Yongsu Jeong, Federico Coluccio Leskow, Kenia El-Jaick, Erich Roessler, Maximilian Muenke, Anastasia Yocum, Christele Dubourg, Xue Li, Xin Geng, Guillermo Oliver, Douglas J Epstein. Nat Genet 2008
Times Cited: 133
Times Cited: 133
Times Cited
Times Co-cited
Similarity
Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly.
Xin Geng, Christina Speirs, Oleg Lagutin, Adi Inbal, Wei Liu, Lilianna Solnica-Krezel, Yongsu Jeong, Douglas J Epstein, Guillermo Oliver. Dev Cell 2008
Xin Geng, Christina Speirs, Oleg Lagutin, Adi Inbal, Wei Liu, Lilianna Solnica-Krezel, Yongsu Jeong, Douglas J Epstein, Guillermo Oliver. Dev Cell 2008
40
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
32
A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers.
Yongsu Jeong, Kenia El-Jaick, Erich Roessler, Maximilian Muenke, Douglas J Epstein. Development 2006
Yongsu Jeong, Kenia El-Jaick, Erich Roessler, Maximilian Muenke, Douglas J Epstein. Development 2006
26
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development.
Oleg V Lagutin, Changqi C Zhu, Daisuke Kobayashi, Jacek Topczewski, Kenji Shimamura, Luis Puelles, Helen R C Russell, Peter J McKinnon, Lilianna Solnica-Krezel, Guillermo Oliver. Genes Dev 2003
Oleg V Lagutin, Changqi C Zhu, Daisuke Kobayashi, Jacek Topczewski, Kenji Shimamura, Luis Puelles, Helen R C Russell, Peter J McKinnon, Lilianna Solnica-Krezel, Guillermo Oliver. Genes Dev 2003
26
A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly.
Laura A Lettice, Simon J H Heaney, Lorna A Purdie, Li Li, Philippe de Beer, Ben A Oostra, Debbie Goode, Greg Elgar, Robert E Hill, Esther de Graaff. Hum Mol Genet 2003
Laura A Lettice, Simon J H Heaney, Lorna A Purdie, Li Li, Philippe de Beer, Ben A Oostra, Debbie Goode, Greg Elgar, Robert E Hill, Esther de Graaff. Hum Mol Genet 2003
25
Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence.
Sabina Benko, Judy A Fantes, Jeanne Amiel, Dirk-Jan Kleinjan, Sophie Thomas, Jacqueline Ramsay, Negar Jamshidi, Abdelkader Essafi, Simon Heaney, Christopher T Gordon,[...]. Nat Genet 2009
Sabina Benko, Judy A Fantes, Jeanne Amiel, Dirk-Jan Kleinjan, Sophie Thomas, Jacqueline Ramsay, Negar Jamshidi, Abdelkader Essafi, Simon Heaney, Christopher T Gordon,[...]. Nat Genet 2009
17
Topological domains in mammalian genomes identified by analysis of chromatin interactions.
Jesse R Dixon, Siddarth Selvaraj, Feng Yue, Audrey Kim, Yan Li, Yin Shen, Ming Hu, Jun S Liu, Bing Ren. Nature 2012
Jesse R Dixon, Siddarth Selvaraj, Feng Yue, Audrey Kim, Yan Li, Yin Shen, Ming Hu, Jun S Liu, Bing Ren. Nature 2012
16
Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia.
Li Zhao, Solsire E Zevallos, Karine Rizzoti, Yongsu Jeong, Robin Lovell-Badge, Douglas J Epstein. Dev Cell 2012
Li Zhao, Solsire E Zevallos, Karine Rizzoti, Yongsu Jeong, Robin Lovell-Badge, Douglas J Epstein. Dev Cell 2012
22
The molecular genetics of holoprosencephaly.
Erich Roessler, Maximilian Muenke. Am J Med Genet C Semin Med Genet 2010
Erich Roessler, Maximilian Muenke. Am J Med Genet C Semin Med Genet 2010
15
Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis.
