A citation-based method for searching scientific literature

Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
Times Cited: 839







List of co-cited articles
1134 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Yasemin Sancak, Carson C Thoreen, Timothy R Peterson, Robert A Lindquist, Seong A Kang, Eric Spooner, Steven A Carr, David M Sabatini. Mol Cell 2007
882
30

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
681
28

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
27

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Kenta Hara, Yoshiko Maruki, Xiaomeng Long, Ken-ichi Yoshino, Noriko Oshiro, Sujuti Hidayat, Chiharu Tokunaga, Joseph Avruch, Kazuyoshi Yonezawa. Cell 2002
26

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
25

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
25

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
24

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Kim. Nat Cell Biol 2007
830
21


Identification of Protor as a novel Rictor-binding component of mTOR complex-2.
Laura R Pearce, Xu Huang, Jérôme Boudeau, Rafał Pawłowski, Stephan Wullschleger, Maria Deak, Adel F M Ibrahim, Robert Gourlay, Mark A Magnuson, Dario R Alessi. Biochem J 2007
316
19

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
19

DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.
Alexandre Caron, David M Briscoe, Denis Richard, Mathieu Laplante. Physiol Rev 2018
42
42

mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s.
Maria A Frias, Carson C Thoreen, Jacob D Jaffe, Wayne Schroder, Tom Sculley, Steven A Carr, David M Sabatini. Curr Biol 2006
496
18

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
18

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
18

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.
Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun-Liang Guan. Nat Cell Biol 2002
18

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
17


mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
504
15

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
Daming Gao, Hiroyuki Inuzuka, Meng-Kwang Marcus Tan, Hidefumi Fukushima, Jason W Locasale, Pengda Liu, Lixin Wan, Bo Zhai, Y Rebecca Chin, Shavali Shaik,[...]. Mol Cell 2011
184
14

mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.
Shanshan Duan, Jeffrey R Skaar, Shafi Kuchay, Alfredo Toschi, Naama Kanarek, Yinon Ben-Neriah, Michele Pagano. Mol Cell 2011
155
14

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.
David A Guertin, Deanna M Stevens, Carson C Thoreen, Aurora A Burds, Nada Y Kalaany, Jason Moffat, Michael Brown, Kevin J Fitzgerald, David M Sabatini. Dev Cell 2006
14

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.
Estela Jacinto, Valeria Facchinetti, Dou Liu, Nelyn Soto, Shiniu Wei, Sung Yun Jung, Qiaojia Huang, Jun Qin, Bing Su. Cell 2006
14

mTOR kinase structure, mechanism and regulation.
Haijuan Yang, Derek G Rudge, Joseph D Koos, Bhamini Vaidialingam, Hyo J Yang, Nikola P Pavletich. Nature 2013
555
14

TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Christian C Dibble, Winfried Elis, Suchithra Menon, Wei Qin, Justin Klekota, John M Asara, Peter M Finan, David J Kwiatkowski, Leon O Murphy, Brendan D Manning. Mol Cell 2012
379
13

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Pengda Liu, Wenjian Gan, Y Rebecca Chin, Kohei Ogura, Jianping Guo, Jinfang Zhang, Bin Wang, John Blenis, Lewis C Cantley, Alex Toker,[...]. Cancer Discov 2015
211
12

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Robbie Loewith, Estela Jacinto, Stephan Wullschleger, Anja Lorberg, José L Crespo, Débora Bonenfant, Wolfgang Oppliger, Paul Jenoe, Michael N Hall. Mol Cell 2002
12

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
12


AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
12

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
12

Deptor: not only a mTOR inhibitor.
Valeria Catena, Maurizio Fanciulli. J Exp Clin Cancer Res 2017
46
23

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.
Tsuneo Ikenoue, Ken Inoki, Qian Yang, Xiaoming Zhou, Kun-Liang Guan. EMBO J 2008
471
11

A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
E J Brown, M W Albers, T B Shin, K Ichikawa, C T Keith, W S Lane, S L Schreiber. Nature 1994
11

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J Yang, Meredith Miller, Angela Yang, Ankita Dhar, Nikola P Pavletich. Nature 2017
201
11

mTOR: from growth signal integration to cancer, diabetes and ageing.
Roberto Zoncu, Alejo Efeyan, David M Sabatini. Nat Rev Mol Cell Biol 2011
11

Regulation of TORC1 by Rag GTPases in nutrient response.
Eunjung Kim, Pankuri Goraksha-Hicks, Li Li, Thomas P Neufeld, Kun-Liang Guan. Nat Cell Biol 2008
883
11

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Carson C Thoreen, Seong A Kang, Jae Won Chang, Qingsong Liu, Jianming Zhang, Yi Gao, Laurie J Reichling, Taebo Sim, David M Sabatini, Nathanael S Gray. J Biol Chem 2009
10

TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
10

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Liron Bar-Peled, Lynne Chantranupong, Andrew D Cherniack, Walter W Chen, Kathleen A Ottina, Brian C Grabiner, Eric D Spear, Scott L Carter, Matthew Meyerson, David M Sabatini. Science 2013
593
10


Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Li Ma, Zhenbang Chen, Hediye Erdjument-Bromage, Paul Tempst, Pier Paolo Pandolfi. Cell 2005
952
10

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.
Louis-Andre Julien, Audrey Carriere, Julie Moreau, Philippe P Roux. Mol Cell Biol 2010
305
10


mTOR signaling at a glance.
Mathieu Laplante, David M Sabatini. J Cell Sci 2009
9


Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.
Yonghao Yu, Sang-Oh Yoon, George Poulogiannis, Qian Yang, Xiaoju Max Ma, Judit Villén, Neil Kubica, Gregory R Hoffman, Lewis C Cantley, Steven P Gygi,[...]. Science 2011
598
9

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R Allegrini, Sara C Kozma, Johan Auwerx,[...]. Nature 2004
9

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells.
C J Sabers, M M Martin, G J Brunn, J M Williams, F J Dumont, G Wiederrecht, R T Abraham. J Biol Chem 1995
647
9

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.
Liron Bar-Peled, Lawrence D Schweitzer, Roberto Zoncu, David M Sabatini. Cell 2012
586
9


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.