Marcia C Haigis, David A Sinclair. Annu Rev Pathol 2010
Times Cited: 1443
Times Cited: 1443
Times Cited
Times Co-cited
Similarity
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.
S Imai, C M Armstrong, M Kaeberlein, L Guarente. Nature 2000
S Imai, C M Armstrong, M Kaeberlein, L Guarente. Nature 2000
14
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
Konrad T Howitz, Kevin J Bitterman, Haim Y Cohen, Dudley W Lamming, Siva Lavu, Jason G Wood, Robert E Zipkin, Phuong Chung, Anne Kisielewski, Li-Li Zhang,[...]. Nature 2003
11
Sirtuins in mammals: insights into their biological function.
Shaday Michan, David Sinclair. Biochem J 2007
Shaday Michan, David Sinclair. Biochem J 2007
11
Sirtuins as regulators of metabolism and healthspan.
Riekelt H Houtkooper, Eija Pirinen, Johan Auwerx. Nat Rev Mol Cell Biol 2012
Riekelt H Houtkooper, Eija Pirinen, Johan Auwerx. Nat Rev Mol Cell Biol 2012
10
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Anne Brunet, Lora B Sweeney, J Fitzhugh Sturgill, Katrin F Chua, Paul L Greer, Yingxi Lin, Hien Tran, Sarah E Ross, Raul Mostoslavsky, Haim Y Cohen,[...]. Science 2004
Anne Brunet, Lora B Sweeney, J Fitzhugh Sturgill, Katrin F Chua, Paul L Greer, Yingxi Lin, Hien Tran, Sarah E Ross, Raul Mostoslavsky, Haim Y Cohen,[...]. Science 2004
10
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.
Michael S Bonkowski, David A Sinclair. Nat Rev Mol Cell Biol 2016
Michael S Bonkowski, David A Sinclair. Nat Rev Mol Cell Biol 2016
8
Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.
Alice E Kane, David A Sinclair. Circ Res 2018
Alice E Kane, David A Sinclair. Circ Res 2018
8
The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
7
SIRT1 and other sirtuins in metabolism.
Hung-Chun Chang, Leonard Guarente. Trends Endocrinol Metab 2014
Hung-Chun Chang, Leonard Guarente. Trends Endocrinol Metab 2014
7
7
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Marcia C Haigis, Raul Mostoslavsky, Kevin M Haigis, Kamau Fahie, Danos C Christodoulou, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Margaret Karow, Gil Blander,[...]. Cell 2006
Marcia C Haigis, Raul Mostoslavsky, Kevin M Haigis, Kamau Fahie, Danos C Christodoulou, Andrew J Murphy, David M Valenzuela, George D Yancopoulos, Margaret Karow, Gil Blander,[...]. Cell 2006
7
Recent progress in the biology and physiology of sirtuins.
Toren Finkel, Chu-Xia Deng, Raul Mostoslavsky. Nature 2009
Toren Finkel, Chu-Xia Deng, Raul Mostoslavsky. Nature 2009
7
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
H Vaziri, S K Dessain, E Ng Eaton, S I Imai, R A Frye, T K Pandita, L Guarente, R A Weinberg. Cell 2001
H Vaziri, S K Dessain, E Ng Eaton, S I Imai, R A Frye, T K Pandita, L Guarente, R A Weinberg. Cell 2001
7
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, Marty W Mayo. EMBO J 2004
Fan Yeung, Jamie E Hoberg, Catherine S Ramsey, Michael D Keller, David R Jones, Roy A Frye, Marty W Mayo. EMBO J 2004
7
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.
Matthew D Hirschey, Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B Lombard, Carrie A Grueter, Charles Harris, Sudha Biddinger, Olga R Ilkayeva,[...]. Nature 2010
Matthew D Hirschey, Tadahiro Shimazu, Eric Goetzman, Enxuan Jing, Bjoern Schwer, David B Lombard, Carrie A Grueter, Charles Harris, Sudha Biddinger, Olga R Ilkayeva,[...]. Nature 2010
7
Sirt1 regulates aging and resistance to oxidative stress in the heart.
Ralph R Alcendor, Shumin Gao, Peiyong Zhai, Daniela Zablocki, Eric Holle, Xianzhong Yu, Bin Tian, Thomas Wagner, Stephen F Vatner, Junichi Sadoshima. Circ Res 2007
Ralph R Alcendor, Shumin Gao, Peiyong Zhai, Daniela Zablocki, Eric Holle, Xianzhong Yu, Bin Tian, Thomas Wagner, Stephen F Vatner, Junichi Sadoshima. Circ Res 2007
7
Sirtuin activators and inhibitors: Promises, achievements, and challenges.
