Shu-Feng Zhou. Clin Pharmacokinet 2009
Times Cited: 454
Times Cited: 454
Times Cited
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Similarity
Prediction of CYP2D6 phenotype from genotype across world populations.
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Andrea Gaedigk, Katrin Sangkuhl, Michelle Whirl-Carrillo, Teri Klein, J Steven Leeder. Genet Med 2017
21
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Shu-Feng Zhou. Clin Pharmacokinet 2009
Shu-Feng Zhou. Clin Pharmacokinet 2009
19
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.
Ulrich M Zanger, Matthias Schwab. Pharmacol Ther 2013
Ulrich M Zanger, Matthias Schwab. Pharmacol Ther 2013
17
The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.
Andrea Gaedigk, Magnus Ingelman-Sundberg, Neil A Miller, J Steven Leeder, Michelle Whirl-Carrillo, Teri E Klein. Clin Pharmacol Ther 2018
Andrea Gaedigk, Magnus Ingelman-Sundberg, Neil A Miller, J Steven Leeder, Michelle Whirl-Carrillo, Teri E Klein. Clin Pharmacol Ther 2018
16
The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
A Gaedigk, S D Simon, R E Pearce, L D Bradford, M J Kennedy, J S Leeder. Clin Pharmacol Ther 2008
A Gaedigk, S D Simon, R E Pearce, L D Bradford, M J Kennedy, J S Leeder. Clin Pharmacol Ther 2008
15
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity.
M Ingelman-Sundberg. Pharmacogenomics J 2005
M Ingelman-Sundberg. Pharmacogenomics J 2005
14
Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
K R Crews, A Gaedigk, H M Dunnenberger, J S Leeder, T E Klein, K E Caudle, C E Haidar, D D Shen, J T Callaghan, S Sadhasivam,[...]. Clin Pharmacol Ther 2014
K R Crews, A Gaedigk, H M Dunnenberger, J S Leeder, T E Klein, K E Caudle, C E Haidar, D D Shen, J T Callaghan, S Sadhasivam,[...]. Clin Pharmacol Ther 2014
13
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Kelly E Caudle, Katrin Sangkuhl, Michelle Whirl-Carrillo, Jesse J Swen, Cyrine E Haidar, Teri E Klein, Roseann S Gammal, Mary V Relling, Stuart A Scott, Daniel L Hertz,[...]. Clin Transl Sci 2020
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13
PharmVar GeneFocus: CYP2D6.
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16
Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects.
Magnus Ingelman-Sundberg, Sarah C Sim, Alvin Gomez, Cristina Rodriguez-Antona. Pharmacol Ther 2007
Magnus Ingelman-Sundberg, Sarah C Sim, Alvin Gomez, Cristina Rodriguez-Antona. Pharmacol Ther 2007
11
Genetic polymorphism in cytochrome P450 2D6 (CYP2D6): Population distribution of CYP2D6 activity.
Patricia Neafsey, Gary Ginsberg, Dale Hattis, Babasaheb Sonawane. J Toxicol Environ Health B Crit Rev 2009
Patricia Neafsey, Gary Ginsberg, Dale Hattis, Babasaheb Sonawane. J Toxicol Environ Health B Crit Rev 2009
14
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
J K Hicks, J R Bishop, K Sangkuhl, D J Müller, Y Ji, S G Leckband, J S Leeder, R L Graham, D L Chiulli, A LLerena,[...]. Clin Pharmacol Ther 2015
J K Hicks, J R Bishop, K Sangkuhl, D J Müller, Y Ji, S G Leckband, J S Leeder, R L Graham, D L Chiulli, A LLerena,[...]. Clin Pharmacol Ther 2015
10
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants.
L DiAnne Bradford. Pharmacogenomics 2002
L DiAnne Bradford. Pharmacogenomics 2002
10
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.
Ulrich M Zanger, Sebastian Raimundo, Michel Eichelbaum. Naunyn Schmiedebergs Arch Pharmacol 2004
Ulrich M Zanger, Sebastian Raimundo, Michel Eichelbaum. Naunyn Schmiedebergs Arch Pharmacol 2004
9
9
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response.
