Kaspar Burger, Bastian Mühl, Thomas Harasim, Michaela Rohrmoser, Anastassia Malamoussi, Mathias Orban, Markus Kellner, Anita Gruber-Eber, Elisabeth Kremmer, Michael Hölzel, Dirk Eick. J Biol Chem 2010
Times Cited: 262
Times Cited: 262
Times Cited
Times Co-cited
Similarity
Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.
Denis Drygin, Amy Lin, Josh Bliesath, Caroline B Ho, Sean E O'Brien, Chris Proffitt, Mayuko Omori, Mustapha Haddach, Michael K Schwaebe, Adam Siddiqui-Jain,[...]. Cancer Res 2011
Denis Drygin, Amy Lin, Josh Bliesath, Caroline B Ho, Sean E O'Brien, Chris Proffitt, Mayuko Omori, Mustapha Haddach, Michael K Schwaebe, Adam Siddiqui-Jain,[...]. Cancer Res 2011
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Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.
Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes,[...]. Cancer Cell 2012
Megan J Bywater, Gretchen Poortinga, Elaine Sanij, Nadine Hein, Abigail Peck, Carleen Cullinane, Meaghan Wall, Leonie Cluse, Denis Drygin, Kenna Anderes,[...]. Cancer Cell 2012
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The nucleolus under stress.
Séverine Boulon, Belinda J Westman, Saskia Hutten, François-Michel Boisvert, Angus I Lamond. Mol Cell 2010
Séverine Boulon, Belinda J Westman, Saskia Hutten, François-Michel Boisvert, Angus I Lamond. Mol Cell 2010
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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.
Karita Peltonen, Laureen Colis, Hester Liu, Rishi Trivedi, Michael S Moubarek, Henna M Moore, Baoyan Bai, Michelle A Rudek, Charles J Bieberich, Marikki Laiho. Cancer Cell 2014
Karita Peltonen, Laureen Colis, Hester Liu, Rishi Trivedi, Michael S Moubarek, Henna M Moore, Baoyan Bai, Michelle A Rudek, Charles J Bieberich, Marikki Laiho. Cancer Cell 2014
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A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.
Peter M Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E Koch, Timothy J Eisen, Justin R Pritchard, Yves Pommier, Stephen J Lippard, Michael T Hemann. Nat Med 2017
Peter M Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E Koch, Timothy J Eisen, Justin R Pritchard, Yves Pommier, Stephen J Lippard, Michael T Hemann. Nat Med 2017
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J O'Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia,[...]. Nat Commun 2017
Hong Xu, Marco Di Antonio, Steven McKinney, Veena Mathew, Brandon Ho, Nigel J O'Neil, Nancy Dos Santos, Jennifer Silvester, Vivien Wei, Jessica Garcia,[...]. Nat Commun 2017
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Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses.
Carlos P Rubbi, Jo Milner. EMBO J 2003
Carlos P Rubbi, Jo Milner. EMBO J 2003
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The multifunctional nucleolus.
François-Michel Boisvert, Silvana van Koningsbruggen, Joaquín Navascués, Angus I Lamond. Nat Rev Mol Cell Biol 2007
François-Michel Boisvert, Silvana van Koningsbruggen, Joaquín Navascués, Angus I Lamond. Nat Rev Mol Cell Biol 2007
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Ribosome biogenesis in cancer: new players and therapeutic avenues.
Joffrey Pelletier, George Thomas, Siniša Volarević. Nat Rev Cancer 2018
Joffrey Pelletier, George Thomas, Siniša Volarević. Nat Rev Cancer 2018
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The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.
Denis Drygin, William G Rice, Ingrid Grummt. Annu Rev Pharmacol Toxicol 2010
Denis Drygin, William G Rice, Ingrid Grummt. Annu Rev Pharmacol Toxicol 2010
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Targeting the nucleolus for cancer intervention.
Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan. Biochim Biophys Acta 2014
Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan. Biochim Biophys Acta 2014
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MYC as a regulator of ribosome biogenesis and protein synthesis.
Jan van Riggelen, Alper Yetil, Dean W Felsher. Nat Rev Cancer 2010
Jan van Riggelen, Alper Yetil, Dean W Felsher. Nat Rev Cancer 2010
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p53 and ribosome biogenesis stress: the essentials.
