Jennifer Bradford, Ji-Yeon Shin, Meredith Roberts, Chuan-En Wang, Xiao-Jiang Li, Shihua Li. Proc Natl Acad Sci U S A 2009
Times Cited: 221
Times Cited: 221
Times Cited
Times Co-cited
Similarity
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity.
Ji-Yeon Shin, Zhi-Hui Fang, Zhao-Xue Yu, Chuan-En Wang, Shi-Hua Li, Xiao-Jiang Li. J Cell Biol 2005
Ji-Yeon Shin, Zhi-Hui Fang, Zhao-Xue Yu, Chuan-En Wang, Shi-Hua Li, Xiao-Jiang Li. J Cell Biol 2005
40
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice.
Xiaoping Tong, Yan Ao, Guido C Faas, Sinifunanya E Nwaobi, Ji Xu, Martin D Haustein, Mark A Anderson, Istvan Mody, Michelle L Olsen, Michael V Sofroniew,[...]. Nat Neurosci 2014
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38
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects.
Mathilde Faideau, Jinho Kim, Kerry Cormier, Richard Gilmore, Mackenzie Welch, Gwennaelle Auregan, Noelle Dufour, Martine Guillermier, Emmanuel Brouillet, Philippe Hantraye,[...]. Hum Mol Genet 2010
Mathilde Faideau, Jinho Kim, Kerry Cormier, Richard Gilmore, Mackenzie Welch, Gwennaelle Auregan, Noelle Dufour, Martine Guillermier, Emmanuel Brouillet, Philippe Hantraye,[...]. Hum Mol Genet 2010
36
Neurotoxic reactive astrocytes are induced by activated microglia.
Shane A Liddelow, Kevin A Guttenplan, Laura E Clarke, Frederick C Bennett, Christopher J Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E Münch, Won-Suk Chung, Todd C Peterson,[...]. Nature 2017
Shane A Liddelow, Kevin A Guttenplan, Laura E Clarke, Frederick C Bennett, Christopher J Bohlen, Lucas Schirmer, Mariko L Bennett, Alexandra E Münch, Won-Suk Chung, Todd C Peterson,[...]. Nature 2017
32
31
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
L Mangiarini, K Sathasivam, M Seller, B Cozens, A Harper, C Hetherington, M Lawton, Y Trottier, H Lehrach, S W Davies,[...]. Cell 1996
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Neuropathological classification of Huntington's disease.
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26
Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice.
Ruotian Jiang, Blanca Diaz-Castro, Loren L Looger, Baljit S Khakh. J Neurosci 2016
Ruotian Jiang, Blanca Diaz-Castro, Loren L Looger, Baljit S Khakh. J Neurosci 2016
26
Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice.
Jennifer Bradford, Ji-Yeon Shin, Meredith Roberts, Chuan-En Wang, Guoqing Sheng, Shihua Li, Xiao-Jiang Li. J Biol Chem 2010
Jennifer Bradford, Ji-Yeon Shin, Meredith Roberts, Chuan-En Wang, Guoqing Sheng, Shihua Li, Xiao-Jiang Li. J Biol Chem 2010
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Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.
J C Liévens, B Woodman, A Mahal, O Spasic-Boscovic, D Samuel, L Kerkerian-Le Goff, G P Bates. Neurobiol Dis 2001
J C Liévens, B Woodman, A Mahal, O Spasic-Boscovic, D Samuel, L Kerkerian-Le Goff, G P Bates. Neurobiol Dis 2001
22
Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.
Abdellatif Benraiss, Su Wang, Stephanie Herrlinger, Xiaojie Li, Devin Chandler-Militello, Joseph Mauceri, Hayley B Burm, Michael Toner, Mikhail Osipovitch, Qiwu Jim Xu,[...]. Nat Commun 2016
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22
Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.