Kazushi Aoto, Yayoi Shikata, Hajime Imai, Daisuke Matsumaru, Tomoyuki Tokunaga, Seiji Shioda, Gen Yamada, Jun Motoyama. Dev Biol 2009
Kazushi Aoto, Yayoi Shikata, Hajime Imai, Daisuke Matsumaru, Tomoyuki Tokunaga, Seiji Shioda, Gen Yamada, Jun Motoyama. Dev Biol 2009
22
Inductive interactions direct early regionalization of the mouse forebrain.
K Shimamura, J L Rubenstein. Development 1997
K Shimamura, J L Rubenstein. Development 1997
13
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development.
G Oliver, A Mailhos, R Wehr, N G Copeland, N A Jenkins, P Gruss. Development 1995
G Oliver, A Mailhos, R Wehr, N G Copeland, N A Jenkins, P Gruss. Development 1995
13
Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye.
Matthias Carl, Felix Loosli, Joachim Wittbrodt. Development 2002
Matthias Carl, Felix Loosli, Joachim Wittbrodt. Development 2002
13
Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly.
D E Wallis, E Roessler, U Hehr, L Nanni, T Wiltshire, A Richieri-Costa, G Gillessen-Kaesbach, E H Zackai, J Rommens, M Muenke. Nat Genet 1999
D E Wallis, E Roessler, U Hehr, L Nanni, T Wiltshire, A Richieri-Costa, G Gillessen-Kaesbach, E H Zackai, J Rommens, M Muenke. Nat Genet 1999
13
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly.
E Roessler, E Belloni, K Gaudenz, P Jay, P Berta, S W Scherer, L C Tsui, M Muenke. Nat Genet 1996
E Roessler, E Belloni, K Gaudenz, P Jay, P Berta, S W Scherer, L C Tsui, M Muenke. Nat Genet 1996
13
Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm.
J K Dale, C Vesque, T J Lints, T K Sampath, A Furley, J Dodd, M Placzek. Cell 1997
J K Dale, C Vesque, T J Lints, T K Sampath, A Furley, J Dodd, M Placzek. Cell 1997
13
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
13
Systematic localization of common disease-associated variation in regulatory DNA.
Matthew T Maurano, Richard Humbert, Eric Rynes, Robert E Thurman, Eric Haugen, Hao Wang, Alex P Reynolds, Richard Sandstrom, Hongzhu Qu, Jennifer Brody,[...]. Science 2012
Matthew T Maurano, Richard Humbert, Eric Rynes, Robert E Thurman, Eric Haugen, Hao Wang, Alex P Reynolds, Richard Sandstrom, Hongzhu Qu, Jennifer Brody,[...]. Science 2012
13
Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.
Alfonso Lavado, Oleg V Lagutin, Guillermo Oliver. Development 2008
Alfonso Lavado, Oleg V Lagutin, Guillermo Oliver. Development 2008
20
12
Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.
Nicholas Warr, Nicola Powles-Glover, Anna Chappell, Joan Robson, Dominic Norris, Ruth M Arkell. Hum Mol Genet 2008
Nicholas Warr, Nicola Powles-Glover, Anna Chappell, Joan Robson, Dominic Norris, Ruth M Arkell. Hum Mol Genet 2008
17
Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation.
Liz Manning, Kyoji Ohyama, Bernhard Saeger, Osamu Hatano, Stuart A Wilson, Malcolm Logan, Marysia Placzek. Dev Cell 2006
Liz Manning, Kyoji Ohyama, Bernhard Saeger, Osamu Hatano, Stuart A Wilson, Malcolm Logan, Marysia Placzek. Dev Cell 2006
12
Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.
Wei Liu, Oleg Lagutin, Eric Swindell, Milan Jamrich, Guillermo Oliver. J Clin Invest 2010
Wei Liu, Oleg Lagutin, Eric Swindell, Milan Jamrich, Guillermo Oliver. J Clin Invest 2010
16
In vivo enhancer analysis of human conserved non-coding sequences.
