A citation-based method for searching scientific literature

Yan Wu, Carol Cain-Hom, Lisa Choy, Thijs J Hagenbeek, Gladys P de Leon, Yongmei Chen, David Finkle, Rayna Venook, Xiumin Wu, John Ridgway, Dorreyah Schahin-Reed, Graham J Dow, Amy Shelton, Scott Stawicki, Ryan J Watts, Jeff Zhang, Robert Choy, Peter Howard, Lisa Kadyk, Minhong Yan, Jiping Zha, Christopher A Callahan, Sarah G Hymowitz, Christian W Siebel. Nature 2010
Times Cited: 530







List of co-cited articles
1367 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Andrew P Weng, Adolfo A Ferrando, Woojoong Lee, John P Morris, Lewis B Silverman, Cheryll Sanchez-Irizarry, Stephen C Blacklow, A Thomas Look, Jon C Aster. Science 2004
25

Direct inhibition of the NOTCH transcription factor complex.
Raymond E Moellering, Melanie Cornejo, Tina N Davis, Cristina Del Bianco, Jon C Aster, Stephen C Blacklow, Andrew L Kung, D Gary Gilliland, Gregory L Verdine, James E Bradner. Nature 2009
572
23

Notch Signaling in Development, Tissue Homeostasis, and Disease.
Chris Siebel, Urban Lendahl. Physiol Rev 2017
430
23

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
Johan H van Es, Marielle E van Gijn, Orbicia Riccio, Maaike van den Born, Marc Vooijs, Harry Begthel, Miranda Cozijnsen, Sylvie Robine, Doug J Winton, Freddy Radtke,[...]. Nature 2005
23

Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.
Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko,[...]. PLoS One 2010
133
20

Therapeutic modulation of Notch signalling--are we there yet?
Emma R Andersson, Urban Lendahl. Nat Rev Drug Discov 2014
331
20

Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J Watts, Christopher Callahan, Ian Kasman,[...]. Nature 2006
746
19

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.
Orbicia Riccio, Marielle E van Gijn, April C Bezdek, Luca Pellegrinet, Johan H van Es, Ursula Zimber-Strobl, Lothar J Strobl, Tasuku Honjo, Hans Clevers, Freddy Radtke. EMBO Rep 2008
297
17

The Varied Roles of Notch in Cancer.
Jon C Aster, Warren S Pear, Stephen C Blacklow. Annu Rev Pathol 2017
337
17

Notch signalling in context.
Sarah J Bray. Nat Rev Mol Cell Biol 2016
531
16

Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts.
V Agnusdei, S Minuzzo, C Frasson, A Grassi, F Axelrod, S Satyal, A Gurney, T Hoey, E Seganfreddo, G Basso,[...]. Leukemia 2014
85
15

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
Daniel Lafkas, Amy Shelton, Cecilia Chiu, Gladys de Leon Boenig, Yongmei Chen, Scott S Stawicki, Christian Siltanen, Mike Reichelt, Meijuan Zhou, Xiumin Wu,[...]. Nature 2015
131
13

Blockade of individual Notch ligands and receptors controls graft-versus-host disease.
Ivy T Tran, Ashley R Sandy, Alexis J Carulli, Christen Ebens, Jooho Chung, Gloria T Shan, Vedran Radojcic, Ann Friedman, Thomas Gridley, Amy Shelton,[...]. J Clin Invest 2013
109
13

Notch signaling: simplicity in design, versatility in function.
Emma R Andersson, Rickard Sandberg, Urban Lendahl. Development 2011
657
13

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.
Irene Noguera-Troise, Christopher Daly, Nicholas J Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W Gale, Hsin Chieh Lin, George D Yancopoulos, Gavin Thurston. Nature 2006
789
12

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
B De Strooper, W Annaert, P Cupers, P Saftig, K Craessaerts, J S Mumm, E H Schroeter, V Schrijvers, M S Wolfe, W J Ray,[...]. Nature 1999
12

Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers.
Lisa Choy, Thijs J Hagenbeek, Margaret Solon, Dorothy French, David Finkle, Amy Shelton, Rayna Venook, Matthew J Brauer, Christian W Siebel. Cancer Res 2017
61
19

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3.
Kang Li, Yucheng Li, Wenjuan Wu, Wendy R Gordon, David W Chang, Mason Lu, Shane Scoggin, Tihui Fu, Long Vien, Gavin Histen,[...]. J Biol Chem 2008
151
12

Deficient T cell fate specification in mice with an induced inactivation of Notch1.
F Radtke, A Wilson, G Stark, M Bauer, J van Meerwijk, H R MacDonald, M Aguet. Immunity 1999
12

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
L W Ellisen, J Bird, D C West, A L Soreng, T C Reynolds, S D Smith, J Sklar. Cell 1991
12

Notch signalling: a simple pathway becomes complex.
Sarah J Bray. Nat Rev Mol Cell Biol 2006
12

A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors.
R Ferrarotto, G Eckhardt, A Patnaik, P LoRusso, L Faoro, J V Heymach, A M Kapoun, L Xu, P Munster. Ann Oncol 2018
49
24

Notch signaling: cell fate control and signal integration in development.
S Artavanis-Tsakonas, M D Rand, R J Lake. Science 1999
11

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.
Wendy R Gordon, Brandon Zimmerman, Li He, Laura J Miles, Jiuhong Huang, Kittichoat Tiyanont, Debbie G McArthur, Jon C Aster, Norbert Perrimon, Joseph J Loparo,[...]. Dev Cell 2015
177
11

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Yunsun Nam, Piotr Sliz, Luyan Song, Jon C Aster, Stephen C Blacklow. Cell 2006
322
11