Lior Golomb, Sinisa Volarevic, Moshe Oren. FEBS Lett 2014
Lior Golomb, Sinisa Volarevic, Moshe Oren. FEBS Lett 2014
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5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.
Giulio Donati, Suresh Peddigari, Carol A Mercer, George Thomas. Cell Rep 2013
Giulio Donati, Suresh Peddigari, Carol A Mercer, George Thomas. Cell Rep 2013
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Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Henna M Moore, Juulia Enbäck, Pirjo Laakkonen, Anne Vaahtokari, Richard J Jones, Taija M af Hällström,[...]. PLoS One 2010
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Henna M Moore, Juulia Enbäck, Pirjo Laakkonen, Anne Vaahtokari, Richard J Jones, Taija M af Hällström,[...]. PLoS One 2010
24
Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis.
Denis Drygin, Adam Siddiqui-Jain, Sean O'Brien, Michael Schwaebe, Amy Lin, Josh Bliesath, Caroline B Ho, Chris Proffitt, Katy Trent, Jeffrey P Whitten,[...]. Cancer Res 2009
Denis Drygin, Adam Siddiqui-Jain, Sean O'Brien, Michael Schwaebe, Amy Lin, Josh Bliesath, Caroline B Ho, Chris Proffitt, Katy Trent, Jeffrey P Whitten,[...]. Cancer Res 2009
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What the nucleolus says to a tumour pathologist.
Massimo Derenzini, Lorenzo Montanaro, Davide Treré. Histopathology 2009
Massimo Derenzini, Lorenzo Montanaro, Davide Treré. Histopathology 2009
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The nucleolus: an emerging target for cancer therapy.
Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan. Trends Mol Med 2013
Nadine Hein, Katherine M Hannan, Amee J George, Elaine Sanij, Ross D Hannan. Trends Mol Med 2013
15
Dynamic sorting of nuclear components into distinct nucleolar caps during transcriptional inhibition.
Yaron Shav-Tal, Janna Blechman, Xavier Darzacq, Cristina Montagna, Billy T Dye, James G Patton, Robert H Singer, Dov Zipori. Mol Biol Cell 2005
Yaron Shav-Tal, Janna Blechman, Xavier Darzacq, Cristina Montagna, Billy T Dye, James G Patton, Robert H Singer, Dov Zipori. Mol Biol Cell 2005
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14
Ribosome biogenesis: An emerging druggable pathway for cancer therapeutics.
Frédéric Catez, Nicole Dalla Venezia, Virginie Marcel, Christiane Zorbas, Denis L J Lafontaine, Jean-Jacques Diaz. Biochem Pharmacol 2019
Frédéric Catez, Nicole Dalla Venezia, Virginie Marcel, Christiane Zorbas, Denis L J Lafontaine, Jean-Jacques Diaz. Biochem Pharmacol 2019
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Nucleolar stress with and without p53.
Allison James, Yubo Wang, Himanshu Raje, Raphyel Rosby, Patrick DiMario. Nucleus 2014
Allison James, Yubo Wang, Himanshu Raje, Raphyel Rosby, Patrick DiMario. Nucleus 2014
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Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.
Mikael S Lindström, Deana Jurada, Sladana Bursac, Ines Orsolic, Jiri Bartek, Sinisa Volarevic. Oncogene 2018
Mikael S Lindström, Deana Jurada, Sladana Bursac, Ines Orsolic, Jiri Bartek, Sinisa Volarevic. Oncogene 2018
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Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress.
Emilien Nicolas, Pascaline Parisot, Celina Pinto-Monteiro, Roxane de Walque, Christophe De Vleeschouwer, Denis L J Lafontaine. Nat Commun 2016
Emilien Nicolas, Pascaline Parisot, Celina Pinto-Monteiro, Roxane de Walque, Christophe De Vleeschouwer, Denis L J Lafontaine. Nat Commun 2016
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Coexisting Liquid Phases Underlie Nucleolar Subcompartments.
