Andrea Gaedigk, Uwe Fuhr, Charlene Johnson, L Anick Bérard, Dianne Bradford, J Steven Leeder. Pharmacogenomics 2010
Times Cited: 51
Times Cited: 51
Times Cited
Times Co-cited
Similarity
Identification of Novel CYP2D7-2D6 Hybrids: Non-Functional and Functional Variants.
Andrea Gaedigk, Lazara Karelia Montane Jaime, Joseph S Bertino, Anick Bérard, Victoria M Pratt, L Dianne Bradfordand, J Steven Leeder. Front Pharmacol 2010
Andrea Gaedigk, Lazara Karelia Montane Jaime, Joseph S Bertino, Anick Bérard, Victoria M Pratt, L Dianne Bradfordand, J Steven Leeder. Front Pharmacol 2010
68
The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype.
A Gaedigk, S D Simon, R E Pearce, L D Bradford, M J Kennedy, J S Leeder. Clin Pharmacol Ther 2008
A Gaedigk, S D Simon, R E Pearce, L D Bradford, M J Kennedy, J S Leeder. Clin Pharmacol Ther 2008
60
Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events.
A Gaedigk, L Ndjountché, K Divakaran, L Dianne Bradford, I Zineh, T F Oberlander, D C Brousseau, D G McCarver, J A Johnson, S W Alander,[...]. Clin Pharmacol Ther 2007
A Gaedigk, L Ndjountché, K Divakaran, L Dianne Bradford, I Zineh, T F Oberlander, D C Brousseau, D G McCarver, J A Johnson, S W Alander,[...]. Clin Pharmacol Ther 2007
50
CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR.
Andrea Gaedigk, Greyson P Twist, J Steven Leeder. Pharmacogenomics 2012
Andrea Gaedigk, Greyson P Twist, J Steven Leeder. Pharmacogenomics 2012
49
CYP2D6*36 gene arrangements within the cyp2d6 locus: association of CYP2D6*36 with poor metabolizer status.
Andrea Gaedigk, L Dianne Bradford, Sarah W Alander, J Steven Leeder. Drug Metab Dispos 2006
Andrea Gaedigk, L Dianne Bradford, Sarah W Alander, J Steven Leeder. Drug Metab Dispos 2006
43
43
Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.
Shu-Feng Zhou. Clin Pharmacokinet 2009
Shu-Feng Zhou. Clin Pharmacokinet 2009
39
Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II.
Shu-Feng Zhou. Clin Pharmacokinet 2009
Shu-Feng Zhou. Clin Pharmacokinet 2009
35
CYP2D6: novel genomic structures and alleles.
Whitney E Kramer, Denise L Walker, Dennis J O'Kane, David A Mrazek, Pamela K Fisher, Brian A Dukek, Jamie K Bruflat, John L Black. Pharmacogenet Genomics 2009
Whitney E Kramer, Denise L Walker, Dennis J O'Kane, David A Mrazek, Pamela K Fisher, Brian A Dukek, Jamie K Bruflat, John L Black. Pharmacogenet Genomics 2009
42
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.
J K Hicks, J R Bishop, K Sangkuhl, D J Müller, Y Ji, S G Leckband, J S Leeder, R L Graham, D L Chiulli, A LLerena,[...]. Clin Pharmacol Ther 2015
J K Hicks, J R Bishop, K Sangkuhl, D J Müller, Y Ji, S G Leckband, J S Leeder, R L Graham, D L Chiulli, A LLerena,[...]. Clin Pharmacol Ther 2015
31
The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database.
Andrea Gaedigk, Magnus Ingelman-Sundberg, Neil A Miller, J Steven Leeder, Michelle Whirl-Carrillo, Teri E Klein. Clin Pharmacol Ther 2018
Andrea Gaedigk, Magnus Ingelman-Sundberg, Neil A Miller, J Steven Leeder, Michelle Whirl-Carrillo, Teri E Klein. Clin Pharmacol Ther 2018
31
Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
K R Crews, A Gaedigk, H M Dunnenberger, J S Leeder, T E Klein, K E Caudle, C E Haidar, D D Shen, J T Callaghan, S Sadhasivam,[...]. Clin Pharmacol Ther 2014
K R Crews, A Gaedigk, H M Dunnenberger, J S Leeder, T E Klein, K E Caudle, C E Haidar, D D Shen, J T Callaghan, S Sadhasivam,[...]. Clin Pharmacol Ther 2014
29
Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants.
