Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani, Angela Woods, Iain C A Robinson, Eugene Schuster, Rachel L Batterham, Sara C Kozma, George Thomas, David Carling, Klaus Okkenhaug, Janet M Thornton, Linda Partridge, David Gems, Dominic J Withers. Science 2009
Times Cited: 781
Times Cited: 781
Times Cited
Times Co-cited
Similarity
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
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The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Pankaj Kapahi, Brian M Zid, Tony Harper, Daniel Koslover, Viveca Sapin, Seymour Benzer. Curr Biol 2004
Pankaj Kapahi, Brian M Zid, Tony Harper, Daniel Koslover, Viveca Sapin, Seymour Benzer. Curr Biol 2004
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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
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Genetics: influence of TOR kinase on lifespan in C. elegans.
Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L Kovacs, László Orosz, Fritz Müller. Nature 2003
Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L Kovacs, László Orosz, Fritz Müller. Nature 2003
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Extending healthy life span--from yeast to humans.
Luigi Fontana, Linda Partridge, Valter D Longo. Science 2010
Luigi Fontana, Linda Partridge, Valter D Longo. Science 2010
22
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
20
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.
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Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster.
Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Martin Holzenberger, Joëlle Dupont, Bertrand Ducos, Patricia Leneuve, Alain Géloën, Patrick C Even, Pascale Cervera, Yves Le Bouc. Nature 2003
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Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith,[...]. Elife 2016
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Promoting health and longevity through diet: from model organisms to humans.
Luigi Fontana, Linda Partridge. Cell 2015
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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
Malene Hansen, Stefan Taubert, Douglas Crawford, Nataliya Libina, Seung-Jae Lee, Cynthia Kenyon. Aging Cell 2007
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The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.
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Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.
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TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Stacey Robida-Stubbs, Kira Glover-Cutter, Dudley W Lamming, Masaki Mizunuma, Sri Devi Narasimhan, Elke Neumann-Haefelin, David M Sabatini, T Keith Blackwell. Cell Metab 2012
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mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
14
13
Caloric restriction delays disease onset and mortality in rhesus monkeys.
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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
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12
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
Morgan E Levine, Jorge A Suarez, Sebastian Brandhorst, Priya Balasubramanian, Chia-Wei Cheng, Federica Madia, Luigi Fontana, Mario G Mirisola, Jaime Guevara-Aguirre, Junxiang Wan,[...]. Cell Metab 2014
Morgan E Levine, Jorge A Suarez, Sebastian Brandhorst, Priya Balasubramanian, Chia-Wei Cheng, Federica Madia, Luigi Fontana, Mario G Mirisola, Jaime Guevara-Aguirre, Junxiang Wan,[...]. Cell Metab 2014
12
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.
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Dos D Sarbassov, Siraj M Ali, Shomit Sengupta, Joon-Ho Sheen, Peggy P Hsu, Alex F Bagley, Andrew L Markhard, David M Sabatini. Mol Cell 2006
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Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila.
Richard C Grandison, Matthew D W Piper, Linda Partridge. Nature 2009
Richard C Grandison, Matthew D W Piper, Linda Partridge. Nature 2009
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Remi-Martin Laberge, Yu Sun, Arturo V Orjalo, Christopher K Patil, Adam Freund, Lili Zhou, Samuel C Curran, Albert R Davalos, Kathleen A Wilson-Edell, Su Liu,[...]. Nat Cell Biol 2015
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11
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Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
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11
TORC1 inhibition enhances immune function and reduces infections in the elderly.
Joan B Mannick, Melody Morris, Hans-Ulrich P Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn,[...]. Sci Transl Med 2018
Joan B Mannick, Melody Morris, Hans-Ulrich P Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn,[...]. Sci Transl Med 2018
10
Sestrin2 is a leucine sensor for the mTORC1 pathway.
Rachel L Wolfson, Lynne Chantranupong, Robert A Saxton, Kuang Shen, Sonia M Scaria, Jason R Cantor, David M Sabatini. Science 2016
Rachel L Wolfson, Lynne Chantranupong, Robert A Saxton, Kuang Shen, Sonia M Scaria, Jason R Cantor, David M Sabatini. Science 2016
10
Extension of chronological life span in yeast by decreased TOR pathway signaling.