Marina Feric, Nilesh Vaidya, Tyler S Harmon, Diana M Mitrea, Lian Zhu, Tiffany M Richardson, Richard W Kriwacki, Rohit V Pappu, Clifford P Brangwynne. Cell 2016
Marina Feric, Nilesh Vaidya, Tyler S Harmon, Diana M Mitrea, Lian Zhu, Tiffany M Richardson, Richard W Kriwacki, Rohit V Pappu, Clifford P Brangwynne. Cell 2016
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First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study.
Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery,[...]. Cancer Discov 2019
Amit Khot, Natalie Brajanovski, Donald P Cameron, Nadine Hein, Kylee H Maclachlan, Elaine Sanij, John Lim, John Soong, Emma Link, Piers Blombery,[...]. Cancer Discov 2019
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Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age.
Rita Ferreira, John S Schneekloth, Konstantin I Panov, Katherine M Hannan, Ross D Hannan. Cells 2020
Rita Ferreira, John S Schneekloth, Konstantin I Panov, Katherine M Hannan, Ross D Hannan. Cells 2020
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Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress.
Sladana Bursać, Maja Cokarić Brdovčak, Martin Pfannkuchen, Ines Orsolić, Lior Golomb, Yan Zhu, Chen Katz, Lilyn Daftuar, Kristina Grabušić, Iva Vukelić,[...]. Proc Natl Acad Sci U S A 2012
Sladana Bursać, Maja Cokarić Brdovčak, Martin Pfannkuchen, Ines Orsolić, Lior Golomb, Yan Zhu, Chen Katz, Lilyn Daftuar, Kristina Grabušić, Iva Vukelić,[...]. Proc Natl Acad Sci U S A 2012
11
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis.
Sladana Bursac, Maja Cokaric Brdovcak, Giulio Donati, Sinisa Volarevic. Biochim Biophys Acta 2014
Sladana Bursac, Maja Cokaric Brdovcak, Giulio Donati, Sinisa Volarevic. Biochim Biophys Acta 2014
11
c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.
Azadeh Arabi, Siqin Wu, Karin Ridderstråle, Holger Bierhoff, Chiounan Shiue, Karoly Fatyol, Sara Fahlén, Per Hydbring, Ola Söderberg, Ingrid Grummt,[...]. Nat Cell Biol 2005
Azadeh Arabi, Siqin Wu, Karin Ridderstråle, Holger Bierhoff, Chiounan Shiue, Karoly Fatyol, Sara Fahlén, Per Hydbring, Ola Söderberg, Ingrid Grummt,[...]. Nat Cell Biol 2005
11
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics.
Mustapha Haddach, Michael K Schwaebe, Jerome Michaux, Johnny Nagasawa, Sean E O'Brien, Jeffrey P Whitten, Fabrice Pierre, Pauline Kerdoncuff, Levan Darjania, Ryan Stansfield,[...]. ACS Med Chem Lett 2012
Mustapha Haddach, Michael K Schwaebe, Jerome Michaux, Johnny Nagasawa, Sean E O'Brien, Jeffrey P Whitten, Fabrice Pierre, Pauline Kerdoncuff, Levan Darjania, Ryan Stansfield,[...]. ACS Med Chem Lett 2012
15
Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint.
Ting Wei, Saman M Najmi, Hester Liu, Karita Peltonen, Alena Kucerova, David A Schneider, Marikki Laiho. Cell Rep 2018
Ting Wei, Saman M Najmi, Hester Liu, Karita Peltonen, Alena Kucerova, David A Schneider, Marikki Laiho. Cell Rep 2018
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The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.
Katherine E Sloan, Markus T Bohnsack, Nicholas J Watkins. Cell Rep 2013
Katherine E Sloan, Markus T Bohnsack, Nicholas J Watkins. Cell Rep 2013
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A localized nucleolar DNA damage response facilitates recruitment of the homology-directed repair machinery independent of cell cycle stage.
Marjolein van Sluis, Brian McStay. Genes Dev 2015
Marjolein van Sluis, Brian McStay. Genes Dev 2015
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Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction.
Stefano Fumagalli, Alessandro Di Cara, Arti Neb-Gulati, Francois Natt, Sandy Schwemberger, Jonathan Hall, George F Babcock, Rosa Bernardi, Pier Paolo Pandolfi, George Thomas. Nat Cell Biol 2009
Stefano Fumagalli, Alessandro Di Cara, Arti Neb-Gulati, Francois Natt, Sandy Schwemberger, Jonathan Hall, George F Babcock, Rosa Bernardi, Pier Paolo Pandolfi, George Thomas. Nat Cell Biol 2009
10
p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.