J K Hicks, J J Swen, C F Thorn, K Sangkuhl, E D Kharasch, V L Ellingrod, T C Skaar, D J Müller, A Gaedigk, J C Stingl. Clin Pharmacol Ther 2013
J K Hicks, J J Swen, C F Thorn, K Sangkuhl, E D Kharasch, V L Ellingrod, T C Skaar, D J Müller, A Gaedigk, J C Stingl. Clin Pharmacol Ther 2013
27
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry.
Ulrich M Zanger, Sebastian Raimundo, Michel Eichelbaum. Naunyn Schmiedebergs Arch Pharmacol 2004
Ulrich M Zanger, Sebastian Raimundo, Michel Eichelbaum. Naunyn Schmiedebergs Arch Pharmacol 2004
25
Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations.
Andrea Gaedigk, Maria Isidoro-García, Robin E Pearce, Santiago Sánchez, Virginia García-Solaesa, Carolina Lorenzo-Romo, Gloria Gonzalez-Tejera, Susan Corey. Eur J Clin Pharmacol 2010
Andrea Gaedigk, Maria Isidoro-García, Robin E Pearce, Santiago Sánchez, Virginia García-Solaesa, Carolina Lorenzo-Romo, Gloria Gonzalez-Tejera, Susan Corey. Eur J Clin Pharmacol 2010
52
The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.
S Kimura, M Umeno, R C Skoda, U A Meyer, F J Gonzalez. Am J Hum Genet 1989
S Kimura, M Umeno, R C Skoda, U A Meyer, F J Gonzalez. Am J Hum Genet 1989
23
Prediction of CYP2D6 phenotype from genotype across world populations.
Andrea Gaedigk, Katrin Sangkuhl, Michelle Whirl-Carrillo, Teri Klein, J Steven Leeder. Genet Med 2017
Andrea Gaedigk, Katrin Sangkuhl, Michelle Whirl-Carrillo, Teri Klein, J Steven Leeder. Genet Med 2017
23
Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update.
J K Hicks, K Sangkuhl, J J Swen, V L Ellingrod, D J Müller, K Shimoda, J R Bishop, E D Kharasch, T C Skaar, A Gaedigk,[...]. Clin Pharmacol Ther 2017
J K Hicks, K Sangkuhl, J J Swen, V L Ellingrod, D J Müller, K Shimoda, J R Bishop, E D Kharasch, T C Skaar, A Gaedigk,[...]. Clin Pharmacol Ther 2017
23
CYP2D6 genotyping for functional-gene dosage analysis by allele copy number detection.
Naoya Hosono, Mamoru Kato, Kazuma Kiyotani, Taisei Mushiroda, Sadaaki Takata, Hiroko Sato, Hanae Amitani, Yumiko Tsuchiya, Keiko Yamazaki, Tatsuhiko Tsunoda,[...]. Clin Chem 2009
Naoya Hosono, Mamoru Kato, Kazuma Kiyotani, Taisei Mushiroda, Sadaaki Takata, Hiroko Sato, Hanae Amitani, Yumiko Tsuchiya, Keiko Yamazaki, Tatsuhiko Tsunoda,[...]. Clin Chem 2009
21
CYP2D6 update: revised nomenclature for CYP2D7/2D6 hybrid genes.
Sarah C Sim, Ann K Daly, Andrea Gaedigk. Pharmacogenet Genomics 2012
Sarah C Sim, Ann K Daly, Andrea Gaedigk. Pharmacogenet Genomics 2012
64
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
Matthew P Goetz, Katrin Sangkuhl, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W Fraser Symmans, Howard L McLeod, Mark J Ratain, Hitoshi Zembutsu,[...]. Clin Pharmacol Ther 2018
Matthew P Goetz, Katrin Sangkuhl, Henk-Jan Guchelaar, Matthias Schwab, Michael Province, Michelle Whirl-Carrillo, W Fraser Symmans, Howard L McLeod, Mark J Ratain, Hitoshi Zembutsu,[...]. Clin Pharmacol Ther 2018
21
Frequency of undetected CYP2D6 hybrid genes in clinical samples: impact on phenotype prediction.