Baljit S Khakh, Vahri Beaumont, Roger Cachope, Ignacio Munoz-Sanjuan, Steven A Goldman, Rosemarie Grantyn. Trends Neurosci 2017
Baljit S Khakh, Vahri Beaumont, Roger Cachope, Ignacio Munoz-Sanjuan, Steven A Goldman, Rosemarie Grantyn. Trends Neurosci 2017
23
Mutant huntingtin reduction in astrocytes slows disease progression in the BACHD conditional Huntington's disease mouse model.
Tara E Wood, Joshua Barry, Zhenquin Yang, Carlos Cepeda, Michael S Levine, Michelle Gray. Hum Mol Genet 2019
Tara E Wood, Joshua Barry, Zhenquin Yang, Carlos Cepeda, Michael S Levine, Michelle Gray. Hum Mol Genet 2019
48
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors.
Andrea Crotti, Christopher Benner, Bilal E Kerman, David Gosselin, Clotilde Lagier-Tourenne, Chiara Zuccato, Elena Cattaneo, Fred H Gage, Don W Cleveland, Christopher K Glass. Nat Neurosci 2014
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20
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Elizabeth J Slow, Jeremy van Raamsdonk, Daniel Rogers, Sarah H Coleman, Rona K Graham, Yu Deng, Rosemary Oh, Nagat Bissada, Sazzad M Hossain, Yu-Zhou Yang,[...]. Hum Mol Genet 2003
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18
Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.
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18
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
Maria Björkqvist, Edward J Wild, Jenny Thiele, Aurelio Silvestroni, Ralph Andre, Nayana Lahiri, Elsa Raibon, Richard V Lee, Caroline L Benn, Denis Soulet,[...]. J Exp Med 2008
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17
Early and progressive accumulation of reactive microglia in the Huntington disease brain.
E Sapp, K B Kegel, N Aronin, T Hashikawa, Y Uchiyama, K Tohyama, P G Bhide, J P Vonsattel, M DiFiglia. J Neuropathol Exp Neurol 2001
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17
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
M DiFiglia, E Sapp, K O Chase, S W Davies, G P Bates, J P Vonsattel, N Aronin. Science 1997
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17
Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice.
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
Michelle Gray, Dyna I Shirasaki, Carlos Cepeda, Véronique M André, Brian Wilburn, Xiao-Hong Lu, Jifang Tao, Irene Yamazaki, Shi-Hua Li, Yi E Sun,[...]. J Neurosci 2008
17
A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease.
Han-Yun Hsiao, Yu-Chen Chen, Hui-Mei Chen, Pang-Hsien Tu, Yijuang Chern. Hum Mol Genet 2013
Han-Yun Hsiao, Yu-Chen Chen, Hui-Mei Chen, Pang-Hsien Tu, Yijuang Chern. Hum Mol Genet 2013
17
Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes.
Brenda Huang, WenJie Wei, Guohao Wang, Marta A Gaertig, Yue Feng, Wei Wang, Xiao-Jiang Li, Shihua Li. Neuron 2015
Brenda Huang, WenJie Wei, Guohao Wang, Marta A Gaertig, Yue Feng, Wei Wang, Xiao-Jiang Li, Shihua Li. Neuron 2015
20
Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP.
Yan Hong, Ting Zhao, Xiao-Jiang Li, Shihua Li. J Neurosci 2016
Yan Hong, Ting Zhao, Xiao-Jiang Li, Shihua Li. J Neurosci 2016
31
Huntington's disease: from molecular pathogenesis to clinical treatment.
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16
Huntington disease.
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15
Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
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14
Microglial activation in presymptomatic Huntington's disease gene carriers.
Yen F Tai, Nicola Pavese, Alexander Gerhard, Sarah J Tabrizi, Roger A Barker, David J Brooks, Paola Piccini. Brain 2007
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14
Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease--an in situ hybridization study.
T Arzberger, K Krampfl, S Leimgruber, A Weindl. J Neuropathol Exp Neurol 1997
T Arzberger, K Krampfl, S Leimgruber, A Weindl. J Neuropathol Exp Neurol 1997
14
Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific.