J Kirchheiner, K Nickchen, M Bauer, M-L Wong, J Licinio, I Roots, J Brockmöller. Mol Psychiatry 2004
J Kirchheiner, K Nickchen, M Bauer, M-L Wong, J Licinio, I Roots, J Brockmöller. Mol Psychiatry 2004
9
Molecular genetics of CYP2D6: clinical relevance with focus on psychotropic drugs.
Leif Bertilsson, Marja-Liisa Dahl, Per Dalén, Ayman Al-Shurbaji. Br J Clin Pharmacol 2002
Leif Bertilsson, Marja-Liisa Dahl, Per Dalén, Ayman Al-Shurbaji. Br J Clin Pharmacol 2002
9
Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
J K Hicks, K Sangkuhl, J J Swen, V L Ellingrod, D J Müller, K Shimoda, J R Bishop, E D Kharasch, T C Skaar, A Gaedigk,[...]. Clin Pharmacol Ther 2017
J K Hicks, K Sangkuhl, J J Swen, V L Ellingrod, D J Müller, K Shimoda, J R Bishop, E D Kharasch, T C Skaar, A Gaedigk,[...]. Clin Pharmacol Ther 2017
8
The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients.
O Lingjaerde, U G Ahlfors, P Bech, S J Dencker, K Elgen. Acta Psychiatr Scand Suppl 1987
O Lingjaerde, U G Ahlfors, P Bech, S J Dencker, K Elgen. Acta Psychiatr Scand Suppl 1987
8
Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.
Y Zhou, M Ingelman-Sundberg, V M Lauschke. Clin Pharmacol Ther 2017
Y Zhou, M Ingelman-Sundberg, V M Lauschke. Clin Pharmacol Ther 2017
7
Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.
Greyson P Twist, Andrea Gaedigk, Neil A Miller, Emily G Farrow, Laurel K Willig, Darrell L Dinwiddie, Josh E Petrikin, Sarah E Soden, Suzanne Herd, Margaret Gibson,[...]. NPJ Genom Med 2016
Greyson P Twist, Andrea Gaedigk, Neil A Miller, Emily G Farrow, Laurel K Willig, Darrell L Dinwiddie, Josh E Petrikin, Sarah E Soden, Suzanne Herd, Margaret Gibson,[...]. NPJ Genom Med 2016
11
CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.
Andrea Gaedigk, Greyson P Twist, J Steven Leeder. Pharmacogenomics 2012
Andrea Gaedigk, Greyson P Twist, J Steven Leeder. Pharmacogenomics 2012
12
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.
C Sachse, J Brockmöller, S Bauer, I Roots. Am J Hum Genet 1997
C Sachse, J Brockmöller, S Bauer, I Roots. Am J Hum Genet 1997
7
Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017.
C Hiemke, N Bergemann, H W Clement, A Conca, J Deckert, K Domschke, G Eckermann, K Egberts, M Gerlach, C Greiner,[...]. Pharmacopsychiatry 2018
C Hiemke, N Bergemann, H W Clement, A Conca, J Deckert, K Domschke, G Eckermann, K Egberts, M Gerlach, C Greiner,[...]. Pharmacopsychiatry 2018
7
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
Matthew P Goetz, Katrin Sangkuhl, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W Fraser Symmans, Howard L McLeod, Mark J Ratain, Hitoshi Zembutsu,[...]. Clin Pharmacol Ther 2018
Matthew P Goetz, Katrin Sangkuhl, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W Fraser Symmans, Howard L McLeod, Mark J Ratain, Hitoshi Zembutsu,[...]. Clin Pharmacol Ther 2018
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Physicochemical Properties, Biotransformation, and Transport Pathways of Established and Newly Approved Medications: A Systematic Review of the Top 200 Most Prescribed Drugs vs. the FDA-Approved Drugs Between 2005 and 2016.
Anitha Saravanakumar, Armin Sadighi, Rachel Ryu, Fatemeh Akhlaghi. Clin Pharmacokinet 2019
Anitha Saravanakumar, Armin Sadighi, Rachel Ryu, Fatemeh Akhlaghi. Clin Pharmacokinet 2019
16
The Evolution of PharmVar.
