Predictors of invasive breast cancer in ductal carcinoma in situ initially diagnosed by core biopsy.
Mun Yew Patrick Chan, Serene Lim. Asian J Surg 2010
Times Cited: 24
Times Cited: 24
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Ductal carcinoma in situ at core-needle biopsy: meta-analysis of underestimation and predictors of invasive breast cancer.
Meagan E Brennan, Robin M Turner, Stefano Ciatto, M Luke Marinovich, James R French, Petra Macaskill, Nehmat Houssami. Radiology 2011
Meagan E Brennan, Robin M Turner, Stefano Ciatto, M Luke Marinovich, James R French, Petra Macaskill, Nehmat Houssami. Radiology 2011
75
Predictors of invasive breast cancer in patients with an initial diagnosis of ductal carcinoma in situ: a guide to selective use of sentinel lymph node biopsy in management of ductal carcinoma in situ.
Tina W F Yen, Kelly K Hunt, Merrick I Ross, Nadeem Q Mirza, Gildy V Babiera, Funda Meric-Bernstam, S Eva Singletary, W Fraser Symmans, Sharon H Giordano, Barry W Feig,[...]. J Am Coll Surg 2005
Tina W F Yen, Kelly K Hunt, Merrick I Ross, Nadeem Q Mirza, Gildy V Babiera, Funda Meric-Bernstam, S Eva Singletary, W Fraser Symmans, Sharon H Giordano, Barry W Feig,[...]. J Am Coll Surg 2005
62
Factors associated with upstaging from ductal carcinoma in situ following core needle biopsy to invasive cancer in subsequent surgical excision.
Jisun Kim, Wonshik Han, Jong Won Lee, Jee-Man You, Hee-Chul Shin, Soo Kyung Ahn, Hyeong-Gon Moon, Nariya Cho, Woo Kyung Moon, In-Ae Park,[...]. Breast 2012
Jisun Kim, Wonshik Han, Jong Won Lee, Jee-Man You, Hee-Chul Shin, Soo Kyung Ahn, Hyeong-Gon Moon, Nariya Cho, Woo Kyung Moon, In-Ae Park,[...]. Breast 2012
50
Predictors of invasive disease in breast cancer when core biopsy demonstrates DCIS only.
Mary F Dillon, Enda W McDermott, Cecily M Quinn, Ann O'Doherty, Niall O'Higgins, Arnold D K Hill. J Surg Oncol 2006
Mary F Dillon, Enda W McDermott, Cecily M Quinn, Ann O'Doherty, Niall O'Higgins, Arnold D K Hill. J Surg Oncol 2006
41
Sonographic lesion size of ductal carcinoma in situ as a preoperative predictor for the presence of an invasive focus.
Jong Won Lee, Wonshik Han, Eunyoung Ko, Jihyoung Cho, Eun-Kyu Kim, So-Youn Jung, Nariya Cho, Woo Kyung Moon, In-Ae Park, Dong-Young Noh. J Surg Oncol 2008
Jong Won Lee, Wonshik Han, Eunyoung Ko, Jihyoung Cho, Eun-Kyu Kim, So-Youn Jung, Nariya Cho, Woo Kyung Moon, In-Ae Park, Dong-Young Noh. J Surg Oncol 2008
41
Risk factors for invasive breast cancer when core needle biopsy shows ductal carcinoma in situ.
Emil D Kurniawan, Allison Rose, Arlene Mou, Malcolm Buchanan, John P Collins, Matthew H Wong, Julie A Miller, G Bruce Mann. Arch Surg 2010
Emil D Kurniawan, Allison Rose, Arlene Mou, Malcolm Buchanan, John P Collins, Matthew H Wong, Julie A Miller, G Bruce Mann. Arch Surg 2010
41
Underestimation of malignancy of breast core-needle biopsy: concepts and precise overall and category-specific estimates.
Nehmat Houssami, Stefano Ciatto, Ian Ellis, Daniela Ambrogetti. Cancer 2007
Nehmat Houssami, Stefano Ciatto, Ian Ellis, Daniela Ambrogetti. Cancer 2007
41
Is there a role of sentinel lymph node biopsy in ductal carcinoma in situ?: analysis of 587 cases.