Han Dai, David A Sinclair, James L Ellis, Clemens Steegborn. Pharmacol Ther 2018
Han Dai, David A Sinclair, James L Ellis, Clemens Steegborn. Pharmacol Ther 2018
7
An overview of Sirtuins as potential therapeutic target: Structure, function and modulators.
Yijie Wang, Jun He, Mengya Liao, Mingxing Hu, Wenzhen Li, Hongling Ouyang, Xin Wang, Tinghong Ye, Yiwen Zhang, Liang Ouyang. Eur J Med Chem 2019
Yijie Wang, Jun He, Mengya Liao, Mingxing Hu, Wenzhen Li, Hongling Ouyang, Xin Wang, Tinghong Ye, Yiwen Zhang, Liang Ouyang. Eur J Med Chem 2019
7
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.
R A Frye. Biochem Biophys Res Commun 2000
R A Frye. Biochem Biophys Res Commun 2000
7
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction.
Shinichi Someya, Wei Yu, William C Hallows, Jinze Xu, James M Vann, Christiaan Leeuwenburgh, Masaru Tanokura, John M Denu, Tomas A Prolla. Cell 2010
Shinichi Someya, Wei Yu, William C Hallows, Jinze Xu, James M Vann, Christiaan Leeuwenburgh, Masaru Tanokura, John M Denu, Tomas A Prolla. Cell 2010
6
The sirtuin SIRT6 regulates lifespan in male mice.
Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph, Haim Y Cohen. Nature 2012
Yariv Kanfi, Shoshana Naiman, Gail Amir, Victoria Peshti, Guy Zinman, Liat Nahum, Ziv Bar-Joseph, Haim Y Cohen. Nature 2012
6
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Joseph T Rodgers, Carlos Lerin, Wilhelm Haas, Steven P Gygi, Bruce M Spiegelman, Pere Puigserver. Nature 2005
Joseph T Rodgers, Carlos Lerin, Wilhelm Haas, Steven P Gygi, Bruce M Spiegelman, Pere Puigserver. Nature 2005
6
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
David B Lombard, Frederick W Alt, Hwei-Ling Cheng, Jakob Bunkenborg, Ryan S Streeper, Raul Mostoslavsky, Jennifer Kim, George Yancopoulos, David Valenzuela, Andrew Murphy,[...]. Mol Cell Biol 2007
David B Lombard, Frederick W Alt, Hwei-Ling Cheng, Jakob Bunkenborg, Ryan S Streeper, Raul Mostoslavsky, Jennifer Kim, George Yancopoulos, David Valenzuela, Andrew Murphy,[...]. Mol Cell Biol 2007
6
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.
Eriko Michishita, Jean Y Park, Jenna M Burneskis, J Carl Barrett, Izumi Horikawa. Mol Biol Cell 2005
Eriko Michishita, Jean Y Park, Jenna M Burneskis, J Carl Barrett, Izumi Horikawa. Mol Biol Cell 2005
6
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
Bong-Hyun Ahn, Hyun-Seok Kim, Shiwei Song, In Hye Lee, Jie Liu, Athanassios Vassilopoulos, Chu-Xia Deng, Toren Finkel. Proc Natl Acad Sci U S A 2008
Bong-Hyun Ahn, Hyun-Seok Kim, Shiwei Song, In Hye Lee, Jie Liu, Athanassios Vassilopoulos, Chu-Xia Deng, Toren Finkel. Proc Natl Acad Sci U S A 2008
6
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Tiago Fleming Outeiro, Eirene Kontopoulos, Stephen M Altmann, Irina Kufareva, Katherine E Strathearn, Allison M Amore, Catherine B Volk, Michele M Maxwell, Jean-Christophe Rochet, Pamela J McLean,[...]. Science 2007
Tiago Fleming Outeiro, Eirene Kontopoulos, Stephen M Altmann, Irina Kufareva, Katherine E Strathearn, Allison M Amore, Catherine B Volk, Michele M Maxwell, Jean-Christophe Rochet, Pamela J McLean,[...]. Science 2007
6
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders.