Andrea Gaedigk, Katrin Sangkuhl, Michelle Whirl-Carrillo, Greyson P Twist, Teri E Klein, Neil A Miller. Clin Pharmacol Ther 2019
Andrea Gaedigk, Katrin Sangkuhl, Michelle Whirl-Carrillo, Greyson P Twist, Teri E Klein, Neil A Miller. Clin Pharmacol Ther 2019
10
7
Effects of CYP2D6 activity on the efficacy and safety of mirtazapine in patients with depressive disorders and comorbid alcohol use disorder.
M S Zastrozhin, V Y Skryabin, V V Smirnov, E A Grishina, K A Ryzhikova, E M Chumakov, E A Bryun, D A Sychev. Can J Physiol Pharmacol 2019
M S Zastrozhin, V Y Skryabin, V V Smirnov, E A Grishina, K A Ryzhikova, E M Chumakov, E A Bryun, D A Sychev. Can J Physiol Pharmacol 2019
63
7
Pharmacogenomics of CYP2D6: molecular genetics, interethnic differences and clinical importance.
Lay Kek Teh, Leif Bertilsson. Drug Metab Pharmacokinet 2012
Lay Kek Teh, Leif Bertilsson. Drug Metab Pharmacokinet 2012
6
CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction.
Andrea Gaedigk, Uwe Fuhr, Charlene Johnson, L Anick Bérard, Dianne Bradford, J Steven Leeder. Pharmacogenomics 2010
Andrea Gaedigk, Uwe Fuhr, Charlene Johnson, L Anick Bérard, Dianne Bradford, J Steven Leeder. Pharmacogenomics 2010
11
Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
A Gaedigk, L Ndjountché, K Divakaran, L Dianne Bradford, I Zineh, T F Oberlander, D C Brousseau, D G McCarver, J A Johnson, S W Alander,[...]. Clin Pharmacol Ther 2007
A Gaedigk, L Ndjountché, K Divakaran, L Dianne Bradford, I Zineh, T F Oberlander, D C Brousseau, D G McCarver, J A Johnson, S W Alander,[...]. Clin Pharmacol Ther 2007
6
A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics.
C M Blake, E D Kharasch, M Schwab, P Nagele. Clin Pharmacol Ther 2013
C M Blake, E D Kharasch, M Schwab, P Nagele. Clin Pharmacol Ther 2013
8
Characterization of Reference Materials for Genetic Testing of CYP2D6 Alleles: A GeT-RM Collaborative Project.
Andrea Gaedigk, Amy Turner, Robin E Everts, Stuart A Scott, Praful Aggarwal, Ulrich Broeckel, Gwendolyn A McMillin, Roberta Melis, Erin C Boone, Victoria M Pratt,[...]. J Mol Diagn 2019
Andrea Gaedigk, Amy Turner, Robin E Everts, Stuart A Scott, Praful Aggarwal, Ulrich Broeckel, Gwendolyn A McMillin, Roberta Melis, Erin C Boone, Victoria M Pratt,[...]. J Mol Diagn 2019
23
Pharmacogenetics: from bench to byte--an update of guidelines.
J J Swen, M Nijenhuis, A de Boer, L Grandia, A H Maitland-van der Zee, H Mulder, G A P J M Rongen, R H N van Schaik, T Schalekamp, D J Touw,[...]. Clin Pharmacol Ther 2011
J J Swen, M Nijenhuis, A de Boer, L Grandia, A H Maitland-van der Zee, H Mulder, G A P J M Rongen, R H N van Schaik, T Schalekamp, D J Touw,[...]. Clin Pharmacol Ther 2011
6
MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation.
Linjuan Zeng, Yinting Chen, Yong Wang, Li-Rong Yu, Bridgett Knox, Jiwei Chen, Tieliu Shi, Si Chen, Zhen Ren, Lei Guo,[...]. Biochem Pharmacol 2017
Linjuan Zeng, Yinting Chen, Yong Wang, Li-Rong Yu, Bridgett Knox, Jiwei Chen, Tieliu Shi, Si Chen, Zhen Ren, Lei Guo,[...]. Biochem Pharmacol 2017
13
Pinoline may be used as a probe for CYP2D6 activity.