John Logan Black, Denise L Walker, Dennis J O'Kane, Maria Harmandayan. Drug Metab Dispos 2012
John Logan Black, Denise L Walker, Dennis J O'Kane, Maria Harmandayan. Drug Metab Dispos 2012
26
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.
K R Crews, A Gaedigk, H M Dunnenberger, T E Klein, D D Shen, J T Callaghan, E D Kharasch, T C Skaar. Clin Pharmacol Ther 2012
K R Crews, A Gaedigk, H M Dunnenberger, T E Klein, D D Shen, J T Callaghan, E D Kharasch, T C Skaar. Clin Pharmacol Ther 2012
19
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.
Ulrich M Zanger, Matthias Schwab. Pharmacol Ther 2013
Ulrich M Zanger, Matthias Schwab. Pharmacol Ther 2013
19
Functional characterization of CYP2D6 enhancer polymorphisms.
Danxin Wang, Audrey C Papp, Xiaochun Sun. Hum Mol Genet 2015
Danxin Wang, Audrey C Papp, Xiaochun Sun. Hum Mol Genet 2015
23
Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences.
Greyson P Twist, Andrea Gaedigk, Neil A Miller, Emily G Farrow, Laurel K Willig, Darrell L Dinwiddie, Josh E Petrikin, Sarah E Soden, Suzanne Herd, Margaret Gibson,[...]. NPJ Genom Med 2016
Greyson P Twist, Andrea Gaedigk, Neil A Miller, Emily G Farrow, Laurel K Willig, Darrell L Dinwiddie, Josh E Petrikin, Sarah E Soden, Suzanne Herd, Margaret Gibson,[...]. NPJ Genom Med 2016
19
CYP2D6 Haplotype Determination Using Long Range Allele-Specific Amplification: Resolution of a Complex Genotype and a Discordant Genotype Involving the CYP2D6*59 Allele.
Andrea Gaedigk, Amanda K Riffel, J Steven Leeder. J Mol Diagn 2015
Andrea Gaedigk, Amanda K Riffel, J Steven Leeder. J Mol Diagn 2015
38
Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group.
Kelly E Caudle, Katrin Sangkuhl, Michelle Whirl-Carrillo, Jesse J Swen, Cyrine E Haidar, Teri E Klein, Roseann S Gammal, Mary V Relling, Stuart A Scott, Daniel L Hertz,[...]. Clin Transl Sci 2020
Kelly E Caudle, Katrin Sangkuhl, Michelle Whirl-Carrillo, Jesse J Swen, Cyrine E Haidar, Teri E Klein, Roseann S Gammal, Mary V Relling, Stuart A Scott, Daniel L Hertz,[...]. Clin Transl Sci 2020
19
PharmVar GeneFocus: CYP2D6.
Charity Nofziger, Amy J Turner, Katrin Sangkuhl, Michelle Whirl-Carrillo, José A G Agúndez, John L Black, Henry M Dunnenberger, Gualberto Ruano, Martin A Kennedy, Michael S Phillips,[...]. Clin Pharmacol Ther 2020
Charity Nofziger, Amy J Turner, Katrin Sangkuhl, Michelle Whirl-Carrillo, José A G Agúndez, John L Black, Henry M Dunnenberger, Gualberto Ruano, Martin A Kennedy, Michael S Phillips,[...]. Clin Pharmacol Ther 2020
19
Differential quantification of CYP2D6 gene copy number by four different quantitative real-time PCR assays.
Anuradha Ramamoorthy, David A Flockhart, Naoya Hosono, Michiaki Kubo, Yusuke Nakamura, Todd C Skaar. Pharmacogenet Genomics 2010
Anuradha Ramamoorthy, David A Flockhart, Naoya Hosono, Michiaki Kubo, Yusuke Nakamura, Todd C Skaar. Pharmacogenet Genomics 2010
34
Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity.