Anne H P Jansen, Maurik van Hal, Ilse C Op den Kelder, Romy T Meier, Anna-Aster de Ruiter, Menno H Schut, Donna L Smith, Corien Grit, Nieske Brouwer, Willem Kamphuis,[...]. Glia 2017
Anne H P Jansen, Maurik van Hal, Ilse C Op den Kelder, Romy T Meier, Anna-Aster de Ruiter, Menno H Schut, Donna L Smith, Corien Grit, Nieske Brouwer, Willem Kamphuis,[...]. Glia 2017
28
Neurological abnormalities in a knock-in mouse model of Huntington's disease.
C H Lin, S Tallaksen-Greene, W M Chien, J A Cearley, W S Jackson, A B Crouse, S Ren, X J Li, R L Albin, P J Detloff. Hum Mol Genet 2001
C H Lin, S Tallaksen-Greene, W M Chien, J A Cearley, W S Jackson, A B Crouse, S Ren, X J Li, R L Albin, P J Detloff. Hum Mol Genet 2001
13
Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation.
P F Behrens, P Franz, B Woodman, K S Lindenberg, G B Landwehrmeyer. Brain 2002
P F Behrens, P Franz, B Woodman, K S Lindenberg, G B Landwehrmeyer. Brain 2002
13
Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's disease.
Nan Wang, Michelle Gray, Xiao-Hong Lu, Jeffrey P Cantle, Sandra M Holley, Erin Greiner, Xiaofeng Gu, Dyna Shirasaki, Carlos Cepeda, Yuqing Li,[...]. Nat Med 2014
Nan Wang, Michelle Gray, Xiao-Hong Lu, Jeffrey P Cantle, Sandra M Holley, Erin Greiner, Xiaofeng Gu, Dyna Shirasaki, Carlos Cepeda, Yuqing Li,[...]. Nat Med 2014
13
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
S W Davies, M Turmaine, B A Cozens, M DiFiglia, A H Sharp, C A Ross, E Scherzinger, E E Wanker, L Mangiarini, G P Bates. Cell 1997
12
Regional and cellular gene expression changes in human Huntington's disease brain.
Angela Hodges, Andrew D Strand, Aaron K Aragaki, Alexandre Kuhn, Thierry Sengstag, Gareth Hughes, Lyn A Elliston, Cathy Hartog, Darlene R Goldstein, Doris Thu,[...]. Hum Mol Genet 2006
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12
Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse.
B R Miller, J L Dorner, M Shou, Y Sari, S J Barton, D R Sengelaub, R T Kennedy, G V Rebec. Neuroscience 2008
B R Miller, J L Dorner, M Shou, Y Sari, S J Barton, D R Sengelaub, R T Kennedy, G V Rebec. Neuroscience 2008
12
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Chiara Zuccato, Marzia Tartari, Andrea Crotti, Donato Goffredo, Marta Valenza, Luciano Conti, Tiziana Cataudella, Blair R Leavitt, Michael R Hayden, Tõnis Timmusk,[...]. Nat Genet 2003
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11
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice.
Austen J Milnerwood, Clare M Gladding, Mahmoud A Pouladi, Alexandra M Kaufman, Rochelle M Hines, Jamie D Boyd, Rebecca W Y Ko, Oana C Vasuta, Rona K Graham, Michael R Hayden,[...]. Neuron 2010
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11
Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis.
Holly B Kordasiewicz, Lisa M Stanek, Edward V Wancewicz, Curt Mazur, Melissa M McAlonis, Kimberly A Pytel, Jonathan W Artates, Andreas Weiss, Seng H Cheng, Lamya S Shihabuddin,[...]. Neuron 2012
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11
Microglial activation correlates with severity in Huntington disease: a clinical and PET study.