Len A Pennacchio, Nadav Ahituv, Alan M Moses, Shyam Prabhakar, Marcelo A Nobrega, Malak Shoukry, Simon Minovitsky, Inna Dubchak, Amy Holt, Keith D Lewis,[...]. Nature 2006
Len A Pennacchio, Nadav Ahituv, Alan M Moses, Shyam Prabhakar, Marcelo A Nobrega, Malak Shoukry, Simon Minovitsky, Inna Dubchak, Amy Holt, Keith D Lewis,[...]. Nature 2006
11
ChIP-seq accurately predicts tissue-specific activity of enhancers.
Axel Visel, Matthew J Blow, Zirong Li, Tao Zhang, Jennifer A Akiyama, Amy Holt, Ingrid Plajzer-Frick, Malak Shoukry, Crystal Wright, Feng Chen,[...]. Nature 2009
Axel Visel, Matthew J Blow, Zirong Li, Tao Zhang, Jennifer A Akiyama, Amy Holt, Ingrid Plajzer-Frick, Malak Shoukry, Crystal Wright, Feng Chen,[...]. Nature 2009
11
Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.
Michael N Weedon, Ines Cebola, Ann-Marie Patch, Sarah E Flanagan, Elisa De Franco, Richard Caswell, Santiago A Rodríguez-Seguí, Charles Shaw-Smith, Candy H-H Cho, Hana Lango Allen,[...]. Nat Genet 2014
Michael N Weedon, Ines Cebola, Ann-Marie Patch, Sarah E Flanagan, Elisa De Franco, Richard Caswell, Santiago A Rodríguez-Seguí, Charles Shaw-Smith, Candy H-H Cho, Hana Lango Allen,[...]. Nat Genet 2014
11
Disruption of autoregulatory feedback by a mutation in a remote, ultraconserved PAX6 enhancer causes aniridia.
Shipra Bhatia, Hemant Bengani, Margaret Fish, Alison Brown, Maria Teresa Divizia, Riccardo de Marco, Guiseppe Damante, Robert Grainger, Veronica van Heyningen, Dirk A Kleinjan. Am J Hum Genet 2013
Shipra Bhatia, Hemant Bengani, Margaret Fish, Alison Brown, Maria Teresa Divizia, Riccardo de Marco, Guiseppe Damante, Robert Grainger, Veronica van Heyningen, Dirk A Kleinjan. Am J Hum Genet 2013
11
Direct interaction of geminin and Six3 in eye development.
Filippo Del Bene, Kristin Tessmar-Raible, Joachim Wittbrodt. Nature 2004
Filippo Del Bene, Kristin Tessmar-Raible, Joachim Wittbrodt. Nature 2004
10
Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles.
Y Ohkubo, C Chiang, J L R Rubenstein. Neuroscience 2002
Y Ohkubo, C Chiang, J L R Rubenstein. Neuroscience 2002
10
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers.
Elaine E Storm, Sonia Garel, Ugo Borello, Jean M Hebert, Salvador Martinez, Susan K McConnell, Gail R Martin, John L R Rubenstein. Development 2006
Elaine E Storm, Sonia Garel, Ugo Borello, Jean M Hebert, Salvador Martinez, Susan K McConnell, Gail R Martin, John L R Rubenstein. Development 2006
10
Elimination of a long-range cis-regulatory module causes complete loss of limb-specific Shh expression and truncation of the mouse limb.
Tomoko Sagai, Masaki Hosoya, Youichi Mizushina, Masaru Tamura, Toshihiko Shiroishi. Development 2005
Tomoko Sagai, Masaki Hosoya, Youichi Mizushina, Masaru Tamura, Toshihiko Shiroishi. Development 2005
10
Highly conserved non-coding sequences are associated with vertebrate development.
