Alice L Rodriguez, Mark D Grier, Carrie K Jones, Elizabeth J Herman, Alexander S Kane, Randy L Smith, Richard Williams, Ya Zhou, Joy E Marlo, Emily L Days, Tasha N Blatt, Satyawan Jadhav, Usha N Menon, Paige N Vinson, Jerri M Rook, Shaun R Stauffer, Colleen M Niswender, Craig W Lindsley, C David Weaver, P Jeffrey Conn. Mol Pharmacol 2010
Times Cited: 144
Times Cited: 144
Times Cited
Times Co-cited
Similarity
Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.
Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Hyekyung P Cho, Emily Days, Y Zhou, Alice L Rodriguez, Hilde Lavreysen, Shaun R Stauffer, Colleen M Niswender,[...]. Mol Pharmacol 2012
Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Hyekyung P Cho, Emily Days, Y Zhou, Alice L Rodriguez, Hilde Lavreysen, Shaun R Stauffer, Colleen M Niswender,[...]. Mol Pharmacol 2012
39
Metabotropic glutamate receptors: physiology, pharmacology, and disease.
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
Colleen M Niswender, P Jeffrey Conn. Annu Rev Pharmacol Toxicol 2010
39
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models.
Gene G Kinney, Julie A O'Brien, Wei Lemaire, Maryann Burno, Denise J Bickel, Michelle K Clements, Tsing-Bau Chen, David D Wisnoski, Craig W Lindsley, Philip R Tiller,[...]. J Pharmacol Exp Ther 2005
Gene G Kinney, Julie A O'Brien, Wei Lemaire, Maryann Burno, Denise J Bickel, Michelle K Clements, Tsing-Bau Chen, David D Wisnoski, Craig W Lindsley, Philip R Tiller,[...]. J Pharmacol Exp Ther 2005
35
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.
Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, Thomas M Bridges, Paige N Vinson, Hyekyung P Cho, Ya Zhou, Rocco D Gogliotti, Jason T Manka, Karen J Gregory,[...]. Biol Psychiatry 2013
Jerri M Rook, Meredith J Noetzel, Wendy A Pouliot, Thomas M Bridges, Paige N Vinson, Hyekyung P Cho, Ya Zhou, Rocco D Gogliotti, Jason T Manka, Karen J Gregory,[...]. Biol Psychiatry 2013
42
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships.
Karen J Gregory, Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Shaun R Stauffer, Alice L Rodriguez, Kyle A Emmitte, Ya Zhou, Aspen C Chun, Andrew S Felts,[...]. Mol Pharmacol 2012
Karen J Gregory, Meredith J Noetzel, Jerri M Rook, Paige N Vinson, Shaun R Stauffer, Alice L Rodriguez, Kyle A Emmitte, Ya Zhou, Aspen C Chun, Andrew S Felts,[...]. Mol Pharmacol 2012
46
A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling.
M J Noetzel, K J Gregory, P N Vinson, J T Manka, S R Stauffer, C W Lindsley, C M Niswender, Z Xiang, P J Conn. Mol Pharmacol 2013
M J Noetzel, K J Gregory, P N Vinson, J T Manka, S R Stauffer, C W Lindsley, C M Niswender, Z Xiang, P J Conn. Mol Pharmacol 2013
46
ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities.
Feng Liu, Steve Grauer, Cody Kelley, Rachel Navarra, Radka Graf, Guoming Zhang, Peter J Atkinson, Michael Popiolek, Caitlin Wantuch, Xavier Khawaja,[...]. J Pharmacol Exp Ther 2008
Feng Liu, Steve Grauer, Cody Kelley, Rachel Navarra, Radka Graf, Guoming Zhang, Peter J Atkinson, Michael Popiolek, Caitlin Wantuch, Xavier Khawaja,[...]. J Pharmacol Exp Ther 2008
29
Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Sophie Parmentier-Batteur, Peter H Hutson, Karsten Menzel, Jason M Uslaner, Britta A Mattson, Julie A O'Brien, Brian C Magliaro, Thomas Forest, Craig A Stump, Robert M Tynebor,[...]. Neuropharmacology 2014
Sophie Parmentier-Batteur, Peter H Hutson, Karsten Menzel, Jason M Uslaner, Britta A Mattson, Julie A O'Brien, Brian C Magliaro, Thomas Forest, Craig A Stump, Robert M Tynebor,[...]. Neuropharmacology 2014
43
A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.