Amit Goyal, Anthony Douglas-Jones, Ian Monypenny, Helen Sweetland, Guy Stevens, Robert E Mansel. Breast Cancer Res Treat 2006
Amit Goyal, Anthony Douglas-Jones, Ian Monypenny, Helen Sweetland, Guy Stevens, Robert E Mansel. Breast Cancer Res Treat 2006
41
An update of sentinel lymph node mapping in patients with ductal carcinoma in situ.
Caren Wilkie, Laura White, Elisabeth Dupont, Alan Cantor, Charles E Cox. Am J Surg 2005
Caren Wilkie, Laura White, Elisabeth Dupont, Alan Cantor, Charles E Cox. Am J Surg 2005
41
Predictors of invasive breast cancer and lymph node involvement in ductal carcinoma in situ initially diagnosed by vacuum-assisted breast biopsy: experience of 733 cases.
Chiara Trentin, Valeria Dominelli, Patrick Maisonneuve, Simona Menna, Barbara Bazolli, Alberto Luini, Enrico Cassano. Breast 2012
Chiara Trentin, Valeria Dominelli, Patrick Maisonneuve, Simona Menna, Barbara Bazolli, Alberto Luini, Enrico Cassano. Breast 2012
37
Predictors of invasion and axillary lymph node metastasis in patients with a core biopsy diagnosis of ductal carcinoma in situ: an analysis of 255 cases.
Jeong S Han, Kyle H Molberg, Venetia Sarode. Breast J 2011
Jeong S Han, Kyle H Molberg, Venetia Sarode. Breast J 2011
37
Predictors of invasion in needle core biopsies of the breast with ductal carcinoma in situ.
Edna May L Go, Siu-Ki Chan, Joaquim S L Vong, Philip C W Lui, Anthony W H Chan, Tony K F Ma, Mark A Ang, Bonita K B Law, Puay-Hoon Tan, Gary M Tse. Mod Pathol 2010
Edna May L Go, Siu-Ki Chan, Joaquim S L Vong, Philip C W Lui, Anthony W H Chan, Tony K F Ma, Mark A Ang, Bonita K B Law, Puay-Hoon Tan, Gary M Tse. Mod Pathol 2010
42
Indication for sentinel lymph node biopsy for breast cancer when core biopsy shows ductal carcinoma in situ.
Tomohiro Miyake, Kenzo Shimazu, Hiroshi Ohashi, Tetsuya Taguchi, Satsuki Ueda, Takahiro Nakayama, Seung Jin Kim, Katsuyuki Aozasa, Yasuhiro Tamaki, Shinzaburo Noguchi. Am J Surg 2011
Tomohiro Miyake, Kenzo Shimazu, Hiroshi Ohashi, Tetsuya Taguchi, Satsuki Ueda, Takahiro Nakayama, Seung Jin Kim, Katsuyuki Aozasa, Yasuhiro Tamaki, Shinzaburo Noguchi. Am J Surg 2011
33
Predictors of residual invasive disease after core needle biopsy diagnosis of ductal carcinoma in situ.
Lisa A Rutstein, Ronald R Johnson, William R Poller, David Dabbs, Jan Groblewski, Tina Rakitt, Allan Tsung, Thomas Kirchner, Jules Sumkin, Donald Keenan,[...]. Breast J 2007
Lisa A Rutstein, Ronald R Johnson, William R Poller, David Dabbs, Jan Groblewski, Tina Rakitt, Allan Tsung, Thomas Kirchner, Jules Sumkin, Donald Keenan,[...]. Breast J 2007
29
Accuracy of 11-gauge vacuum-assisted core biopsy of mammographic breast lesions.
Steven Pandelidis, David Heiland, David Jones, Kelly Stough, Joanne Trapeni, Yasir Suliman. Ann Surg Oncol 2003
Steven Pandelidis, David Heiland, David Jones, Kelly Stough, Joanne Trapeni, Yasir Suliman. Ann Surg Oncol 2003
29
Accuracy of a preoperative model for predicting invasive breast cancer in women with ductal carcinoma-in-situ on vacuum-assisted core needle biopsy.