Chronic DLL4 blockade induces vascular neoplasms.
Minhong Yan, Christopher A Callahan, Joseph C Beyer, Krishna P Allamneni, Gu Zhang, John Brady Ridgway, Kyle Niessen, Greg D Plowman. Nature 2010
219
11

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.
Joseph Milano, Jenny McKay, Claude Dagenais, Linda Foster-Brown, Francois Pognan, Reto Gadient, Robert T Jacobs, Anna Zacco, Barry Greenberg, Paul J Ciaccio. Toxicol Sci 2004
425
11


Notch Signaling and the Skeleton.
Stefano Zanotti, Ernesto Canalis. Endocr Rev 2016
149
10

A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.
C Papayannidis, D J DeAngelo, W Stock, B Huang, M N Shaik, R Cesari, X Zheng, J M Reynolds, P A English, M Ozeck,[...]. Blood Cancer J 2015
73
13

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition.
Roger A Habets, Charles E de Bock, Lutgarde Serneels, Inge Lodewijckx, Delphine Verbeke, David Nittner, Rajeshwar Narlawar, Sofie Demeyer, James Dooley, Adrian Liston,[...]. Sci Transl Med 2019
53
18

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia.
Pedro J Real, Valeria Tosello, Teresa Palomero, Mireia Castillo, Eva Hernando, Elisa de Stanchina, Maria Luisa Sulis, Kelly Barnes, Catherine Sawai, Irene Homminga,[...]. Nat Med 2009
331
10

Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Vincent C Luca, Kevin M Jude, Nathan W Pierce, Maxence V Nachury, Suzanne Fischer, K Christopher Garcia. Science 2015
163
10

A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors.
David C Smith, Peter D Eisenberg, Georgy Manikhas, Rashmi Chugh, Matthew A Gubens, Robert J Stagg, Ann M Kapoun, Lu Xu, Jakob Dupont, Branimir Sikic. Clin Cancer Res 2014
99
10

Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.
Wan-Ching Yen, Marcus M Fischer, Fumiko Axelrod, Christopher Bond, Jennifer Cain, Belinda Cancilla, William R Henner, Rene Meisner, Aaron Sato, Jalpa Shah,[...]. Clin Cancer Res 2015
171
10

First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer.
C Massard, A Azaro, J-C Soria, U Lassen, C Le Tourneau, D Sarker, C Smith, U Ohnmacht, G Oakley, B K R Patel,[...]. Ann Oncol 2018
78
11


Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption.
Ernesto Canalis, Lauren Schilling, Siu-Pok Yee, Sun-Kyeong Lee, Stefano Zanotti. J Biol Chem 2016
56
16

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors.
Jennifer O'Neil, Jonathan Grim, Peter Strack, Sudhir Rao, Deanne Tibbitts, Christopher Winter, James Hardwick, Markus Welcker, Jules P Meijerink, Rob Pieters,[...]. J Exp Med 2007
511
9

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.
Andrew P Weng, John M Millholland, Yumi Yashiro-Ohtani, Marie Laure Arcangeli, Arthur Lau, Carol Wai, Cristina Del Bianco, Carlos G Rodriguez, Hong Sai, John Tobias,[...]. Genes Dev 2006
642
9

Notch signaling: an emerging therapeutic target for cancer treatment.
Xun Yuan, Hua Wu, Hanxiao Xu, Huihua Xiong, Qian Chu, Shiying Yu, Gen Sheng Wu, Kongming Wu. Cancer Lett 2015
254
9

γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.
Yong Ran, Fokhrul Hossain, Antonio Pannuti, Christian B Lessard, Gabriela Z Ladd, Joo In Jung, Lisa M Minter, Barbara A Osborne, Lucio Miele, Todd E Golde. EMBO Mol Med 2017
88
10

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.
Dan R Robinson, Shanker Kalyana-Sundaram, Yi-Mi Wu, Sunita Shankar, Xuhong Cao, Bushra Ateeq, Irfan A Asangani, Matthew Iyer, Christopher A Maher, Catherine S Grasso,[...]. Nat Med 2011
250
9

Structural basis for autoinhibition of Notch.
Wendy R Gordon, Didem Vardar-Ulu, Gavin Histen, Cheryll Sanchez-Irizarry, Jon C Aster, Stephen C Blacklow. Nat Struct Mol Biol 2007
243
9

Notch signals control the fate of immature progenitor cells in the intestine.
Silvia Fre, Mathilde Huyghe, Philippos Mourikis, Sylvie Robine, Daniel Louvard, Spyros Artavanis-Tsakonas. Nature 2005
659
9

The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis.
Rui Benedito, Cristina Roca, Inga Sörensen, Susanne Adams, Achim Gossler, Marcus Fruttiger, Ralf H Adams. Cell 2009
723
9

Notch signaling is essential for vascular morphogenesis in mice.
L T Krebs, Y Xue, C R Norton, J R Shutter, M Maguire, J P Sundberg, D Gallahan, V Closson, J Kitajewski, R Callahan,[...]. Genes Dev 2000
755
8

NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth.
Thaned Kangsamaksin, Aino Murtomaki, Natalie M Kofler, Henar Cuervo, Reyhaan A Chaudhri, Ian W Tattersall, Paul E Rosenstiel, Carrie J Shawber, Jan Kitajewski. Cancer Discov 2015
107
8

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.
Kelli L VanDussen, Alexis J Carulli, Theresa M Keeley, Sanjeevkumar R Patel, Brent J Puthoff, Scott T Magness, Ivy T Tran, Ivan Maillard, Christian Siebel, Åsa Kolterud,[...]. Development 2012
359
8


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.