Julie A O'Brien, Wei Lemaire, Marion Wittmann, Marlene A Jacobson, Sookhee N Ha, David D Wisnoski, Craig W Lindsley, Hervé J Schaffhauser, Blake Rowe, Cyrille Sur,[...]. J Pharmacol Exp Ther 2004
Julie A O'Brien, Wei Lemaire, Marion Wittmann, Marlene A Jacobson, Sookhee N Ha, David D Wisnoski, Craig W Lindsley, Hervé J Schaffhauser, Blake Rowe, Cyrille Sur,[...]. J Pharmacol Exp Ther 2004
27
mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning.
Jennifer E Ayala, Yelin Chen, Jessica L Banko, Douglas J Sheffler, Richard Williams, Alexandra N Telk, Noreen L Watson, Zixiu Xiang, Yongqin Zhang, Paulianda J Jones,[...]. Neuropsychopharmacology 2009
Jennifer E Ayala, Yelin Chen, Jessica L Banko, Douglas J Sheffler, Richard Williams, Alexandra N Telk, Noreen L Watson, Zixiu Xiang, Yongqin Zhang, Paulianda J Jones,[...]. Neuropsychopharmacology 2009
25
A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators.
Alice L Rodriguez, Yi Nong, Nishant K Sekaran, David Alagille, Gilles D Tamagnan, P Jeffrey Conn. Mol Pharmacol 2005
Alice L Rodriguez, Yi Nong, Nishant K Sekaran, David Alagille, Gilles D Tamagnan, P Jeffrey Conn. Mol Pharmacol 2005
25
Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology.
Alexis S Hammond, Alice L Rodriguez, Steven D Townsend, Colleen M Niswender, Karen J Gregory, Craig W Lindsley, P Jeffrey Conn. ACS Chem Neurosci 2010
Alexis S Hammond, Alice L Rodriguez, Steven D Townsend, Colleen M Niswender, Karen J Gregory, Craig W Lindsley, P Jeffrey Conn. ACS Chem Neurosci 2010
41
Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes.
Yongqin Zhang, Alice L Rodriguez, P Jeffrey Conn. J Pharmacol Exp Ther 2005
Yongqin Zhang, Alice L Rodriguez, P Jeffrey Conn. J Pharmacol Exp Ther 2005
29
Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia.
P Jeffrey Conn, Craig W Lindsley, Carrie K Jones. Trends Pharmacol Sci 2009
P Jeffrey Conn, Craig W Lindsley, Carrie K Jones. Trends Pharmacol Sci 2009
24
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders.
P Jeffrey Conn, Arthur Christopoulos, Craig W Lindsley. Nat Rev Drug Discov 2009
P Jeffrey Conn, Arthur Christopoulos, Craig W Lindsley. Nat Rev Drug Discov 2009
24
Pharmacology and functions of metabotropic glutamate receptors.
P J Conn, J P Pin. Annu Rev Pharmacol Toxicol 1997
P J Conn, J P Pin. Annu Rev Pharmacol Toxicol 1997
23
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
F Gasparini, K Lingenhöhl, N Stoehr, P J Flor, M Heinrich, I Vranesic, M Biollaz, H Allgeier, R Heckendorn, S Urwyler,[...]. Neuropharmacology 1999
F Gasparini, K Lingenhöhl, N Stoehr, P J Flor, M Heinrich, I Vranesic, M Biollaz, H Allgeier, R Heckendorn, S Urwyler,[...]. Neuropharmacology 1999
22
"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.
Michael R Wood, Corey R Hopkins, John T Brogan, P Jeffrey Conn, Craig W Lindsley. Biochemistry 2011
Michael R Wood, Corey R Hopkins, John T Brogan, P Jeffrey Conn, Craig W Lindsley. Biochemistry 2011
22
Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.
Katie Leach, Patrick M Sexton, Arthur Christopoulos. Trends Pharmacol Sci 2007
Katie Leach, Patrick M Sexton, Arthur Christopoulos. Trends Pharmacol Sci 2007
22
Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity.
Richard H P Porter, Georg Jaeschke, Will Spooren, Theresa M Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira,[...]. J Pharmacol Exp Ther 2005
Richard H P Porter, Georg Jaeschke, Will Spooren, Theresa M Ballard, Bernd Büttelmann, Sabine Kolczewski, Jens-Uwe Peters, Eric Prinssen, Jürgen Wichmann, Eric Vieira,[...]. J Pharmacol Exp Ther 2005
22
Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents.
