A citation-based method for searching scientific literature

M Michael Cohen. Am J Med Genet A 2010
Times Cited: 77







List of co-cited articles
691 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity



Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened.
James K Chen, Jussi Taipale, Michael K Cooper, Philip A Beachy. Genes Dev 2002
18

Mutations affecting segment number and polarity in Drosophila.
C Nüsslein-Volhard, E Wieschaus. Nature 1980
14

Hedgehog signaling in development and cancer.
Jin Jiang, Chi-Chung Hui. Dev Cell 2008
744
12

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
J Taipale, J K Chen, M K Cooper, B Wang, R K Mann, L Milenkovic, M P Scott, P A Beachy. Nature 2000
12

Hedgehog: functions and mechanisms.
Markku Varjosalo, Jussi Taipale. Genes Dev 2008
825
11

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
C Chiang, Y Litingtung, E Lee, K E Young, J L Corden, H Westphal, P A Beachy. Nature 1996
11

The primary cilium: a signalling centre during vertebrate development.
Sarah C Goetz, Kathryn V Anderson. Nat Rev Genet 2010
11

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.
Matthias Lauth, Asa Bergström, Takashi Shimokawa, Rune Toftgård. Proc Natl Acad Sci U S A 2007
559
11

The hedgehog signaling network.
M Michael Cohen. Am J Med Genet A 2003
338
10


Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.
H Hahn, C Wicking, P G Zaphiropoulous, M R Gailani, S Shanley, A Chidambaram, I Vorechovsky, E Holmberg, A B Unden, S Gillies,[...]. Cell 1996
10

Small molecule modulation of Smoothened activity.
James K Chen, Jussi Taipale, Keith E Young, Tapan Maiti, Philip A Beachy. Proc Natl Acad Sci U S A 2002
745
10

Altered neural cell fates and medulloblastoma in mouse patched mutants.
L V Goodrich, L Milenković, K M Higgins, M P Scott. Science 1997
10

Activating Smoothened mutations in sporadic basal-cell carcinoma.
J Xie, M Murone, S M Luoh, A Ryan, Q Gu, C Zhang, J M Bonifas, C W Lam, M Hynes, A Goddard,[...]. Nature 1998
986
10

Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways.
Pilar Chinchilla, Liqing Xiao, Marcelo G Kazanietz, Natalia A Riobo. Cell Cycle 2010
144
10

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer.
Monique T Barakat, Eric W Humke, Matthew P Scott. Trends Mol Med 2010
161
10

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.
Miao-Hsueh Chen, Ya-Jun Li, Takatoshi Kawakami, Shan-Mei Xu, Pao-Tien Chuang. Genes Dev 2004
250
9



Patched acts catalytically to suppress the activity of Smoothened.
J Taipale, M K Cooper, T Maiti, P A Beachy. Nature 2002
574
9

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.
Charles M Rudin, Christine L Hann, John Laterra, Robert L Yauch, Christopher A Callahan, Ling Fu, Thomas Holcomb, Jeremy Stinson, Stephen E Gould, Barbara Coleman,[...]. N Engl J Med 2009
747
9

Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.
Yong Pan, Chunyang Brian Bai, Alexandra L Joyner, Baolin Wang. Mol Cell Biol 2006
379
9

Hedgehog signalling in the mouse requires intraflagellar transport proteins.
Danwei Huangfu, Aimin Liu, Andrew S Rakeman, Noel S Murcia, Lee Niswander, Kathryn V Anderson. Nature 2003
966
9

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
Robert L Yauch, Gerrit J P Dijkgraaf, Bruno Alicke, Thomas Januario, Christina P Ahn, Thomas Holcomb, Kanan Pujara, Jeremy Stinson, Christopher A Callahan, Tracy Tang,[...]. Science 2009
621
9

Identification of a palmitic acid-modified form of human Sonic hedgehog.
R B Pepinsky, C Zeng, D Wen, P Rayhorn, D P Baker, K P Williams, S A Bixler, C M Ambrose, E A Garber, K Miatkowski,[...]. J Biol Chem 1998
527
9

Teratogen-mediated inhibition of target tissue response to Shh signaling.
M K Cooper, J A Porter, K E Young, P A Beachy. Science 1998
698
9


