, histone modifications and leukaemia stem-cell development.
Andrei V Krivtsov, Scott A Armstrong. Nat Rev Cancer 2007
775
24

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.
Akihiko Yokoyama, Zhong Wang, Joanna Wysocka, Mrinmoy Sanyal, Deborah J Aufiero, Issay Kitabayashi, Winship Herr, Michael L Cleary. Mol Cell Biol 2004
504
23

Interaction of MLL amino terminal sequences with menin is required for transformation.
Corrado Caslini, Zhaohai Yang, Mohamad El-Osta, Thomas A Milne, Robert K Slany, Jay L Hess. Cancer Res 2007
121
21

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.
Sara El Ashkar, Juerg Schwaller, Tim Pieters, Steven Goossens, Jonas Demeulemeester, Frauke Christ, Siska Van Belle, Sabine Juge, Nancy Boeckx, Alan Engelman,[...]. Blood 2018
29
72

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
Szymon Klossowski, Hongzhi Miao, Katarzyna Kempinska, Tao Wu, Trupta Purohit, EunGi Kim, Brian M Linhares, Dong Chen, Gloria Jih, Eric Perkey,[...]. J Clin Invest 2020
62
33

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.
Andrei V Krivtsov, Kathryn Evans, Jayant Y Gadrey, Benjamin K Eschle, Charlie Hatton, Hannah J Uckelmann, Kenneth N Ross, Florian Perner, Sarah N Olsen, Tara Pritchard,[...]. Cancer Cell 2019
93
22

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.
Andrew G Muntean, Jiaying Tan, Kajal Sitwala, Yongsheng Huang, Joel Bronstein, James A Connelly, Venkatesha Basrur, Kojo S J Elenitoba-Johnson, Jay L Hess. Cancer Cell 2010
158
20

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9.
Andrei V Krivtsov, David Twomey, Zhaohui Feng, Matthew C Stubbs, Yingzi Wang, Joerg Faber, Jason E Levine, Jing Wang, William C Hahn, D Gary Gilliland,[...]. Nature 2006
20

Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.
Michael W M Kühn, Evelyn Song, Zhaohui Feng, Amit Sinha, Chun-Wei Chen, Aniruddha J Deshpande, Monica Cusan, Noushin Farnoud, Annalisa Mupo, Carolyn Grove,[...]. Cancer Discov 2016
89
22

Regulation of MLL1 H3K4 methyltransferase activity by its core components.
Yali Dou, Thomas A Milne, Alexander J Ruthenburg, Seunghee Lee, Jae Woon Lee, Gregory L Verdine, C David Allis, Robert G Roeder. Nat Struct Mol Biol 2006
514
19


Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.
Thomas A Milne, Jaehoon Kim, Gang G Wang, Sonja C Stadler, Venkatesha Basrur, Sarah J Whitcomb, Zhanxin Wang, Alexander J Ruthenburg, Kojo S J Elenitoba-Johnson, Robert G Roeder,[...]. Mol Cell 2010
148
18

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia.
Eytan M Stein, Guillermo Garcia-Manero, David A Rizzieri, Raoul Tibes, Jesus G Berdeja, Michael R Savona, Mojca Jongen-Lavrenic, Jessica K Altman, Blythe Thomson, Stephen J Blakemore,[...]. Blood 2018
169
18

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.
Mark A Dawson, Rab K Prinjha, Antje Dittmann, George Giotopoulos, Marcus Bantscheff, Wai-In Chan, Samuel C Robson, Chun-wa Chung, Carsten Hopf, Mikhail M Savitski,[...]. Nature 2011
17

Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.
Kateřina Cermáková, Petr Tesina, Jonas Demeulemeester, Sara El Ashkar, Hélène Méreau, Juerg Schwaller, Pavlína Rezáčová, Vaclav Veverka, Jan De Rijck. Cancer Res 2014
34
50

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.
Jocelyn O Eidahl, Brandon L Crowe, Justin A North, Christopher J McKee, Nikoloz Shkriabai, Lei Feng, Matthew Plumb, Robert L Graham, Robert J Gorelick, Sonja Hess,[...]. Nucleic Acids Res 2013
132
17

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
Li Zhu, Qin Li, Stephen H K Wong, Min Huang, Brianna J Klein, Jinfeng Shen, Larissa Ikenouye, Masayuki Onishi, Dominik Schneidawind, Corina Buechele,[...]. Cancer Discov 2016
75
22

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Yali Dou, Thomas A Milne, Alan J Tackett, Edwin R Smith, Aya Fukuda, Joanna Wysocka, C David Allis, Brian T Chait, Jay L Hess, Robert G Roeder. Cell 2005
482
17

hDOT1L links histone methylation to leukemogenesis.
Yuki Okada, Qin Feng, Yihui Lin, Qi Jiang, Yaqiang Li, Vernon M Coffield, Lishan Su, Guoliang Xu, Yi Zhang. Cell 2005
571
17

Transcription control by the ENL YEATS domain in acute leukaemia.
Michael A Erb, Thomas G Scott, Bin E Li, Huafeng Xie, Joshiawa Paulk, Hyuk-Soo Seo, Amanda Souza, Justin M Roberts, Shiva Dastjerdi, Dennis L Buckley,[...]. Nature 2017
127
17

ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.
Liling Wan, Hong Wen, Yuanyuan Li, Jie Lyu, Yuanxin Xi, Takayuki Hoshii, Julia K Joseph, Xiaolu Wang, Yong-Hwee E Loh, Michael A Erb,[...]. Nature 2017
103
17

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Chun-Wei Chen, Richard P Koche, Amit U Sinha, Aniruddha J Deshpande, Nan Zhu, Rowena Eng, John G Doench, Haiming Xu, Scott H Chu, Jun Qi,[...]. Nat Med 2015
133
17

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
Johannes Zuber, Junwei Shi, Eric Wang, Amy R Rappaport, Harald Herrmann, Edward A Sison, Daniel Magoon, Jun Qi, Katharina Blatt, Mark Wunderlich,[...]. Nature 2011
16

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
Petr Tesina, Kateřina Čermáková, Magdalena Hořejší, Kateřina Procházková, Milan Fábry, Subhalakshmi Sharma, Frauke Christ, Jonas Demeulemeester, Zeger Debyser, Jan De Rijck,[...]. Nat Commun 2015
34
47

AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation.
Yuanyuan Li, Hong Wen, Yuanxin Xi, Kaori Tanaka, Haibo Wang, Danni Peng, Yongfeng Ren, Qihuang Jin, Sharon Y R Dent, Wei Li,[...]. Cell 2014
194
16

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.
Akihiko Yokoyama, Min Lin, Alpana Naresh, Issay Kitabayashi, Michael L Cleary. Cancer Cell 2010
245
16

MLL targets SET domain methyltransferase activity to Hox gene promoters.
Thomas A Milne, Scott D Briggs, Hugh W Brock, Mary Ellen Martin, Denise Gibbs, C David Allis, Jay L Hess. Mol Cell 2002
775
16

High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction.
Shihan He, Timothy J Senter, Jonathan Pollock, Changho Han, Sunil Kumar Upadhyay, Trupta Purohit, Rocco D Gogliotti, Craig W Lindsley, Tomasz Cierpicki, Shaun R Stauffer,[...]. J Med Chem 2014
59
25

MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.
Amanda C Winters, Kathrin M Bernt. Front Pediatr 2017
179
15

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein.
P Ernst, J Wang, M Huang, R H Goodman, S J Korsmeyer. Mol Cell Biol 2001
178
15

Altered Hox expression and segmental identity in Mll-mutant mice.
B D Yu, J L Hess, S E Horning, G A Brown, S J Korsmeyer. Nature 1995
679
14

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).
H Méreau, J De Rijck, K Cermáková, A Kutz, S Juge, J Demeulemeester, R Gijsbers, F Christ, Z Debyser, J Schwaller. Leukemia 2013
37
37

Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.
Fang Cao, Elizabeth C Townsend, Hacer Karatas, Jing Xu, Li Li, Shirley Lee, Liu Liu, Yong Chen, Peter Ouillette, Jidong Zhu,[...]. Mol Cell 2014
188
14

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Florian Grebien, Masoud Vedadi, Matthäus Getlik, Roberto Giambruno, Amit Grover, Roberto Avellino, Anna Skucha, Sarah Vittori, Ekaterina Kuznetsova, David Smil,[...]. Nat Chem Biol 2015
140
14

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
Ya-Xiong Chen, Jizhou Yan, Karen Keeshan, Anthony T Tubbs, Haoren Wang, Albert Silva, Eric J Brown, Jay L Hess, Warren S Pear, Xianxin Hua. Proc Natl Acad Sci U S A 2006
114
14

The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation.
Marco Birke, Silke Schreiner, María-Paz García-Cuéllar, Kerstin Mahr, Fritz Titgemeyer, Robert K Slany. Nucleic Acids Res 2002
158
14

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Christina M Hughes, Orit Rozenblatt-Rosen, Thomas A Milne, Terry D Copeland, Stuart S Levine, Jeffrey C Lee, D Neil Hayes, Kalai Selvi Shanmugam, Arindam Bhattacharjee, Christine A Biondi,[...]. Mol Cell 2004
460
14

AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
Aniruddha J Deshpande, Anagha Deshpande, Amit U Sinha, Liying Chen, Jenny Chang, Ali Cihan, Maurizio Fazio, Chun-Wei Chen, Nan Zhu, Richard Koche,[...]. Cancer Cell 2014
105
14

Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia.
C Dafflon, V J Craig, H Méreau, J Gräsel, B Schacher Engstler, G Hoffman, F Nigsch, S Gaulis, L Barys, M Ito,[...]. Leukemia 2017
45
31

A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.
Dorothee Mueller, Christian Bach, Deniz Zeisig, Maria-Paz Garcia-Cuellar, Sara Monroe, Arun Sreekumar, Rong Zhou, Alexey Nesvizhskii, Arul Chinnaiyan, Jay L Hess,[...]. Blood 2007
273
14

Therapeutic targeting of preleukemia cells in a mouse model of NPM1 mutant acute myeloid leukemia.
Hannah J Uckelmann, Stephanie M Kim, Eric M Wong, Charles Hatton, Hugh Giovinazzo, Jayant Y Gadrey, Andrei V Krivtsov, Frank G Rücker, Konstanze Döhner, Gerard M McGeehan,[...]. Science 2020
56
25


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.