A citation-based method for searching scientific literature

Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
Times Cited: 2257







List of co-cited articles
685 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Notch signalling in context.
Sarah J Bray. Nat Rev Mol Cell Biol 2016
479
19

Notch signalling: a simple pathway becomes complex.
Sarah J Bray. Nat Rev Mol Cell Biol 2006
13

Notch Signaling in Development, Tissue Homeostasis, and Disease.
Chris Siebel, Urban Lendahl. Physiol Rev 2017
352
12

Notch signaling: cell fate control and signal integration in development.
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
12

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
11

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.
Rui Benedito, Cristina Roca, Inga Sörensen, Susanne Adams, Achim Gossler, Marcus Fruttiger, Ralf H Adams. Cell 2009
690
10

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.
Wendy R Gordon, Brandon Zimmerman, Li He, Laura J Miles, Jiuhong Huang, Kittichoat Tiyanont, Debbie G McArthur, Jon C Aster, Norbert Perrimon, Joseph J Loparo,[...]. Dev Cell 2015
165
8

Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Vincent C Luca, Kevin M Jude, Nathan W Pierce, Maxence V Nachury, Suzanne Fischer, K Christopher Garcia. Science 2015
151
8


Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
Vincent C Luca, Byoung Choul Kim, Chenghao Ge, Shinako Kakuda, Di Wu, Mehdi Roein-Peikar, Robert S Haltiwanger, Cheng Zhu, Taekjip Ha, K Christopher Garcia. Science 2017
141
7

The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.
Rhett A Kovall, Brian Gebelein, David Sprinzak, Raphael Kopan. Dev Cell 2017
168
7

The Notch1 receptor is cleaved constitutively by a furin-like convertase.
F Logeat, C Bessia, C Brou, O LeBail, S Jarriault, N G Seidah, A Israël. Proc Natl Acad Sci U S A 1998
544
7

Structural basis for autoinhibition of Notch.
Wendy R Gordon, Didem Vardar-Ulu, Gavin Histen, Cheryll Sanchez-Irizarry, Jon C Aster, Stephen C Blacklow. Nat Struct Mol Biol 2007
236
7

Therapeutic modulation of Notch signalling--are we there yet?
Emma R Andersson, Urban Lendahl. Nat Rev Drug Discov 2014
314
7

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, J S Mumm, E H Schroeter, V Schrijvers, M S Wolfe, W J Ray,[...]. Nature 1999
6

Fringe is a glycosyltransferase that modifies Notch.
D J Moloney, V M Panin, S H Johnston, J Chen, L Shao, R Wilson, Y Wang, P Stanley, K D Irvine, R S Haltiwanger,[...]. Nature 2000
662
6

Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways.
Shaolin Shi, Pamela Stanley. Proc Natl Acad Sci U S A 2003
288
6


Notch signaling at a glance.
Kazuya Hori, Anindya Sen, Spyros Artavanis-Tsakonas. J Cell Sci 2013
348
6

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.
J S Mumm, E H Schroeter, M T Saxena, A Griesemer, X Tian, D J Pan, W J Ray, R Kopan. Mol Cell 2000
654
6

Non-canonical Notch signaling: emerging role and mechanism.
Peter Andersen, Hideki Uosaki, Lincoln T Shenje, Chulan Kwon. Trends Cell Biol 2012
147
5

First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer.
C Massard, A Azaro, J-C Soria, U Lassen, C Le Tourneau, D Sarker, C Smith, U Ohnmacht, G Oakley, B K R Patel,[...]. Ann Oncol 2018
61
8

O-glucose trisaccharide is present at high but variable stoichiometry at multiple sites on mouse Notch1.
Nadia A Rana, Aleksandra Nita-Lazar, Hideyuki Takeuchi, Shinako Kakuda, Kelvin B Luther, Robert S Haltiwanger. J Biol Chem 2011
66
7

Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling.
Hideyuki Takeuchi, Michael Schneider, Daniel B Williamson, Atsuko Ito, Megumi Takeuchi, Penny A Handford, Robert S Haltiwanger. Proc Natl Acad Sci U S A 2018
38
13

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway.
Ryan McDaniell, Daniel M Warthen, Pedro A Sanchez-Lara, Athma Pai, Ian D Krantz, David A Piccoli, Nancy B Spinner. Am J Hum Genet 2006
431
5

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi.
Rodrigo Fernandez-Valdivia, Hideyuki Takeuchi, Amin Samarghandi, Mario Lopez, Jessica Leonardi, Robert S Haltiwanger, Hamed Jafar-Nejad. Development 2011
110
5

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1.
L Li, I D Krantz, Y Deng, A Genin, A B Banta, C C Collins, M Qi, B J Trask, W L Kuo, J Cochran,[...]. Nat Genet 1997
859
5

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.
Xose S Puente, Magda Pinyol, Víctor Quesada, Laura Conde, Gonzalo R Ordóñez, Neus Villamor, Georgia Escaramis, Pedro Jares, Sílvia Beà, Marcos González-Díaz,[...]. Nature 2011
5