Nehmat Houssami, Daniela Ambrogetti, M Luke Marinovich, Simonetta Bianchi, Petra Macaskill, Vania Vezzosi, Eleftherios P Mamounas, Stefano Ciatto. Ann Surg Oncol 2011
Nehmat Houssami, Daniela Ambrogetti, M Luke Marinovich, Simonetta Bianchi, Petra Macaskill, Vania Vezzosi, Eleftherios P Mamounas, Stefano Ciatto. Ann Surg Oncol 2011
29
Predicting invasion in the excision specimen from breast core needle biopsy specimens with only ductal carcinoma in situ.
Andrew A Renshaw. Arch Pathol Lab Med 2002
Andrew A Renshaw. Arch Pathol Lab Med 2002
25
Role of sentinel lymph node biopsy in ductal carcinoma-in-situ treated by mastectomy.
Jensen C C Tan, David R McCready, Alexandra M Easson, Wey L Leong. Ann Surg Oncol 2007
Jensen C C Tan, David R McCready, Alexandra M Easson, Wey L Leong. Ann Surg Oncol 2007
25
Risk of invasion and axillary lymph node metastasis in ductal carcinoma in situ diagnosed by core-needle biopsy.
P Meijnen, H S A Oldenburg, C E Loo, O E Nieweg, J L Peterse, E J T Rutgers. Br J Surg 2007
P Meijnen, H S A Oldenburg, C E Loo, O E Nieweg, J L Peterse, E J T Rutgers. Br J Surg 2007
25
Predictors of invasion in patients with core-needle biopsy-diagnosed ductal carcinoma in situ and recommendations for a selective approach to sentinel lymph node biopsy in ductal carcinoma in situ.
Lei Huo, Nour Sneige, Kelly K Hunt, Constance T Albarracin, Adriana Lopez, Erika Resetkova. Cancer 2006
Lei Huo, Nour Sneige, Kelly K Hunt, Constance T Albarracin, Adriana Lopez, Erika Resetkova. Cancer 2006
25
Stereotactic breast biopsy of nonpalpable lesions: determinants of ductal carcinoma in situ underestimation rates.
R J Jackman, F Burbank, S H Parker, W P Evans, M C Lechner, T R Richardson, A A Smid, H B Borofsky, C H Lee, H M Goldstein,[...]. Radiology 2001
R J Jackman, F Burbank, S H Parker, W P Evans, M C Lechner, T R Richardson, A A Smid, H B Borofsky, C H Lee, H M Goldstein,[...]. Radiology 2001
25
Risk predictors of underestimation and the need for sentinel node biopsy in patients diagnosed with ductal carcinoma in situ by preoperative needle biopsy.
Hyung Seok Park, Seho Park, Junghoon Cho, Ji Min Park, Seung Il Kim, Byeong-Woo Park. J Surg Oncol 2013
Hyung Seok Park, Seho Park, Junghoon Cho, Ji Min Park, Seung Il Kim, Byeong-Woo Park. J Surg Oncol 2013
25
Prediction of underestimated invasiveness in patients with ductal carcinoma in situ of the breast on percutaneous biopsy as rationale for recommending concurrent sentinel lymph node biopsy.
Sophie Schulz, Peter Sinn, Michael Golatta, Geraldine Rauch, Hans Junkermann, Florian Schuetz, Christof Sohn, Joerg Heil. Breast 2013
Sophie Schulz, Peter Sinn, Michael Golatta, Geraldine Rauch, Hans Junkermann, Florian Schuetz, Christof Sohn, Joerg Heil. Breast 2013
25
Importance of lymphatic mapping in ductal carcinoma in situ (DCIS): why map DCIS?
C E Cox, K Nguyen, R J Gray, C Salud, N N Ku, E Dupont, L Hutson, E Peltz, G Whitehead, D Reintgen,[...]. Am Surg 2001
C E Cox, K Nguyen, R J Gray, C Salud, N N Ku, E Dupont, L Hutson, E Peltz, G Whitehead, D Reintgen,[...]. Am Surg 2001
25
Nomogram for predicting invasion in patients with a preoperative diagnosis of ductal carcinoma in situ of the breast.