Jerri M Rook, Zixiu Xiang, Xiaohui Lv, Ayan Ghoshal, Jonathan W Dickerson, Thomas M Bridges, Kari A Johnson, Daniel J Foster, Karen J Gregory, Paige N Vinson,[...]. Neuron 2015
Jerri M Rook, Zixiu Xiang, Xiaohui Lv, Ayan Ghoshal, Jonathan W Dickerson, Thomas M Bridges, Kari A Johnson, Daniel J Foster, Karen J Gregory, Paige N Vinson,[...]. Neuron 2015
26
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
Julie A O'Brien, Wei Lemaire, Tsing-Bau Chen, Raymond S L Chang, Marlene A Jacobson, Sookhee N Ha, Craig W Lindsley, Hervé J Schaffhauser, Cyrille Sur, Douglas J Pettibone,[...]. Mol Pharmacol 2003
Julie A O'Brien, Wei Lemaire, Tsing-Bau Chen, Raymond S L Chang, Marlene A Jacobson, Sookhee N Ha, Craig W Lindsley, Hervé J Schaffhauser, Cyrille Sur, Douglas J Pettibone,[...]. Mol Pharmacol 2003
21
Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.
Yelin Chen, Yi Nong, Cyril Goudet, Kamondanai Hemstapat, Tomas de Paulis, Jean-Philippe Pin, P Jeffrey Conn. Mol Pharmacol 2007
Yelin Chen, Yi Nong, Cyril Goudet, Kamondanai Hemstapat, Tomas de Paulis, Jean-Philippe Pin, P Jeffrey Conn. Mol Pharmacol 2007
27
N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.
Yelin Chen, Cyril Goudet, Jean-Philippe Pin, P Jeffrey Conn. Mol Pharmacol 2008
Yelin Chen, Cyril Goudet, Jean-Philippe Pin, P Jeffrey Conn. Mol Pharmacol 2008
27
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator.
Huixian Wu, Chong Wang, Karen J Gregory, Gye Won Han, Hyekyung P Cho, Yan Xia, Colleen M Niswender, Vsevolod Katritch, Jens Meiler, Vadim Cherezov,[...]. Science 2014
Huixian Wu, Chong Wang, Karen J Gregory, Gye Won Han, Hyekyung P Cho, Yan Xia, Colleen M Niswender, Vsevolod Katritch, Jens Meiler, Vadim Cherezov,[...]. Science 2014
21
Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.
Karen J Gregory, Elizabeth D Nguyen, Sean D Reiff, Emma F Squire, Shaun R Stauffer, Craig W Lindsley, Jens Meiler, P Jeffrey Conn. Mol Pharmacol 2013
Karen J Gregory, Elizabeth D Nguyen, Sean D Reiff, Emma F Squire, Shaun R Stauffer, Craig W Lindsley, Jens Meiler, P Jeffrey Conn. Mol Pharmacol 2013
31
Biotransformation of a novel positive allosteric modulator of metabotropic glutamate receptor subtype 5 contributes to seizure-like adverse events in rats involving a receptor agonism-dependent mechanism.
Thomas M Bridges, Jerri M Rook, Meredith J Noetzel, Ryan D Morrison, Ya Zhou, Rocco D Gogliotti, Paige N Vinson, Zixiu Xiang, Carrie K Jones, Colleen M Niswender,[...]. Drug Metab Dispos 2013
Thomas M Bridges, Jerri M Rook, Meredith J Noetzel, Ryan D Morrison, Ya Zhou, Rocco D Gogliotti, Paige N Vinson, Zixiu Xiang, Carrie K Jones, Colleen M Niswender,[...]. Drug Metab Dispos 2013
48
(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
A J Doherty, M J Palmer, J M Henley, G L Collingridge, D E Jane. Neuropharmacology 1997
A J Doherty, M J Palmer, J M Henley, G L Collingridge, D E Jane. Neuropharmacology 1997
18
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.
G Mannaioni, M J Marino, O Valenti, S F Traynelis, P J Conn. J Neurosci 2001
G Mannaioni, M J Marino, O Valenti, S F Traynelis, P J Conn. J Neurosci 2001
18
Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.