Virginie Marcel, Sandra E Ghayad, Stéphane Belin, Gabriel Therizols, Anne-Pierre Morel, Eduardo Solano-Gonzàlez, Julie A Vendrell, Sabine Hacot, Hichem C Mertani, Marie Alexandra Albaret,[...]. Cancer Cell 2013
Virginie Marcel, Sandra E Ghayad, Stéphane Belin, Gabriel Therizols, Anne-Pierre Morel, Eduardo Solano-Gonzàlez, Julie A Vendrell, Sabine Hacot, Hichem C Mertani, Marie Alexandra Albaret,[...]. Cancer Cell 2013
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Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population.
Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch,[...]. Blood 2017
Nadine Hein, Donald P Cameron, Katherine M Hannan, Nhu-Y N Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch,[...]. Blood 2017
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Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?
Elisa Brighenti, Davide Treré, Massimo Derenzini. Oncotarget 2015
Elisa Brighenti, Davide Treré, Massimo Derenzini. Oncotarget 2015
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The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.
Simone J Woods, Katherine M Hannan, Richard B Pearson, Ross D Hannan. Biochim Biophys Acta 2015
Simone J Woods, Katherine M Hannan, Richard B Pearson, Ross D Hannan. Biochim Biophys Acta 2015
10
Nucleolar reorganization in response to rDNA damage.
Marjolein van Sluis, Brian McStay. Curr Opin Cell Biol 2017
Marjolein van Sluis, Brian McStay. Curr Opin Cell Biol 2017
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Nucleolus, ribosomes, and cancer.
Lorenzo Montanaro, Davide Treré, Massimo Derenzini. Am J Pathol 2008
Lorenzo Montanaro, Davide Treré, Massimo Derenzini. Am J Pathol 2008
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Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George,[...]. Oncotarget 2016
Jaclyn Quin, Keefe T Chan, Jennifer R Devlin, Donald P Cameron, Jeannine Diesch, Carleen Cullinane, Jessica Ahern, Amit Khot, Nadine Hein, Amee J George,[...]. Oncotarget 2016
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ATM Dependent Silencing Links Nucleolar Chromatin Reorganization to DNA Damage Recognition.
Shane M Harding, Jonathan A Boiarsky, Roger A Greenberg. Cell Rep 2015
Shane M Harding, Jonathan A Boiarsky, Roger A Greenberg. Cell Rep 2015
9
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
Michael Kruhlak, Elizabeth E Crouch, Marika Orlov, Carolina Montaño, Stanislaw A Gorski, André Nussenzweig, Tom Misteli, Robert D Phair, Rafael Casellas. Nature 2007
Michael Kruhlak, Elizabeth E Crouch, Marika Orlov, Carolina Montaño, Stanislaw A Gorski, André Nussenzweig, Tom Misteli, Robert D Phair, Rafael Casellas. Nature 2007
9
Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency.
Maria Barna, Aya Pusic, Ornella Zollo, Maria Costa, Nadya Kondrashov, Eduardo Rego, Pulivarthi H Rao, Davide Ruggero. Nature 2008
Maria Barna, Aya Pusic, Ornella Zollo, Maria Costa, Nadya Kondrashov, Eduardo Rego, Pulivarthi H Rao, Davide Ruggero. Nature 2008
9
Ribosomopathies: human disorders of ribosome dysfunction.
Anupama Narla, Benjamin L Ebert. Blood 2010
Anupama Narla, Benjamin L Ebert. Blood 2010
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Ribosome biogenesis and cancer.
Massimo Derenzini, Lorenzo Montanaro, Davide Trerè. Acta Histochem 2017
Massimo Derenzini, Lorenzo Montanaro, Davide Trerè. Acta Histochem 2017
13
Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint.
Stefano Fumagalli, Vasily V Ivanenkov, Teng Teng, George Thomas. Genes Dev 2012
Stefano Fumagalli, Vasily V Ivanenkov, Teng Teng, George Thomas. Genes Dev 2012
9
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