A citation-based method for searching scientific literature

Roberto Zoncu, Alejo Efeyan, David M Sabatini. Nat Rev Mol Cell Biol 2011
Times Cited: 2824







List of co-cited articles
454 articles co-cited >1



Times Cited
  Times     Co-cited
Similarity


mTOR signaling in growth control and disease.
Mathieu Laplante, David M Sabatini. Cell 2012
19

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
17

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.
Joungmok Kim, Mondira Kundu, Benoit Viollet, Kun-Liang Guan. Nat Cell Biol 2011
11

AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M Gwinn, David B Shackelford, Daniel F Egan, Maria M Mihaylova, Annabelle Mery, Debbie S Vasquez, Benjamin E Turk, Reuben J Shaw. Mol Cell 2008
10

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival.
Timothy R Peterson, Mathieu Laplante, Carson C Thoreen, Yasemin Sancak, Seong A Kang, W Michael Kuehl, Nathanael S Gray, David M Sabatini. Cell 2009
839
9

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex.
D D Sarbassov, David A Guertin, Siraj M Ali, David M Sabatini. Science 2005
9

mTOR at the nexus of nutrition, growth, ageing and disease.
Grace Y Liu, David M Sabatini. Nat Rev Mol Cell Biol 2020
504
8

Defining the role of mTOR in cancer.
David A Guertin, David M Sabatini. Cancer Cell 2007
7

Molecular mechanisms of mTOR-mediated translational control.
Xiaoju Max Ma, John Blenis. Nat Rev Mol Cell Biol 2009
7

AKT/PKB signaling: navigating downstream.
Brendan D Manning, Lewis C Cantley. Cell 2007
6

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J Yang, Meredith Miller, Angela Yang, Ankita Dhar, Nikola P Pavletich. Nature 2017
201
6

Hallmarks of cancer: the next generation.
Douglas Hanahan, Robert A Weinberg. Cell 2011
6

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.
Chang Hwa Jung, Chang Bong Jun, Seung-Hyun Ro, Young-Mi Kim, Neil Michael Otto, Jing Cao, Mondira Kundu, Do-Hyung Kim. Mol Biol Cell 2009
6

mTOR Signaling in Growth, Metabolism, and Disease.
Robert A Saxton, David M Sabatini. Cell 2017
944
6

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.
Morris E Feldman, Beth Apsel, Aino Uotila, Robbie Loewith, Zachary A Knight, Davide Ruggero, Kevan M Shokat. PLoS Biol 2009
850
6

TOR signaling in growth and metabolism.
Stephan Wullschleger, Robbie Loewith, Michael N Hall. Cell 2006
6

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Jessie E King, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Cell 2002
6

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Estela Jacinto, Robbie Loewith, Anja Schmidt, Shuo Lin, Markus A Rüegg, Alan Hall, Michael N Hall. Nat Cell Biol 2004
6

Ras, PI(3)K and mTOR signalling controls tumour cell growth.
Reuben J Shaw, Lewis C Cantley. Nature 2006
5

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Kathryn E O'Reilly, Fredi Rojo, Qing-Bai She, David Solit, Gordon B Mills, Debra Smith, Heidi Lane, Francesco Hofmann, Daniel J Hicklin, Dale L Ludwig,[...]. Cancer Res 2006
5

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli,[...]. Autophagy 2016
5

mTOR signalling and cellular metabolism are mutual determinants in cancer.
Dirk Mossmann, Sujin Park, Michael N Hall. Nat Rev Cancer 2018
302
5

Regulation of mTORC1 by PI3K signaling.
Christian C Dibble, Lewis C Cantley. Trends Cell Biol 2015
413
5

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.
Ken Inoki, Yong Li, Tian Xu, Kun-Liang Guan. Genes Dev 2003
5

Mechanism and medical implications of mammalian autophagy.
Ivan Dikic, Zvulun Elazar. Nat Rev Mol Cell Biol 2018
5

Autophagy in the pathogenesis of disease.
Beth Levine, Guido Kroemer. Cell 2008
5

