A citation-based method for searching scientific literature

Ivana Bjedov, Janne M Toivonen, Fiona Kerr, Cathy Slack, Jake Jacobson, Andrea Foley, Linda Partridge. Cell Metab 2010
Times Cited: 611







List of co-cited articles
1242 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.
David E Harrison, Randy Strong, Zelton Dave Sharp, James F Nelson, Clinton M Astle, Kevin Flurkey, Nancy L Nadon, J Erby Wilkinson, Krystyna Frenkel, Christy S Carter,[...]. Nature 2009
40

The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
27

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Stacey Robida-Stubbs, Kira Glover-Cutter, Dudley W Lamming, Masaki Mizunuma, Sri Devi Narasimhan, Elke Neumann-Haefelin, David M Sabatini, T Keith Blackwell. Cell Metab 2012
347
22

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.
Pankaj Kapahi, Brian M Zid, Tony Harper, Daniel Koslover, Viveca Sapin, Seymour Benzer. Curr Biol 2004
880
21

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
760
18

Extension of chronological life span in yeast by decreased TOR pathway signaling.
R Wilson Powers, Matt Kaeberlein, Seth D Caldwell, Brian K Kennedy, Stanley Fields. Genes Dev 2006
650
17

mTOR is a key modulator of ageing and age-related disease.
Simon C Johnson, Peter S Rabinovitch, Matt Kaeberlein. Nature 2013
940
16

Extending healthy life span--from yeast to humans.
Luigi Fontana, Linda Partridge, Valter D Longo. Science 2010
15

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Richard A Miller, David E Harrison, C M Astle, Joseph A Baur, Angela Rodriguez Boyd, Rafael de Cabo, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, James F Nelson,[...]. J Gerontol A Biol Sci Med Sci 2011
581
13

Genetics: influence of TOR kinase on lifespan in C. elegans.
Tibor Vellai, Krisztina Takacs-Vellai, Yue Zhang, Attila L Kovacs, László Orosz, Fritz Müller. Nature 2003
723
13

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
13

The genetics of ageing.
Cynthia J Kenyon. Nature 2010
12

mTOR inhibition improves immune function in the elderly.
Joan B Mannick, Giuseppe Del Giudice, Maria Lattanzi, Nicholas M Valiante, Jens Praestgaard, Baisong Huang, Michael A Lonetto, Holden T Maecker, John Kovarik, Simon Carson,[...]. Sci Transl Med 2014
357
12

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients.
Matt Kaeberlein, R Wilson Powers, Kristan K Steffen, Eric A Westman, Di Hu, Nick Dang, Emily O Kerr, Kathryn T Kirkland, Stanley Fields, Brian K Kennedy. Science 2005
907
12

A role for autophagy in the extension of lifespan by dietary restriction in C. elegans.
Malene Hansen, Abha Chandra, Laura L Mitic, Brian Onken, Monica Driscoll, Cynthia Kenyon. PLoS Genet 2008
476
11

Induction of autophagy by spermidine promotes longevity.
Tobias Eisenberg, Heide Knauer, Alexandra Schauer, Sabrina Büttner, Christoph Ruckenstuhl, Didac Carmona-Gutierrez, Julia Ring, Sabrina Schroeder, Christoph Magnes, Lucia Antonacci,[...]. Nat Cell Biol 2009
880
11

Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.
J Julie Wu, Jie Liu, Edmund B Chen, Jennifer J Wang, Liu Cao, Nisha Narayan, Marie M Fergusson, Ilsa I Rovira, Michele Allen, Danielle A Springer,[...]. Cell Rep 2013
189
11


Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans.
Malene Hansen, Stefan Taubert, Douglas Crawford, Nataliya Libina, Seung-Jae Lee, Cynthia Kenyon. Aging Cell 2007
558
10

Caloric restriction delays disease onset and mortality in rhesus monkeys.
Ricki J Colman, Rozalyn M Anderson, Sterling C Johnson, Erik K Kastman, Kristopher J Kosmatka, T Mark Beasley, David B Allison, Christina Cruzen, Heather A Simmons, Joseph W Kemnitz,[...]. Science 2009
10

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice.
Álvaro F Fernández, Salwa Sebti, Yongjie Wei, Zhongju Zou, Mingjun Shi, Kathryn L McMillan, Congcong He, Tabitha Ting, Yang Liu, Wei-Chung Chiang,[...]. Nature 2018
238
10

Metformin as a Tool to Target Aging.
Nir Barzilai, Jill P Crandall, Stephen B Kritchevsky, Mark A Espeland. Cell Metab 2016
426
10

TORC1 inhibition enhances immune function and reduces infections in the elderly.
Joan B Mannick, Melody Morris, Hans-Ulrich P Hockey, Guglielmo Roma, Martin Beibel, Kenneth Kulmatycki, Mollie Watkins, Tea Shavlakadze, Weihua Zhou, Dean Quinn,[...]. Sci Transl Med 2018
162
10

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice.
Martin Holzenberger, Joëlle Dupont, Bertrand Ducos, Patricia Leneuve, Alain Géloën, Patrick C Even, Pascale Cervera, Yves Le Bouc. Nature 2003
10