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Andrew P Weng, John M Millholland, Yumi Yashiro-Ohtani, Marie Laure Arcangeli, Arthur Lau, Carol Wai, Cristina Del Bianco, Carlos G Rodriguez, Hong Sai, John Tobias,[...]. Genes Dev 2006
627
5


Notch activation of Jagged1 contributes to the assembly of the arterial wall.
Lauren J Manderfield, Frances A High, Kurt A Engleka, Feiyan Liu, Li Li, Stacey Rentschler, Jonathan A Epstein. Circulation 2012
101
5

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.
Frances A High, Min Min Lu, Warren S Pear, Kathleen M Loomes, Klaus H Kaestner, Jonathan A Epstein. Proc Natl Acad Sci U S A 2008
221
5

Dynamic Ligand Discrimination in the Notch Signaling Pathway.
Nagarajan Nandagopal, Leah A Santat, Lauren LeBon, David Sprinzak, Marianne E Bronner, Michael B Elowitz. Cell 2018
138
5

Mutations in the human Jagged1 gene are responsible for Alagille syndrome.
T Oda, A G Elkahloun, B L Pike, K Okajima, I D Krantz, A Genin, D A Piccoli, P S Meltzer, N B Spinner, F S Collins,[...]. Nat Genet 1997
761
5

Targeting Notch in oncology: the path forward.
Samarpan Majumder, Judy S Crabtree, Todd E Golde, Lisa M Minter, Barbara A Osborne, Lucio Miele. Nat Rev Drug Discov 2021
45
11

Notch3 is required for arterial identity and maturation of vascular smooth muscle cells.
Valérie Domenga, Peggy Fardoux, Pierre Lacombe, Marie Monet, Jacqueline Maciazek, Luke T Krebs, Bernard Klonjkowski, Eliane Berrou, Matthias Mericskay, Zhen Li,[...]. Genes Dev 2004
358
5

Therapeutic antibody targeting of individual Notch receptors.
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
516
5

Cis-activation in the Notch signaling pathway.
Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz. Elife 2019
31
16

The Varied Roles of Notch in Cancer.
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
280
5

Deficient T cell fate specification in mice with an induced inactivation of Notch1.
F Radtke, A Wilson, G Stark, M Bauer, J van Meerwijk, H R MacDonald, M Aguet. Immunity 1999
5

Notch3 signaling promotes the development of pulmonary arterial hypertension.
Xiaodong Li, Xiaoxue Zhang, Robin Leathers, Ayako Makino, Chengqun Huang, Pouria Parsa, Jesus Macias, Jason X-J Yuan, Stuart W Jamieson, Patricia A Thistlethwaite. Nat Med 2009
231
5

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.
Hannah Harrison, Gillian Farnie, Sacha J Howell, Rebecca E Rock, Spyros Stylianou, Keith R Brennan, Nigel J Bundred, Robert B Clarke. Cancer Res 2010
366
4

A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors.
David C Smith, Rashmi Chugh, Amita Patnaik, Kyriakos P Papadopoulos, Min Wang, Ann M Kapoun, Lu Xu, Jakob Dupont, Robert J Stagg, Anthony Tolcher. Invest New Drugs 2019
28
14

Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch.
Maya K Sethi, Falk F R Buettner, Angel Ashikov, Vadim B Krylov, Hideyuki Takeuchi, Nikolay E Nifantiev, Robert S Haltiwanger, Rita Gerardy-Schahn, Hans Bakker. J Biol Chem 2012
52
7

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands.
Paul Taylor, Hideyuki Takeuchi, Devon Sheppard, Chandramouli Chillakuri, Susan M Lea, Robert S Haltiwanger, Penny A Handford. Proc Natl Acad Sci U S A 2014
68
5

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Dieter Hartmann, Bart de Strooper, Lutgarde Serneels, Katleen Craessaerts, An Herreman, Wim Annaert, Lieve Umans, Torben Lübke, Anna Lena Illert, Kurt von Figura,[...]. Hum Mol Genet 2002
519
4

RBPJ mutations identified in two families affected by Adams-Oliver syndrome.
Susan J Hassed, Graham B Wiley, Shaofeng Wang, Ji-Yun Lee, Shibo Li, Weihong Xu, Zhizhuang J Zhao, John J Mulvihill, James Robertson, James Warner,[...]. Am J Hum Genet 2012
76
5

Multifaceted regulation of Notch signaling by glycosylation.
Ashutosh Pandey, Nima Niknejad, Hamed Jafar-Nejad. Glycobiology 2021
9
44

Multiple roles for O-glycans in Notch signalling.
Shweta Varshney, Pamela Stanley. FEBS Lett 2018
32
12

Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2.
Shinako Kakuda, Rachel K LoPilato, Atsuko Ito, Robert S Haltiwanger. J Biol Chem 2020
15
26


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.