Marco Sardiello, Michela Palmieri, Alberto di Ronza, Diego Luis Medina, Marta Valenza, Vincenzo Alessandro Gennarino, Chiara Di Malta, Francesca Donaudy, Valerio Embrione, Roman S Polishchuk, Sandro Banfi, Giancarlo Parenti, Elena Cattaneo, Andrea Ballabio. Science 2009
Times Cited: 1504
Times Cited: 1504
Times Cited
Times Co-cited
Similarity
TFEB links autophagy to lysosomal biogenesis.
Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, Serpil Uckac Erdin, Tuong Huynh, Diego Medina, Pasqualina Colella,[...]. Science 2011
Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito, Moises Garcia Arencibia, Francesco Vetrini, Serkan Erdin, Serpil Uckac Erdin, Tuong Huynh, Diego Medina, Pasqualina Colella,[...]. Science 2011
55
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard,[...]. EMBO J 2012
Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard,[...]. EMBO J 2012
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Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.
Diego L Medina, Simone Di Paola, Ivana Peluso, Andrea Armani, Diego De Stefani, Rossella Venditti, Sandro Montefusco, Anna Scotto-Rosato, Carolina Prezioso, Alison Forrester,[...]. Nat Cell Biol 2015
Diego L Medina, Simone Di Paola, Ivana Peluso, Andrea Armani, Diego De Stefani, Rossella Venditti, Sandro Montefusco, Anna Scotto-Rosato, Carolina Prezioso, Alison Forrester,[...]. Nat Cell Biol 2015
22
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
Jose A Martina, Yong Chen, Marjan Gucek, Rosa Puertollano. Autophagy 2012
Jose A Martina, Yong Chen, Marjan Gucek, Rosa Puertollano. Autophagy 2012
22
The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.
Agnes Roczniak-Ferguson, Constance S Petit, Florian Froehlich, Sharon Qian, Jennifer Ky, Brittany Angarola, Tobias C Walther, Shawn M Ferguson. Sci Signal 2012
Agnes Roczniak-Ferguson, Constance S Petit, Florian Froehlich, Sharon Qian, Jennifer Ky, Brittany Angarola, Tobias C Walther, Shawn M Ferguson. Sci Signal 2012
19
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.
Carmine Settembre, Rossella De Cegli, Gelsomina Mansueto, Pradip K Saha, Francesco Vetrini, Orane Visvikis, Tuong Huynh, Annamaria Carissimo, Donna Palmer, Tiemo Jürgen Klisch,[...]. Nat Cell Biol 2013
Carmine Settembre, Rossella De Cegli, Gelsomina Mansueto, Pradip K Saha, Francesco Vetrini, Orane Visvikis, Tuong Huynh, Annamaria Carissimo, Donna Palmer, Tiemo Jürgen Klisch,[...]. Nat Cell Biol 2013
16
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.
Michela Palmieri, Soren Impey, Hyojin Kang, Alberto di Ronza, Carl Pelz, Marco Sardiello, Andrea Ballabio. Hum Mol Genet 2011
Michela Palmieri, Soren Impey, Hyojin Kang, Alberto di Ronza, Carl Pelz, Marco Sardiello, Andrea Ballabio. Hum Mol Genet 2011
15
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
12
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism.
Rushika M Perera, Svetlana Stoykova, Brandon N Nicolay, Kenneth N Ross, Julien Fitamant, Myriam Boukhali, Justine Lengrand, Vikram Deshpande, Martin K Selig, Cristina R Ferrone,[...]. Nature 2015
Rushika M Perera, Svetlana Stoykova, Brandon N Nicolay, Kenneth N Ross, Julien Fitamant, Myriam Boukhali, Justine Lengrand, Vikram Deshpande, Martin K Selig, Cristina R Ferrone,[...]. Nature 2015
12
mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.
Michela Palmieri, Rituraj Pal, Hemanth R Nelvagal, Parisa Lotfi, Gary R Stinnett, Michelle L Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V Bondar, Laura Bremner,[...]. Nat Commun 2017
Michela Palmieri, Rituraj Pal, Hemanth R Nelvagal, Parisa Lotfi, Gary R Stinnett, Michelle L Seymour, Arindam Chaudhury, Lakshya Bajaj, Vitaliy V Bondar, Laura Bremner,[...]. Nat Commun 2017
12
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
12
A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome.
Gennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E G de Araujo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk,[...]. Nature 2020
Gennaro Napolitano, Chiara Di Malta, Alessandra Esposito, Mariana E G de Araujo, Salvatore Pece, Giovanni Bertalot, Maria Matarese, Valerio Benedetti, Angela Zampelli, Taras Stasyk,[...]. Nature 2020
11
Transcriptional activation of lysosomal exocytosis promotes cellular clearance.