Adam Woolfe, Martin Goodson, Debbie K Goode, Phil Snell, Gayle K McEwen, Tanya Vavouri, Sarah F Smith, Phil North, Heather Callaway, Krys Kelly,[...]. PLoS Biol 2005
Adam Woolfe, Martin Goodson, Debbie K Goode, Phil Snell, Gayle K McEwen, Tanya Vavouri, Sarah F Smith, Phil North, Heather Callaway, Krys Kelly,[...]. PLoS Biol 2005
10
Role of neuroepithelial Sonic hedgehog in hypothalamic patterning.
Nora-Emöke Szabó, Tianyu Zhao, Murat Cankaya, Thomas Theil, Xunlei Zhou, Gonzalo Alvarez-Bolado. J Neurosci 2009
Nora-Emöke Szabó, Tianyu Zhao, Murat Cankaya, Thomas Theil, Xunlei Zhou, Gonzalo Alvarez-Bolado. J Neurosci 2009
12
A genomic atlas of mouse hypothalamic development.
Tomomi Shimogori, Daniel A Lee, Ana Miranda-Angulo, Yanqin Yang, Hong Wang, Lizhi Jiang, Aya C Yoshida, Ayane Kataoka, Hiromi Mashiko, Marina Avetisyan,[...]. Nat Neurosci 2010
Tomomi Shimogori, Daniel A Lee, Ana Miranda-Angulo, Yanqin Yang, Hong Wang, Lizhi Jiang, Aya C Yoshida, Ayane Kataoka, Hiromi Mashiko, Marina Avetisyan,[...]. Nat Neurosci 2010
10
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip.
Fedik Rahimov, Mary L Marazita, Axel Visel, Margaret E Cooper, Michael J Hitchler, Michele Rubini, Frederick E Domann, Manika Govil, Kaare Christensen, Camille Bille,[...]. Nat Genet 2008
Fedik Rahimov, Mary L Marazita, Axel Visel, Margaret E Cooper, Michael J Hitchler, Michele Rubini, Frederick E Domann, Manika Govil, Kaare Christensen, Camille Bille,[...]. Nat Genet 2008
10
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.
Laura A Lettice, Taizo Horikoshi, Simon J H Heaney, Marijke J van Baren, Herma C van der Linde, Guido J Breedveld, Marijke Joosse, Nurten Akarsu, Ben A Oostra, Naoto Endo,[...]. Proc Natl Acad Sci U S A 2002
Laura A Lettice, Taizo Horikoshi, Simon J H Heaney, Marijke J van Baren, Herma C van der Linde, Guido J Breedveld, Marijke Joosse, Nurten Akarsu, Ben A Oostra, Naoto Endo,[...]. Proc Natl Acad Sci U S A 2002
10
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly.
E Belloni, M Muenke, E Roessler, G Traverso, J Siegel-Bartelt, A Frumkin, H F Mitchell, H Donis-Keller, C Helms, A V Hing,[...]. Nat Genet 1996
E Belloni, M Muenke, E Roessler, G Traverso, J Siegel-Bartelt, A Frumkin, H F Mitchell, H Donis-Keller, C Helms, A V Hing,[...]. Nat Genet 1996
10
Six3 dosage mediates the pathogenesis of holoprosencephaly.
Xin Geng, Sandra Acosta, Oleg Lagutin, Hyea Jin Gil, Guillermo Oliver. Development 2016
Xin Geng, Sandra Acosta, Oleg Lagutin, Hyea Jin Gil, Guillermo Oliver. Development 2016
47
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired.
S A Brown, D Warburton, L Y Brown, C Y Yu, E R Roeder, S Stengel-Rutkowski, R C Hennekam, M Muenke. Nat Genet 1998
S A Brown, D Warburton, L Y Brown, C Y Yu, E R Roeder, S Stengel-Rutkowski, R C Hennekam, M Muenke. Nat Genet 1998
9
A unique chromatin signature uncovers early developmental enhancers in humans.
