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Times Cited: 3005
Times Cited: 3005
Times Cited
Times Co-cited
Similarity
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Kiichi Nakahira, Jeffrey Adam Haspel, Vijay A K Rathinam, Seon-Jin Lee, Tamas Dolinay, Hilaire C Lam, Joshua A Englert, Marlene Rabinovitch, Manuela Cernadas, Hong Pyo Kim,[...]. Nat Immunol 2011
Kiichi Nakahira, Jeffrey Adam Haspel, Vijay A K Rathinam, Seon-Jin Lee, Tamas Dolinay, Hilaire C Lam, Joshua A Englert, Marlene Rabinovitch, Manuela Cernadas, Hong Pyo Kim,[...]. Nat Immunol 2011
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Kenichi Shimada, Timothy R Crother, Justin Karlin, Jargalsaikhan Dagvadorj, Norika Chiba, Shuang Chen, V Krishnan Ramanujan, Andrea J Wolf, Laurent Vergnes, David M Ojcius,[...]. Immunity 2012
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Jianjin Shi, Yue Zhao, Kun Wang, Xuyan Shi, Yue Wang, Huanwei Huang, Yinghua Zhuang, Tao Cai, Fengchao Wang, Feng Shao. Nature 2015
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Thioredoxin-interacting protein links oxidative stress to inflammasome activation.
Rongbin Zhou, Aubry Tardivel, Bernard Thorens, Inpyo Choi, Jürg Tschopp. Nat Immunol 2010
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
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The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation.
Nathan Kelley, Devon Jeltema, Yanhui Duan, Yuan He. Int J Mol Sci 2019
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MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition.
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
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Pharmacological Inhibitors of the NLRP3 Inflammasome.
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Non-canonical inflammasome activation targets caspase-11.
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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.
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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.
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NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.
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K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.
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Critical role for calcium mobilization in activation of the NLRP3 inflammasome.
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Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation.
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics.
Karen V Swanson, Meng Deng, Jenny P-Y Ting. Nat Rev Immunol 2019
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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Hexin Shi, Ying Wang, Xiaohong Li, Xiaoming Zhan, Miao Tang, Maggy Fina, Lijing Su, David Pratt, Chun Hui Bu, Sara Hildebrand,[...]. Nat Immunol 2016
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Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome.
Takuma Misawa, Michihiro Takahama, Tatsuya Kozaki, Hanna Lee, Jian Zou, Tatsuya Saitoh, Shizuo Akira. Nat Immunol 2013
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Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors.
Yang Yang, Huanan Wang, Mohammed Kouadir, Houhui Song, Fushan Shi. Cell Death Dis 2019
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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
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Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity.
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Targeting the NLRP3 inflammasome in inflammatory diseases.
Matthew S J Mangan, Edward J Olhava, William R Roush, H Martin Seidel, Gary D Glick, Eicke Latz. Nat Rev Drug Discov 2018
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Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death.
Jianjin Shi, Wenqing Gao, Feng Shao. Trends Biochem Sci 2017
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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.
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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction.
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A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation.
Jonathan L Schmid-Burgk, Dhruv Chauhan, Tobias Schmidt, Thomas S Ebert, Julia Reinhardt, Elmar Endl, Veit Hornung. J Biol Chem 2016
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Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
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Tranilast directly targets NLRP3 to treat inflammasome-driven diseases.
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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Catherine Dostert, Virginie Pétrilli, Robin Van Bruggen, Chad Steele, Brooke T Mossman, Jürg Tschopp. Science 2008
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Inflammasomes: mechanism of assembly, regulation and signalling.
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The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation.
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PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.
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NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice.
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Mechanism and Regulation of NLRP3 Inflammasome Activation.
Yuan He, Hideki Hara, Gabriel Núñez. Trends Biochem Sci 2016
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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.
Paul M Ridker, Brendan M Everett, Tom Thuren, Jean G MacFadyen, William H Chang, Christie Ballantyne, Francisco Fonseca, Jose Nicolau, Wolfgang Koenig, Stefan D Anker,[...]. N Engl J Med 2017
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Interplay Between NLRP3 Inflammasome and Autophagy.
Monika Biasizzo, Nataša Kopitar-Jerala. Front Immunol 2020
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The role of mitochondria in NLRP3 inflammasome activation.
Qiuyun Liu, Danyan Zhang, Diyu Hu, Xiangmei Zhou, Yang Zhou. Mol Immunol 2018
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Gout-associated uric acid crystals activate the NALP3 inflammasome.
Fabio Martinon, Virginie Pétrilli, Annick Mayor, Aubry Tardivel, Jürg Tschopp. Nature 2006
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Inflammasomes in health and disease.
Till Strowig, Jorge Henao-Mejia, Eran Elinav, Richard Flavell. Nature 2012
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Mitochondrial DNA stress primes the antiviral innate immune response.
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6
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Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.