S K Lee, J-H Yang, S-Y Woo, J E Lee, S J Nam. Br J Surg 2013
S K Lee, J-H Yang, S-Y Woo, J E Lee, S J Nam. Br J Surg 2013
25
A mass on breast imaging predicts coexisting invasive carcinoma in patients with a core biopsy diagnosis of ductal carcinoma in situ.
T A King, G H Farr, G J Cederbom, D H Smetherman, J S Bolton, A J Stolier, G M Fuhrman. Am Surg 2001
T A King, G H Farr, G J Cederbom, D H Smetherman, J S Bolton, A J Stolier, G M Fuhrman. Am Surg 2001
20
Accuracy and underestimation of malignancy of breast core needle biopsy: the Florence experience of over 4000 consecutive biopsies.
Stefano Ciatto, Nehmat Houssami, Daniela Ambrogetti, Simonetta Bianchi, Rita Bonardi, Beniamino Brancato, Sandra Catarzi, Gabriella G Risso. Breast Cancer Res Treat 2007
Stefano Ciatto, Nehmat Houssami, Daniela Ambrogetti, Simonetta Bianchi, Rita Bonardi, Beniamino Brancato, Sandra Catarzi, Gabriella G Risso. Breast Cancer Res Treat 2007
20
The role of breast MR imaging in pre-operative determination of invasive disease for ductal carcinoma in situ diagnosed by needle biopsy.
Mariko Goto, Sachiko Yuen, Kentaro Akazawa, Kaori Nishida, Eiichi Konishi, Mariko Kajihara, Nobuhiko Shinkura, Kei Yamada. Eur Radiol 2012
Mariko Goto, Sachiko Yuen, Kentaro Akazawa, Kaori Nishida, Eiichi Konishi, Mariko Kajihara, Nobuhiko Shinkura, Kei Yamada. Eur Radiol 2012
20
Ductal carcinoma in situ diagnosed at US-guided 14-gauge core-needle biopsy for breast mass: preoperative predictors of invasive breast cancer.
Ah Young Park, Hye Mi Gweon, Eun Ju Son, Miri Yoo, Jeong-Ah Kim, Ji Hyun Youk. Eur J Radiol 2014
Ah Young Park, Hye Mi Gweon, Eun Ju Son, Miri Yoo, Jeong-Ah Kim, Ji Hyun Youk. Eur J Radiol 2014
20
Core biopsy diagnosis of ductal carcinoma in situ: an indication for sentinel lymph node biopsy.
Elizabeth A Mittendorf, Cletus A Arciero, Veronica Gutchell, Jeff Hooke, Craig D Shriver. Curr Surg 2005
Elizabeth A Mittendorf, Cletus A Arciero, Veronica Gutchell, Jeff Hooke, Craig D Shriver. Curr Surg 2005
16
Role of ultrasound and sonographically guided core biopsy in the diagnostic evaluation of ductal carcinoma in situ (DCIS) of the breast.
V Londero, C Zuiani, A Furlan, J Nori, M Bazzocchi. Radiol Med 2007
V Londero, C Zuiani, A Furlan, J Nori, M Bazzocchi. Radiol Med 2007
23
Prediction of the presence of invasive disease from the measurement of extent of malignant microcalcification on mammography and ductal carcinoma in situ grade at core biopsy.
E A M O'Flynn, J C Morel, J Gonzalez, N Dutt, D Evans, R Wasan, M J Michell. Clin Radiol 2009
E A M O'Flynn, J C Morel, J Gonzalez, N Dutt, D Evans, R Wasan, M J Michell. Clin Radiol 2009
16
Ductal carcinoma in situ diagnosed with stereotactic core needle biopsy: can invasion be predicted?
C H Lee, D Carter, L E Philpotts, M E Couce, L J Horvath, R C Lange, I Tocino. Radiology 2000
C H Lee, D Carter, L E Philpotts, M E Couce, L J Horvath, R C Lange, I Tocino. Radiology 2000
16
Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes.
Beth A Virnig, Todd M Tuttle, Tatyana Shamliyan, Robert L Kane. J Natl Cancer Inst 2010
Beth A Virnig, Todd M Tuttle, Tatyana Shamliyan, Robert L Kane. J Natl Cancer Inst 2010
16
Underestimation of DCIS at MRI-guided vacuum-assisted breast biopsy.