The mechanisms of Hedgehog signalling and its roles in development and disease.
James Briscoe, Pascal P Thérond. Nat Rev Mol Cell Biol 2013
979
9

Holoprosencephaly: clinical, anatomic, and molecular dimensions.
M Michael Cohen. Birth Defects Res A Clin Mol Teratol 2006
139
7

Targeting the Hedgehog pathway in cancer.
Lee L Rubin, Frederic J de Sauvage. Nat Rev Drug Discov 2006
581
7

A small molecule that binds Hedgehog and blocks its signaling in human cells.
Benjamin Z Stanton, Lee F Peng, Nicole Maloof, Kazuo Nakai, Xiang Wang, Jay L Duffner, Kennedy M Taveras, Joel M Hyman, Sam W Lee, Angela N Koehler,[...]. Nat Chem Biol 2009
207
7

Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.
Maarten F Bijlsma, C Arnold Spek, Danica Zivkovic, Sandra van de Water, Farhad Rezaee, Maikel P Peppelenbosch. PLoS Biol 2006
226
7

Hedgehog beyond medulloblastoma and basal cell carcinoma.
Stephan Teglund, Rune Toftgård. Biochim Biophys Acta 2010
332
7

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.
Jessica Svärd, Karin Heby-Henricson, Madelen Persson-Lek, Björn Rozell, Matthias Lauth, Asa Bergström, Johan Ericson, Rune Toftgård, Stephan Teglund. Dev Cell 2006
351
7

Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
R L Johnson, A L Rothman, J Xie, L V Goodrich, J W Bare, J M Bonifas, A G Quinn, R M Myers, D R Cox, E H Epstein,[...]. Science 1996
7

Beta-arrestin-mediated localization of smoothened to the primary cilium.
Jeffrey J Kovacs, Erin J Whalen, Renshui Liu, Kunhong Xiao, Jihee Kim, Minyong Chen, Jiangbo Wang, Wei Chen, Robert J Lefkowitz. Science 2008
198
7

Boc is a receptor for sonic hedgehog in the guidance of commissural axons.
Ami Okada, Frédéric Charron, Steves Morin, David S Shin, Karen Wong, Pierre J Fabre, Marc Tessier-Lavigne, Susan K McConnell. Nature 2006
213
7

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog.
D M Stone, M Hynes, M Armanini, T A Swanson, Q Gu, R L Johnson, M P Scott, D Pennica, A Goddard, H Phillips,[...]. Nature 1996
894
7

Vertebrate Smoothened functions at the primary cilium.
Kevin C Corbit, Pia Aanstad, Veena Singla, Andrew R Norman, Didier Y R Stainier, Jeremy F Reiter. Nature 2005
7

Sonic hedgehog induces angiogenesis via Rho kinase-dependent signaling in endothelial cells.
Marie-Ange Renault, Jérôme Roncalli, Jörn Tongers, Tina Thorne, Ekaterina Klyachko, Sol Misener, Olga V Volpert, Shanu Mehta, Aaron Burg, Corinne Luedemann,[...]. J Mol Cell Cardiol 2010
87
7


The molecular genetics of holoprosencephaly.
Erich Roessler, Maximilian Muenke. Am J Med Genet C Semin Med Genet 2010
157
7

Gli proteins in development and disease.
Chi-Chung Hui, Stephane Angers. Annu Rev Cell Dev Biol 2011
437
7

Biochemical evidence that patched is the Hedgehog receptor.
V Marigo, R A Davey, Y Zuo, J M Cunningham, C J Tabin. Nature 1996
665
7

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Y Echelard, D J Epstein, B St-Jacques, L Shen, J Mohler, J A McMahon, A P McMahon. Cell 1993
7



Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation.
Luisa Izzi, Martin Lévesque, Steves Morin, Dominique Laniel, Brian C Wilkes, Frédéric Mille, Robert S Krauss, Andrew P McMahon, Benjamin L Allen, Frédéric Charron. Dev Cell 2011
162
7

The Hedgehog signal transduction network.
David J Robbins, Dennis Liang Fei, Natalia A Riobo. Sci Signal 2012
256
7


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.