Diego L Medina, Alessandro Fraldi, Valentina Bouche, Fabio Annunziata, Gelsomina Mansueto, Carmine Spampanato, Claudia Puri, Antonella Pignata, Jose A Martina, Marco Sardiello,[...]. Dev Cell 2011
Diego L Medina, Alessandro Fraldi, Valentina Bouche, Fabio Annunziata, Gelsomina Mansueto, Carmine Spampanato, Claudia Puri, Antonella Pignata, Jose A Martina, Marco Sardiello,[...]. Dev Cell 2011
11
Lysosomes as dynamic regulators of cell and organismal homeostasis.
Andrea Ballabio, Juan S Bonifacino. Nat Rev Mol Cell Biol 2020
Andrea Ballabio, Juan S Bonifacino. Nat Rev Mol Cell Biol 2020
11
Signals from the lysosome: a control centre for cellular clearance and energy metabolism.
Carmine Settembre, Alessandro Fraldi, Diego L Medina, Andrea Ballabio. Nat Rev Mol Cell Biol 2013
Carmine Settembre, Alessandro Fraldi, Diego L Medina, Andrea Ballabio. Nat Rev Mol Cell Biol 2013
10
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.
Mickael Decressac, Bengt Mattsson, Pia Weikop, Martin Lundblad, Johan Jakobsson, Anders Björklund. Proc Natl Acad Sci U S A 2013
Mickael Decressac, Bengt Mattsson, Pia Weikop, Martin Lundblad, Johan Jakobsson, Anders Björklund. Proc Natl Acad Sci U S A 2013
10
The nutrient-responsive transcription factor TFE3 promotes autophagy, lysosomal biogenesis, and clearance of cellular debris.
José A Martina, Heba I Diab, Li Lishu, Lim Jeong-A, Simona Patange, Nina Raben, Rosa Puertollano. Sci Signal 2014
José A Martina, Heba I Diab, Li Lishu, Lim Jeong-A, Simona Patange, Nina Raben, Rosa Puertollano. Sci Signal 2014
9
Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.
Jose A Martina, Rosa Puertollano. J Cell Biol 2013
Jose A Martina, Rosa Puertollano. J Cell Biol 2013
9
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
Louis R Lapierre, C Daniel De Magalhaes Filho, Philip R McQuary, Chu-Chiao Chu, Orane Visvikis, Jessica T Chang, Sara Gelino, Binnan Ong, Andrew E Davis, Javier E Irazoqui,[...]. Nat Commun 2013
Louis R Lapierre, C Daniel De Magalhaes Filho, Philip R McQuary, Chu-Chiao Chu, Orane Visvikis, Jessica T Chang, Sara Gelino, Binnan Ong, Andrew E Davis, Javier E Irazoqui,[...]. Nat Commun 2013
9
TFEB and TFE3 are novel components of the integrated stress response.
José A Martina, Heba I Diab, Owen A Brady, Rosa Puertollano. EMBO J 2016
José A Martina, Heba I Diab, Owen A Brady, Rosa Puertollano. EMBO J 2016
9
The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective.
Heidi Martini-Stoica, Yin Xu, Andrea Ballabio, Hui Zheng. Trends Neurosci 2016
Heidi Martini-Stoica, Yin Xu, Andrea Ballabio, Hui Zheng. Trends Neurosci 2016
9
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.
Rosa Puertollano, Shawn M Ferguson, James Brugarolas, Andrea Ballabio. EMBO J 2018
Rosa Puertollano, Shawn M Ferguson, James Brugarolas, Andrea Ballabio. EMBO J 2018
8
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
8
Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis.
Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto Gonzales, Danielle L Tripoli, Leah Czerniewski, Andrea Ballabio,[...]. J Neurosci 2015
Qingli Xiao, Ping Yan, Xiucui Ma, Haiyan Liu, Ronaldo Perez, Alec Zhu, Ernesto Gonzales, Danielle L Tripoli, Leah Czerniewski, Andrea Ballabio,[...]. J Neurosci 2015
8
mTOR-dependent phosphorylation controls TFEB nuclear export.
Gennaro Napolitano, Alessandra Esposito, Heejun Choi, Maria Matarese, Valerio Benedetti, Chiara Di Malta, Jlenia Monfregola, Diego Luis Medina, Jennifer Lippincott-Schwartz, Andrea Ballabio. Nat Commun 2018
Gennaro Napolitano, Alessandra Esposito, Heejun Choi, Maria Matarese, Valerio Benedetti, Chiara Di Malta, Jlenia Monfregola, Diego Luis Medina, Jennifer Lippincott-Schwartz, Andrea Ballabio. Nat Commun 2018
8
Autophagy regulates lipid metabolism.