N Pavese, A Gerhard, Y F Tai, A K Ho, F Turkheimer, R A Barker, D J Brooks, P Piccini. Neurology 2006
N Pavese, A Gerhard, Y F Tai, A K Ho, F Turkheimer, R A Barker, D J Brooks, P Piccini. Neurology 2006
11
Diversity of astrocyte functions and phenotypes in neural circuits.
Baljit S Khakh, Michael V Sofroniew. Nat Neurosci 2015
Baljit S Khakh, Michael V Sofroniew. Nat Neurosci 2015
11
Genomic analysis of reactive astrogliosis.
Jennifer L Zamanian, Lijun Xu, Lynette C Foo, Navid Nouri, Lu Zhou, Rona G Giffard, Ben A Barres. J Neurosci 2012
Jennifer L Zamanian, Lijun Xu, Lynette C Foo, Navid Nouri, Lu Zhou, Rona G Giffard, Ben A Barres. J Neurosci 2012
11
Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice.
Xiaofeng Gu, Chenjian Li, Weizheng Wei, Victor Lo, Shiaoching Gong, Shi-Hua Li, Takuji Iwasato, Shigeyoshi Itohara, Xiao-Jiang Li, Istvan Mody,[...]. Neuron 2005
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11
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
Hua Chai, Blanca Diaz-Castro, Eiji Shigetomi, Emma Monte, J Christopher Octeau, Xinzhu Yu, Whitaker Cohn, Pradeep S Rajendran, Thomas M Vondriska, Julian P Whitelegge,[...]. Neuron 2017
Hua Chai, Blanca Diaz-Castro, Eiji Shigetomi, Emma Monte, J Christopher Octeau, Xinzhu Yu, Whitaker Cohn, Pradeep S Rajendran, Thomas M Vondriska, Julian P Whitelegge,[...]. Neuron 2017
11
Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism.
Niels H Skotte, Jens V Andersen, Alberto Santos, Blanca I Aldana, Cecilie W Willert, Anne Nørremølle, Helle S Waagepetersen, Michael L Nielsen. Cell Rep 2018
Niels H Skotte, Jens V Andersen, Alberto Santos, Blanca I Aldana, Cecilie W Willert, Anne Nørremølle, Helle S Waagepetersen, Michael L Nielsen. Cell Rep 2018
22
Astrocyte molecular signatures in Huntington's disease.
Blanca Diaz-Castro, Mohitkumar R Gangwani, Xinzhu Yu, Giovanni Coppola, Baljit S Khakh. Sci Transl Med 2019
Blanca Diaz-Castro, Mohitkumar R Gangwani, Xinzhu Yu, Giovanni Coppola, Baljit S Khakh. Sci Transl Med 2019
16
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
J S Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, Y Z Zhu, H Gohler, E E Wanker, G P Bates, D E Housman, L M Thompson. Proc Natl Acad Sci U S A 2000
J S Steffan, A Kazantsev, O Spasic-Boskovic, M Greenwald, Y Z Zhu, H Gohler, E E Wanker, G P Bates, D E Housman, L M Thompson. Proc Natl Acad Sci U S A 2000
10
Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules.
Laurent R Gauthier, Bénédicte C Charrin, Maria Borrell-Pagès, Jim P Dompierre, Hélène Rangone, Fabrice P Cordelières, Jan De Mey, Marcy E MacDonald, Volkmar Lessmann, Sandrine Humbert,[...]. Cell 2004
Laurent R Gauthier, Bénédicte C Charrin, Maria Borrell-Pagès, Jim P Dompierre, Hélène Rangone, Fabrice P Cordelières, Jan De Mey, Marcy E MacDonald, Volkmar Lessmann, Sandrine Humbert,[...]. Cell 2004
10
Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease.
Cécile Meunier, Nicolas Merienne, Charlotte Jollé, Nicole Déglon, Luc Pellerin. Glia 2016
Cécile Meunier, Nicolas Merienne, Charlotte Jollé, Nicole Déglon, Luc Pellerin. Glia 2016
40
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.