H Awad, G W Hubert, Y Smith, A I Levey, P J Conn. J Neurosci 2000
H Awad, G W Hubert, Y Smith, A I Levey, P J Conn. J Neurosci 2000
18
The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats.
Una C Campbell, Kush Lalwani, Lisa Hernandez, Gene G Kinney, P Jeffrey Conn, Linda J Bristow. Psychopharmacology (Berl) 2004
Una C Campbell, Kush Lalwani, Lisa Hernandez, Gene G Kinney, P Jeffrey Conn, Linda J Bristow. Psychopharmacology (Berl) 2004
18
Discovery of molecular switches that modulate modes of metabotropic glutamate receptor subtype 5 (mGlu5) pharmacology in vitro and in vivo within a series of functionalized, regioisomeric 2- and 5-(phenylethynyl)pyrimidines.
Sameer Sharma, Jeffrey Kedrowski, Jerri M Rook, Randy L Smith, Carrie K Jones, Alice L Rodriguez, P Jeffrey Conn, Craig W Lindsley. J Med Chem 2009
Sameer Sharma, Jeffrey Kedrowski, Jerri M Rook, Randy L Smith, Carrie K Jones, Alice L Rodriguez, P Jeffrey Conn, Craig W Lindsley. J Med Chem 2009
26
3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity.
Nicholas D P Cosford, Lida Tehrani, Jeffrey Roppe, Edwin Schweiger, Nicholas D Smith, Jeffrey Anderson, Linda Bristow, Jesse Brodkin, Xiaohui Jiang, Ian McDonald,[...]. J Med Chem 2003
Nicholas D P Cosford, Lida Tehrani, Jeffrey Roppe, Edwin Schweiger, Nicholas D Smith, Jeffrey Anderson, Linda Bristow, Jesse Brodkin, Xiaohui Jiang, Ian McDonald,[...]. J Med Chem 2003
18
Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.
Colleen M Niswender, Kari A Johnson, Nicole R Miller, Jennifer E Ayala, Qingwei Luo, Richard Williams, Samir Saleh, Darren Orton, C David Weaver, P Jeffrey Conn. Mol Pharmacol 2010
Colleen M Niswender, Kari A Johnson, Nicole R Miller, Jennifer E Ayala, Qingwei Luo, Richard Williams, Samir Saleh, Darren Orton, C David Weaver, P Jeffrey Conn. Mol Pharmacol 2010
28
Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
Andrew S Doré, Krzysztof Okrasa, Jayesh C Patel, Maria Serrano-Vega, Kirstie Bennett, Robert M Cooke, James C Errey, Ali Jazayeri, Samir Khan, Ben Tehan,[...]. Nature 2014
Andrew S Doré, Krzysztof Okrasa, Jayesh C Patel, Maria Serrano-Vega, Kirstie Bennett, Robert M Cooke, James C Errey, Ali Jazayeri, Samir Khan, Ben Tehan,[...]. Nature 2014
18
Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.
Jason M Uslaner, Sophie Parmentier-Batteur, Rosemarie B Flick, Nathaniel O Surles, June S H Lam, Caitlyn H McNaughton, Marlene A Jacobson, Pete H Hutson. Neuropharmacology 2009
Jason M Uslaner, Sophie Parmentier-Batteur, Rosemarie B Flick, Nathaniel O Surles, June S H Lam, Caitlyn H McNaughton, Marlene A Jacobson, Pete H Hutson. Neuropharmacology 2009
17
N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.
K J Gregory, E J Herman, A J Ramsey, A S Hammond, N E Byun, S R Stauffer, J T Manka, S Jadhav, T M Bridges, C D Weaver,[...]. J Pharmacol Exp Ther 2013
K J Gregory, E J Herman, A J Ramsey, A S Hammond, N E Byun, S R Stauffer, J T Manka, S Jadhav, T M Bridges, C D Weaver,[...]. J Pharmacol Exp Ther 2013
51
Metabotropic glutamate receptors as therapeutic targets for schizophrenia.
Paige N Vinson, P Jeffrey Conn. Neuropharmacology 2012
Paige N Vinson, P Jeffrey Conn. Neuropharmacology 2012
23
Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.
Karen J Gregory, Elizabeth N Dong, Jens Meiler, P Jeffrey Conn. Neuropharmacology 2011
Karen J Gregory, Elizabeth N Dong, Jens Meiler, P Jeffrey Conn. Neuropharmacology 2011
17
A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.