Anu Kauppinen, Tiina Suuronen, Johanna Ojala, Kai Kaarniranta, Antero Salminen. Cell Signal 2013
Anu Kauppinen, Tiina Suuronen, Johanna Ojala, Kai Kaarniranta, Antero Salminen. Cell Signal 2013
5
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Jintang Du, Yeyun Zhou, Xiaoyang Su, Jiu Jiu Yu, Saba Khan, Hong Jiang, Jungwoo Kim, Jimin Woo, Jun Huyn Kim, Brian Hyun Choi,[...]. Science 2011
Jintang Du, Yeyun Zhou, Xiaoyang Su, Jiu Jiu Yu, Saba Khan, Hong Jiang, Jungwoo Kim, Jimin Woo, Jun Huyn Kim, Brian Hyun Choi,[...]. Science 2011
5
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.
Tiara L A Kawahara, Eriko Michishita, Adam S Adler, Mara Damian, Elisabeth Berber, Meihong Lin, Ron A McCord, Kristine C L Ongaigui, Lisa D Boxer, Howard Y Chang,[...]. Cell 2009
Tiara L A Kawahara, Eriko Michishita, Adam S Adler, Mara Damian, Elisabeth Berber, Meihong Lin, Ron A McCord, Kristine C L Ongaigui, Lisa D Boxer, Howard Y Chang,[...]. Cell 2009
5
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae.
S J Lin, P A Defossez, L Guarente. Science 2000
S J Lin, P A Defossez, L Guarente. Science 2000
5
Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.
Olesya Vakhrusheva, Christian Smolka, Praveen Gajawada, Sawa Kostin, Thomas Boettger, Thomas Kubin, Thomas Braun, Eva Bober. Circ Res 2008
Olesya Vakhrusheva, Christian Smolka, Praveen Gajawada, Sawa Kostin, Thomas Boettger, Thomas Kubin, Thomas Braun, Eva Bober. Circ Res 2008
5
miR-34a repression of SIRT1 regulates apoptosis.
Munekazu Yamakuchi, Marcella Ferlito, Charles J Lowenstein. Proc Natl Acad Sci U S A 2008
Munekazu Yamakuchi, Marcella Ferlito, Charles J Lowenstein. Proc Natl Acad Sci U S A 2008
5
Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1.
Masaya Tanno, Jun Sakamoto, Tetsuji Miura, Kazuaki Shimamoto, Yoshiyuki Horio. J Biol Chem 2007
Masaya Tanno, Jun Sakamoto, Tetsuji Miura, Kazuaki Shimamoto, Yoshiyuki Horio. J Biol Chem 2007
5
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.
Hongying Yang, Tianle Yang, Joseph A Baur, Evelyn Perez, Takashi Matsui, Juan J Carmona, Dudley W Lamming, Nadja C Souza-Pinto, Vilhelm A Bohr, Anthony Rosenzweig,[...]. Cell 2007
Hongying Yang, Tianle Yang, Joseph A Baur, Evelyn Perez, Takashi Matsui, Juan J Carmona, Dudley W Lamming, Nadja C Souza-Pinto, Vilhelm A Bohr, Anthony Rosenzweig,[...]. Cell 2007
5
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.
Yasukazu Nakahata, Saurabh Sahar, Giuseppe Astarita, Milota Kaluzova, Paolo Sassone-Corsi. Science 2009
Yasukazu Nakahata, Saurabh Sahar, Giuseppe Astarita, Milota Kaluzova, Paolo Sassone-Corsi. Science 2009
5
SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
Gad Asher, David Gatfield, Markus Stratmann, Hans Reinke, Charna Dibner, Florian Kreppel, Raul Mostoslavsky, Frederick W Alt, Ueli Schibler. Cell 2008
Gad Asher, David Gatfield, Markus Stratmann, Hans Reinke, Charna Dibner, Florian Kreppel, Raul Mostoslavsky, Frederick W Alt, Ueli Schibler. Cell 2008
5
SIRT1 Activation by Natural Phytochemicals: An Overview.
Concetta Iside, Marika Scafuro, Angela Nebbioso, Lucia Altucci. Front Pharmacol 2020
Concetta Iside, Marika Scafuro, Angela Nebbioso, Lucia Altucci. Front Pharmacol 2020
6
SIRT1 is downregulated by autophagy in senescence and ageing.
Caiyue Xu, Lu Wang, Parinaz Fozouni, Gry Evjen, Vemika Chandra, Jing Jiang, Congcong Lu, Michael Nicastri, Corey Bretz, Jeffrey D Winkler,[...]. Nat Cell Biol 2020
Caiyue Xu, Lu Wang, Parinaz Fozouni, Gry Evjen, Vemika Chandra, Jing Jiang, Congcong Lu, Michael Nicastri, Corey Bretz, Jeffrey D Winkler,[...]. Nat Cell Biol 2020
5
The Role of Sirtuins in Antioxidant and Redox Signaling.