Jung-min Lee, Jennifer B Kaplan, Melissa P Murray, Marzena Mazur-Grbec, Tade Tadic, Damir Stimac, Laura Liberman. AJR Am J Roentgenol 2007
Jung-min Lee, Jennifer B Kaplan, Melissa P Murray, Marzena Mazur-Grbec, Tade Tadic, Damir Stimac, Laura Liberman. AJR Am J Roentgenol 2007
16
Sentinel lymph node biopsy for patients with early-stage breast cancer: American Society of Clinical Oncology clinical practice guideline update.
Gary H Lyman, Sarah Temin, Stephen B Edge, Lisa A Newman, Roderick R Turner, Donald L Weaver, Al B Benson, Linda D Bosserman, Harold J Burstein, Hiram Cody,[...]. J Clin Oncol 2014
Gary H Lyman, Sarah Temin, Stephen B Edge, Lisa A Newman, Roderick R Turner, Donald L Weaver, Al B Benson, Linda D Bosserman, Harold J Burstein, Hiram Cody,[...]. J Clin Oncol 2014
16
MRI findings of cancers preoperatively diagnosed as pure DCIS at core needle biopsy.
Yu-Ting Huang, Yun-Chung Cheung, Yung-Feng Lo, Shir-Hwa Ueng, Wen-Ling Kuo, Shin-Cheh Chen. Acta Radiol 2011
Yu-Ting Huang, Yun-Chung Cheung, Yung-Feng Lo, Shir-Hwa Ueng, Wen-Ling Kuo, Shin-Cheh Chen. Acta Radiol 2011
26
MRI of the breast in patients with DCIS to exclude the presence of invasive disease.
Eline E Deurloo, Jincey D Sriram, Hendrik J Teertstra, Claudette E Loo, Jelle Wesseling, Emiel J Th Rutgers, Kenneth G A Gilhuijs. Eur Radiol 2012
Eline E Deurloo, Jincey D Sriram, Hendrik J Teertstra, Claudette E Loo, Jelle Wesseling, Emiel J Th Rutgers, Kenneth G A Gilhuijs. Eur Radiol 2012
17
Features of occult invasion in biopsy-proven DCIS at breast MRI.
Dorota Jakubowski Wisner, E Shelley Hwang, C Belinda Chang, Hilda H Tso, Bonnie N Joe, Juan N Lessing, Ying Lu, Nola M Hylton. Breast J 2013
Dorota Jakubowski Wisner, E Shelley Hwang, C Belinda Chang, Hilda H Tso, Bonnie N Joe, Juan N Lessing, Ying Lu, Nola M Hylton. Breast J 2013
26
A model to predict upstaging to invasive carcinoma in patients preoperatively diagnosed with ductal carcinoma in situ of the breast.
Takafumi Kondo, Naoki Hayashi, Sachiko Ohde, Koyu Suzuki, Atsushi Yoshida, Hiroshi Yagata, Naoki Niikura, Takayuki Iwamoto, Kumiko Kida, Michiko Murai,[...]. J Surg Oncol 2015
Takafumi Kondo, Naoki Hayashi, Sachiko Ohde, Koyu Suzuki, Atsushi Yoshida, Hiroshi Yagata, Naoki Niikura, Takayuki Iwamoto, Kumiko Kida, Michiko Murai,[...]. J Surg Oncol 2015
16
Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial.
Robert E Mansel, Lesley Fallowfield, Mark Kissin, Amit Goyal, Robert G Newcombe, J Michael Dixon, Constantinos Yiangou, Kieran Horgan, Nigel Bundred, Ian Monypenny,[...]. J Natl Cancer Inst 2006
Robert E Mansel, Lesley Fallowfield, Mark Kissin, Amit Goyal, Robert G Newcombe, J Michael Dixon, Constantinos Yiangou, Kieran Horgan, Nigel Bundred, Ian Monypenny,[...]. J Natl Cancer Inst 2006
12
Histologic and radiographic analysis of ductal carcinoma in situ diagnosed using stereotactic incisional core breast biopsy.