Alvaro Rada-Iglesias, Ruchi Bajpai, Tomek Swigut, Samantha A Brugmann, Ryan A Flynn, Joanna Wysocka. Nature 2011
Alvaro Rada-Iglesias, Ruchi Bajpai, Tomek Swigut, Samantha A Brugmann, Ryan A Flynn, Joanna Wysocka. Nature 2011
9
Comprehensive mapping of long-range interactions reveals folding principles of the human genome.
Erez Lieberman-Aiden, Nynke L van Berkum, Louise Williams, Maxim Imakaev, Tobias Ragoczy, Agnes Telling, Ido Amit, Bryan R Lajoie, Peter J Sabo, Michael O Dorschner,[...]. Science 2009
Erez Lieberman-Aiden, Nynke L van Berkum, Louise Williams, Maxim Imakaev, Tobias Ragoczy, Agnes Telling, Ido Amit, Bryan R Lajoie, Peter J Sabo, Michael O Dorschner,[...]. Science 2009
9
VISTA Enhancer Browser--a database of tissue-specific human enhancers.
Axel Visel, Simon Minovitsky, Inna Dubchak, Len A Pennacchio. Nucleic Acids Res 2007
Axel Visel, Simon Minovitsky, Inna Dubchak, Len A Pennacchio. Nucleic Acids Res 2007
9
A map of the cis-regulatory sequences in the mouse genome.
Yin Shen, Feng Yue, David F McCleary, Zhen Ye, Lee Edsall, Samantha Kuan, Ulrich Wagner, Jesse Dixon, Leonard Lee, Victor V Lobanenkov,[...]. Nature 2012
Yin Shen, Feng Yue, David F McCleary, Zhen Ye, Lee Edsall, Samantha Kuan, Ulrich Wagner, Jesse Dixon, Leonard Lee, Victor V Lobanenkov,[...]. Nature 2012
9
Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node.
Yongsu Jeong, Douglas J Epstein. Development 2003
Yongsu Jeong, Douglas J Epstein. Development 2003
9
Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.
Mark-Oliver Trowe, Li Zhao, Anna-Carina Weiss, Vincent Christoffels, Douglas J Epstein, Andreas Kispert. Development 2013
Mark-Oliver Trowe, Li Zhao, Anna-Carina Weiss, Vincent Christoffels, Douglas J Epstein, Andreas Kispert. Development 2013
21
New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases.
Sandra Mercier, Christèle Dubourg, Nicolas Garcelon, Boris Campillo-Gimenez, Isabelle Gicquel, Marion Belleguic, Leslie Ratié, Laurent Pasquier, Philippe Loget, Claude Bendavid,[...]. J Med Genet 2011
Sandra Mercier, Christèle Dubourg, Nicolas Garcelon, Boris Campillo-Gimenez, Isabelle Gicquel, Marion Belleguic, Leslie Ratié, Laurent Pasquier, Philippe Loget, Claude Bendavid,[...]. J Med Genet 2011
11
A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping.
Suhas S P Rao, Miriam H Huntley, Neva C Durand, Elena K Stamenova, Ivan D Bochkov, James T Robinson, Adrian L Sanborn, Ido Machol, Arina D Omer, Eric S Lander,[...]. Cell 2014
Suhas S P Rao, Miriam H Huntley, Neva C Durand, Elena K Stamenova, Ivan D Bochkov, James T Robinson, Adrian L Sanborn, Ido Machol, Arina D Omer, Eric S Lander,[...]. Cell 2014
9
Holoprosencephaly.
Christèle Dubourg, Claude Bendavid, Laurent Pasquier, Catherine Henry, Sylvie Odent, Véronique David. Orphanet J Rare Dis 2007
Christèle Dubourg, Claude Bendavid, Laurent Pasquier, Catherine Henry, Sylvie Odent, Véronique David. Orphanet J Rare Dis 2007
8
Genetics of ventral forebrain development and holoprosencephaly.
M Muenke, P A Beachy. Curr Opin Genet Dev 2000
M Muenke, P A Beachy. Curr Opin Genet Dev 2000
8
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.