R Wilson Powers, Matt Kaeberlein, Seth D Caldwell, Brian K Kennedy, Stanley Fields. Genes Dev 2006
R Wilson Powers, Matt Kaeberlein, Seth D Caldwell, Brian K Kennedy, Stanley Fields. Genes Dev 2006
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The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
Brian K Kennedy, Dudley W Lamming. Cell Metab 2016
Brian K Kennedy, Dudley W Lamming. Cell Metab 2016
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A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon. PLoS Genet 2008
Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon. PLoS Genet 2008
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Regulation of longevity and stress resistance by Sch9 in yeast.
P Fabrizio, F Pozza, S D Pletcher, C M Gendron, V D Longo. Science 2001
P Fabrizio, F Pozza, S D Pletcher, C M Gendron, V D Longo. Science 2001
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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.
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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.
Sarah J Mitchell, Julio Madrigal-Matute, Morten Scheibye-Knudsen, Evandro Fang, Miguel Aon, José A González-Reyes, Sonia Cortassa, Susmita Kaushik, Marta Gonzalez-Freire, Bindi Patel,[...]. Cell Metab 2016
Sarah J Mitchell, Julio Madrigal-Matute, Morten Scheibye-Knudsen, Evandro Fang, Miguel Aon, José A González-Reyes, Sonia Cortassa, Susmita Kaushik, Marta Gonzalez-Freire, Bindi Patel,[...]. Cell Metab 2016
10
4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.
Brian M Zid, Aric N Rogers, Subhash D Katewa, Misha A Vargas, Marysia C Kolipinski, Tony Au Lu, Seymour Benzer, Pankaj Kapahi. Cell 2009
Brian M Zid, Aric N Rogers, Subhash D Katewa, Misha A Vargas, Marysia C Kolipinski, Tony Au Lu, Seymour Benzer, Pankaj Kapahi. Cell 2009
10
Caloric restriction improves health and survival of rhesus monkeys.
Julie A Mattison, Ricki J Colman, T Mark Beasley, David B Allison, Joseph W Kemnitz, George S Roth, Donald K Ingram, Richard Weindruch, Rafael de Cabo, Rozalyn M Anderson. Nat Commun 2017
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The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
Kailiang Jia, Di Chen, Donald L Riddle. Development 2004
Kailiang Jia, Di Chen, Donald L Riddle. Development 2004
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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
Yasemin Sancak, Timothy R Peterson, Yoav D Shaul, Robert A Lindquist, Carson C Thoreen, Liron Bar-Peled, David M Sabatini. Science 2008
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mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.
Chong Chen, Yu Liu, Yang Liu, Pan Zheng. Sci Signal 2009
Chong Chen, Yu Liu, Yang Liu, Pan Zheng. Sci Signal 2009
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Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.
Vladimir N Anisimov, Mark A Zabezhinski, Irina G Popovich, Tatiana S Piskunova, Anna V Semenchenko, Margarita L Tyndyk, Maria N Yurova, Svetlana V Rosenfeld, Mikhail V Blagosklonny. Cell Cycle 2011
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Rapamycin slows aging in mice.
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The sirtuin SIRT6 regulates lifespan in male mice.
Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph, Haim Y Cohen. Nature 2012
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Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
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With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging.
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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.
Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe, Frédéric Picard, Manel Joaquin, Melanie Sticker, Stefano Fumagalli, Peter R Allegrini, Sara C Kozma, Johan Auwerx,[...]. Nature 2004
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Overexpression of Atg5 in mice activates autophagy and extends lifespan.
Jong-Ok Pyo, Seung-Min Yoo, Hye-Hyun Ahn, Jihoon Nah, Se-Hoon Hong, Tae-In Kam, Sunmin Jung, Yong-Keun Jung. Nat Commun 2013
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Extended longevity in mice lacking the insulin receptor in adipose tissue.
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A C. elegans mutant that lives twice as long as wild type.
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The senescence-associated secretory phenotype: the dark side of tumor suppression.
Jean-Philippe Coppé, Pierre-Yves Desprez, Ana Krtolica, Judith Campisi. Annu Rev Pathol 2010
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9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.