Michelle Bonnett, Tracy Wallis, Michelle Rossmann, Nat L Pernick, Kathryn A Carolin, Mark Segel, David Bouwman, Daniel Visscher. Mod Pathol 2002
Michelle Bonnett, Tracy Wallis, Michelle Rossmann, Nat L Pernick, Kathryn A Carolin, Mark Segel, David Bouwman, Daniel Visscher. Mod Pathol 2002
12
Predicting invasion in patients with DCIS in the preoperative percutaneous biopsy.
Junnu Leikola, Päivi Heikkilä, Martti Pamilo, Kaisa Salmenkivi, Karl Von Smitten, Marjut Leidenius. Acta Oncol 2007
Junnu Leikola, Päivi Heikkilä, Martti Pamilo, Kaisa Salmenkivi, Karl Von Smitten, Marjut Leidenius. Acta Oncol 2007
30
The finding of invasive cancer after a preoperative diagnosis of ductal carcinoma-in-situ: causes of ductal carcinoma-in-situ underestimates with stereotactic 14-gauge needle biopsy.
Lidewij E Hoorntje, Marguerite E I Schipper, Petra H M Peeters, Frank Bellot, Remmert K Storm, Inne H M Borel Rinkes. Ann Surg Oncol 2003
Lidewij E Hoorntje, Marguerite E I Schipper, Petra H M Peeters, Frank Bellot, Remmert K Storm, Inne H M Borel Rinkes. Ann Surg Oncol 2003
12
Axillary sentinel lymph node biopsy in patients with pure ductal carcinoma in situ of the breast.
Mattia Intra, Paolo Veronesi, Giovanni Mazzarol, Viviana Galimberti, Alberto Luini, Virgilio Sacchini, Giuseppe Trifirò, Oreste Gentilini, Giancarlo Pruneri, Paola Naninato,[...]. Arch Surg 2003
Mattia Intra, Paolo Veronesi, Giovanni Mazzarol, Viviana Galimberti, Alberto Luini, Virgilio Sacchini, Giuseppe Trifirò, Oreste Gentilini, Giancarlo Pruneri, Paola Naninato,[...]. Arch Surg 2003
12
Value of sentinel lymph node biopsy in breast ductal carcinoma in situ upstaged to invasive carcinoma.
Rita Sakr, Martine Antoine, Emmanuel Barranger, Gil Dubernard, Christine Salem, Emile Daraï, Serge Uzan. Breast J 2008
Rita Sakr, Martine Antoine, Emmanuel Barranger, Gil Dubernard, Christine Salem, Emile Daraï, Serge Uzan. Breast J 2008
13
American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer.
Gary H Lyman, Armando E Giuliano, Mark R Somerfield, Al B Benson, Diane C Bodurka, Harold J Burstein, Alistair J Cochran, Hiram S Cody, Stephen B Edge, Sharon Galper,[...]. J Clin Oncol 2005
Gary H Lyman, Armando E Giuliano, Mark R Somerfield, Al B Benson, Diane C Bodurka, Harold J Burstein, Alistair J Cochran, Hiram S Cody, Stephen B Edge, Sharon Galper,[...]. J Clin Oncol 2005
12
Ductal carcinoma in situ and sentinel lymph node biopsy.
Bok Kyoung Son, Jin Gu Bong, Sung Hwan Park, Young Ju Jeong. J Breast Cancer 2011
Bok Kyoung Son, Jin Gu Bong, Sung Hwan Park, Young Ju Jeong. J Breast Cancer 2011
15
Intraductal carcinoma of the breast (208 cases). Clinical factors influencing treatment choice.
M J Silverstein, J R Waisman, P Gamagami, E D Gierson, W J Colburn, R J Rosser, P S Gordon, B S Lewinsky, A Fingerhut. Cancer 1990
M J Silverstein, J R Waisman, P Gamagami, E D Gierson, W J Colburn, R J Rosser, P S Gordon, B S Lewinsky, A Fingerhut. Cancer 1990
12
Factors associated with upstaging of ductal carcinoma in situ diagnosed by core needle biopsy using imaging guidance.
Cholatip Wiratkapun, Pachara Patanajareet, Bussanee Wibulpholprasert, Panuwat Lertsithichai. Jpn J Radiol 2011
Cholatip Wiratkapun, Pachara Patanajareet, Bussanee Wibulpholprasert, Panuwat Lertsithichai. Jpn J Radiol 2011
42
Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.