Rajat Singh, Susmita Kaushik, Yongjun Wang, Youqing Xiang, Inna Novak, Masaaki Komatsu, Keiji Tanaka, Ana Maria Cuervo, Mark J Czaja. Nature 2009
Rajat Singh, Susmita Kaushik, Yongjun Wang, Youqing Xiang, Inna Novak, Masaaki Komatsu, Keiji Tanaka, Ana Maria Cuervo, Mark J Czaja. Nature 2009
8
7
Termination of autophagy and reformation of lysosomes regulated by mTOR.
Li Yu, Christina K McPhee, Lixin Zheng, Gonzalo A Mardones, Yueguang Rong, Junya Peng, Na Mi, Ying Zhao, Zhihua Liu, Fengyi Wan,[...]. Nature 2010
Li Yu, Christina K McPhee, Lixin Zheng, Gonzalo A Mardones, Yueguang Rong, Junya Peng, Na Mi, Ying Zhao, Zhihua Liu, Fengyi Wan,[...]. Nature 2010
7
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase.
Roberto Zoncu, Liron Bar-Peled, Alejo Efeyan, Shuyu Wang, Yasemin Sancak, David M Sabatini. Science 2011
Roberto Zoncu, Liron Bar-Peled, Alejo Efeyan, Shuyu Wang, Yasemin Sancak, David M Sabatini. Science 2011
7
The lysosome as a cellular centre for signalling, metabolism and quality control.
Rosalie E Lawrence, Roberto Zoncu. Nat Cell Biol 2019
Rosalie E Lawrence, Roberto Zoncu. Nat Cell Biol 2019
7
PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.
Taiji Tsunemi, Travis D Ashe, Bradley E Morrison, Kathryn R Soriano, Jonathan Au, Ruben A Vázquez Roque, Eduardo R Lazarowski, Vincent A Damian, Eliezer Masliah, Albert R La Spada. Sci Transl Med 2012
Taiji Tsunemi, Travis D Ashe, Bradley E Morrison, Kathryn R Soriano, Jonathan Au, Ruben A Vázquez Roque, Eduardo R Lazarowski, Vincent A Damian, Eliezer Masliah, Albert R La Spada. Sci Transl Med 2012
7
Compromised autophagy and neurodegenerative diseases.
Fiona M Menzies, Angeleen Fleming, David C Rubinsztein. Nat Rev Neurosci 2015
Fiona M Menzies, Angeleen Fleming, David C Rubinsztein. Nat Rev Neurosci 2015
7
Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB.
Vinicia A Polito, Hongmei Li, Heidi Martini-Stoica, Baiping Wang, Li Yang, Yin Xu, Daniel B Swartzlander, Michela Palmieri, Alberto di Ronza, Virginia M-Y Lee,[...]. EMBO Mol Med 2014
Vinicia A Polito, Hongmei Li, Heidi Martini-Stoica, Baiping Wang, Li Yang, Yin Xu, Daniel B Swartzlander, Michela Palmieri, Alberto di Ronza, Virginia M-Y Lee,[...]. EMBO Mol Med 2014
7
Protein kinase C controls lysosome biogenesis independently of mTORC1.
Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, Xin Wang, Youli Jian, Guihua Tang,[...]. Nat Cell Biol 2016
Yang Li, Meng Xu, Xiao Ding, Chen Yan, Zhiqin Song, Lianwan Chen, Xiahe Huang, Xin Wang, Youli Jian, Guihua Tang,[...]. Nat Cell Biol 2016
7
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.
Daniel F Egan, David B Shackelford, Maria M Mihaylova, Sara Gelino, Rebecca A Kohnz, William Mair, Debbie S Vasquez, Aashish Joshi, Dana M Gwinn, Rebecca Taylor,[...]. Science 2011
Daniel F Egan, David B Shackelford, Maria M Mihaylova, Sara Gelino, Rebecca A Kohnz, William Mair, Debbie S Vasquez, Aashish Joshi, Dana M Gwinn, Rebecca Taylor,[...]. Science 2011
6
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice.
Xiaojuan Chao, Shaogui Wang, Katrina Zhao, Yuan Li, Jessica A Williams, Tiangang Li, Hemantkumar Chavan, Partha Krishnamurthy, Xi C He, Linheng Li,[...]. Gastroenterology 2018
Xiaojuan Chao, Shaogui Wang, Katrina Zhao, Yuan Li, Jessica A Williams, Tiangang Li, Hemantkumar Chavan, Partha Krishnamurthy, Xi C He, Linheng Li,[...]. Gastroenterology 2018
6
CDK4/6 regulate lysosome biogenesis through TFEB/TFE3.
