A citation-based method for searching scientific literature

J W Tobias, T E Shrader, G Rocap, A Varshavsky. Science 1991
Times Cited: 422







List of co-cited articles
896 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



The N-end rule pathway and regulation by proteolysis.
Alexander Varshavsky. Protein Sci 2011
456
41

ClpS is an essential component of the N-end rule pathway in Escherichia coli.
A Erbse, R Schmidt, T Bornemann, J Schneider-Mergener, A Mogk, R Zahn, D A Dougan, B Bukau. Nature 2006
171
28

The N-end rule pathway.
Takafumi Tasaki, Shashikanth M Sriram, Kyong Soo Park, Yong Tae Kwon. Annu Rev Biochem 2012
254
25

N-degron and C-degron pathways of protein degradation.
Alexander Varshavsky. Proc Natl Acad Sci U S A 2019
221
22

The N-end rule pathway: from recognition by N-recognins, to destruction by AAA+proteases.
D A Dougan, D Micevski, K N Truscott. Biochim Biophys Acta 2012
85
24

Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS.
Verena J Schuenemann, Stephanie M Kralik, Reinhard Albrecht, Sukhdeep K Spall, Kaye N Truscott, David A Dougan, Kornelius Zeth. EMBO Rep 2009
68
30

N-terminal acetylation of cellular proteins creates specific degradation signals.
Cheol-Sang Hwang, Anna Shemorry, Alexander Varshavsky. Science 2010
442
21

Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
Anna Shemorry, Cheol-Sang Hwang, Alexander Varshavsky. Mol Cell 2013
200
19

The molecular basis of N-end rule recognition.
Kevin H Wang, Giselle Roman-Hernandez, Robert A Grant, Robert T Sauer, Tania A Baker. Mol Cell 2008
73
24

Universality and structure of the N-end rule.
D K Gonda, A Bachmair, I Wünning, J W Tobias, W S Lane, A Varshavsky. J Biol Chem 1989
360
18

The N-degradome of Escherichia coli: limited proteolysis in vivo generates a large pool of proteins bearing N-degrons.
Matthew A Humbard, Serhiy Surkov, Gian Marco De Donatis, Lisa M Jenkins, Michael R Maurizi. J Biol Chem 2013
35
48

ClpS is the recognition component for Escherichia coli substrates of the N-end rule degradation pathway.
Ronny Schmidt, Regina Zahn, Bernd Bukau, Axel Mogk. Mol Microbiol 2009
64
26

An essential role of N-terminal arginylation in cardiovascular development.
Yong Tae Kwon, Anna S Kashina, Ilia V Davydov, Rong-Gui Hu, Jee Young An, Jai Wha Seo, Fangyong Du, Alexander Varshavsky. Science 2002
248
17

ClpS, a substrate modulator of the ClpAP machine.
David A Dougan, Brian G Reid, Arthur L Horwich, Bernd Bukau. Mol Cell 2002
224
17

The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments.
Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Proc Natl Acad Sci U S A 2012
102
17

The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease.
Giselle Román-Hernández, Jennifer Y Hou, Robert A Grant, Robert T Sauer, Tania A Baker. Mol Cell 2011
46
34

The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators.
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T Takahashi, Alexander Varshavsky. Nature 2005
226
16


The degradation signal in a short-lived protein.
A Bachmair, A Varshavsky. Cell 1989
358
16

Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates.
Izarys Rivera-Rivera, Giselle Román-Hernández, Robert T Sauer, Tania A Baker. Proc Natl Acad Sci U S A 2014
33
48

The eukaryotic N-end rule pathway: conserved mechanisms and diverse functions.
Daniel J Gibbs, Jaume Bacardit, Andreas Bachmair, Michael J Holdsworth. Trends Cell Biol 2014
134
15

Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen.
Emmanuelle Graciet, Rong-Gui Hu, Konstantin Piatkov, Joon Haeng Rhee, Erich M Schwarz, Alexander Varshavsky. Proc Natl Acad Sci U S A 2006
72
20

Modification of PATase by L/F-transferase generates a ClpS-dependent N-end rule substrate in Escherichia coli.
Robert L Ninnis, Sukhdeep K Spall, Gert H Talbo, Kaye N Truscott, David A Dougan. EMBO J 2009
74
20

Glutamine-specific N-terminal amidase, a component of the N-end rule pathway.
Haiqing Wang, Konstantin I Piatkov, Christopher S Brower, Alexander Varshavsky. Mol Cell 2009
68
20

The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Konstantin I Piatkov, Luca Colnaghi, Miklos Békés, Alexander Varshavsky, Tony T Huang. Mol Cell 2012
51
27

The N-terminal methionine of cellular proteins as a degradation signal.
Heon-Ki Kim, Ryu-Ryun Kim, Jang-Hyun Oh, Hanna Cho, Alexander Varshavsky, Cheol-Sang Hwang. Cell 2014
121
14

