A citation-based method for searching scientific literature


List of co-cited articles
562 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
23


Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
G L Wang, B H Jiang, E A Rue, G L Semenza. Proc Natl Acad Sci U S A 1995
12

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression.
Luana Schito, Gregg L Semenza. Trends Cancer 2016
376
12

Targeting HIF-1 for cancer therapy.
Gregg L Semenza. Nat Rev Cancer 2003
10

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation.
Muhammad Zaeem Noman, Giacomo Desantis, Bassam Janji, Meriem Hasmim, Saoussen Karray, Philippe Dessen, Vincenzo Bronte, Salem Chouaib. J Exp Med 2014
984
9

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.
Freddie Bray, Jacques Ferlay, Isabelle Soerjomataram, Rebecca L Siegel, Lindsey A Torre, Ahmedin Jemal. CA Cancer J Clin 2018
9

HIF-1α pathway: role, regulation and intervention for cancer therapy.
Georgina N Masoud, Wei Li. Acta Pharm Sin B 2015
743
8

Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
8

The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V Liberti, Jason W Locasale. Trends Biochem Sci 2016
8

The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy.
Barbara Muz, Pilar de la Puente, Feda Azab, Abdel Kareem Azab. Hypoxia (Auckl) 2015
630
8

Hypoxia--a key regulatory factor in tumour growth.
Adrian L Harris. Nat Rev Cancer 2002
8

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
P H Maxwell, M S Wiesener, G W Chang, S C Clifford, E C Vaux, M E Cockman, C C Wykoff, C W Pugh, E R Maher, P J Ratcliffe. Nature 1999
7

A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells.
Ivraym B Barsoum, Chelsea A Smallwood, D Robert Siemens, Charles H Graham. Cancer Res 2014
353
6

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.
Andrea Facciabene, Xiaohui Peng, Ian S Hagemann, Klara Balint, Andrea Barchetti, Li-Ping Wang, Phyllis A Gimotty, C Blake Gilks, Priti Lal, Lin Zhang,[...]. Nature 2011
706
6

Hypoxic control of metastasis.
Erinn B Rankin, Amato J Giaccia. Science 2016
573
6

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response.
Mark W Dewhirst, Yiting Cao, Benjamin Moeller. Nat Rev Cancer 2008
670
6

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.
H Zhong, A M De Marzo, E Laughner, M Lim, D A Hilton, D Zagzag, P Buechler, W B Isaacs, G L Semenza, J W Simons. Cancer Res 1999
6

On the origin of cancer cells.
O WARBURG. Science 1956
6

Tumor suppressors and cell metabolism: a recipe for cancer growth.
Russell G Jones, Craig B Thompson. Genes Dev 2009
683
6

Hypoxia-inducible factors and the response to hypoxic stress.
Amar J Majmundar, Waihay J Wong, M Celeste Simon. Mol Cell 2010
6

Cancer statistics, 2019.
Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal. CA Cancer J Clin 2019
6



Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
P Jaakkola, D R Mole, Y M Tian, M I Wilson, J Gielbert, S J Gaskell, A von Kriegsheim, H F Hebestreit, M Mukherji, C J Schofield,[...]. Science 2001
5

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression.
Brian Keith, Randall S Johnson, M Celeste Simon. Nat Rev Cancer 2011
5

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation.
Ralph J DeBerardinis, Julian J Lum, Georgia Hatzivassiliou, Craig B Thompson. Cell Metab 2008
5

HIF-1: upstream and downstream of cancer metabolism.
Gregg L Semenza. Curr Opin Genet Dev 2010
840
5

Hypoxia in cancer: significance and impact on clinical outcome.
Peter Vaupel, Arnulf Mayer. Cancer Metastasis Rev 2007
5

Exploiting tumour hypoxia in cancer treatment.
J Martin Brown, William R Wilson. Nat Rev Cancer 2004
5

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.
Edurne Berra, Emmanuel Benizri, Amandine Ginouvès, Véronique Volmat, Danièle Roux, Jacques Pouysségur. EMBO J 2003
973
5

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.
KangAe Lee, Huafeng Zhang, David Z Qian, Sergio Rey, Jun O Liu, Gregg L Semenza. Proc Natl Acad Sci U S A 2009
314
5

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Weibo Luo, Hongxia Hu, Ryan Chang, Jun Zhong, Matthew Knabel, Robert O'Meally, Robert N Cole, Akhilesh Pandey, Gregg L Semenza. Cell 2011
832
5


Hypoxia-Inducible Factors and Cancer.
Jonathan C Jun, Aman Rathore, Haris Younas, Daniele Gilkes, Vsevolod Y Polotsky. Curr Sleep Med Rep 2017
69
7


Role of hypoxia in the hallmarks of human cancer.
Kai Ruan, Gang Song, Gaoliang Ouyang. J Cell Biochem 2009
287
4

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
Huafeng Zhang, David Z Qian, Yee Sun Tan, Kangae Lee, Ping Gao, Yunzhao R Ren, Sergio Rey, Hans Hammers, Daniel Chang, Roberto Pili,[...]. Proc Natl Acad Sci U S A 2008
449
4

Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.
Carmen Chak-Lui Wong, Daniele M Gilkes, Huafeng Zhang, Jasper Chen, Hong Wei, Pallavi Chaturvedi, Stephanie I Fraley, Chun-Ming Wong, Ui-Soon Khoo, Irene Oi-Lin Ng,[...]. Proc Natl Acad Sci U S A 2011
268
4

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.
M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, J M Asara, W S Lane, W G Kaelin. Science 2001
4

Direct regulation of TWIST by HIF-1alpha promotes metastasis.
Muh-Hwa Yang, Min-Zu Wu, Shih-Hwa Chiou, Po-Min Chen, Shyue-Yih Chang, Chung-Ji Liu, Shu-Chun Teng, Kou-Juey Wu. Nat Cell Biol 2008
918
4

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer.
Caroline Wigerup, Sven Påhlman, Daniel Bexell. Pharmacol Ther 2016
299
4





Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.
Zhizhong Li, Shideng Bao, Qiulian Wu, Hui Wang, Christine Eyler, Sith Sathornsumetee, Qing Shi, Yiting Cao, Justin Lathia, Roger E McLendon,[...]. Cancer Cell 2009
855
4

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Surendra K Shukla, Vinee Purohit, Kamiya Mehla, Venugopal Gunda, Nina V Chaika, Enza Vernucci, Ryan J King, Jaime Abrego, Gennifer D Goode, Aneesha Dasgupta,[...]. Cancer Cell 2017
187
4

Why do cancers have high aerobic glycolysis?
Robert A Gatenby, Robert J Gillies. Nat Rev Cancer 2004
4

Microenvironmental regulation of tumor progression and metastasis.
Daniela F Quail, Johanna A Joyce. Nat Med 2013
4


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.