Xi-Ling Jiang, Hong-Wu Shen, Ai-Ming Yu. Drug Metab Dispos 2009
Xi-Ling Jiang, Hong-Wu Shen, Ai-Ming Yu. Drug Metab Dispos 2009
27
The correlation between CYP2D6 isoenzyme activity and haloperidol efficacy and safety profile in patients with alcohol addiction during the exacerbation of the addiction.
Dmitry Alekseevich Sychev, Mikhail Sergeevich Zastrozhin, Valery Valerieevich Smirnov, Elena Anatolievna Grishina, Ludmila Mikhailovna Savchenko, Evgeny Alekseevich Bryun. Pharmgenomics Pers Med 2016
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42
Antidepressant treatment and altered CYP2D6 activity: are pharmacokinetic variations clinically relevant?
Inna D'Empaire, Christine J Guico-Pabia, Sheldon H Preskorn. J Psychiatr Pract 2011
Inna D'Empaire, Christine J Guico-Pabia, Sheldon H Preskorn. J Psychiatr Pract 2011
20
The clinical global impressions scale: applying a research tool in clinical practice.
Joan Busner, Steven D Targum. Psychiatry (Edgmont) 2007
Joan Busner, Steven D Targum. Psychiatry (Edgmont) 2007
6
Codeine intoxication associated with ultrarapid CYP2D6 metabolism.
Yvan Gasche, Youssef Daali, Marc Fathi, Alberto Chiappe, Silvia Cottini, Pierre Dayer, Jules Desmeules. N Engl J Med 2004
Yvan Gasche, Youssef Daali, Marc Fathi, Alberto Chiappe, Silvia Cottini, Pierre Dayer, Jules Desmeules. N Engl J Med 2004
5
Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users.
M J Bijl, L E Visser, R H N van Schaik, J A Kors, J C M Witteman, A Hofman, A G Vulto, T van Gelder, B H Ch Stricker. Clin Pharmacol Ther 2009
M J Bijl, L E Visser, R H N van Schaik, J A Kors, J C M Witteman, A Hofman, A G Vulto, T van Gelder, B H Ch Stricker. Clin Pharmacol Ther 2009
5
Impact of the CYP2D6 genotype on the clinical effects of metoprolol: a prospective longitudinal study.
T Rau, H Wuttke, L M Michels, U Werner, K Bergmann, M Kreft, M F Fromm, T Eschenhagen. Clin Pharmacol Ther 2009
T Rau, H Wuttke, L M Michels, U Werner, K Bergmann, M Kreft, M F Fromm, T Eschenhagen. Clin Pharmacol Ther 2009
6
Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.
Andrea Gaedigk, Jean C Dinh, Hyunyoung Jeong, Bhagwat Prasad, J Steven Leeder. J Pers Med 2018
Andrea Gaedigk, Jean C Dinh, Hyunyoung Jeong, Bhagwat Prasad, J Steven Leeder. J Pers Med 2018
6
Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
Danxin Wang, Ming J Poi, Xiaochun Sun, Andrea Gaedigk, J Steven Leeder, Wolfgang Sadee. Hum Mol Genet 2014
Danxin Wang, Ming J Poi, Xiaochun Sun, Andrea Gaedigk, J Steven Leeder, Wolfgang Sadee. Hum Mol Genet 2014
6
Polymorphism of human cytochrome P450 enzymes and its clinical impact.
Shu-Feng Zhou, Jun-Ping Liu, Balram Chowbay. Drug Metab Rev 2009
Shu-Feng Zhou, Jun-Ping Liu, Balram Chowbay. Drug Metab Rev 2009
5
Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization.
J Kevin Hicks, Jesse J Swen, Andrea Gaedigk. Curr Drug Metab 2014
J Kevin Hicks, Jesse J Swen, Andrea Gaedigk. Curr Drug Metab 2014
5
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