Chandra K Singh, Gagan Chhabra, Mary Ann Ndiaye, Liz Mariely Garcia-Peterson, Nicholas J Mack, Nihal Ahmad. Antioxid Redox Signal 2018
Chandra K Singh, Gagan Chhabra, Mary Ann Ndiaye, Liz Mariely Garcia-Peterson, Nicholas J Mack, Nihal Ahmad. Antioxid Redox Signal 2018
5
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.
Riekelt H Houtkooper, Carles Cantó, Ronald J Wanders, Johan Auwerx. Endocr Rev 2010
Riekelt H Houtkooper, Carles Cantó, Ronald J Wanders, Johan Auwerx. Endocr Rev 2010
5
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
In Hye Lee, Liu Cao, Raul Mostoslavsky, David B Lombard, Jie Liu, Nicholas E Bruns, Maria Tsokos, Frederick W Alt, Toren Finkel. Proc Natl Acad Sci U S A 2008
In Hye Lee, Liu Cao, Raul Mostoslavsky, David B Lombard, Jie Liu, Nicholas E Bruns, Maria Tsokos, Frederick W Alt, Toren Finkel. Proc Natl Acad Sci U S A 2008
5
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
H A Tissenbaum, L Guarente. Nature 2001
H A Tissenbaum, L Guarente. Nature 2001
5
Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man.
Ethan Hoffmann, Jeff Wald, Siva Lavu, John Roberts, Claire Beaumont, Jon Haddad, Peter Elliott, Christoph Westphal, Eric Jacobson. Br J Clin Pharmacol 2013
Ethan Hoffmann, Jeff Wald, Siva Lavu, John Roberts, Claire Beaumont, Jon Haddad, Peter Elliott, Christoph Westphal, Eric Jacobson. Br J Clin Pharmacol 2013
5
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Jill C Milne, Philip D Lambert, Simon Schenk, David P Carney, Jesse J Smith, David J Gagne, Lei Jin, Olivier Boss, Robert B Perni, Chi B Vu,[...]. Nature 2007
Jill C Milne, Philip D Lambert, Simon Schenk, David P Carney, Jesse J Smith, David J Gagne, Lei Jin, Olivier Boss, Robert B Perni, Chi B Vu,[...]. Nature 2007
5
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
Brian J North, Brett L Marshall, Margie T Borra, John M Denu, Eric Verdin. Mol Cell 2003
Brian J North, Brett L Marshall, Margie T Borra, John M Denu, Eric Verdin. Mol Cell 2003
5
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
Carles Cantó, Zachary Gerhart-Hines, Jerome N Feige, Marie Lagouge, Lilia Noriega, Jill C Milne, Peter J Elliott, Pere Puigserver, Johan Auwerx. Nature 2009
Carles Cantó, Zachary Gerhart-Hines, Jerome N Feige, Marie Lagouge, Lilia Noriega, Jill C Milne, Peter J Elliott, Pere Puigserver, Johan Auwerx. Nature 2009
5
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Nathan L Price, Ana P Gomes, Alvin J Y Ling, Filipe V Duarte, Alejandro Martin-Montalvo, Brian J North, Beamon Agarwal, Lan Ye, Giorgio Ramadori, Joao S Teodoro,[...]. Cell Metab 2012
Nathan L Price, Ana P Gomes, Alvin J Y Ling, Filipe V Duarte, Alejandro Martin-Montalvo, Brian J North, Beamon Agarwal, Lan Ye, Giorgio Ramadori, Joao S Teodoro,[...]. Cell Metab 2012
4
The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice.
Lindsey B Gano, Anthony J Donato, Hamza M Pasha, Christopher M Hearon, Amy L Sindler, Douglas R Seals. Am J Physiol Heart Circ Physiol 2014
Lindsey B Gano, Anthony J Donato, Hamza M Pasha, Christopher M Hearon, Amy L Sindler, Douglas R Seals. Am J Physiol Heart Circ Physiol 2014
4
NAD+ metabolism and its roles in cellular processes during ageing.
Anthony J Covarrubias, Rosalba Perrone, Alessia Grozio, Eric Verdin. Nat Rev Mol Cell Biol 2021
Anthony J Covarrubias, Rosalba Perrone, Alessia Grozio, Eric Verdin. Nat Rev Mol Cell Biol 2021
4
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
Colin Selman, Jennifer M A Tullet, Daniela Wieser, Elaine Irvine, Steven J Lingard, Agharul I Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani,[...]. Science 2009
4
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.