Danxin Wang, Ming J Poi, Xiaochun Sun, Andrea Gaedigk, J Steven Leeder, Wolfgang Sadee. Hum Mol Genet 2014
Danxin Wang, Ming J Poi, Xiaochun Sun, Andrea Gaedigk, J Steven Leeder, Wolfgang Sadee. Hum Mol Genet 2014
17
Physicochemical Properties, Biotransformation, and Transport Pathways of Established and Newly Approved Medications: A Systematic Review of the Top 200 Most Prescribed Drugs vs. the FDA-Approved Drugs Between 2005 and 2016.
Anitha Saravanakumar, Armin Sadighi, Rachel Ryu, Fatemeh Akhlaghi. Clin Pharmacokinet 2019
Anitha Saravanakumar, Armin Sadighi, Rachel Ryu, Fatemeh Akhlaghi. Clin Pharmacokinet 2019
22
Identification and characterization of novel sequence variations in the cytochrome P4502D6 (CYP2D6) gene in African Americans.
A Gaedigk, A Bhathena, L Ndjountché, R E Pearce, S M Abdel-Rahman, S W Alander, L DiAnne Bradford, P K Rogan, J Steven Leeder. Pharmacogenomics J 2005
A Gaedigk, A Bhathena, L Ndjountché, R E Pearce, S M Abdel-Rahman, S W Alander, L DiAnne Bradford, P K Rogan, J Steven Leeder. Pharmacogenomics J 2005
15
The CYP2D6 gene locus in South African Coloureds: unique allele distributions, novel alleles and gene arrangements.
Andrea Gaedigk, Christa Coetsee. Eur J Clin Pharmacol 2008
Andrea Gaedigk, Christa Coetsee. Eur J Clin Pharmacol 2008
18
Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan.
K Abduljalil, D Frank, A Gaedigk, T Klaassen, D Tomalik-Scharte, A Jetter, U Jaehde, J Kirchheiner, U Fuhr. Clin Pharmacol Ther 2010
K Abduljalil, D Frank, A Gaedigk, T Klaassen, D Tomalik-Scharte, A Jetter, U Jaehde, J Kirchheiner, U Fuhr. Clin Pharmacol Ther 2010
18
Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response.
J Kirchheiner, K Nickchen, M Bauer, M-L Wong, J Licinio, I Roots, J Brockmöller. Mol Psychiatry 2004
J Kirchheiner, K Nickchen, M Bauer, M-L Wong, J Licinio, I Roots, J Brockmöller. Mol Psychiatry 2004
15
Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants.
Lazara Karelia Montané Jaime, Anthony Lalla, Werner Steimer, Andrea Gaedigk. Pharmacogenomics 2013
Lazara Karelia Montané Jaime, Anthony Lalla, Werner Steimer, Andrea Gaedigk. Pharmacogenomics 2013
23
Pharmacogenetics: from bench to byte--an update of guidelines.
J J Swen, M Nijenhuis, A de Boer, L Grandia, A H Maitland-van der Zee, H Mulder, G A P J M Rongen, R H N van Schaik, T Schalekamp, D J Touw,[...]. Clin Pharmacol Ther 2011
J J Swen, M Nijenhuis, A de Boer, L Grandia, A H Maitland-van der Zee, H Mulder, G A P J M Rongen, R H N van Schaik, T Schalekamp, D J Touw,[...]. Clin Pharmacol Ther 2011
15
Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization.
J Kevin Hicks, Jesse J Swen, Andrea Gaedigk. Curr Drug Metab 2014
J Kevin Hicks, Jesse J Swen, Andrea Gaedigk. Curr Drug Metab 2014
15
Long-Read Single Molecule Real-Time Full Gene Sequencing of Cytochrome P450-2D6.
Wanqiong Qiao, Yao Yang, Robert Sebra, Geetu Mendiratta, Andrea Gaedigk, Robert J Desnick, Stuart A Scott. Hum Mutat 2016
Wanqiong Qiao, Yao Yang, Robert Sebra, Geetu Mendiratta, Andrea Gaedigk, Robert J Desnick, Stuart A Scott. Hum Mutat 2016
15
Characterization of Reference Materials for Genetic Testing of CYP2D6 Alleles: A GeT-RM Collaborative Project.