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.
Vanessa S Rodrik-Outmezguine, Masanori Okaniwa, Zhan Yao, Chris J Novotny, Claire McWhirter, Arpitha Banaji, Helen Won, Wai Wong, Mike Berger, Elisa de Stanchina,[...]. Nature 2016
215
5

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
D D Sarbassov, Siraj M Ali, Do-Hyung Kim, David A Guertin, Robert R Latek, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Curr Biol 2004
5

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
Robbie Loewith, Estela Jacinto, Stephan Wullschleger, Anja Lorberg, José L Crespo, Débora Bonenfant, Wolfgang Oppliger, Paul Jenoe, Michael N Hall. Mol Cell 2002
5

PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.
Lauren M Thorpe, Haluk Yuzugullu, Jean J Zhao. Nat Rev Cancer 2015
748
4


The hallmarks of aging.
Carlos López-Otín, Maria A Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer. Cell 2013
4

Methods in mammalian autophagy research.
Noboru Mizushima, Tamotsu Yoshimori, Beth Levine. Cell 2010
4



Understanding the Warburg effect: the metabolic requirements of cell proliferation.
Matthew G Vander Heiden, Lewis C Cantley, Craig B Thompson. Science 2009
4

Regulation of cancer cell metabolism.
Rob A Cairns, Isaac S Harris, Tak W Mak. Nat Rev Cancer 2011
4

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.
Christian C Dibble, Brendan D Manning. Nat Cell Biol 2013
470
4

A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
QiWen Fan, Ozlem Aksoy, Robyn A Wong, Shirin Ilkhanizadeh, Chris J Novotny, William C Gustafson, Albert Yi-Que Truong, Geraldine Cayanan, Erin F Simonds, Daphne Haas-Kogan,[...]. Cancer Cell 2017
88
4

mTOR as a central hub of nutrient signalling and cell growth.
Joungmok Kim, Kun-Liang Guan. Nat Cell Biol 2019
381
4

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.
Carmine Settembre, Roberto Zoncu, Diego L Medina, Francesco Vetrini, Serkan Erdin, SerpilUckac Erdin, Tuong Huynh, Mathieu Ferron, Gerard Karsenty, Michel C Vellard,[...]. EMBO J 2012
4

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.
Michelle C Mendoza, E Emrah Er, John Blenis. Trends Biochem Sci 2011
4

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.
Yiqun Zhang, Patrick Kwok-Shing Ng, Melanie Kucherlapati, Fengju Chen, Yuexin Liu, Yiu Huen Tsang, Guillermo de Velasco, Kang Jin Jeong, Rehan Akbani, Angela Hadjipanayis,[...]. Cancer Cell 2017
252
4

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.
Yasemin Sancak, Liron Bar-Peled, Roberto Zoncu, Andrew L Markhard, Shigeyuki Nada, David M Sabatini. Cell 2010
4

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation.
Andrew Y Choo, Sang-Oh Yoon, Sang Gyun Kim, Philippe P Roux, John Blenis. Proc Natl Acad Sci U S A 2008
604
4

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Kim. Nat Cell Biol 2007
830
4

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling.
Tsuneo Ikenoue, Ken Inoki, Qian Yang, Xiaoming Zhou, Kun-Liang Guan. EMBO J 2008
471
4

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth.
Jingxiang Huang, Brendan D Manning. Biochem J 2008
808
4

A unifying model for mTORC1-mediated regulation of mRNA translation.
Carson C Thoreen, Lynne Chantranupong, Heather R Keys, Tim Wang, Nathanael S Gray, David M Sabatini. Nature 2012
898
4

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.
Do-Hyung Kim, D D Sarbassov, Siraj M Ali, Robert R Latek, Kalyani V P Guntur, Hediye Erdjument-Bromage, Paul Tempst, David M Sabatini. Mol Cell 2003
681
4


Co-cited is the co-citation frequency, indicating how many articles cite the article together with the query article. Similarity is the co-citation as percentage of the times cited of the query article or the article in the search results, whichever is the lowest. These numbers are calculated for the last 100 citations when articles are cited more than 100 times.