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Times Cited: 228
Times Cited: 228
Times Cited
Times Co-cited
Similarity
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.
Wenjun Song, Jin Chen, Alejandra Petrilli, Geraldine Liot, Eva Klinglmayr, Yue Zhou, Patrick Poquiz, Jonathan Tjong, Mahmoud A Pouladi, Michael R Hayden,[...]. Nat Med 2011
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39
34
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.
Ulziibat P Shirendeb, Marcus J Calkins, Maria Manczak, Vishwanath Anekonda, Brett Dufour, Jodi L McBride, Peizhong Mao, P Hemachandra Reddy. Hum Mol Genet 2012
Ulziibat P Shirendeb, Marcus J Calkins, Maria Manczak, Vishwanath Anekonda, Brett Dufour, Jodi L McBride, Peizhong Mao, P Hemachandra Reddy. Hum Mol Genet 2012
32
Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.
Ulziibat Shirendeb, Arubala P Reddy, Maria Manczak, Marcus J Calkins, Peizhong Mao, Danilo A Tagle, P Hemachandra Reddy. Hum Mol Genet 2011
Ulziibat Shirendeb, Arubala P Reddy, Maria Manczak, Marcus J Calkins, Peizhong Mao, Danilo A Tagle, P Hemachandra Reddy. Hum Mol Genet 2011
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Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.
Libin Cui, Hyunkyung Jeong, Fran Borovecki, Christopher N Parkhurst, Naoko Tanese, Dimitri Krainc. Cell 2006
Libin Cui, Hyunkyung Jeong, Fran Borovecki, Christopher N Parkhurst, Naoko Tanese, Dimitri Krainc. Cell 2006
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Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.
Alexander V Panov, Claire-Anne Gutekunst, Blair R Leavitt, Michael R Hayden, James R Burke, Warren J Strittmatter, J Timothy Greenamyre. Nat Neurosci 2002
Alexander V Panov, Claire-Anne Gutekunst, Blair R Leavitt, Michael R Hayden, James R Burke, Warren J Strittmatter, J Timothy Greenamyre. Nat Neurosci 2002
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N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
Adam L Orr, Shihua Li, Chuan-En Wang, He Li, Jianjun Wang, Juan Rong, Xingshun Xu, Pier Giorgio Mastroberardino, J Timothy Greenamyre, Xiao-Jiang Li. J Neurosci 2008
Adam L Orr, Shihua Li, Chuan-En Wang, He Li, Jianjun Wang, Juan Rong, Xingshun Xu, Pier Giorgio Mastroberardino, J Timothy Greenamyre, Xiao-Jiang Li. J Neurosci 2008
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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.
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Mitochondrial defect in Huntington's disease caudate nucleus.
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Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.
Xing Guo, Marie-Helene Disatnik, Marie Monbureau, Mehrdad Shamloo, Daria Mochly-Rosen, Xin Qi. J Clin Invest 2013
Xing Guo, Marie-Helene Disatnik, Marie Monbureau, Mehrdad Shamloo, Daria Mochly-Rosen, Xin Qi. J Clin Invest 2013
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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release.
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Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli.
Veronica Costa, Marta Giacomello, Roman Hudec, Raffaele Lopreiato, Gennady Ermak, Dmitri Lim, Walter Malorni, Kelvin J A Davies, Ernesto Carafoli, Luca Scorrano. EMBO Mol Med 2010
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Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.
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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.
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VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.
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Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration.
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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice.
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PINK1-induced mitophagy promotes neuroprotection in Huntington's disease.
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Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons.
Diane T W Chang, Gordon L Rintoul, Sruthi Pandipati, Ian J Reynolds. Neurobiol Dis 2006
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Inhibition of mitochondrial protein import by mutant huntingtin.
Hiroko Yano, Sergei V Baranov, Oxana V Baranova, Jinho Kim, Yanchun Pan, Svitlana Yablonska, Diane L Carlisle, Robert J Ferrante, Albert H Kim, Robert M Friedlander. Nat Neurosci 2014
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PGC-1α, mitochondrial dysfunction, and Huntington's disease.
Ashu Johri, Abhishek Chandra, M Flint Beal. Free Radic Biol Med 2013
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Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease.
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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.
Hsiuchen Chen, Scott A Detmer, Andrew J Ewald, Erik E Griffin, Scott E Fraser, David C Chan. J Cell Biol 2003
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PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.
Joo-Ho Shin, Han Seok Ko, Hochul Kang, Yunjong Lee, Yun-Il Lee, Olga Pletinkova, Juan C Troconso, Valina L Dawson, Ted M Dawson. Cell 2011
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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
Xinglong Wang, Bo Su, Hyoung-gon Lee, Xinyi Li, George Perry, Mark A Smith, Xiongwei Zhu. J Neurosci 2009
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Huntington's disease: from molecular pathogenesis to clinical treatment.
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Proteomic and oxidative stress analysis in human brain samples of Huntington disease.
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The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
Yvette C Wong, Erika L F Holzbaur. J Neurosci 2014
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Michael Lazarou, Danielle A Sliter, Lesley A Kane, Shireen A Sarraf, Chunxin Wang, Jonathon L Burman, Dionisia P Sideris, Adam I Fogel, Richard J Youle. Nature 2015
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Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease.
Baiyang Sheng, Xinglong Wang, Bo Su, Hyoung-gon Lee, Gemma Casadesus, George Perry, Xiongwei Zhu. J Neurochem 2012
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Huntingtin functions as a scaffold for selective macroautophagy.
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Impaired PGC-1alpha function in muscle in Huntington's disease.
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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
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Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease.
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Mitochondria in Huntington's disease.
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Potential function for the Huntingtin protein as a scaffold for selective autophagy.
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Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin.
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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.
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Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease.
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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy.
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Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission.
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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism.
T Kitada, S Asakawa, N Hattori, H Matsumine, Y Yamamura, S Minoshima, M Yokochi, Y Mizuno, N Shimizu. Nature 1998
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Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
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HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.
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9
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.