Etienne Doumazane, Pauline Scholler, Jurriaan M Zwier, Eric Trinquet, Philippe Rondard, Jean-Philippe Pin. FASEB J 2011
Etienne Doumazane, Pauline Scholler, Jurriaan M Zwier, Eric Trinquet, Philippe Rondard, Jean-Philippe Pin. FASEB J 2011
16
Development of allosteric modulators of GPCRs for treatment of CNS disorders.
Hilary Highfield Nickols, P Jeffrey Conn. Neurobiol Dis 2014
Hilary Highfield Nickols, P Jeffrey Conn. Neurobiol Dis 2014
16
The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors.
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15
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
Craig W Lindsley, David D Wisnoski, William H Leister, Julie A O'brien, Wei Lemaire, David L Williams, Maryann Burno, Cyrille Sur, Gene G Kinney, Doug J Pettibone,[...]. J Med Chem 2004
Craig W Lindsley, David D Wisnoski, William H Leister, Julie A O'brien, Wei Lemaire, David L Williams, Maryann Burno, Cyrille Sur, Gene G Kinney, Doug J Pettibone,[...]. J Med Chem 2004
15
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS.
Shen Yin, Meredith J Noetzel, Kari A Johnson, Rocio Zamorano, Nidhi Jalan-Sakrikar, Karen J Gregory, P Jeffrey Conn, Colleen M Niswender. J Neurosci 2014
Shen Yin, Meredith J Noetzel, Kari A Johnson, Rocio Zamorano, Nidhi Jalan-Sakrikar, Karen J Gregory, P Jeffrey Conn, Colleen M Niswender. J Neurosci 2014
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Metabotropic glutamate receptors: from the workbench to the bedside.
F Nicoletti, J Bockaert, G L Collingridge, P J Conn, F Ferraguti, D D Schoepp, J T Wroblewski, J P Pin. Neuropharmacology 2011
F Nicoletti, J Bockaert, G L Collingridge, P J Conn, F Ferraguti, D D Schoepp, J T Wroblewski, J P Pin. Neuropharmacology 2011
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Pharmacological agents acting at subtypes of metabotropic glutamate receptors.
D D Schoepp, D E Jane, J A Monn. Neuropharmacology 1999
D D Schoepp, D E Jane, J A Monn. Neuropharmacology 1999
14
[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor.
Nicholas D P Cosford, Jeffrey Roppe, Lida Tehrani, Edwin J Schweiger, T Jon Seiders, Ashok Chaudary, Sara Rao, Mark A Varney. Bioorg Med Chem Lett 2003
Nicholas D P Cosford, Jeffrey Roppe, Lida Tehrani, Edwin J Schweiger, T Jon Seiders, Ashok Chaudary, Sara Rao, Mark A Varney. Bioorg Med Chem Lett 2003
14
Discovery of molecular switches within the ADX-47273 mGlu5 PAM scaffold that modulate modes of pharmacology to afford potent mGlu5 NAMs, PAMs and partial antagonists.
Jeffrey P Lamb, Darren W Engers, Colleen M Niswender, Alice L Rodriguez, Daryl F Venable, P Jeffrey Conn, Craig W Lindsley. Bioorg Med Chem Lett 2011
Jeffrey P Lamb, Darren W Engers, Colleen M Niswender, Alice L Rodriguez, Daryl F Venable, P Jeffrey Conn, Craig W Lindsley. Bioorg Med Chem Lett 2011
35
Challenges in the development of mGluR5 positive allosteric modulators: the discovery of CPPHA.
Zhijian Zhao, David D Wisnoski, Julie A O'Brien, Wei Lemaire, David L Williams, Marlene A Jacobson, Marion Wittman, Sookhee N Ha, Herve Schaffhauser, Cyrille Sur,[...]. Bioorg Med Chem Lett 2007
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21
Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4.
Colleen M Niswender, Kari A Johnson, C David Weaver, Carrie K Jones, Zixiu Xiang, Qingwei Luo, Alice L Rodriguez, Joy E Marlo, Tomas de Paulis, Analisa D Thompson,[...]. Mol Pharmacol 2008
Colleen M Niswender, Kari A Johnson, C David Weaver, Carrie K Jones, Zixiu Xiang, Qingwei Luo, Alice L Rodriguez, Joy E Marlo, Tomas de Paulis, Analisa D Thompson,[...]. Mol Pharmacol 2008
14
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.