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.
Shun-Jia Chen, Xia Wu, Brandon Wadas, Jang-Hyun Oh, Alexander Varshavsky. Science 2017
112
14

RGS4 and RGS5 are in vivo substrates of the N-end rule pathway.
Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V Davydov, Yong Tae Kwon. Proc Natl Acad Sci U S A 2005
186
13

Control of mammalian G protein signaling by N-terminal acetylation and the N-end rule pathway.
Sang-Eun Park, Jeong-Mok Kim, Ok-Hee Seok, Hanna Cho, Brandon Wadas, Seon-Young Kim, Alexander Varshavsky, Cheol-Sang Hwang. Science 2015
95
13

Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Christopher S Brower, Konstantin I Piatkov, Alexander Varshavsky. Mol Cell 2013
79
16

AAA+ proteases: ATP-fueled machines of protein destruction.
Robert T Sauer, Tania A Baker. Annu Rev Biochem 2011
495
12


The bacterial N-end rule pathway: expect the unexpected.
D A Dougan, K N Truscott, K Zeth. Mol Microbiol 2010
74
16

The N-end rule pathway for regulated proteolysis: prokaryotic and eukaryotic strategies.
Axel Mogk, Ronny Schmidt, Bernd Bukau. Trends Cell Biol 2007
193
12

Structural basis of substrate recognition and specificity in the N-end rule pathway.
Edna Matta-Camacho, Guennadi Kozlov, Flora F Li, Kalle Gehring. Nat Struct Mol Biol 2010
75
16

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.
Woo Suk Choi, Byung-Cheon Jeong, Yoo Jin Joo, Myeong-Ryeol Lee, Joon Kim, Michael J Eck, Hyun Kyu Song. Nat Struct Mol Biol 2010
101
12

Molecular basis of substrate selection by the N-end rule adaptor protein ClpS.
Giselle Román-Hernández, Robert A Grant, Robert T Sauer, Tania A Baker. Proc Natl Acad Sci U S A 2009
48
25

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.
Hyunjoo Cha-Molstad, Ki Sa Sung, Joonsung Hwang, Kyoung A Kim, Ji Eun Yu, Young Dong Yoo, Jun Min Jang, Dong Hoon Han, Michael Molstad, Jung Gi Kim,[...]. Nat Cell Biol 2015
143
12

Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.
Konstantin I Piatkov, Jang-Hyun Oh, Yuan Liu, Alexander Varshavsky. Proc Natl Acad Sci U S A 2014
61
19

ClpS1 is a conserved substrate selector for the chloroplast Clp protease system in Arabidopsis.
Kenji Nishimura, Yukari Asakura, Giulia Friso, Jitae Kim, Soo-Hyun Oh, Heidi Rutschow, Lalit Ponnala, Klaas J van Wijk. Plant Cell 2013
81
13

Structural analysis of the adaptor protein ClpS in complex with the N-terminal domain of ClpA.
Kornelius Zeth, Raimond B Ravelli, Klaus Paal, Stephen Cusack, Bernd Bukau, David A Dougan. Nat Struct Biol 2002
107
11

Formyl-methionine as a degradation signal at the N-termini of bacterial proteins.
Konstantin I Piatkov, Tri T M Vu, Cheol-Sang Hwang, Alexander Varshavsky. Microb Cell 2015
42
26

ClpS modulates but is not essential for bacterial N-end rule degradation.
Kevin H Wang, Robert T Sauer, Tania A Baker. Genes Dev 2007
60
16

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.
Mark Ditzel, Rebecca Wilson, Tencho Tenev, Anna Zachariou, Angela Paul, Emma Deas, Pascal Meier. Nat Cell Biol 2003
200
10

Tuning the strength of a bacterial N-end rule degradation signal.
Kevin H Wang, Elizabeth S C Oakes, Robert T Sauer, Tania A Baker. J Biol Chem 2008
47
21

The N-end rule: functions, mysteries, uses.
A Varshavsky. Proc Natl Acad Sci U S A 1996
663
10

Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).
Martin Zenker, Julia Mayerle, Markus M Lerch, Andreas Tagariello, Klaus Zerres, Peter R Durie, Matthias Beier, Georg Hülskamp, Celina Guzman, Helga Rehder,[...]. Nat Genet 2005
175
9

Protein N-terminal acetyltransferases: when the start matters.
Kristian K Starheim, Kris Gevaert, Thomas Arnesen. Trends Biochem Sci 2012
197
9

The N-end rule pathway is mediated by a complex of the RING-type Ubr1 and HECT-type Ufd4 ubiquitin ligases.
Cheol-Sang Hwang, Anna Shemorry, Daniel Auerbach, Alexander Varshavsky. Nat Cell Biol 2010
102
9


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.