Andrea Gaedigk, Amy Turner, Robin E Everts, Stuart A Scott, Praful Aggarwal, Ulrich Broeckel, Gwendolyn A McMillin, Roberta Melis, Erin C Boone, Victoria M Pratt,[...]. J Mol Diagn 2019
Andrea Gaedigk, Amy Turner, Robin E Everts, Stuart A Scott, Praful Aggarwal, Ulrich Broeckel, Gwendolyn A McMillin, Roberta Melis, Erin C Boone, Victoria M Pratt,[...]. J Mol Diagn 2019
30
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.
I Johansson, E Lundqvist, L Bertilsson, M L Dahl, F Sjöqvist, M Ingelman-Sundberg. Proc Natl Acad Sci U S A 1993
I Johansson, E Lundqvist, L Bertilsson, M L Dahl, F Sjöqvist, M Ingelman-Sundberg. Proc Natl Acad Sci U S A 1993
13
Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences.
C Sachse, J Brockmöller, S Bauer, I Roots. Am J Hum Genet 1997
C Sachse, J Brockmöller, S Bauer, I Roots. Am J Hum Genet 1997
13
CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure.
Johanna Sistonen, Antti Sajantila, Oscar Lao, Jukka Corander, Guido Barbujani, Silvia Fuselli. Pharmacogenet Genomics 2007
Johanna Sistonen, Antti Sajantila, Oscar Lao, Jukka Corander, Guido Barbujani, Silvia Fuselli. Pharmacogenet Genomics 2007
13
A novel intronic mutation, 2988G>A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects.
Sebastian Raimundo, Claudia Toscano, Kathrin Klein, Joachim Fischer, Ernst-Ulrich Griese, Michel Eichelbaum, Matthias Schwab, Ulrich M Zanger. Clin Pharmacol Ther 2004
Sebastian Raimundo, Claudia Toscano, Kathrin Klein, Joachim Fischer, Ernst-Ulrich Griese, Michel Eichelbaum, Matthias Schwab, Ulrich M Zanger. Clin Pharmacol Ther 2004
13
Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data.
A Gaedigk, R R Gotschall, N S Forbes, S D Simon, G L Kearns, J S Leeder. Pharmacogenetics 1999
A Gaedigk, R R Gotschall, N S Forbes, S D Simon, G L Kearns, J S Leeder. Pharmacogenetics 1999
13
Ontogeny of dextromethorphan O- and N-demethylation in the first year of life.
M J Blake, A Gaedigk, R E Pearce, L R Bomgaars, M L Christensen, C Stowe, L P James, J T Wilson, G L Kearns, J S Leeder. Clin Pharmacol Ther 2007
M J Blake, A Gaedigk, R E Pearce, L R Bomgaars, M L Christensen, C Stowe, L P James, J T Wilson, G L Kearns, J S Leeder. Clin Pharmacol Ther 2007
13
Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation.
Ulrich M Zanger, Miia Turpeinen, Kathrin Klein, Matthias Schwab. Anal Bioanal Chem 2008
Ulrich M Zanger, Miia Turpeinen, Kathrin Klein, Matthias Schwab. Anal Bioanal Chem 2008
13
Characterization of 107 genomic DNA reference materials for CYP2D6, CYP2C19, CYP2C9, VKORC1, and UGT1A1: a GeT-RM and Association for Molecular Pathology collaborative project.
Victoria M Pratt, Barbara Zehnbauer, Jean Amos Wilson, Ruth Baak, Nikolina Babic, Maria Bettinotti, Arlene Buller, Ken Butz, Matthew Campbell, Chris Civalier,[...]. J Mol Diagn 2010
Victoria M Pratt, Barbara Zehnbauer, Jean Amos Wilson, Ruth Baak, Nikolina Babic, Maria Bettinotti, Arlene Buller, Ken Butz, Matthew Campbell, Chris Civalier,[...]. J Mol Diagn 2010
13
Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual.
Andrea Gaedigk, Dorothee Frank, Uwe Fuhr. Eur J Clin Pharmacol 2009
Andrea Gaedigk, Dorothee Frank, Uwe Fuhr. Eur J Clin Pharmacol 2009
53
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.