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
D J Clancy, D Gems, L G Harshman, S Oldham, H Stocker, E Hafen, S J Leevers, L Partridge. Science 2001
986
10

Metformin improves healthspan and lifespan in mice.
Alejandro Martin-Montalvo, Evi M Mercken, Sarah J Mitchell, Hector H Palacios, Patricia L Mote, Morten Scheibye-Knudsen, Ana P Gomes, Theresa M Ward, Robin K Minor, Marie-José Blouin,[...]. Nat Commun 2013
690
10

Rapamycin slows aging in mice.
John E Wilkinson, Lisa Burmeister, Susan V Brooks, Chi-Chao Chan, Sabrina Friedline, David E Harrison, James F Hejtmancik, Nancy Nadon, Randy Strong, Lauren K Wood,[...]. Aging Cell 2012
394
10

A C. elegans mutant that lives twice as long as wild type.
C Kenyon, J Chang, E Gensch, A Rudner, R Tabtiang. Nature 1993
10

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila.
Richard C Grandison, Matthew D W Piper, Linda Partridge. Nature 2009
439
9

TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
9

Overexpression of Atg5 in mice activates autophagy and extends lifespan.
Jong-Ok Pyo, Seung-Min Yoo, Hye-Hyun Ahn, Jihoon Nah, Se-Hoon Hong, Tae-In Kam, Sunmin Jung, Yong-Keun Jung. Nat Commun 2013
372
9

AMPK modulates tissue and organismal aging in a non-cell-autonomous manner.
Matthew Ulgherait, Anil Rana, Michael Rera, Jacqueline Graniel, David W Walker. Cell Rep 2014
142
9

Molecular evolution and functional characterization of Drosophila insulin-like peptides.
Sebastian Grönke, David-Francis Clarke, Susan Broughton, T Daniel Andrews, Linda Partridge. PLoS Genet 2010
358
9

Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans.
Márton L Tóth, Tímea Sigmond, Eva Borsos, János Barna, Péter Erdélyi, Krisztina Takács-Vellai, László Orosz, Attila L Kovács, György Csikós, Miklós Sass,[...]. Autophagy 2008
276
9

mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
9

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.
Dudley W Lamming, Lan Ye, Pekka Katajisto, Marcus D Goncalves, Maki Saitoh, Deanna M Stevens, James G Davis, Adam B Salmon, Arlan Richardson, Rexford S Ahima,[...]. Science 2012
727
9

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.
Wilson C Fok, Yidong Chen, Alex Bokov, Yiqiang Zhang, Adam B Salmon, Vivian Diaz, Martin Javors, William H Wood, Yongqing Zhang, Kevin G Becker,[...]. PLoS One 2014
83
10

Autophagy maintains stemness by preventing senescence.
Laura García-Prat, Marta Martínez-Vicente, Eusebio Perdiguero, Laura Ortet, Javier Rodríguez-Ubreva, Elena Rebollo, Vanessa Ruiz-Bonilla, Susana Gutarra, Esteban Ballestar, Antonio L Serrano,[...]. Nature 2016
633
8

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Brinda Ravikumar, Coralie Vacher, Zdenek Berger, Janet E Davies, Shouqing Luo, Lourdes G Oroz, Francesco Scaravilli, Douglas F Easton, Rainer Duden, Cahir J O'Kane,[...]. Nat Genet 2004
8

Autophagy genes are essential for dauer development and life-span extension in C. elegans.
Alicia Meléndez, Zsolt Tallóczy, Matthew Seaman, Eeva-Liisa Eskelinen, David H Hall, Beth Levine. Science 2003
919
8

Facing up to the global challenges of ageing.
Linda Partridge, Joris Deelen, P Eline Slagboom. Nature 2018
224
8

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.
Richard A Miller, David E Harrison, Clinton M Astle, Elizabeth Fernandez, Kevin Flurkey, Melissa Han, Martin A Javors, Xinna Li, Nancy L Nadon, James F Nelson,[...]. Aging Cell 2014
294
8

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands.
Susan J Broughton, Matthew D W Piper, Tomoatsu Ikeya, Timothy M Bass, Jake Jacobson, Yasmine Driege, Pedro Martinez, Ernst Hafen, Dominic J Withers, Sally J Leevers,[...]. Proc Natl Acad Sci U S A 2005
514
8

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
M Tatar, A Kopelman, D Epstein, M P Tu, C M Yin, R S Garofalo. Science 2001
8

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith,[...]. Elife 2016
152
8

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
7

The serial cultivation of human diploid cell strains.
L HAYFLICK, P S MOORHEAD. Exp Cell Res 1961
7

Cardioprotection and lifespan extension by the natural polyamine spermidine.
Tobias Eisenberg, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger, Julia Schipke, Andreas Zimmermann, Albrecht Schmidt,[...]. Nat Med 2016
459
7

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.
Sebastian I Arriola Apelo, Dudley W Lamming. J Gerontol A Biol Sci Med Sci 2016
94
7

Autophagy and aging.
David C Rubinsztein, Guillermo Mariño, Guido Kroemer. Cell 2011
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.