Qiuyuan Yin, Youli Jian, Meng Xu, Xiahe Huang, Niya Wang, Zhifang Liu, Qian Li, Jinglin Li, Hejiang Zhou, Lin Xu,[...]. J Cell Biol 2020
Qiuyuan Yin, Youli Jian, Meng Xu, Xiahe Huang, Niya Wang, Zhifang Liu, Qian Li, Jinglin Li, Hejiang Zhou, Lin Xu,[...]. J Cell Biol 2020
14
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
Nao Hosokawa, Taichi Hara, Takeshi Kaizuka, Chieko Kishi, Akito Takamura, Yutaka Miura, Shun-ichiro Iemura, Tohru Natsume, Kenji Takehana, Naoyuki Yamada,[...]. Mol Biol Cell 2009
Nao Hosokawa, Taichi Hara, Takeshi Kaizuka, Chieko Kishi, Akito Takamura, Yutaka Miura, Shun-ichiro Iemura, Tohru Natsume, Kenji Takehana, Naoyuki Yamada,[...]. Mol Biol Cell 2009
6
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Paola Rusmini, Katia Cortese, Valeria Crippa, Riccardo Cristofani, Maria Elena Cicardi, Veronica Ferrari, Giulia Vezzoli, Barbara Tedesco, Marco Meroni, Elio Messi,[...]. Autophagy 2019
Paola Rusmini, Katia Cortese, Valeria Crippa, Riccardo Cristofani, Maria Elena Cicardi, Veronica Ferrari, Giulia Vezzoli, Barbara Tedesco, Marco Meroni, Elio Messi,[...]. Autophagy 2019
6
mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
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Lysosomes as a therapeutic target.
Srinivasa Reddy Bonam, Fengjuan Wang, Sylviane Muller. Nat Rev Drug Discov 2019
Srinivasa Reddy Bonam, Fengjuan Wang, Sylviane Muller. Nat Rev Drug Discov 2019
6
5
Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers.
Eric C Kauffman, Christopher J Ricketts, Soroush Rais-Bahrami, Youfeng Yang, Maria J Merino, Donald P Bottaro, Ramaprasad Srinivasan, W Marston Linehan. Nat Rev Urol 2014
Eric C Kauffman, Christopher J Ricketts, Soroush Rais-Bahrami, Youfeng Yang, Maria J Merino, Donald P Bottaro, Ramaprasad Srinivasan, W Marston Linehan. Nat Rev Urol 2014
5
Autophagy fights disease through cellular self-digestion.
Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky. Nature 2008
Noboru Mizushima, Beth Levine, Ana Maria Cuervo, Daniel J Klionsky. Nature 2008
5
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth.
Chiara Di Malta, Diletta Siciliano, Alessia Calcagni, Jlenia Monfregola, Simona Punzi, Nunzia Pastore, Andrea N Eastes, Oliver Davis, Rossella De Cegli, Angela Zampelli,[...]. Science 2017
Chiara Di Malta, Diletta Siciliano, Alessia Calcagni, Jlenia Monfregola, Simona Punzi, Nunzia Pastore, Andrea N Eastes, Oliver Davis, Rossella De Cegli, Angela Zampelli,[...]. Science 2017
5
Increased expression of transcription factor EB (TFEB) is associated with autophagy, migratory phenotype and poor prognosis in non-small cell lung cancer.
Alexandra Giatromanolaki, Dimitra Kalamida, Efthimios Sivridis, Ilias V Karagounis, Kevin C Gatter, Adrian L Harris, Michael I Koukourakis. Lung Cancer 2015
Alexandra Giatromanolaki, Dimitra Kalamida, Efthimios Sivridis, Ilias V Karagounis, Kevin C Gatter, Adrian L Harris, Michael I Koukourakis. Lung Cancer 2015
7
Transcription Factor EB Controls Metabolic Flexibility during Exercise.
Gelsomina Mansueto, Andrea Armani, Carlo Viscomi, Luca D'Orsi, Rossella De Cegli, Elena V Polishchuk, Costanza Lamperti, Ivano Di Meo, Vanina Romanello, Silvia Marchet,[...]. Cell Metab 2017
Gelsomina Mansueto, Andrea Armani, Carlo Viscomi, Luca D'Orsi, Rossella De Cegli, Elena V Polishchuk, Costanza Lamperti, Ivano Di Meo, Vanina Romanello, Silvia Marchet,[...]. Cell Metab 2017
5
The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
5
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.