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Times Cited: 563
Times Cited: 563
Times Cited
Times Co-cited
Similarity
Therapeutic antibody targeting of individual Notch receptors.
Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway,[...]. Nature 2010
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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
Loren D Walensky, Andrew L Kung, Iris Escher, Thomas J Malia, Scott Barbuto, Renee D Wright, Gerhard Wagner, Gregory L Verdine, Stanley J Korsmeyer. Science 2004
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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
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Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.
Federico Bernal, Andrew F Tyler, Stanley J Korsmeyer, Loren D Walensky, Gregory L Verdine. J Am Chem Soc 2007
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Hydrocarbon-stapled peptides: principles, practice, and progress.
Loren D Walensky, Gregory H Bird. J Med Chem 2014
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Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy.
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The canonical Notch signaling pathway: unfolding the activation mechanism.
Raphael Kopan, Maria Xenia G Ilagan. Cell 2009
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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
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Notch Signaling in Development, Tissue Homeostasis, and Disease.
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The Varied Roles of Notch in Cancer.
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
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The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.
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A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
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Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices.
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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.
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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
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TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
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Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.
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Therapeutic modulation of Notch signalling--are we there yet?
Emma R Andersson, Urban Lendahl. Nat Rev Drug Discov 2014
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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
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Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.
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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
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Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.
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The cautionary tale of side effects of chronic Notch1 inhibition.
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Chronic DLL4 blockade induces vascular neoplasms.
Minhong Yan, Christopher A Callahan, Joseph C Beyer, Krishna P Allamneni, Gu Zhang, John Brady Ridgway, Kyle Niessen, Greg D Plowman. Nature 2010
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Deficient T cell fate specification in mice with an induced inactivation of Notch1.
F Radtke, A Wilson, G Stark, M Bauer, J van Meerwijk, H R MacDonald, M Aguet. Immunity 1999
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Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.
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Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch?
Ma Xenia G Ilagan, Raphael Kopan. Cancer Cell 2013
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Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
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Design and structure of stapled peptides binding to estrogen receptors.
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Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin.
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Design of triazole-stapled BCL9 α-helical peptides to target the β-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction.
Steven A Kawamoto, Adriana Coleska, Xu Ran, Han Yi, Chao-Yie Yang, Shaomeng Wang. J Med Chem 2012
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Preclinical analysis of the γ-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia.
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10
Notch signalling in solid tumours: a little bit of everything but not all the time.
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Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.
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Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis.
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Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
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A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors.
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Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
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The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.
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Notch signaling: cell fate control and signal integration in development.
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Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.
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A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling.
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Structure of the stapled p53 peptide bound to Mdm2.
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Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.
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Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis.
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Notch signaling is essential for vascular morphogenesis in mice.
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.